List of works - Leonidas Stamatatos

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

scientific article

Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection

scientific article

Characteristics of the earliest cross-neutralizing antibody response to HIV-1.

scientific article

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

scientific article published on 25 March 2013

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

scientific article

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

scientific article

Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope

scientific article

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

scientific article

N-linked glycosylation of the V3 loop and the immunologically silent face of gp120 protects human immunodeficiency virus type 1 SF162 from neutralization by anti-gp120 and anti-gp41 antibodies

scientific article published on April 2004

Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs

scientific article

Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles

scientific article

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.

scientific article published on 24 February 2016

The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner

scientific article

Changes in the immunogenic properties of soluble gp140 human immunodeficiency virus envelope constructs upon partial deletion of the second hypervariable region

scientific article

Purification and characterization of oligomeric envelope glycoprotein from a primary R5 subtype B human immunodeficiency virus

scientific article

HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies.

scientific article

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

scientific article published on September 2016

Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies

scientific article

Antibody responses elicited in macaques immunized with human immunodeficiency virus type 1 (HIV-1) SF162-derived gp140 envelope immunogens: comparison with those elicited during homologous simian/human immunodeficiency virus SHIVSF162P4 and heterolo

scientific article

Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.

scientific article

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

scientific article published on April 2017

Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies

scientific article

Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses

scientific article

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

scientific article published on 28 August 2017

HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA

scientific article

Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection

scientific article

Macaques infected with a CCR5-tropic simian/human immunodeficiency virus (SHIV) develop broadly reactive anti-HIV neutralizing antibodies

scientific article published on 28 March 2007

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1

scientific article

Epitope specificities of broadly neutralizing plasmas from HIV-1 infected subjects

scientific article

Prospects of HIV Env modification as an approach to HIV vaccine design

scientific article

Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies

scientific article

Binding interactions between soluble HIV envelope glycoproteins and quaternary-structure-specific monoclonal antibodies PG9 and PG16.

scientific article

Interactions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing Activity

scientific article

Broadly Neutralizing Antibodies Developed by an HIV-Positive Elite Neutralizer Exact a Replication Fitness Cost on the Contemporaneous Virus

scientific article published on September 12, 2012

Emergence of broadly neutralizing antibodies and viral coevolution in two subjects during the early stages of infection with human immunodeficiency virus type 1

scientific article

Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV-1 Env glycoprotein when combined with IL-21 and IL-15 gene delivery

scientific article published on July 2006

Structural basis for germline antibody recognition of HIV-1 immunogens

scientific article published on 21 March 2016

Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens

scientific article published on 4 March 2016

A multivalent clade C HIV-1 Env trimer cocktail elicits a higher magnitude of neutralizing antibodies than any individual component

scientific article

Generation and evaluation of clade C simian-human immunodeficiency virus challenge stocks

scientific article

Isolation and characterization of monoclonal antibodies elicited by trimeric HIV-1 Env gp140 protein immunogens

scientific article

Engineering, Expression, Purification, and Characterization of Stable Clade A/B Recombinant Soluble Heterotrimeric gp140 Proteins

scientific article published on October 26, 2011

Comparative immunogenicity of subtype a Human Immunodeficiency Virus type 1 envelope exhibiting differential exposure of conserved neutralization epitopes

scientific article

Role of neutralizing antibodies in HIV infection

scientific article published on January 2003

Characterization of neutralizing antibody responses elicited by clade A envelope immunogens derived from early transmitted viruses

scientific article published on 9 April 2008

Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10

scientific article published on September 25, 2014

Soluble HIV-1 envelope immunogens derived from an elite neutralizer elicit cross-reactive V1V2 antibodies and low potency neutralizing antibodies

scientific article published on 23 January 2014

Repertoire comparison of the B-cell receptor-encoding loci in humans and rhesus macaques by next-generation sequencing

scientific article published on 22 July 2016

Motif-optimized subtype A HIV envelope-based DNA vaccines rapidly elicit neutralizing antibodies when delivered sequentially

scientific article

Silibinin Inhibits HIV-1 Infection by Reducing Cellular Activation and Proliferation

scientific article published on July 25, 2012

List of works by Leonidas Stamatatos

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection

Characteristics of the earliest cross-neutralizing antibody response to HIV-1.

Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

N-linked glycosylation of the V3 loop and the immunologically silent face of gp120 protects human immunodeficiency virus type 1 SF162 from neutralization by anti-gp120 and anti-gp41 antibodies

Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs

Identification of a new quaternary neutralizing epitope on human immunodeficiency virus type 1 virus particles

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.

The V1, V2, and V3 regions of the human immunodeficiency virus type 1 envelope differentially affect the viral phenotype in an isolate-dependent manner

Changes in the immunogenic properties of soluble gp140 human immunodeficiency virus envelope constructs upon partial deletion of the second hypervariable region

Purification and characterization of oligomeric envelope glycoprotein from a primary R5 subtype B human immunodeficiency virus

HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies.

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies

Antibody responses elicited in macaques immunized with human immunodeficiency virus type 1 (HIV-1) SF162-derived gp140 envelope immunogens: comparison with those elicited during homologous simian/human immunodeficiency virus SHIVSF162P4 and heterolo

Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies

Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA

Early preservation of CXCR5+ PD-1+ helper T cells and B cell activation predict the breadth of neutralizing antibody responses in chronic HIV-1 infection

Macaques infected with a CCR5-tropic simian/human immunodeficiency virus (SHIV) develop broadly reactive anti-HIV neutralizing antibodies

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1

Epitope specificities of broadly neutralizing plasmas from HIV-1 infected subjects

Prospects of HIV Env modification as an approach to HIV vaccine design

Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies

Binding interactions between soluble HIV envelope glycoproteins and quaternary-structure-specific monoclonal antibodies PG9 and PG16.

Interactions between Lipids and Human Anti-HIV Antibody 4E10 Can Be Reduced without Ablating Neutralizing Activity

Broadly Neutralizing Antibodies Developed by an HIV-Positive Elite Neutralizer Exact a Replication Fitness Cost on the Contemporaneous Virus

Emergence of broadly neutralizing antibodies and viral coevolution in two subjects during the early stages of infection with human immunodeficiency virus type 1

Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV-1 Env glycoprotein when combined with IL-21 and IL-15 gene delivery

Structural basis for germline antibody recognition of HIV-1 immunogens

Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens

A multivalent clade C HIV-1 Env trimer cocktail elicits a higher magnitude of neutralizing antibodies than any individual component

Generation and evaluation of clade C simian-human immunodeficiency virus challenge stocks

Isolation and characterization of monoclonal antibodies elicited by trimeric HIV-1 Env gp140 protein immunogens

Engineering, Expression, Purification, and Characterization of Stable Clade A/B Recombinant Soluble Heterotrimeric gp140 Proteins

Comparative immunogenicity of subtype a Human Immunodeficiency Virus type 1 envelope exhibiting differential exposure of conserved neutralization epitopes

Role of neutralizing antibodies in HIV infection

Characterization of neutralizing antibody responses elicited by clade A envelope immunogens derived from early transmitted viruses

Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10

Soluble HIV-1 envelope immunogens derived from an elite neutralizer elicit cross-reactive V1V2 antibodies and low potency neutralizing antibodies

Repertoire comparison of the B-cell receptor-encoding loci in humans and rhesus macaques by next-generation sequencing

Motif-optimized subtype A HIV envelope-based DNA vaccines rapidly elicit neutralizing antibodies when delivered sequentially

Silibinin Inhibits HIV-1 Infection by Reducing Cellular Activation and Proliferation