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List of works by Stephen Friend

A Crowdsourcing Approach to Developing and Assessing Prediction Algorithms for AML Prognosis

scientific article

A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients

scientific article

A functional assay for heterozygous mutations in the GTPase activating protein related domain of the neurofibromatosis type 1 gene.

scientific article published in March 1995

A functional screen for germ line p53 mutations based on transcriptional activation ⬇️

scientific article published on December 15, 1992

A gene-expression signature as a predictor of survival in breast cancer

scientific article (publication date: 19 December 2002)

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

scientific article (publication date: October 1986)

A network view of disease and compound screening

scientific article published in April 2009

A new paradigm for drug discovery: integrating clinical, genetic, genomic and molecular phenotype data to identify drug targets

scientific article

A simple recipe for drug interaction networks earns its stars

scientific article published on 01 April 2006

A systems genetics study of swine illustrates mechanisms underlying human phenotypic traits

scientific article

Accelerating drug discovery: Open source cancer cell biology?

scientific article published on November 2006

Acute pulmonary response and lung burden following solid surface composite dust inhalation ⬇️

abstract published in 2023

Alfred Knudson: The importance of a visionary who enables scientists ⬇️

scientific article published on December 1, 2003

An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines

scientific article published on February 1996

An accelerated pathway for targeted cancer therapies.

scientific article

An information-intensive approach to the molecular pharmacology of cancer.

scientific article published on January 1997

Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases.

scientific article published on 11 April 2016

Anti-oncogenes and the negative regulation of cell growth

scientific article published in January 1988

App-enabled trial participation: Tectonic shift or tepid rumble?

scientific article

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

scientific article (publication date: 14 July 1988)

Breast cancer information on the web ⬇️

scientific article published on 01 November 1995

CANCER. The cancer predisposition revolution

scientific article published on 01 May 2016

Cancer biomarkers--an invitation to the table

scientific article

Cancer risks from germ line tumor suppressor gene mutations

scientific article published on 01 January 1991

Cancer risks from germline p53 mutations ⬇️

scientific article published on November 1, 1992

Cancer. Potential of the synthetic lethality principle

scientific article

Challenges in identifying cancer genes by analysis of exome sequencing data.

scientific article

Characterization of different consumable wires in a novel thermal spray coating aerosol generator and inhalation exposure system ⬇️

abstract published in 2022

Characterization of human Gadd45, a p53-regulated protein

scientific article

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

scientific article published on October 1997

Charge-site communication in proteins: electrostatic heme linkage of azide binding by sperm whale myoglobin

scientific article published in June 1980

Cheap DNA arrays-it's not all smoke and mirrors

scientific article published on 01 October 1999

Combined long-term effects of metal nanocatalysts and UVB on human epidermal keratinocytes ⬇️

abstract published in 2023

Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection

scientific article published on 06 November 2018

Combining tumor genome simulation with crowdsourcing to benchmark somatic single-nucleotide-variant detection

scientific article published on 18 May 2015

Constant denaturant gel electrophoresis as a rapid screening technique for p53 mutations

scientific article published on October 1991

Contributions of individual amino acid residues to the structural stability of cetacean myoglobins

scientific article published in December 1983

Correction for Bernards et al., Structure and Expression of the Murine Retinoblastoma Gene and Characterization of its Encoded Protein, PNAS 1989 86:6474-6478

scholarly article

Correction: a Li-Fraumeni syndrome p53 mutation

scientific article published in February 1993

Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

scientific article published on 23 August 2016

Crowdsourcing biomedical research: leveraging communities as innovation engines

scientific article (publication date: 15 July 2016)

Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge

scientific article

Database of genomic biomarkers for cancer drugs and clinical targetability in solid tumors

scientific article

Deletions of a DNA sequence in retinoblastomas and mesenchymal tumors: organization of the sequence and its encoded protein

scientific article

Detecting the impact of subject characteristics on machine learning-based diagnostic applications

scientific article published on 11 October 2019

Developing Predictive Molecular Maps of Human Disease through Community-based Modeling

Developing Predictive Molecular Maps of Human Disease through Community-based Modeling

Developing predictive molecular maps of human disease through community-based modeling

scientific article (publication date: 27 January 2012)

Development of a thermal spray coating aerosol generator and inhalation exposure system

journal article published in 2022

Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay.

scientific article

Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae

scientific article published on 01 January 2000

Drug target validation and identification of secondary drug target effects using DNA microarrays

scientific article published on 01 November 1998

Electrostatic stabilization in myoglobin. Interactive free energies between individual sites

scientific article published on October 1979

Electrostatic stabilization in myoglobin. pH dependence of summed electrostatic contributions

scientific article published on October 1979

Embracing complexity, inching closer to reality

scientific article

Enabling transparent and collaborative computational analysis of 12 tumor types within The Cancer Genome Atlas

scientific article

Equal transcription of wild-type and mutant p53 using bicistronic vectors results in the wild-type phenotype

scientific article published on 01 February 1994

Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis

scientific article published on 10 October 2016

Erratum: Prediction of human population responses to toxic compounds by a collaborative competition

article

Evaluation of Combined Artificial Intelligence and Radiologist Assessment to Interpret Screening Mammograms

scientific article published on 02 March 2020

Evaluation of pulmonary effects of 3-D printer emissions from acrylonitrile butadiene styrene using an air-liquid interface model of primary normal human-derived bronchial epithelial cells

journal article published in 2022

Evaluation of pulmonary effects of 3-D printer emissions from acrylonitrile butadiene styrene using an air-liquid interface model of primary normal human-derived bronchial epithelial cells (dataset) ⬇️

research dataset published in 2022

Evaluation of pulmonary effects of 3D printer emissions from acrylonitrile butadiene styrene using an air-liquid interface model of primary normal human-derived bronchial epithelial cells ⬇️

abstract published in 2022

Expression profiling predicts outcome in breast cancer

scientific article

Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer

scientific article (publication date: April 2001)

First, design for data sharing

scientific article

Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

scientific article (publication date: 6 August 1999)

Functional discovery via a compendium of expression profiles

scientific article

Gene expression changes associated with progression and response in chronic myeloid leukemia

scholarly article

Gene expression profiling predicts clinical outcome of breast cancer

scientific article (publication date: 31 January 2002)

Genetic selection of peptide inhibitors of biological pathways.

scientific article

Genetic sequences that predispose to retinoblastoma and osteosarcoma

scientific article

Genetics of gene expression surveyed in maize, mouse and man

scientific article (publication date: 20 March 2003)

Genome-wide methylation profiles reveal quantitative views of human aging rates

scientific article

Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer

scientific article published on 01 January 1996

Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein ⬇️

scientific article published on July 15, 1992

Germ-line mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms

scientific article published on 01 March 1997

Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.

scientific article published on March 1995

Germline mutations of the p53 tumor suppressor gene in children with osteosarcoma

scientific article published on 01 May 1994

Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms

scientific article published on May 14, 1992

Global optimization of somatic variant identification in cancer genomes with a global community challenge

scientific article

How molecular profiling could revolutionize drug discovery

scientific article

Identification of cancer-prone individuals: p53 and family cancer syndromes.

scientific article published on January 1992

Impact of bioinformatic procedures in the development and translation of high-throughput molecular classifiers in oncology.

scientific article published on 18 June 2013

Impact of centralization on aCGH-based genomic profiles for precision medicine in oncology

scientific article

Improvement of size-selective sampling of diesel aerosols in underground mines

conference proceedings item published in 2023

Improving breast cancer survival analysis through competition-based multidimensional modeling

scientific article

In vitro toxicity assessment of spinel ferrite nanoparticles and UVB co-exposure in human epidermal keratinocytes ⬇️

abstract published in 2024

In vivo and in vitro toxicity of a stainless-steel aerosol generated during thermal spray coating

journal article published in 2022

Inferring causal molecular networks: empirical assessment through a community-based effort

scientific article

Influence of impurities from manufacturing process on the toxicity profile of boron nitride nanotubes

journal article published in 2022

Integrating Genetic Approaches into the Discovery of Anticancer Drugs ⬇️

scientific article published on November 7, 1997

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.

scientific article published on March 1990

Leveraging crowdsourcing to facilitate the discovery of new medicines

scientific article

Leveraging models of cell regulation and GWAS data in integrative network-based association studies

scientific article (publication date: 27 July 2012)

Lithium-ion battery explosion aerosols: morphology and elemental composition

journal article published in 2021

Lung toxicity in rats after inhalation of aerosols generated during thermal spray coating using different consumable materials ⬇️

abstract published in 2023

Lung toxicity, deposition, and clearance of thermal spray coating particles with different metal profiles after inhalation in rats

journal article published in 2023

Metcalfe's law and the biology information commons ⬇️

scientific article published on 01 April 2013

Mining the NCI Anticancer Drug Discovery Databases: Genetic Function Approximation for the QSAR Study of Anticancer Ellipticine Analogues ⬇️

scientific article published on March 1, 1998

Mining the National Cancer Institute Anticancer Drug Discovery Database: Cluster Analysis of Ellipticine Analogs with p53-Inverse and Central Nervous System-Selective Patterns of Activity ⬇️

scientific article published on February 1, 1998

Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients

scientific article

Mutational analysis of the carboxy-terminal portion of p53 using both yeast and mammalian cell assays in vivo

scientific article published on April 1995

Oncogenes and tumor-suppressing genes

scientific article published on March 1988

Opening Up to Precompetitive Collaboration ⬇️

scientific article published on 01 October 2010

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints ⬇️

scientific article published on January 2, 1998

Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure

journal article published in 2021

PERSONALIZED HYPOTHESIS TESTS FOR DETECTING MEDICATION RESPONSE IN PARKINSON DISEASE PATIENTS USING iPHONE SENSOR DATA.

scientific article

Peracetic acid effects on human bronchial cells in an air liquid interface ⬇️

abstract published in 2024

Point: Are we prepared for the future doctor visit?

scientific article published in March 2011

Precompetitive Data Sharing as a Catalyst to Address Unmet Needs in Parkinson's Disease

scientific article

Prediction of human population responses to toxic compounds by a collaborative competition

scientific article

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data

scientific article

Predictive genes in adjacent normal tissue are preferentially altered by sCNV during tumorigenesis in liver cancer and may rate limiting

scientific article (publication date: 2011)

Predictive, personalized, preventive, participatory (P4) cancer medicine

scientific article

Prolonged survival of a child with metastatic retinoblastoma.

scientific article published in September 1987

Pulmonary evaluation of whole-body inhalation exposure of polycarbonate (PC) filament 3D printer emissions in rats ⬇️

abstract published in 2023

Pulmonary evaluation of whole-body inhalation exposure of polycarbonate (PC) filament 3D printer emissions in rats

journal article published in 2024

Pulmonary inflammation response comparison of nano-clay to machined dusts of nano-clay-enabled composite ⬇️

abstract published in 2021

Q&A: Stephen Friend on a Bioinformation Commons ⬇️

scientific article published on July 19, 2012

Recommendations on predictive testing for germ line p53 mutations among cancer-prone individuals

scientific article

Screening patients for heterozygous p53 mutations using a functional assay in yeast

scientific article published on 01 October 1993

Secondary breast cancer in patients presenting with osteosarcoma: possible involvement of germline p53 mutations.

scientific article

Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles

scientific article

Signatures of environmental exposures using peripheral leukocyte gene expression: tobacco smoke.

scientific article

Small interfering RNA screens reveal enhanced cisplatin cytotoxicity in tumor cells having both BRCA network and TP53 disruptions

scientific article published on 25 September 2006

Smartphones as new tools in the management and understanding of Parkinson's disease

scientific article published on 3 March 2016

Social interactomes for enabling research communities

scientific article published on November 2014

Something in common

scientific article published on 01 July 2010

Something wiki this way comes. Interview by Bryn Nelson

scientific article published in March 2009

Stephen Friend: The hunt for "unexpected genetic heroes"

TED2014

Strange bedfellows in even stranger places: the role of ATM in meiotic cells, lymphocytes, tumors, and its functional links to p53.

scientific article published on October 1996

Structure and expression of the Xenopus retinoblastoma gene

scientific article published on September 1, 1992

Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein

scientific article

Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.

scientific article

Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer

scientific article

Systematic assessment of analytical methods for drug sensitivity prediction from cancer cell line data

scientific article

The NIH BD2K center for big data in translational genomics

scientific article

The Precompetitive Space: Time to Move the Yardsticks

article published in 2011

The Prostate Cancer DREAM Challenge: A Community-Wide Effort to Use Open Clinical Trial Data for the Quantitative Prediction of Outcomes in Metastatic Prostate Cancer

scientific article

The Stream algorithm: computationally efficient ridge-regression via Bayesian model averaging, and applications to pharmacogenomic prediction of cancer cell line sensitivity

scientific article published on January 2014

The Use of Smartphones for Health Research

scientific article

The consensus molecular subtypes of colorectal cancer

scientific article

The importance of p53 gene alterations in human cancer: is there more than circumstantial evidence?

scientific article published on October 1993

The inconvenience of data of convenience: computational research beyond post-mortem analyses

scientific article

The mPower study, Parkinson disease mobile data collected using ResearchKit

scientific article

The magic of microarrays

scientific article published on 01 February 2002

Thirteenth annual pezcoller symposium: focusing analytical tools on complexity in cancer

scientific article published in July 2002

Toxicogenomics and drug discovery: will new technologies help us produce better drugs?

scientific article published on 01 January 2002

Translational genomics. Clues from the resilient

scientific article

US-EU Scientific Research Collaborations: Sage Bionetworks’ Experience Navigating the Complex Regulatory Landscape

Understanding toxicity associated with boron nitride nanotubes: review of toxicity studies, exposure assessment at manufacturing facilities, and read-across

journal article published in 2022

Unlocking stress and forecasting its consequences with digital technology

scientific article published on 31 July 2019

Using Patient-Initiated Study Participation in the Development of Evidence for Personalized Cancer Therapy ⬇️

scientific article published on November 1, 2011

Widespread aneuploidy revealed by DNA microarray expression profiling

scientific article published in July 2000

p53: a glimpse at the puppet behind the shadow play

scientific article

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