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List of works by Andrey Korshunov

A biobank of patient-derived pediatric brain tumor models

scientific article published on 22 October 2018

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing.

scientific article

A comprehensive multicenter comparison of whole genome sequencing pipelines using a uniform tumor-normal sample pair

A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors

scientific article published on 11 September 2017

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat

scientific article

A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

scientific article published on 01 November 2020

AT-03ATYPICAL TERATOID/RHABDOID TUMOUR IS A GENETICALLY HOMOGENEOUS BUT EPIGENETICALLY HETEROGENEOUS DISEASE THAT IS DEFINED BY SUBGROUP SPECIFIC SUPER-ENHANCERS.

scientific article published on 21 April 2015

AT-10ATYPICAL TERATOID RHABDOID TUMORS AND POORLY DIFFERENTIATED CHORDOMAS: DISTINCT MOLECULAR ENTITIES WITH SMARCB1/INI1 LOSS AND DISMAL PROGNOSIS.

scientific article published on 30 May 2016

ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

scientific article published on 27 November 2014

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis

scientific article

Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling

scientific article published on 01 September 2018

Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

scientific article published on 25 November 2012

Absence of chromosome 19q13.41 amplification in a case of atypical teratoid/rhabdoid tumor with ependymoblastic differentiation

Abstract 3089: (Epi)genetic profiling enables molecular re-classification of CNS-primitive neuroectodermal tumors

Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups

Abstract LB-198: Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

Accumulation of genomic aberrations during clinical progression of medulloblastoma

scientific article published on 15 August 2008

Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data

scientific article published on 17 December 2020

Active medulloblastoma enhancers reveal subgroup-specific cellular origins

scientific article published on 27 January 2016

Acyl-CoA-Binding Protein Drives Glioblastoma Tumorigenesis by Sustaining Fatty Acid Oxidation

scientific article published on 02 May 2019

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

scientific article published on 19 June 2015

Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification

scientific article published on 17 May 2010

Adult medulloblastoma comprises three major molecular variants.

scientific article

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

scientific article

An animal model of MYC-driven medulloblastoma

scientific article published on February 2012

An essential role for p38 MAPK in cerebellar granule neuron precursor proliferation

scientific article published on April 2012

An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data

scientific article published on 31 May 2020

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

scientific article published on 29 January 2011

Analysis of the IDH1 codon 132 mutation in brain tumors

scientific article

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

scientific article published on 21 March 2018

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

scientific article

BAF complexes facilitate decatenation of DNA by topoisomerase IIα

scientific article published on 22 May 2013

BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas

scientific article published on May 2008

Biological and clinical heterogeneity of MYCN-amplified medulloblastoma.

scientific article

CSF1R inhibition depletes tumor-associated macrophages and attenuates tumor progression in a mouse sonic Hedgehog-Medulloblastoma model

scientific article published on 06 November 2020

Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors

scientific article published on 27 October 2009

Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.

scientific article published on 20 March 2017

Chromosomal imbalances in clear cell ependymomas.

scientific article published on 28 April 2006

Clinical utility of fluorescence in situ hybridization (FISH) in nonbrainstem glioblastomas of childhood.

scientific article published in September 2005

Clonal selection drives genetic divergence of metastatic medulloblastoma

scientific article published on 15 February 2012

Combined molecular analysis of BRAF and IDH1 distinguishes pilocytic astrocytoma from diffuse astrocytoma.

scientific article published on 19 June 2009

Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

scientific article

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

scientific article published on 27 December 2018

Corrigendum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

scientific article published in Nature

Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome

scientific article published on 6 July 2016

Cytogenetic prognostication within medulloblastoma subgroups

scientific article published on 03 February 2014

DNA copy number alterations in central primitive neuroectodermal tumors and tumors of the pineal region: an international individual patient data meta-analysis

scientific article

DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas

scientific article published on 01 February 2019

DNA methylation-based classification of central nervous system tumours

scientific article published on 14 March 2018

DNA topoisomerase II-alpha and cyclin A immunoexpression in meningiomas and its prognostic significance: an analysis of 263 cases

scientific article published in September 2002

DNA-methylation profiling discloses significant advantages over NanoString method for molecular classification of medulloblastoma

scientific article published on 13 October 2017

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

scientific article

Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation.

scientific article published on 12 February 2018

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

scientific article published in Nature Communications

Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma

scientific article

Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations

article

Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles

scientific article published on 02 March 2019

Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma

scientific article published on 10 May 2013

Differential nuclear ATRX expression in sarcomas

scientific article published on 20 August 2015

Dissecting the genomic complexity underlying medulloblastoma

scientific article

Distinct Histomorphology in Molecular Subgroups of Glioblastomas in Young Patients

scientific article published on 14 March 2016

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

scientific article published on 24 October 2013

Divergent clonal selection dominates medulloblastoma at recurrence

scientific article published on 13 January 2016

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

scientific article (publication date: 29 January 2012)

Droplet digital PCR is a powerful technique to demonstrate frequent FGFR1 duplication in dysembryoplastic neuroepithelial tumors

scientific article published on 25 October 2016

Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas.

scientific article

EMBR-10. GENOMIC COMPLEXITY AND EVOLUTION OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR)

EMBR-12. IMPROVED DIAGNOSTIC ALGORITHM FOR DIFFERENTIAL DIAGNOSTICS OF CNS EMBRYONAL TUMORS (FORMER CNS-PNET) BY NEUROPATHOLOGICAL RE-EVALUATION OF 256 CASES AND CROSSVALIDATION BY METHYLATION CLASSIFICATION

EMBR-15. DIAGNOSTIC RE-EVALUATION AND POOLED CLINICAL DATA ANALYSIS OF PATIENTS WITH PREVIOUS DIAGNOSIS OF CNS-PNET

EP-03MOLECULAR CLASSIFICATION OF EPENDYMAL TUMORS ACROSS ALL CNS COMPARTMENTS, HISTOPATHOLOGICAL GRADES AND AGE GROUPS.

scientific article published on 21 April 2015

EPEN-06. YAP1 SUBGROUP SUPRATENTORIAL EPENDYMOMA REQUIRES TEAD AND NUCLEAR FACTOR I-MEDIATED TRANSCRIPTIONAL PROGRAMS FOR TUMORIGENESIS

scientific article published on 23 April 2019

EPEN-23. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA

EPEN-24. YAP1 FUSION PROTEINS MEDIATE ONCOGENIC ACTIVITY IN EPENDYMOMA VIA INTERACTION WITH TEAD TRANSCRIPTION FACTORS.

scientific article published on 22 June 2018

EPEN-28. HETEROGENEITY WITHIN THE PFB EPENDYMOMA SUBGROUP.

scientific article published on 22 June 2018

EPIGENOME ALTERATIONS DEFINE LETHAL CIMP POSITIVE EPENDYMOMAS OF INFANCY.

scientific article published in July 2014

EPN-30YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE.

scientific article published on 30 May 2016

EPN-31MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

scientific article published on 30 May 2016

EPND-07. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

scientific article published on 31 May 2017

EPND-13. YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE.

scientific article

ETMR: a tumor entity in its infancy

scientific article published on 29 June 2020

Embryonal tumor with abundant neuropil and true rosettes (ETANTR) with loss of morphological but retained genetic key features during progression

scientific article published on 06 November 2011

Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity

scientific article

Emerging insights into the ependymoma epigenome

scientific article published on March 2013

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

scientific article

Epithelioid Glioblastomas and Anaplastic Epithelioid Pleomorphic Xanthoastrocytomas--Same Entity or First Cousins?

scientific article

Epithelioid glioblastomas stratify into established diagnostic subsets upon integrated molecular analysis.

scientific article

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

scientific article published on 17 December 2016

FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

scientific article

FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.

scientific article

FORETINIB IS EFFECTIVE THERAPY FOR METASTATIC SONIC HEDGEHOG MEDULLOBLASTOMA.

scientific article published in July 2014

FSTL5 is a marker of poor prognosis in non-WNT/non-SHH medulloblastoma

scientific article

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes.

scientific article published on 21 April 2010

Foretinib is effective therapy for metastatic sonic hedgehog medulloblastoma.

scientific article

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

scientific article

Functional characterization of a BRAF insertion mutant associated with pilocytic astrocytoma

scientific article published on 25 July 2011

Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation

scientific article published on 20 August 2020

GENE-06. DISTINCT MOLECULAR SUBGROUPS OF TUMORS OF THE PINEAL REGION CORRELATE WITH CLINICAL PARAMETERS AND GENETIC ALTERATIONS

scientific article published on 23 April 2019

GENE-12. ANAPLASTIC NEUROEPITHELIAL TUMOR WITH CONDENSED NUCLEI (ANTCON): A NOVEL BRAIN TUMOR ENTITY WITH RECURRENT NTRK FUSION

GENE-13. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

scientific article published on 23 April 2019

Gain of 12p encompassing CCND2 is associated with gemistocytic histology in IDH mutant astrocytomas

scientific article published on 20 December 2016

Gains at the 1p36 chromosomal region are associated with symptomatic leptomeningeal dissemination of supratentorial glioblastomas.

scientific article published in April 2007

Gene Expression Patterns in Ependymomas Correlate with Tumor Location, Grade, and Patient Age ⬇️

scientific article published on November 1, 2003

Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas

scientific article published on 24 May 2011

Genetic confirmation that ependymoma can arise as part of multiple endocrine neoplasia type 1 (MEN1) syndrome.

scientific article published on 25 February 2017

Genetically distinct and clinically relevant subtypes of glioblastoma defined by array-based comparative genomic hybridization (array-CGH).

scientific article published on 24 March 2006

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

scientific article

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

scientific article

Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma

scientific article

Genomic and expression profiling of glioblastoma stem cell-like spheroid cultures identifies novel tumor-relevant genes associated with survival

scientific article published on 27 October 2009

Genomic and protein expression profiling identifies CDK6 as novel independent prognostic marker in medulloblastoma

scientific article

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

scientific article published on 01 April 2020

H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers

scientific article published on 11 April 2017

HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.

scientific article

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth

scientific article published on 22 April 2010

HGNET-BCOR Tumors of the Cerebellum: Clinicopathologic and Molecular Characterization of 3 Cases

scientific article published on 12 July 2017

Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma

scientific article published on 11 March 2012

Heterogeneity within the PF-EPN-B ependymoma subgroup

article

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

scientific article published on 19 October 2015

Histology and molecular pathology of pediatric brain tumors

scientific article

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

scientific article published on 20 November 2020

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

scientific article published in October 2012

Hypermutation of the inactive X chromosome is a frequent event in cancer

scientific article published on 17 October 2013

ICGC PedBrain - dissecting the genomic complexity underlying medulloblastoma using whole-genome sequencing.

scientific article

IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO.

scientific article published on 12 May 2015

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

scientific article published on 07 November 2019

Identification of CD24 as a marker of Patched1 deleted medulloblastoma-initiating neural progenitor cells

scientific article published in PLoS ONE

Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma

scientific article

Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome

scientific article

Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome

scientific article published on 01 May 2003

Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome

scientific article

Immunohistochemical markers for prognosis of anaplastic astrocytomas.

scientific article published in July 2002

Immunohistochemical markers for prognosis of cerebral glioblastomas

scientific article published in July 2002

Immunohistochemical markers for prognosis of ependymal neoplasms

scientific article published in July 2002

Immunohistochemical markers for prognosis of oligodendroglial neoplasms

scientific article published in July 2002

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

scientific article published on 10 July 2014

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

scientific article published on 10 March 2015

Integrating Tenascin-C protein expression and 1q25 copy number status in pediatric intracranial ependymoma prognostication: A new model for risk stratification

scientific article

International Society Of Neuropathology--Haarlem consensus guidelines for nervous system tumor classification and grading

scientific article published on 10 September 2014

International network of cancer genome projects

scientific article

Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC.

scientific article

Intratumoral platelet aggregate formation in a murine preclinical glioma model depends on podoplanin expression on tumor cells

scientific article published on 01 April 2019

Isochromosome breakpoints on 17p in medulloblastoma are flanked by different classes of DNA sequence repeats

scientific article (publication date: 2006)

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course

scientific article published on 28 September 2019

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

scientific article

LGG-04. CHARACTERIZATION OF ONCOGENE-INDUCED SENESCENCE AND THE ROLE OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA.

scientific article published on 31 May 2017

LGG-11. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA.

scientific article published on 22 June 2018

LGG-20. MOLECULARLY-DEFINED DIFFUSE LEPTOMENINGEAL GLIONEURONAL TUMOR (DLGNT) COMPRISES TWO SUBGROUPS WITH DISTINCT CLINICAL AND GENETIC FEATURES

LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)

scientific article published on 16 November 2012

Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation

scientific article published on 12 March 2018

Long-term survival in a case of ETANTR with histological features of neuronal maturation after therapy

scientific article published on 20 February 2015

Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma

scientific article published on 20 August 2016

MB-08MOLECULAR (RE-)CLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS.

scientific article published on 21 April 2015

MB-18DYSFUNCTION OF THE CHROMATIN REMODELER Chd7 CAUSES ABNORMAL CEREBELLAR DEVELOPMENT AND ACCELERATES MEDULLOBLASTOMA FORMATION.

scientific article published on 30 May 2016

MBCL-35. CURRENT PROGNOSTIC FACTORS AND TREATMENT RESULTS IN YOUNG CHILDREN MEDULLOBLASTOMAS

MBCL-44. THE MOLECULAR AND CLINICAL LANDSCAPE OF INFANT MEDULLOBLASTOMA (iMB): RESULTS AND MOLECULAR ANALYSIS FROM A PROSPECTIVE, MULTICENTER PHASE II TRIAL (SJYC07)

MBRS-07. BCOR LOSS IMPACTS SHH MEDULLOBLASTOMA FORMATION VIA TRANSCRIPTIONAL UP-REGULATION OF

MEDU-11. MOLECULAR CHARACTERIZATION OF ETMRs REVEALS A ROLE FOR R-LOOP MEDIATED CHROMOSOMAL INSTABILITY

scientific article published on 23 April 2019

MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION

MOLECULAR (RE-)CLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS.

scientific article published in July 2014

MPTH-15MOLECULAR RECLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS INTO WELL-KNOWN AND NOVEL TUMOR ENTITIES.

scientific article

MPTH-23DISTINCT MORPHOLOGY IN MOLECULAR SUBGROUPS OF GLIOBLASTOMA IN YOUNG PATIENTS.

scientific article

MPTH-26MOLECULAR REFINEMENT OF PEDIATRIC POSTERIOR FOSSA EPENDYMOMA.

scientific article

MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma

scientific article published on 3 December 2011

MYCN amplification drives an aggressive form of spinal ependymoma

scientific article published on 14 August 2019

Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis

scientific article published on 11 June 2012

Medulloblastoma comprises four distinct molecular variants

scientific article published on 07 September 2010

Medulloblastoma subgroups remain stable across primary and metastatic compartments

scientific article

Medulloblastomics: the end of the beginning

scientific article published on December 2012

Medulloepithelioma with peculiar clinical presentation, stem cell phenotype and aberrant DNA-methylation profile

scientific article published on 29 June 2015

Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups

scientific article published on 28 January 2016

MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma

scientific article published on 2 December 2011

Microarray-based screening for molecular markers in medulloblastoma revealed STK15 as independent predictor for survival.

scientific article published in May 2004

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

scientific article

Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation

scientific article published on 03 February 2021

Molecular approaches to ependymoma: the next step(s).

scientific article published on December 2012

Molecular characterization of medulloblastomas with extensive nodularity (MBEN).

scientific article published on 22 March 2018

Molecular diagnostics of CNS embryonal tumors

scientific article published on 30 September 2010

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

scientific article published on 16 June 2018

Molecular profiling of long-term survivors identifies a subgroup of glioblastoma characterized by chromosome 19/20 co-gain

scientific article published on May 2015

Molecular progression of SHH-activated medulloblastomas

scientific article published on 27 April 2019

Molecular staging of intracranial ependymoma in children and adults

scientific article published in June 2010

Molecular stratification of diagnostically challenging high-grade gliomas composed of small cells: the utility of fluorescence in situ hybridization.

scientific article published in December 2004

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

scientific article published on 25 November 2019

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

scientific article

Molecular subgroups of medulloblastoma: the current consensus

scientific article

Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features.

scientific article

Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay

scientific article published on 26 September 2020

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas

scientific article published on 16 February 2013

Myxoid glioneuronal tumor of the septum pellucidum and lateral ventricle is defined by a recurrent PDGFRA p.K385 mutation and DNT-like methylation profile

scientific article published on 13 July 2018

NEXT-GENERATION NEUROPATHOLOGY - IMPROVING DIAGNOSTIC ACCURACY FOR BRAIN TUMORS USING DNA METHYLATION ARRAY-BASED MOLECULAR PROFILING.

scientific article published in July 2014

NFM-11. PEDIATRIC MENINGIOMAS ARE MOLECULARLY DISTINCT FROM ADULT COUNTERPARTS

article published in 2018

Nestin Mediates Hedgehog Pathway Tumorigenesis

scientific article

Nestin expression identifies ependymoma patients with poor outcome

scientific article published on 30 May 2012

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

scientific article

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

scientific article published on 15 December 2015

Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age.

scientific article published on 10 September 2015

Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort

scientific article published on 24 April 2020

Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes.

scientific article

Novel oncogene amplifications in tumors from a family with Li-Fraumeni syndrome

scientific article published in July 2009

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas

scientific article published on 23 April 2018

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

scientific article published on 20 March 2011

Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci

scientific article (publication date: April 2009)

Overcoming multiple drug resistance mechanisms in medulloblastoma.

scientific article

PATH-32. MOLECULAR HETEROGENEITY AMONG PEDIATRIC POSTERIOR FOSSA EPENDYMOMA

PCM-15SOMATIC CRISPR/Cas9-MEDIATED TUMOR SUPPRESSOR DISRUPTION ENABLES VERSATILE BRAIN TUMOR MODELING.

scientific article

PCM-20PRE-CLINICAL DRUG SCREEN IN A PDX ETMR MOUSE MODEL.

scientific article

PDTM-38. PEDIATRIC MENINGIOMAS ARE CHARACTERIZED BY DISTINCT METHYLATION PROFILES DIFFERENT FROM ADULT MENINGIOMAS

PDTM-47. CHARACTERIZATION OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA AND ITS ROLE IN ONCOGENE-INDUCED SENESCENCE

PDTM-49. GLOBAL REDUCTION IN H3K27me3, SIMILAR TO H3K27M MUTANT GLIOMAS, IS A MOLECULAR SURROGATE FOR PEDIATRIC POSTERIOR FOSSA- GROUP A EPENDYMOMAS

scientific article published on 6 November 2017

PNR-12GENOME-WIDE PROFILING OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR).

scientific article published on 30 May 2016

PNR-21FOUR NEW BRAIN TUMOR ENTITIES EMERGE FROM MOLECULAR CLASSIFICATION OF CNS PNETs

scientific article published on 30 May 2016

PNR-23SHH AND WNT SIGNALLING ARE UPREGULATED IN HUMAN INTRAOCULAR MEDULLOEPITHELIOMA AND LEAD TO RETINAL TUMOR-LIKE LESIONS IN THE MOUSE.

scientific article published on 30 May 2016

PROGNOSTIC AND PREDICTIVE BIOMARKER-BASED SUBGROUPS IN THE NOA-04 TRIAL.

scientific article published in July 2014

PROGNOSTIC SIGNIFICANCE OF CLINICAL, HISTOPATHOLOGICAL, AND MOLECULAR CHARACTERISTICS OF MEDULLOBLASTOMAS IN THE PROSPECTIVE HIT2000 MULTICENTER CLINICAL TRIAL COHORT

PTPS-11ATYPICAL TERATOID/RHABDOID TUMOUR IS AN EPIGENETICALLY HETEROGENEOUS DISEASE CHARACTERIZED BY SUBGROUP SPECIFIC SUPER-ENHANCERS.

scientific article

Paired box gene 8 (PAX8) expression is associated with sonic hedgehog (SHH)/wingless int (WNT) subtypes, desmoplastic histology and patient survival in human medulloblastomas

scientific article published in February 2015

Papillary Tumor of the Pineal Region: A Distinct Molecular Entity

scientific article

Papillary glioneuronal tumor (PGNT) exhibits a characteristic methylation profile and fusions involving PRKCA

scientific article published on 13 February 2019

Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors

scientific article published on 7 October 2015

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

scientific article

Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas.

scientific article

Pilocytic Astrocytoma demethylation and transcriptional landscapes link bZIP transcription factors to immune response

scientific article published on 13 February 2020

Poorly differentiated chordoma with SMARCB1/INI1 loss: a distinct molecular entity with dismal prognosis

scientific article published on 11 April 2016

Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation

scientific article published on 15 November 2019

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.

scientific article

Pre-clinical drug screen reveals topotecan, actinomycin D and volasertib as potential new therapeutic candidates for ETMR brain tumor patients

scientific article published on 08 May 2017

Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1

scientific article published on 16 January 2019

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.

scientific article

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

scientific article published on 20 November 2020

Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort

scientific article

Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

scientific article published on 11 March 2016

Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups

scientific article published on 01 September 2018

Quantification of telomere features in tumor tissue sections by an automated 3D imaging-based workflow

scientific article

Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma

scientific article published on 19 June 2014

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

scientific article published on 20 September 2021

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

scientific article published on 6 November 2011

Real-time PCR assay based on the differential expression of microRNAs and protein-coding genes for molecular classification of formalin-fixed paraffin embedded medulloblastomas

scientific article

Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

scientific article published on 17 October 2013

Recurrent cytogenetic aberrations in central neurocytomas and their biological relevance.

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Recurrent fusions in PLAGL1 define a distinct subset of pediatric-type supratentorial neuroepithelial tumors

scientific article published on 05 August 2021

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

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Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

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Reply to J.C. Lindsey et al

Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial

scientific article published on 16 May 2018

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

scientific article published on 14 May 2013

Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma

scientific article

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions

scientific article published on 05 July 2019

Sarcoma classification by DNA methylation profiling

scientific article published on 21 January 2021

Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes

scientific article published on 10 May 2019

Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling

scientific article published on 11 June 2015

Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas

scientific article

Somatostatin receptor subtype 2 (sst₂) is a potential prognostic marker and a therapeutic target in medulloblastoma

scientific article published on 16 May 2013

Sorafenib plus valproic acid for infant spinal glioblastoma

scientific article published on August 2010

Spatial heterogeneity in medulloblastoma

scientific article published on 10 April 2017

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas

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Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

scientific article

Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype.

scientific article

Spinal metastasis of gliosarcoma: array-based comparative genomic hybridization for confirmation of metastatic spread

scientific article published on 22 July 2014

Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma

scientific article published in March 2009

Subgroup-specific prognostic implications of TP53 mutation in medulloblastoma

scientific article published on 08 July 2013

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

scientific article

Supratentorial primitive neuroectodermal tumors of the central nervous system frequently harbor deletions of the CDKN2A locus and other genomic aberrations distinct from medulloblastomas

scientific article

TBIO-10. PEDIATRIC TARGETED THERAPY 2.0: DEVELOPMENT OF PERSONALIZED PEDIATRIC ONCOLOGY

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

scientific article published on 31 October 2013

TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma

scientific article

TRTH-09. PTT2.0: DEVELOPING PERSONALIZED PEDIATRIC ONCOLOGY.

scientific article published on 31 May 2017

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

scientific article

Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival

scientific article published on 15 May 2014

Telomerase activation in posterior fossa group A ependymomas is associated with dismal prognosis and chromosome 1q gain

scientific article

Telomere dysfunction and chromothripsis

scientific article published on 9 February 2016

The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis

scientific article

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

scientific article published on 07 December 2018

The Shh receptor Boc promotes progression of early medulloblastoma to advanced tumors

scientific article published on 25 September 2014

The clinical implications of medulloblastoma subgroups

scientific article published on 08 May 2012

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

scientific article

The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

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The histologic grade is a main prognostic factor for patients with intracranial ependymomas treated in the microneurosurgical era: an analysis of 258 patients.

scientific article published in March 2004

The molecular landscape of ETMR at diagnosis and relapse

scientific article published on 04 December 2019

The next generation of glioma biomarkers: MGMT methylation, BRAF fusions and IDH1 mutations

scientific article published on January 2011

The prognostic relevance of molecular alterations in glioblastomas for patients age < 50 years

scientific article published in August 2005

The transcription factor evi-1 is overexpressed, promotes proliferation, and is prognostically unfavorable in infratentorial ependymomas

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The whole-genome landscape of medulloblastoma subtypes

scientific article published in July 2017

Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis

scientific article published on 06 June 2016

Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling

scientific article published on 20 December 2017

Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment

scientific article published on 11 December 2015

Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker

scientific article published on 28 November 2019

Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

scientific article published on 28 October 2019

Ultra high-risk PFA ependymoma is characterized by loss of chromosome 6q

scientific article published on 01 August 2021

Update on molecular and genetic alterations in adult medulloblastoma

scientific article

WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

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YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

scientific article published on 02 September 2019

YAP1-fusions in pediatric NF2-wildtype meningioma

scientific article published on 16 November 2019

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