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List of works by Sima Lev

A disaccharide derived from chondroitin sulphate proteoglycan promotes central nervous system repair in rats and mice

scientific article published in October 2004

A recombinant ectodomain of the receptor for the stem cell factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses ⬇️

scientific article (publication date: 25 May 1992)

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

scientific article

A specific combination of substrates is involved in signal transduction by the kit-encoded receptor.

scientific article published in March 1991

Accelerating AXL targeting for TNBC therapy

scientific article published in 2021

Activation of Pyk2 by stress signals and coupling with JNK signaling pathway

scientific article

BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators

scientific article published on 03 September 2021

Cellular and developmental distribution of human homologues of the Drosophilia rdgB protein in the rat retina.

scientific article

Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells

scientific journal article

Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport

scientific article

Correction: Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis

scientific article published on 01 January 2020

Correction: The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis (doi:10.1242/jcs.155721)

scientific article published on 07 March 2019

Deficiency of the Cog8 subunit in normal and CDG-derived cells impairs the assembly of the COG and Golgi SNARE complexes

scientific article

Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices

scientific journal article

Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction

scientific article

Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor ⬇️

scientific article published on August 5, 1992

Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing

scientific article

Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein

scientific article

Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase ⬇️

scientific article published on January 15, 1992

Interspecies molecular chimeras of kit help define the binding site of the stem cell factor

scientific article published on April 1993

Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer

scientific article published on 01 January 2019

Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function.

scientific article

Mammalian PITPs at the Golgi and ER-Golgi Membrane Contact Sites

MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells

scientific article published on 20 December 2016

Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion.

scientific article

Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

scientific article published on 16 December 2020

Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance

Mouse Modeling Dissecting Macrophage-Breast Cancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis

Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis

scientific article

Nir2, a novel regulator of cell morphogenesis

scientific article

Non-vesicular lipid transport by lipid-transfer proteins and beyond

scientific article published on 08 September 2010

Nonvesicular Lipid Transfer from the Endoplasmic Reticulum ⬇️

scientific article published on October 1, 2012

Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors

scientific article published on 01 February 2022

PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop

scientific article

PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein

scientific article published on 24 September 2018

PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition.

scientific article

Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions

scientific article

Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response

scientific article published on 02 October 2020

RNA interference screen for human genes associated with West Nile virus infection

scientific article (publication date: 11 September 2008)

Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene ⬇️

scientific article published on November 1, 1990

Soluble c-kit proteins and antireceptor monoclonal antibodies confine the binding site of the stem cell factor ⬇️

scientific article published on February 25, 1993

Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops

scientific journal article

Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity.

scientific article published on 5 March 2010

Structure-function analyses of the kit receptor for the steel factor ⬇️

scientific article published on July 1, 1993

Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis

scientific article published on 21 August 2020

Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer.

scientific article published on 19 June 2018

Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis

scientific article published on 20 April 2020

Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain

scientific article

Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis

scientific article

Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells.

scientific article published on 6 February 2017

Tethering the assembly of SNARE complexes

scientific article

The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC

The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice

scientific article published on 30 April 2020

The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport

scientific article

The COG complex interacts with multiple Golgi SNAREs and enhances fusogenic assembly of SNARE complexes.

scientific article

The VAP protein family: from cellular functions to motor neuron disease

scientific article

The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin

scientific article

The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction

scientific article published on 01 January 1995

The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis

scientific article published on September 2014

The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling

scientific article published on 30 July 2013

The role of phosphatidylinositol-transfer proteins at membrane contact sites.

scientific article published on April 2016

The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling

scientific article published on July 2004

Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling

scientific article

VAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity

scientific article

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