List of works - Silvia Paoletta

2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition

scientific article published in December 2009

A Novel Generalized 3D-QSAR Model of Camptothecin Analogs

Agonist-bound structure of the human P2Y12 receptor

scientific article

Computational studies to predict or explain G protein coupled receptor polypharmacology

scientific article

Demystifying P2Y1 Receptor Ligand Recognition through Docking and Molecular Dynamics Analyses

scientific article

Discovery of novel A3 adenosine receptor ligands based on chromone scaffold

scientific article

Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?

scientific article published on 23 August 2011

Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes

scientific article

Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists

scientific article published on 9 November 2012

Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.

scientific article

Fluorescent ligands for adenosine receptors

scientific article published on 5 November 2012

In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists

scientific article

Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.

scientific article

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors

scientific article published on 16 October 2014

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information

scientific article

Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands.

scientific article

Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry

scientific article published in March 2012

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function

scientific article published on 2 April 2015

Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects.

scientific article

Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain

scientific article published on 03 July 2013

Receptor-driven identification of novel human A₃ adenosine receptor antagonists as potential therapeutic agents

scientific article published on January 2010

Revisiting a receptor-based pharmacophore hypothesis for human A(2A) adenosine receptor antagonists

scientific article published on 20 June 2013

Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

scientific article published on 20 May 2015

Species differences and mechanism of action of A3 adenosine receptor allosteric modulators

scientific article

Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners

scientific article (publication date: 2014)

Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity

scientific article

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

scientific article

Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor

scientific article published on 02 May 2016

Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor

scientific article

Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists

scientific article published in January 2015

Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility

scientific article published on 7 January 2011

Synthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators

scientific article

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process

scientific article

The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists

scientific article published on 14 March 2011

The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relation

scientific article published in April 2010

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

scientific article

Two disparate ligand-binding sites in the human P2Y1 receptor

scientific article

List of works by Silvia Paoletta

2-Phenylpyrazolo[4,3-d]pyrimidin-7-one as a new scaffold to obtain potent and selective human A3 adenosine receptor antagonists: new insights into the receptor-antagonist recognition

A Novel Generalized 3D-QSAR Model of Camptothecin Analogs

Agonist-bound structure of the human P2Y12 receptor

Computational studies to predict or explain G protein coupled receptor polypharmacology

Demystifying P2Y1 Receptor Ligand Recognition through Docking and Molecular Dynamics Analyses

Discovery of novel A3 adenosine receptor ligands based on chromone scaffold

Does the combination of optimal substitutions at the C²-, N⁵- and N⁸-positions of the pyrazolo-triazolo-pyrimidine scaffold guarantee selective modulation of the human A₃ adenosine receptors?

Exploring a 2-naphthoic acid template for the structure-based design of P2Y14 receptor antagonist molecular probes

Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists

Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.

Fluorescent ligands for adenosine receptors

In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists

Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders.

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information

Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands.

Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function

Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects.

Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain

Receptor-driven identification of novel human A₃ adenosine receptor antagonists as potential therapeutic agents

Revisiting a receptor-based pharmacophore hypothesis for human A(2A) adenosine receptor antagonists

Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

Species differences and mechanism of action of A3 adenosine receptor allosteric modulators

Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners

Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

Structure-Activity Analysis of Biased Agonism at the Human Adenosine A3 Receptor

Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor

Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists

Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility

Synthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process

The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists

The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relation

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

Two disparate ligand-binding sites in the human P2Y1 receptor