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List of works by Zhan-Guo Gao

"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists

scientific article

(N)-methanocarba 2,N6-disubstituted adenine nucleosides as highly potent and selective A3 adenosine receptor agonists.

scientific article

2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists

scientific article published on December 2006

A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists

scientific article

A2B adenosine receptor blockade inhibits growth of prostate cancer cells.

scientific article

A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy

scientific article

Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors

scientific article published on January 2006

Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells.

scientific article

Agonist-bound structure of the human P2Y12 receptor

scientific article

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor

scientific article published on 27 December 2017

Allosteric modulation and functional selectivity of G protein-coupled receptors.

scientific article published on January 2013

Allosteric modulation of purine and pyrimidine receptors

scientific article

Allosteric modulation of the adenosine family of receptors

scientific article

Application of the functionalized congener approach to dendrimer-based signaling agents acting through A(2A) adenosine receptors.

scientific article published on 04 July 2008

Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

scientific article

Author Correction: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y and P2Y receptors

scientific article published in Scientific Reports

Caged agonist of P2Y1 and P2Y12 receptors for light-directed facilitation of platelet aggregation.

scientific article published on 4 December 2007

Click modification in the N6 region of A3 adenosine receptor-selective carbocyclic nucleosides for dendrimeric tethering that preserves pharmacophore recognition.

scientific article published on 11 January 2012

Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety

scientific article

CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors

scientific article

Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor

scientific article published in October 2004

Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists

scientific article

Design of (N)-methanocarba adenosine 5'-uronamides as species-independent A3 receptor-selective agonists.

scientific article published on 4 April 2008

Design, synthesis and binding affinity of 3'-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands

scientific article published on March 2003

Design, synthesis, and anti-tumor activity of 4'-thionucleosides as potent and selective agonists at the human A3 adenosine receptor

scientific article published on January 2007

Design, synthesis, and biological activity of N6-substituted-4'-thioadenosines at the human A3 adenosine receptor

scientific article published on 05 April 2006

Dexamethasone enhances ATP-induced inflammatory responses in endothelial cells

scientific article

Differential allosteric modulation by amiloride analogues of agonist and antagonist binding at A(1) and A(3) adenosine receptors

scientific article

Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors.

scientific article

Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine.

scientific article

Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists

scientific article published on 08 June 2007

Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors

scientific article

Emerging adenosine receptor agonists

scientific article

Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates.

scientific article published on 23 October 2008

Evaluation of molecular modeling of agonist binding in light of the crystallographic structure of an agonist-bound A₂A adenosine receptor

scientific article published on 12 December 2011

Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands.

scientific article

Exploring human adenosine A3 receptor complementarity and activity for adenosine analogues modified in the ribose and purine moiety

scientific article

Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.

scientific article

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor

scientific article published on 20 June 2018

Flexible modulation of agonist efficacy at the human A3 adenosine receptor by the imidazoquinoline allosteric enhancer LUF6000

scientific article

Functionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.

scientific article

Functionally biased modulation of A(3) adenosine receptor agonist efficacy and potency by imidazoquinolinamine allosteric enhancers

scientific article

GPCR ligand dendrimer (GLiDe) conjugates: adenosine receptor interactions of a series of multivalent xanthine antagonists

scientific article

Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor

scientific article

In vivo phenotypic screening for treating chronic neuropathic pain: modification of C2-arylethynyl group of conformationally constrained A3 adenosine receptor agonists

scientific article

John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y Receptors

scientific article published on 16 October 2014

Limits of ligand selectivity from docking to models: in silico screening for A(1) adenosine receptor antagonists

scientific article

Modulation of G protein-coupled adenosine receptors by strategically functionalized agonists and antagonists immobilized on gold nanoparticles.

scientific article published on 20 November 2012

Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position

scientific article

Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffold

scientific article

N6-Substituted 5'-N-Methylcarbamoyl-4'-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation

scientific article published on 5 April 2017

N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor

scientific article published on August 2003

Neoceptors: reengineering GPCRs to recognize tailored ligands

scientific article published on 5 February 2007

New 8-substituted xanthiene derivatives as potent bronchodilators

scientific article published on 21 October 2005

Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor

scientific article published on April 2009

Novel fluorescent antagonist as a molecular probe in A(3) adenosine receptor binding assays using flow cytometry

scientific article published in March 2012

Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists

scientific article

Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species.

scientific article published on 28 October 2009

Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors ⬇️

scientific article

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function

scientific article published on 2 April 2015

On the selectivity of the Gαq inhibitor UBO-QIC: A comparison with the Gαi inhibitor pertussis toxin.

scientific article published on 5 March 2016

Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening

scientific article

Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists

scientific article

P2Y(13) receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells.

scientific article

P2Y6 nucleotide receptor activates PKC to protect 1321N1 astrocytoma cells against tumor necrosis factor-induced apoptosis ⬇️

scientific article

PEGylated dendritic unimolecular micelles as versatile carriers for ligands of G protein-coupled receptors

scientific article published on 28 September 2009

Partial agonists for A(3) adenosine receptors.

scientific article published on January 2004

Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists.

scientific article published on 6 March 2008

Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides.

scientific article

Programmable nanoscaffolds that control ligand display to a G-protein-coupled receptor in membranes to allow dissection of multivalent effects.

scientific article

Progress in the pursuit of therapeutic adenosine receptor antagonists

scientific article

Protection from myocardial ischemia/reperfusion injury by a positive allosteric modulator of the A₃ adenosine receptor

scientific article published on 19 October 2011

Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.

scientific article

Purinergic Signaling in Mast Cell Degranulation and Asthma

scientific article published on 22 December 2017

Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain

scientific article published on 03 July 2013

Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors.

scientific article

Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

scientific article published on 20 May 2015

Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors.

scientific article

Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters

scientific article

Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system

scientific article published on 07 August 2008

Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives

scientific article published on July 2002

Signaling of the Human P2Y(1) Receptor Measured by a Yeast Growth Assay with Comparisons to Assays of Phospholipase C and Calcium Mobilization in 1321N1 Human Astrocytoma Cells

scientific article

Species differences and mechanism of action of A3 adenosine receptor allosteric modulators

scientific article

Stereoselective synthesis of 1'-functionalized-4'-thionucleosides

scientific article published on January 2007

Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling

scientific article published on 26 January 2018

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary

scientific article published in September 2002

Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety.

scientific article

Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activity

scientific article

Structure of an agonist-bound human A2A adenosine receptor

scientific article

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

scientific article

Structure-Based Design of Reactive Nucleosides for Site-Specific Modification of the A2A Adenosine Receptor

scientific article

Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT2B/5HT2C Serotonin Receptor Antagonists

scientific article

Structure-Based Screening of Uncharted Chemical Space for Atypical Adenosine Receptor Agonists.

scientific article

Structure-activity relationships and molecular modeling of 1,2,4-triazoles as adenosine receptor antagonists

scientific article published on 30 July 2012

Structure-activity relationships of 2,N(6),5'-substituted adenosine derivatives with potent activity at the A2B adenosine receptor.

scientific article

Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor

scientific article published on January 2006

Structure-activity relationships of new 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric enhancers of the A3 adenosine receptor

scientific article published on June 2006

Structure-activity relationships of thiazole and thiadiazole derivatives as potent and selective human adenosine A3 receptor antagonists

scientific article

Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands.

scientific article published on 28 December 2011

Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists

scientific article published on 24 September 2008

Structure-based discovery of A2A adenosine receptor ligands

scientific article

Structure-guided design of A(3) adenosine receptor-selective nucleosides: combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions.

scientific article

Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.

scientific article published on 05 February 2014

Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility

scientific article published on 7 January 2011

Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography

scientific article published on January 2009

Synthesis and evaluation of 1,2,4-triazolo[1,5-c]pyrimidine derivatives as A2A receptor-selective antagonists

scientific article

Synthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators

scientific article

Synthesis and pharmacological characterization of [(125)I]MRS1898, a high-affinity, selective radioligand for the rat A(3) adenosine receptor.

scientific article published on 05 June 2008

Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process

scientific article

Synthesis of 3'-acetamidoadenosine derivatives as potential A3 adenosine receptor agonists

scientific article published on April 2008

Synthesis of 3'-ureidoadenosine analogues and their binding affinity to the A3 adenosine receptor

scientific article

Synthesis of N6-substituted 3'-ureidoadenosine derivatives as highly potent agonists at the mutant A3 adenosine receptor

scientific article published on January 2007

Synthesis of hypermodified adenosine derivatives as selective adenosine A3 receptor ligands

scientific article published on 2 November 2005

Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist

scientific article published on August 2002

The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells

scientific article published on 24 July 2012

The role of activated adenosine receptors in degranulation of human LAD2 mast cells.

scientific article

Translocation of arrestin induced by human A(3) adenosine receptor ligands in an engineered cell line: comparison with G protein-dependent pathways

scientific article

Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition Element

scientific article

Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions

scientific article

Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors

scientific article

Two disparate ligand-binding sites in the human P2Y1 receptor

scientific article

UDP-glucose acting at P2Y14 receptors is a mediator of mast cell degranulation

scientific article

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