List of works - John B Bruning

A comparison of steroid and lipid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis

scientific article published on 20 May 2020

An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C in Vitis vinifera

scientific article published on 04 September 2019

Biophysical Techniques for Distinguishing Ligand Binding Modes in Cytochrome P450 Monooxygenases

scientific article published on 24 February 2020

Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes

scientific article published in 2022

Combining random microseed matrix screening and the magic triangle for the efficient structure solution of a potential lysin from bacteriophage P68

scientific article published on 02 July 2019

D-alanine-D-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations

scientific article published on 25 April 2020

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex ⬇️

scientific article published on April 10, 2011

Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering

scientific article published in December 2022

Engineering C-C Bond Cleavage Activity into a P450 Monooxygenase Enzyme

scientific article published on 26 April 2023

Exploring the Factors which Result in Cytochrome P450 Catalyzed Desaturation Versus Hydroxylation

scientific article published on 14 December 2022

Investigating the Active Oxidants Involved in Cytochrome P450 Catalyzed Sulfoxidation Reactions

scientific article published on 27 December 2022

Investigation of the requirements for efficient and selective cytochrome P450 monooxygenase catalysis across different reactions

scientific article published on 13 November 2019

Nucleoside selectivity of Aspergillus fumigatus nucleoside-diphosphate kinase

scientific article published on 21 October 2020

Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase

scientific article published on 02 October 2018

Rational Design of a 310 -Helical PIP-Box Mimetic Targeting PCNA, the Human Sliding Clamp

scientific article published on 19 July 2018

Simplified heavy-atom derivatization of protein structures via co-crystallization with the MAD tetragon tetrabromoterephthalic acid

scientific article published in May 2021

Structural and functional characterisation of the cytochrome P450 enzyme CYP268A2 from Mycobacterium marinum

scientific article published on 17 January 2018

Structural insights into the role of the acid-alcohol pair of residues required for dioxygen activation in cytochrome P450 enzymes

scientific article published on 04 April 2020

Structure of the Apo Form of Bacillus stearothermophilus Phosphofructokinase ⬇️

scientific article published on January 11, 2012

Structure of the Mycobacterium tuberculosis d -Alanine: d -Alanine Ligase, a Target of the Antituberculosis Drug d -Cycloserine ⬇️

scientific article published on October 18, 2010

Structure of the sliding clamp from the fungal pathogen Aspergillus fumigatus (AfumPCNA) and interactions with Human p21.

scientific article

Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPARγ-Targeted Antidiabetics

scientific article published on 09 May 2017

Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads

scientific article published on 21 August 2019

Targeting PCNA with Peptide Mimetics for Therapeutic Purposes

scientific article published on 15 October 2019

The characterisation of two members of the cytochrome P450 CYP150 family: CYP150A5 and CYP150A6 from Mycobacterium marinum

scientific article published on 28 February 2019

The role of N-terminal heterocycles in hydrogen bonding to α-chymotrypsin

scientific article published on 14 December 2018

Unique Polypharmacology Nuclear Receptor Modulator Blocks Inflammatory Signaling Pathways

scientific article published on 15 April 2019

Unlocking the PIP-box: A peptide library reveals interactions that drive high-affinity binding to human PCNA

scientific article published on 01 January 2021

Vanishing white matter: Eukaryotic initiation factor 2B model and the impact of missense mutations

scientific article published on 12 January 2021

List of works by John B Bruning