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List of works by Tito Fojo

68Ga-DOTATATE PET/CT in the Localization of Head and Neck Paragangliomas Compared with Other Functional Imaging Modalities and CT/MRI

scientific article published on 12 November 2015

A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days.

scientific article published in May 2005

A Phase I study of infusional vinblastine in combination with the P-glycoprotein antagonist PSC 833 (valspodar).

scientific article published on September 2001

A Phase II Multi-Center Study of Bevacizumab in Combination with Ixabepilone in Subjects with Advanced Renal Cell Carcinoma

scientific article

A Serial Analysis of Gene Expression (SAGE) database analysis of chemosensitivity: comparing solid tumors with cell lines and comparing solid tumors from different tissue origins.

scientific article published in April 2004

A common pharmacophore for epothilone and taxanes: molecular basis for drug resistance conferred by tubulin mutations in human cancer cells

scholarly article

A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients

scientific article published on 25 January 2007

A novel approach to assess real-world efficacy of cancer therapy in metastatic prostate cancer. Analysis of national data on Veterans treated with abiraterone and enzalutamide

scientific article published on 01 August 2019

A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy.

scientific article

A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer.

scientific article

A pharmacodynamic study of the P-glycoprotein antagonist CBT-1® in combination with paclitaxel in solid tumors.

scientific article published on 13 March 2012

A phase I study of the P-glycoprotein antagonist tariquidar in combination with vinorelbine

scientific article

A phase I/II study of infusional vinblastine with the P-glycoprotein antagonist valspodar (PSC 833) in renal cell carcinoma

scientific article

A phase II clinical trial of ixabepilone (Ixempra; BMS-247550; NSC 710428), an epothilone B analog, in patients with metastatic renal cell carcinoma

scientific article published on 23 February 2010

A phase II trial of combination chemotherapy and surgical resection for the treatment of metastatic adrenocortical carcinoma: continuous infusion doxorubicin, vincristine, and etoposide with daily mitotane as a P-glycoprotein antagonist.

scientific article

ANG1005 for breast cancer brain metastases: correlation between 18F-FLT-PET after first cycle and MRI in response assessment.

scientific article

Aberrant transcription from an unrelated promoter can result in MDR-1 expression following drug selection in vitro and in relapsed lymphoma samples

scientific article published on 01 December 2005

Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism.

scientific article

Acetyl-L-carnitine and prevention of chemotherapy-induced peripheral neuropathy: can anything work?

scientific article published on January 2013

Adenovirus HSV-TK construct with thyroid-specific promoter: enhancement of activity and specificity with histone deacetylase inhibitors and agents modulating the camp pathway

scientific article

Adjuvant and neoadjuvant cancer therapies: A historical review and a rational approach to understand outcomes

scientific article published on 26 January 2019

Adjuvant mitotane for adrenocortical cancer--a recurring controversy

scientific article published on October 2008

Adrenocortical Cancer: A Molecularly Complex Disease Where Surgery Matters

scientific article published on October 2016

Alu-associated interstitial deletions and chromosomal re-arrangement in 2 human multidrug-resistant cell lines

scientific article

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells

scientific article

An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding domain

scientific article

An Appraisal of Clinically Meaningful Outcomes Guidelines for Oncology Clinical Trials

scientific article published on 9 June 2016

An information-intensive approach to the molecular pharmacology of cancer.

scientific article published on January 1997

Analyzing the pivotal trial that compared sunitinib and IFN-α in renal cell carcinoma, using a method that assesses tumor regression and growth.

scientific article published on 17 February 2012

Anti-Hu paraneoplastic brainstem encephalitis caused by a pancreatic neuroendocrine tumor presenting with central hypoventilation.

scientific article

Are patients with hormonally functional phaeochromocytoma and paraganglioma initially receiving a proper adrenoceptor blockade? A retrospective cohort study

scientific article published on 21 March 2016

Arsenic trioxide (As(2)O(3)): still a mystery

scientific article published on 01 May 2002

Assessing the Eventual Publication of Clinical Trial Abstracts Submitted to a Large Annual Oncology Meeting

scientific article published on 17 February 2016

BEZ235: When Promising Science Meets Clinical Reality

scientific article published on 26 August 2016

Bevacizumab and breast cancer: the E2100 outlier

scientific article published on 01 December 2010

Bevacizumab reduces the growth rate constants of renal carcinomas: a novel algorithm suggests early discontinuation of bevacizumab resulted in a lack of survival advantage

scientific article published on 30 September 2008

Biologically targeted cancer therapy and marginal benefits: are we making too much of too little or are we achieving too little by giving too much?

scientific article published on December 2010

Brain metastasis in patients with adrenocortical carcinoma: a clinical series

scientific article

Breast implant-associated anaplastic large cell lymphoma in a patient with Li-Fraumeni syndrome

scientific article

CDK4/6 Inhibition as a therapeutic strategy in breast cancer: palbociclib, ribociclib, and abemaciclib

scientific article published on 01 December 2017

CHARACTERISTICS AND OUTCOMES OF METASTATIC SDHB AND SPORADIC PHEOCHROMOCYTOMA/PARAGANGLIOMA: AN NATIONAL INSTITUTES OF HEALTH STUDY.

scientific article published on 2 November 2015

Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells

scientific article

Can mutations in gamma-actin modulate the toxicity of microtubule targeting agents?

scientific article published on 01 October 2006

Cancer drugs in the United States: Justum Pretium--the just price ⬇️

scientific article published on 06 May 2013

Cancer therapies and the problem of me too many

scientific article published in April 2017

Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma

scientific article published on 01 June 2006

Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.

scientific article

Challenges of evaluating the cardiac effects of anticancer agents

scientific article published on 01 July 2006

Characterization of adriamycin-resistant human breast cancer cells which display overexpression of a novel resistance-related membrane protein

scientific article published on June 1990

Characterization of gene rearrangements leading to activation of MDR-1.

scientific article published on 5 September 2006

Cisplatin Every 3 Weeks Versus Weekly With Definitive Concurrent Radiotherapy for Squamous Cell Carcinoma of the Head and Neck

scientific article published on 01 May 2019

Cisplatin versus cetuximab with definitive concurrent radiotherapy for head and neck squamous cell carcinoma: An analysis of veterans health affairs data

article

Clinical Reversal of Multidrug Resistance

scientific article published on 01 January 1996

Clinical reversal of multidrug resistance

scientific article published on 01 January 1996

Clinical trial results: Sharing results, speeding discoveries

scientific article published in January 2013

Clinical trial results: a clinical trial bazaar!

scientific article published on 25 March 2014

Clinical trials: New drug for pancreatic cancer highlights the dual effect of regulatory approvals

scientific article published on 23 February 2016

Colorectal Cancer Survival Gains and Novel Treatment Regimens: A Systematic Review and Analysis

scientific article published on 25 June 2015

Combination chemotherapy in advanced adrenocortical carcinoma

scientific article published on 2 May 2012

Combinations of paclitaxel and vinblastine and their effects on tubulin polymerization and cellular cytotoxicity: characterization of a synergistic schedule

scientific article published on 01 January 1998

Commentary: Novel therapies for cancer: why dirty might be better

scientific article published on March 2008

Comparison by Race of Conservative Management for Low-Risk and Intermediate-Risk Prostate Cancers in Veterans From 2004 to 2018

scientific article published on 01 September 2020

Complementation of two mutant p53: implications for loss of heterozygosity in cancer

scientific article

Conservation of the class I beta-tubulin gene in human populations and lack of mutations in lung cancers and paclitaxel-resistant ovarian cancers.

scientific article published in January 2002

Continued Tumor Reduction of Metastatic Pheochromocytoma/Paraganglioma Harboring Succinate Dehydrogenase Subunit B Mutations with Cyclical Chemotherapy

scientific article published on 5 April 2018

Continuing a cancer treatment despite tumor growth may be valuable: sunitinib in renal cell carcinoma as example

scientific article

Contribution of glutathione and glutathione-dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines ⬇️

scientific article published on November 11, 1991

Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy ⬇️

scientific article published on 01 August 1995

Correction: Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using Cu-plerixafor PET

Cuba Sí. Cancer No

scientific article published on 01 January 2018

Current approaches and recent developments in the management of head and neck paragangliomas

scientific article

Cytogenetic and molecular characterization of random chromosomal rearrangements activating the drug resistance gene, MDR1/P-glycoprotein, in drug-selected cell lines and patients with drug refractory ALL.

scientific article published on September 1998

Decade in review-funding in cancer research: National Cancer Institute awards-a work in progress

scientific article published on 14 October 2014

Delivering affordable cancer care in high-income countries

article

Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors

scientific article published on August 2005

Design of placebo-controlled randomized trials of anticancer agents: Ethical considerations based on a review of published trials

scientific article published on 25 October 2021

Desperation Oncology

scientific article published on 01 June 2018

Differential expression of cell adhesion genes: implications for drug resistance

scientific article

Differential modulation of P-glycoprotein transport by protein kinase inhibition ⬇️

scientific article published on September 7, 1993

Distribution of cancer genes in human chromosomes

scientific article published on 19 June 2020

Do patient access schemes for high-cost cancer drugs deliver value to society?-lessons from the NHS Cancer Drugs Fund

scientific article published on 27 April 2017

Drug resistance in adult lymphomas

scientific article published on January 1994

EPOCH chemotherapy: toxicity and efficacy in relapsed and refractory non-Hodgkin's lymphoma ⬇️

scientific article published on August 1, 1993

Editor's Note …Clinical Trial Reports: A New Section ⬇️

scientific article published on January 1, 2012

Efflux of rhodamine from CD56+ cells as a surrogate marker for reversal of P-glycoprotein-mediated drug efflux by PSC 833

scientific article published on 01 January 1999

Emerging Therapeutic Implications of STK11 Mutation: Case Series

scientific article published on 12 May 2020

Enhanced detection of treatment effects on metastatic colorectal cancer with volumetric CT measurements for tumor burden growth rate evaluation

scientific article published on 28 September 2020

Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics

scientific article

Enhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profile

scientific article published on September 2005

Epidemiologic trends in neuroendocrine tumors: An examination of incidence rates and survival of specific patient subgroups over the past 20 years

scientific article published on 01 August 2018

Epidermal growth factor receptor inhibitors: a moving target?

scientific article published in October 2005

Epothilones: a novel class of non-taxane microtubule-stabilizing agents

scientific article

Estimation of tumour regression and growth rates during treatment in patients with advanced prostate cancer: a retrospective analysis

scientific article published on 12 December 2016

Evidence for microtubule target engagement in tumors of patients receiving ixabepilone

scientific article published on December 2007

Ex vivo rapamycin generates apoptosis-resistant donor Th2 cells that persist in vivo and prevent hemopoietic stem cell graft rejection

scientific article

Expression of ATP binding cassette superfamily (multidrug resistance-1, multidrug resistance-associated protein, human canalicular multispecific organ anion transporter) mRNA in etoposide and m-AMSA resistant cell lines

scientific article published on 01 October 1997

Expression of DNA topoisomerases (I, II alpha, II beta) mRNA in etoposide- and mAMSA-resistant cell lines

scientific article published on December 1, 1997

Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation

scientific article published on October 1989

Expression of a multidrug resistance gene in human cancers

scientific article published on 01 January 1989

Expression of a multidrug-resistance gene in human tumors and tissues

scientific article

Expression of drug resistance genes in VP-16 and mAMSA-selected human carcinoma cells

scientific article

Expression of the mdr-1/P-170 gene in patients with acute lymphoblastic leukemia.

scientific article

Expression of the multidrug resistance, MDR1, gene in neuroblastomas

scientific article published on January 1990

Expression of the multidrug resistance-associated protein gene in refractory lymphoma: quantitation by a validated polymerase chain reaction assay

scientific article published on 01 May 1997

Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver.

scientific article

External beam radiation therapy in treatment of malignant pheochromocytoma and paraganglioma

scientific article

False-negative 123I-MIBG SPECT is most commonly found in SDHB-related pheochromocytoma or paraganglioma with high frequency to develop metastatic disease ⬇️

scientific article published on February 13, 2012

Female fertility following dose-adjusted EPOCH-R chemotherapy in primary mediastinal B-cell lymphomas

scientific article

From the guest editor: monitoring of therapeutic response to cancer treatment

scientific article published on 01 September 2009

Functional Imaging Signature of Patients Presenting with Polycythemia/Paraganglioma Syndromes

scientific article published on 23 March 2017

Gefitinib and erlotinib in metastatic non-small cell lung cancer: a meta-analysis of toxicity and efficacy of randomized clinical trials.

scientific article

Genetic and epigenetic modeling of the origins of multidrug-resistant cells in a human sarcoma cell line

scientific article

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

scientific article published in April 2003

Hazard ratios in cancer clinical trials--a primer.

scientific article published on 31 January 2012

High-Dose Sirolimus and Immune-Selective Pentostatin plus Cyclophosphamide Conditioning Yields Stable Mixed Chimerism and Insufficient Graft-versus-Tumor Responses

scientific article

Histone deacetylase inhibitor FR901228 enhances adenovirus infection of hematopoietic cells

scientific article published in March 2002

Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.

scientific article published on September 2002

How much is life worth: cetuximab, non-small cell lung cancer, and the $440 billion question

scientific article published on 29 June 2009

Hypophosphorylation of topoisomerase IIalpha in etoposide (VP-16)-resistant human carcinoma cell lines associated with carboxy-terminal truncation

scientific article published in July 2001

Identification of Non-Small Cell Lung Cancer Sensitive to Systemic Cancer Therapies Using Radiomics

scientific article published on 20 March 2020

Identification of mutations at DNA topoisomerase I responsible for camptothecin resistance.

scientific article published on April 1997

Identification of non-cross-resistant platinum compounds with novel cytotoxicity profiles using the NCI anticancer drug screen and clustered image map visualizations

scientific article published in January 2005

Immunotherapy for adrenocortical cancer

scientific article published on 01 February 2019

Impaired p53 binding to importin: a novel mechanism of cytoplasmic sequestration identified in oxaliplatin-resistant cells

scientific article

Incidence of Mutation and Deletion in Topoisomerase IIα mRNA of Etoposide and mAMSA–resistant Cell Lines ⬇️

scientific article published on October 1, 2001

Increased 99mTc-sestamibi accumulation in normal liver and drug-resistant tumors after the administration of the glycoprotein inhibitor, XR9576.

scientific article

Increased DNA repair as a mechanism of acquired resistance to cis-diamminedichloroplatinum (II) in human ovarian cancer cell lines

scientific article published on 01 October 1988

Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).

scientific article published in March 2006

Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists.

scientific article published on February 1993

Increased uptake of [¹²³I]meta-iodobenzylguanidine, [¹⁸F]fluorodopamine, and [³H]norepinephrine in mouse pheochromocytoma cells and tumors after treatment with the histone deacetylase inhibitors

scientific article

Influence of Cancer on COVID-19 Incidence, Outcomes, and Vaccine Effectiveness: A Prospective Cohort Study of U.S. Veterans

scientific article published in 2022

Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome

scientific article

Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).

scientific article

Inhibition of transcription results in accumulation of Wt p53 followed by delayed outburst of p53-inducible proteins: p53 as a sensor of transcriptional integrity.

scientific article published in January 2002

Inhibitors Targeting Mitosis: Tales of How Great Drugs against a Promising Target Were Brought Down by a Flawed Rationale ⬇️

scientific article published on January 1, 2012

Initial pharmacokinetics and bioavailability of PSC 833, a P-glycoprotein antagonist

scientific article

Interleukin‐13 receptor alpha2 is a novel therapeutic target for human adrenocortical carcinoma ⬇️

scientific article published on May 8, 2012

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

scientific article

Introduction: chemotherapies in the treatment of breast cancer

scientific article

Is cell death a critical end point for anticancer therapies or is cytostasis sufficient?

scientific article published on December 2007

Is there room for improvement in adverse event reporting in the era of targeted therapies?

scientific article published on 12 February 2008

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

scientific article published in March 1985

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells

scientific article published on June 1986

Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma

scientific article

Liver resection and ablation for metastatic adrenocortical carcinoma

scientific article published on 8 February 2011

Localization of multidrug resistance-associated DNA sequences to human chromosome 7.

scientific article published in July 1986

Long-acting somatostatin analogues in the treatment of unresectable/metastatic neuroendocrine tumors

scientific article published in April 2017

Management of endocrine manifestations and the use of mitotane as a chemotherapeutic agent for adrenocortical carcinoma

scientific article published on 10 August 2009

Mechanisms of Resistance to PARP Inhibitors—Three and Counting ⬇️

scientific article published on January 1, 2013

Mechanisms of resistance to cisplatin and alkylating agents.

scientific article published on January 1989

Mediastinal paragangliomas: association with mutations in the succinate dehydrogenase genes and aggressive behavior

scientific article

Metallothionein gene expression and resistance to cisplatin in human ovarian cancer

scientific article published on March 1990

Metastatic and recurrent adrenocortical cancer is not defined by its genomic landscape

scientific article published on 04 November 2020

Metastatic pheochromocytoma/paraganglioma related to primary tumor development in childhood or adolescence: significant link to SDHB mutations

scientific article published on 3 October 2011

Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations

scientific article published on July 1996

MiR-34a and miR-483-5p are candidate serum biomarkers for adrenocortical tumors

scientific article published on December 2013

MicroRNA profiling of adrenocortical tumors reveals miR‐483 as a marker of malignancy ⬇️

scientific article published on November 8, 2010

Microtubule targeting agents: basic mechanisms of multidrug resistance (MDR).

scientific article

Microtubule-disrupting chemotherapeutics result in enhanced proteasome-mediated degradation and disappearance of tubulin in neural cells

scientific article

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

scientific article published in Journal of Biological Chemistry

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

scientific article

Mitosis is not a key target of microtubule agents in patient tumors.

scientific article published in February 2011

Mitotane Enhances Cytotoxicity of Chemotherapy in Cell Lines Expressing a Multidrug Resistance Gene (mdr-1/P-Glycoprotein) which is also Expressed by Adrenocortical Carcinomas ⬇️

scientific article (publication date: July 1991)

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

scientific article published on July 21, 1992

Modulation of multidrug resistance by dexverapamil in EPOCH-refractory lymphomas.

scientific article published in January 1995

Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents.

scientific article published in October 1989

Molecular biology of drug resistance

scientific article published on January 1987

Molecular effects of paclitaxel: myths and reality (a critical review).

scientific article

Molecular targets in the National Cancer Institute drug screen

scientific article published on January 1995

Moving a pioneer journal into the future

scientific article

Multidrug resistance in cancer: role of ATP-dependent transporters

scientific article (publication date: 2002)

Multidrug resistance in ovarian cancer

scientific article published on October 1987

Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene

scientific article published on November 1986

Multidrug resistance: P-glycoprotein and its allies--the elusive foes.

scientific article

Multiple paths to a drug resistance phenotype: mutations, translocations, deletions and amplification of coding genes or promoter regions, epigenetic changes and microRNAs

scientific article published on February 2007

Multiplying therapies and reducing toxicity in metastatic melanoma

scientific article

Neutral evolution of drug resistant colorectal cancer cell populations is independent of their KRAS status.

scientific article published on 5 October 2017

New syndrome of paraganglioma and somatostatinoma associated with polycythemia

scientific article published on 18 March 2013

Non-inferiority trials: why oncologists must remain wary

scientific article published on 01 April 2015

Novel Tumor Growth Rate Analysis in the Randomized CLARINET Study Establishes the Efficacy of Lanreotide Depot/Autogel 120 mg With Prolonged Administration in Indolent Neuroendocrine Tumors

scientific article published on 03 January 2021

Novel insights into the polycythemia-paraganglioma-somatostatinoma syndrome

scientific article

Oligomerization of p53 precedes its association with dynein and nuclear accumulation

scientific article published on October 2006

Operative management for recurrent and metastatic adrenocortical carcinoma

scientific article

Oral anticancer drugs: how limited dosing options and dose reductions may affect outcomes in comparative trials and efficacy in patients

scientific article

P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines

scientific article published in November 1991

PET/CT comparing (68)Ga-DOTATATE and other radiopharmaceuticals and in comparison with CT/MRI for the localization of sporadic metastatic pheochromocytoma and paraganglioma

scientific article

Paclitaxel in doxorubicin-refractory or mitoxantrone-refractory breast cancer: a phase I/II trial of 96-hour infusion.

scientific article

Paclitaxel-induced FasL-independent apoptosis and slow (non-apoptotic) cell death.

scientific article published in March 2002

Pancreatic cancer: Targeting KRAS and the vitamin D receptor via microtubules

scientific article published on 14 July 2015

Percutaneous tumor ablation with radiofrequency

scientific article

Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma

scientific article

Phase I Trial of a New Schedule of Romidepsin in Patients with Advanced Cancers ⬇️

scientific article published on June 11, 2013

Phase I study of infusional paclitaxel in combination with the P-glycoprotein antagonist PSC 833.

scientific article

Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days.

scientific article published on May 2003

Phase I trial and pharmacokinetic study of ixabepilone administered daily for 5 days in children and adolescents with refractory solid tumors

scientific article published on 15 December 2008

Phase I trial of belinostat with cisplatin and etoposide in advanced solid tumors, with a focus on neuroendocrine and small cell cancers of the lung.

scientific article published on 7 February 2018

Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms

scientific article

Phase I/II Trial of Vandetanib and Bortezomib in Adults with Locally Advanced or Metastatic Medullary Thyroid Cancer

article

Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma

scientific article published on 3 June 2015

Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer

scientific article

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

scientific article

Phase II study of paclitaxel in relapsed non-Hodgkin's lymphomas

scientific article published on 01 February 1995

Potential Pitfalls of Crossover and Thoughts on Iniparib in Triple-Negative Breast Cancer ⬇️

scientific article published on December 7, 2011

Practical considerations in the evaluation and management of adrenocortical cancer

scientific article published on December 2010

Precision oncology: a strategy we were not ready to deploy

scientific article published on 28 January 2016

Precision oncology: origins, optimism, and potential

scientific article published on February 2016

Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs

scientific article

Price, value, and the cost of cancer drugs

scientific article

Progress and Opportunities to Advance Clinical Cancer Therapeutics Using Tumor Dynamic Models

scientific article published on 23 December 2019

Progression-free survival is simply a measure of a drug's effect while administered and is not a surrogate for overall survival.

scientific article published on September 2009

Proteasome inhibitors increase tubulin polymerization and stabilization in tissue culture cells: a possible mechanism contributing to peripheral neuropathy and cellular toxicity following proteasome inhibition.

scientific article

Pseudo-progressing to an unmet need

scientific article published on 24 February 2017

Pulmonary Resection for Metastatic Adrenocortical Carcinoma: The National Cancer Institute Experience ⬇️

scientific article published on October 1, 2011

RECIST: no longer the sharpest tool in the oncology clinical trials toolbox--reply to point

Radiofrequency ablation for tumor-related massive hematuria

scientific article published on March 2005

Radiofrequency ablation of adrenal tumors and adrenocortical carcinoma metastases

scientific article published on February 2003

Radiofrequency ablation of metastatic lesions in adrenocortical cancer

scientific article published on 01 August 2000

Radiofrequency ablation of metastatic pheochromocytoma

scientific article published on November 2009

Radiofrequency ablation: a novel approach for treatment of metastatic pheochromocytoma

scientific article

Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer

scientific article

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

scientific article published in July 1985

Renal cell carcinoma: trying but failing to improve the only curative therapy

scientific article

Reply to 'H-STS, L-STS and KRJ-I are not authentic GEPNET cell lines'

scientific article published on 01 October 2019

Retained platinum uptake and indifference to p53 status make novel transplatinum agents active in platinum-resistant cells compared to cisplatin and oxaliplatin.

scientific article published on March 2012

Reversal of Multidrug Resistance

scientific article published on 01 January 1994

Reversal of multidrug resistance.

scientific article

Reversal of multidrug resistance: lessons from clinical oncology.

scientific article

Revisiting the role of ABC transporters in multidrug-resistant cancer.

scientific article published on 11 April 2018

Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen.

scientific article published on October 1994

Role of Radiotherapy in Adrenocortical Carcinoma ⬇️

scientific article published on July 1, 2013

Role of a doxorubicin-containing regimen in relapsed and resistant lymphomas: an 8-year follow-up study of EPOCH.

scientific article

Romidepsin in peripheral and cutaneous T-cell lymphoma: mechanistic implications from clinical and correlative data

scientific article

SDHB-related pheochromocytoma and paraganglioma penetrance and genotype-phenotype correlations

scientific article

Screening of cancer tissue arrays identifies CXCR4 on adrenocortical carcinoma: correlates with expression and quantification on metastases using 64Cu-plerixafor PET.

scientific article published on 4 August 2017

Somatic HIF2A gain-of-function mutations in paraganglioma with polycythemia

scientific article

Sorafenib-induced eruptive melanocytic lesions.

scientific article published on June 2008

Stable disease is not preferentially observed with targeted therapies and as currently defined has limited value in drug development.

scientific article published on September 2009

Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells

scientific article published in April 1996

Strategies for reversing drug resistance ⬇️

scientific article published on October 20, 2003

Successful chemotherapy of hepatic metastases in a case of succinate dehydrogenase subunit B-related paraganglioma

scientific article

Succinate dehydrogenase gene mutations in cardiac paragangliomas

scientific article published on 24 March 2015

Sunitinib Does Not Accelerate Tumor Growth in Patients with Metastatic Renal Cell Carcinoma

scientific article published on 07 February 2013

Superiority of [68Ga]-DOTATATE PET/CT to Other Functional Imaging Modalities in the Localization of SDHB-Associated Metastatic Pheochromocytoma and Paraganglioma

scientific article

Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones

scientific article published on 01 January 2001

TARP vaccination is associated with slowing in PSA velocity and decreasing tumor growth rates in patients with Stage D0 prostate cancer

scientific article published on July 2016

Taccalonolides: a microtubule stabilizer poses a new puzzle with old pieces

scientific article

Tales of How Great Drugs Were Brought Down by a Flawed Rationale—Response ⬇️

scientific article published on 07 February 2013

Targeting MDR in breast and lung cancer: discriminating its potential importance from the failure of drug resistance reversal studies.

scientific article published on February 2012

The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6alpha-hydroxypaclitaxel, a major metabolite of paclitaxel.

scientific article published in June 2001

The Role of ABC Transporters in Clinical Practice ⬇️

scientific article published on January 1, 2003

The Role of Wild-Type p53 in Cisplatin-Induced Chk2 Phosphorylation and the Inhibition of Platinum Resistance with a Chk2 Inhibitor ⬇️

scientific article published on January 1, 2011

The VEGF inhibitor axitinib has limited effectiveness as a therapy for adrenocortical cancer

scientific article published on January 2014

The clinical development of new mitotic inhibitors that stabilize the microtubule

scientific article published on July 2004

The evidence framework for precision cancer medicine

scientific article

The extent of chromosomal aberrations induced by chemotherapy in non-human primates depends on the schedule of administration

scientific article published on June 2005

The high cost of ignorance in oncology

scientific article published on 15 November 2016

The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems

scientific article published in February 2007

The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells ⬇️

scientific article published on November 1, 2003

The histone deacetylase inhibitor FR901228 (desipeptide) restores expression and function of pseudo-null p53.

scientific article

The role of efflux pumps in drug-resistant metastatic breast cancer: new insights and treatment strategies

scientific article published on October 2007

The size of the primary tumor and age at initial diagnosis are independent predictors of the metastatic behavior and survival of patients with SDHB-related pheochromocytoma and paraganglioma: a retrospective cohort study

scientific article

Therapeutic Cancer Vaccines in Prostate Cancer: The Paradox of Improved Survival Without Changes in Time to Progression ⬇️

scientific article published on August 26, 2010

Therapies with diverse mechanisms of action kill cells by a similar exponential process in advanced cancers.

scientific article published in September 2014

Treatment of malignant pheochromocytoma/paraganglioma with cyclophosphamide, vincristine, and dacarbazine: recommendation from a 22-year follow-up of 18 patients

scientific article

Treatment of metastatic disease in patients with neuroendocrine tumors

scientific article published on July 2006

Treatment of recurrent cervical adenocarcinoma with BMS-247550, an epothilone B analog

scientific article

Tubulin from paclitaxel-resistant cells as a probe for novel antimicrotubule agents

scientific article published on 01 January 1997

Tubulin/microtubules: still a promising target for new chemotherapeutic agents

scientific article published on 01 February 2000

Tumor Regression and Growth Rates Determined in Five Intramural NCI Prostate Cancer Trials: The Growth Rate Constant as an Indicator of Therapeutic Efficacy ⬇️

scientific article published on November 24, 2010

Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability

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Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: a novel strategy for evaluation of clinical trial data

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Tumour stem cells and drug resistance

scientific article (publication date: April 2005)

Unintended consequences of expensive cancer therapeutics—the pursuit of marginal indications and a me-too mentality that stifles innovation and creativity: the John Conley Lecture

scientific article published in December 2014

Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression.

scientific article published in November 1990

Using the national cancer institute anticancer drug screen to assess the effect of MRP expression on drug sensitivity profiles

scientific article published on 01 November 1998

Various methods of analysis of mdr-1/P-glycoprotein in human colon cancer cell lines

scientific article published on May 6, 1992

Why Do Phase III Clinical Trials in Oncology Fail so Often? ⬇️

scientific article published on 06 April 2012

Why RECIST Works and Why It Should Stay—Counterpoint ⬇️

scientific article published on 04 September 2012

bcl-2 protein downregulation is not required for differentiation of multidrug resistant HL60 leukemia cells

scientific article published on February 1996

p53 Inhibits Hypoxia-inducible Factor-stimulated Transcription ⬇️

scientific article published on May 15, 1998

p53 as a therapeutic target: unresolved issues on the road to cancer therapy targeting mutant p53.

scientific article

p53 is associated with cellular microtubules and is transported to the nucleus by dynein

scientific article published on 01 October 2000

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