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List of works by Halina Offner

17Beta-estradiol treatment profoundly down-regulates gene expression in spinal cord tissue in mice protected from experimental autoimmune encephalomyelitis

scientific article published in January 2003

5-androstenediol ameliorates pleurisy, septic shock, and experimental autoimmune encephalomyelitis in mice

scientific article

A Novel Hypothesis: Regulatory B Lymphocytes Shape Outcome from Experimental Stroke ⬇️

scientific article published on May 9, 2012

A Novel Partial MHC Class II Construct, DRmQ, Inhibits Central and Peripheral Inflammatory Responses to Promote Neuroprotection in Experimental Stroke

scientific article published on 03 December 2019

A novel HLA-DRα1-MOG-35-55 construct treats experimental stroke

scientific article published on March 2014

A novel mouse model of thromboembolic stroke

scientific article published on 16 September 2015

A novel neurotherapeutic for multiple sclerosis, ischemic injury, methamphetamine addiction, and traumatic brain injury

A novel regulatory pathway for autoimmune disease: binding of partial MHC class II constructs to monocytes reduces CD74 expression and induces both specific and bystander T-cell tolerance

scientific article published on 29 September 2012

A potential role for estrogen in experimental autoimmune encephalomyelitis and multiple sclerosis

scientific article published on November 2006

A promising therapeutic approach for multiple sclerosis: recombinant T-cell receptor ligands modulate experimental autoimmune encephalomyelitis by reducing interleukin-17 production and inhibiting migration of encephalitogenic cells into the CNS.

scientific article published in November 2007

A synthetic androstene analogue inhibits collagen-induced arthritis in the mouse

scientific article published in February 2004

A synthetic androstene derivative and a natural androstene metabolite inhibit relapsing-remitting EAE.

scientific article

Adoptive transfer of immune subsets prior to MCAO does not exacerbate stroke outcome in splenectomized mice.

scientific article

AlphaB-crystallin-reactive T cells from knockout mice are not encephalitogenic

scientific article published on 14 July 2006

An orally bioavailable synthetic analog of an active dehydroepiandrosterone metabolite reduces established disease in rodent models of rheumatoid arthritis

scientific article

Antibiotics protect against EAE by increasing regulatory and anti-inflammatory cells

scientific article published on 18 June 2018

Antigen-specific therapy promotes repair of myelin and axonal damage in established EAE.

scientific article

Attenuation of Th1 effector cell responses and susceptibility to experimental allergic encephalomyelitis in histamine H2 receptor knockout mice is due to dysregulation of cytokine production by antigen-presenting cells

scientific article

Binding of recombinant T cell receptor ligands (RTL) to antigen presenting cells prevents upregulation of CD11b and inhibits T cell activation and transfer of experimental autoimmune encephalomyelitis.

scientific article

CCR6: a biomarker for Alzheimer's-like disease in a triple transgenic mouse model

scientific article

CD4+FoxP3+ regulatory T-cells in cerebral ischemic stroke

scientific article

CNS gene expression pattern associated with spontaneous experimental autoimmune encephalomyelitis.

scientific article published in September 2003

Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS.

scholarly article

Characterization of human platelet binding of recombinant T cell receptor ligand.

scientific article

Congruent effects of estrogen and T-cell receptor peptide therapy on regulatory T cells in EAE and MS.

scientific article

Contribution of GPR30 for 1,25 dihydroxyvitamin D₃ protection in EAE.

scientific article published on 13 October 2011

Critical evaluation of regulatory T cells in autoimmunity: are the most potent regulatory specificities being ignored?

scientific article published on September 2008

Cutting Edge: OX40 agonists can drive regulatory T cell expansion if the cytokine milieu is right

scientific article

Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment

scientific article

Cytokine switch and bystander suppression of autoimmune responses to multiple antigens in experimental autoimmune encephalomyelitis by a single recombinant T-cell receptor ligand

scientific article published on March 2009

DRα1-MOG-35-55 Reduces Permanent Ischemic Brain Injury

scientific article published on 17 December 2016

DRα1-MOG-35-55 treatment reduces lesion volumes and improves neurological deficits after traumatic brain injury

scientific article published on 16 March 2017

Decreased FOXP3 levels in multiple sclerosis patients

scientific article published on July 2005

Different immunological mechanisms govern protection from experimental stroke in young and older mice with recombinant TCR ligand therapy

scientific article

Down-modulation of programmed death 1 alters regulatory T cells and promotes experimental autoimmune encephalomyelitis

scientific article published on January 2010

Effects of cytokine deficiency on chemokine expression in CNS of mice with EAE

scientific article published on 01 March 2002

Endogenous CD4+BV8S2- T cells from TG BV8S2+ donors confer complete protection against spontaneous experimental encephalomyelitis (Sp-EAE) in TCR transgenic, RAG-/- mice

scientific article published on 01 January 2003

Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice

scientific article

Epitope spreading is not required for relapses in experimental autoimmune encephalomyelitis

scientific article published on 01 February 2003

Estradiol and G1 reduce infarct size and improve immunosuppression after experimental stroke

scientific article

Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis

scientific article published on December 2003

Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis

scientific article published on 13 February 2016

Estrogen inhibition of EAE involves effects on dendritic cell function.

scientific article published in October 2002

Estrogen inhibits systemic T cell expression of TNF-alpha and recruitment of TNF-alpha(+) T cells and macrophages into the CNS of mice developing experimental encephalomyelitis.

scientific article published in March 2002

Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells.

scientific article

Estrogen protects both sexes against EAE by promoting common regulatory cell subtypes independent of endogenous estrogen

scientific article

Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice

scientific article

Estrogen treatment induces a novel population of regulatory cells, which suppresses experimental autoimmune encephalomyelitis

scientific article published in July 2004

Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE

scientific article published on 29 October 2019

Estrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway

scientific article

Estrogen‐induced protection against experimental autoimmune encephalomyelitis is abrogated in the absence of B cells ⬇️

scientific article published on March 17, 2011

Ethinyl estradiol treats collagen-induced arthritis in DBA/1LacJ mice by inhibiting the production of TNF-alpha and IL-1beta

scientific article published in May 2005

Evaluation of the effects of 17beta-estradiol (17beta-e2) on gene expression in experimental autoimmune encephalomyelitis using DNA microarray

scientific article published in January 2002

Experimental stroke induces massive, rapid activation of the peripheral immune system

scientific article published on 01 May 2006

Functional assay for human CD4+CD25+ Treg cells reveals an age-dependent loss of suppressive activity

scientific article

Functional role of regulatory lymphocytes in stroke: facts and controversies

scientific article published on 19 March 2015

GPR30 FORMS AN INTEGRAL PART OF E2-PROTECTIVE PATHWAY IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

scientific article published on December 2011

GPR30 contributes to estrogen-induced thymic atrophy

scientific article

GPR30, but not estrogen receptor-alpha, is crucial in the treatment of experimental autoimmune encephalomyelitis by oral ethinyl estradiol

scientific article

Gilt required for RTL550-CYS-MOG to treat experimental autoimmune encephalomyelitis

scientific article

HLA-DRB1*1501 risk association in multiple sclerosis may not be related to presentation of myelin epitopes

scientific article published on October 2004

HLA-DRα1 constructs block CD74 expression and MIF effects in experimental autoimmune encephalomyelitis

scientific article

HLA-DRα1-mMOG-35-55 treatment of experimental autoimmune encephalomyelitis reduces CNS inflammation, enhances M2 macrophage frequency, and promotes neuroprotection

scientific article published on 24 June 2015

IL-10 producing B cells partially restore E2-mediated protection against EAE in PD-L1 deficient mice

scientific article published on 11 June 2015

IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke

scientific article published on 03 May 2013

IL-13-mediated gender difference in susceptibility to autoimmune encephalomyelitis.

scientific article published on February 2008

Identification of Bphs, an autoimmune disease locus, as histamine receptor H1.

scientific article

Increased CD74 binding and EAE treatment efficacy of a modified DRα1 molecular construct

scientific article published on 23 October 2018

Inhibitory effects of incomplete Freund's adjuvant on experimental autoimmune encephalomyelitis

scientific article published on 01 February 2002

Interferon-beta-1a treatment increases CD56bright natural killer cells and CD4+CD25+ Foxp3 expression in subjects with multiple sclerosis

scientific article published on 15 September 2009

Intrastriatal B-cell administration limits infarct size after stroke in B-cell deficient mice ⬇️

scientific article published on May 18, 2012

Loss of PPARα perpetuates sex differences in stroke reflected by peripheral immune mechanisms

scientific article published on 12 February 2016

MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis

scientific article

MIF and D-DT are potential disease severity modifiers in male MS subjects

scientific article published on 18 September 2017

Membrane estrogen receptor regulates experimental autoimmune encephalomyelitis through up-regulation of programmed death 1.

scientific article published on March 2009

Middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapy

scientific article published in February 2005

Modeling immunity and inflammation in stroke: don't be afraid of mice?

scientific article

Monomeric DR2/MOG-35-55 recombinant TCR ligand treats relapses of experimental encephalomyelitis in DR2 transgenic mice

scientific article published on 24 January 2007

Monomeric recombinant TCR ligand reduces relapse rate and severity of experimental autoimmune encephalomyelitis in SJL/J mice through cytokine switch

scientific article published in April 2004

Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice.

scientific article published in May 2004

Myelin specific cells infiltrate MCAO lesions and exacerbate stroke severity ⬇️

scientific article published on October 12, 2011

Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis

scientific article

Novel feedback loop between M2 macrophages/microglia and regulatory B cells in estrogen-protected EAE mice.

scientific article published on 28 January 2017

Novel humanized recombinant T cell receptor ligands protect the female brain after experimental stroke

scientific article

Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1.

scientific article published in March 2009

Oestrogen treatment of experimental autoimmune encephalomyelitis requires 17β‐oestradiol‐receptor‐positive B cells that up‐regulate PD‐1 on CD4+ Foxp3+ regulatory T cells ⬇️

scientific article published on 01 December 2012

Oestrogen-mediated protection of experimental autoimmune encephalomyelitis in the absence of Foxp3+ regulatory T cells implicates compensatory pathways including regulatory B cells ⬇️

scientific article published on November 23, 2010

Opposing roles for TGF-beta1 and TGF-beta3 isoforms in experimental autoimmune encephalomyelitis

scientific article published in January 2004

Oral feeding with ethinyl estradiol suppresses and treats experimental autoimmune encephalomyelitis in SJL mice and inhibits the recruitment of inflammatory cells into the central nervous system

scientific article published in February 2003

PD-1 Interaction with PD-L1 but not PD-L2 on B-cells Mediates Protective Effects of Estrogen against EAE

scientific article published on May 2013

PD-L1 Monoclonal Antibody Treats Ischemic Stroke by Controlling Central Nervous System Inflammation

scientific article

PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1.

scientific article published on 09 September 2013

Partial MHC Constructs Treat Thromboembolic Ischemic Stroke Characterized by Early Immune Expansion

scientific article published on December 2015

Partial MHC class II constructs as novel immunomodulatory therapy for stroke

scientific article

Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects

scientific article published on 10 April 2013

Phenotypic changes in immune cell subsets reflect increased infarct volume in male vs. female mice

scientific article published on October 2013

Preclinical evaluation of recombinant T cell receptor ligand RTL1000 as a therapeutic agent in ischemic stroke

scientific article

Prevention and treatment of experimental autoimmune encephalomyelitis with clonotypic CDR3 peptides: CD4(+) Foxp3(+) T-regulatory cells suppress interleukin-2-dependent expansion of myelin basic protein-specific T cells

scientific article published on 06 January 2010

Programmed Death-1 Pathway Limits Central Nervous System Inflammation and Neurologic Deficits in Murine Experimental Stroke ⬇️

scientific article published on July 7, 2011

RTL therapy for multiple sclerosis: a Phase I clinical study.

scientific article

RTL551 treatment of EAE reduces CD226 and T-bet+ CD4 T cells in periphery and prevents infiltration of T-bet+ IL-17, IFN-γ producing T cells into CNS

scientific article (publication date: 2011)

Recombinant T Cell Receptor Ligands Improve Outcome After Experimental Cerebral Ischemia ⬇️

scientific article published on September 1, 2011

Recombinant T cell receptor ligand treatment improves neurological outcome in the presence of tissue plasminogen activator in experimental ischemic stroke

scientific article

Recombinant T cell receptor ligand treats experimental stroke

scientific article published on 14 May 2009

Recombinant T cell receptor ligands: immunomodulatory, neuroprotective and neuroregenerative effects suggest application as therapy for multiple sclerosis

scientific article published on January 2008

Recombinant T-Cell Receptor Ligand (RTL) for Treatment of Multiple Sclerosis: A Double-Blind, Placebo-Controlled, Phase 1, Dose-Escalation Study

scientific article published on 5 April 2012

Recombinant TCR ligand induces early TCR signaling and a unique pattern of downstream activation

scientific article published in August 2003

Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice

scientific article published in July 2003

Recombinant TCR ligand reverses clinical signs and CNS damage of EAE induced by recombinant human MOG

scientific article

Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke ⬇️

scientific article published on June 8, 2011

Regulatory B cells in Experimental Stroke

scientific article published on 3 January 2018

Regulatory CD8(+)CD122 (+) T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells.

scientific article published on 25 December 2014

Regulatory T cells play a role in T‐cell receptor CDR2 peptide regulation of experimental autoimmune encephalomyelitis ⬇️

scientific article published on 01 February 2012

Role for microglia in sex differences after ischemic stroke: importance of M2

scientific article

Role of dihydrotestosterone in post-stroke peripheral immunosuppression after cerebral ischemia

scientific article

Sex differences and the role of PPAR alpha in experimental stroke

scientific article published on 18 November 2015

Sex differences in EAE reveal common and distinct cellular and molecular components

scientific article published on 22 October 2020

Sex differences in regulatory cells in experimental stroke

scientific article published on 8 June 2017

Sex differences in the immune response to experimental stroke: Implications for translational research

scientific article published on January 2017

Sex differences in the therapeutic effects of anti-PDL2 neutralizing antibody on stroke

scientific article published on 13 August 2019

Sex-dependent treatment of chronic EAE with partial MHC class II constructs

scientific article

Specificity of regulatory CD4+CD25+ T cells for self-T cell receptor determinants

scientific article published in April 2004

Spleen participation in partial MHC class II construct neuroprotection in stroke

scientific article published on 31 March 2020

Splenectomy reduces infarct volume and neuroinflammation in male but not female mice in experimental stroke

scientific article

Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages

scientific article published in June 2006

Stroke and other cerebrovascular diseases

scientific article published on 6 April 2017

Surviving the storm: Dealing with COVID-19

scientific article published on 13 June 2020

Sustained expression of circulating human alpha-1 antitrypsin reduces inflammation, increases CD4+FoxP3+ Treg cell population and prevents signs of experimental autoimmune encephalomyelitis in mice ⬇️

scientific article published on March 25, 2011

T lymphocytes do not directly mediate the protective effect of estrogen on experimental autoimmune encephalomyelitis

scientific article

T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation

scientific article published on 28 March 2007

T-cell hybridoma specific for myelin oligodendrocyte glycoprotein-35-55 peptide produced from HLA-DRB1*1501-transgenic mice

scientific article published on September 2004

TCR-like antibodies distinguish conformational and functional differences in two- versus four-domain auto reactive MHC class II-peptide complexes

scientific article published on 12 April 2011

Targeting immune co-stimulatory effects of PD-L1 and PD-L2 might represent an effective therapeutic strategy in stroke.

scientific article

The protective effect of 17beta-estradiol on experimental autoimmune encephalomyelitis is mediated through estrogen receptor-alpha

scientific article published on October 2003

The role of the spleen in ischemic stroke

scientific article

The splenic response to stroke: from rodents to stroke subjects.

scientific article published on 3 July 2018

Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis

scientific article published on 16 October 2007

Thrombin mutant W215A/E217A treatment improves neurological outcome and attenuates central nervous system damage in experimental autoimmune encephalomyelitis.

scientific article

Tissue-Dependent Expression of Estrogen Receptor β in 17β -Estradiol- Mediated Attenuation of Autoimmune CNS Inflammation~!2010-04-23~!2010-06-30~!2010-07-14~! ⬇️

scientific article published on January 1, 2010

Transfer of severe experimental autoimmune encephalomyelitis by IL-12- and IL-18-potentiated T cells is estrogen sensitive

scientific article published on May 2003

Treatment of autoimmune anterior uveitis with recombinant TCR ligands

scientific article published in June 2006

Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice

scientific article published on 28 December 2013

Treatment of passive experimental autoimmune encephalomyelitis in SJL mice with a recombinant TCR ligand induces IL-13 and prevents axonal injury

scientific article published in September 2005

Treatment with IL-10 producing B cells in combination with E2 ameliorates EAE severity and decreases CNS inflammation in B cell-deficient mice.

scientific article

Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1)

scientific article published on 30 January 2007

Tyrphostin A9 protects axons in experimental autoimmune encephalomyelitis through activation of ERKs

scientific article published on 07 February 2022

Uncovering the Rosetta Stone: Report from the First Annual Conference on Key Elements in Translating Stroke Therapeutics from Pre-Clinical to Clinical

scientific article published on 10 April 2018

Upregulation of CD74 and its potential association with disease severity in subjects with ischemic stroke.

scientific article published on 21 November 2016

von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis

scientific article published on 7 August 2008

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