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List of works by Andrew M Scharenberg

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels

scientific article

Analysis of O-acetyl-ADP-ribose as a target for Nudix ADP-ribose hydrolases

scientific article

Calcium signaling, ion channels and more. The DT40 system as a model of vertebrate ion homeostasis and cell physiology.

scientific article published on January 2006

Calcium signalling and cell-fate choice in B cells

scientific article published on October 2007

Characterization of homing endonuclease binding and cleavage specificities using yeast surface display SELEX (YSD-SELEX)

scientific article

Characterization of parameters required for effective use of tamoxifen-regulated recombination

scientific article

Coupling endonucleases with DNA end–processing enzymes to drive gene disruption ⬇️

scientific article published on September 2, 2012

Development and validation of a cell-based high-throughput screening assay for TRPM2 channel modulators

scientific article

Digital detection of endonuclease mediated gene disruption in the HIV provirus.

scientific article published on 2 February 2016

Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms.

scientific article published on 5 February 2004

Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template

scientific article published on September 2015

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

scientific article

Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases

scientific article

Ethical and regulatory aspects of genome editing.

scientific article published on 6 April 2016

Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases

scientific article published on 27 October 2015

Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space ⬇️

scientific article published on February 14, 2012

Exploitation of binding energy for catalysis and design

scientific article published on October 2009

Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases

scientific article

Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function

scientific article published on 01 June 2020

Genome Engineering with TAL-Effector Nucleases and Alternative Modular Nuclease Technologies ⬇️

scientific article published on August 1, 2013

High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display

scientific article published on 08 September 2009

Immunologic reconstitution during PEG-ADA therapy in an unusual mosaic ADA deficient patient

scientific article published on 25 October 2008

In vitro Inactivation of Latent HSV by Targeted Mutagenesis Using an HSV-specific Homing Endonuclease

scientific article published on 04 February 2014

Intravenous injection of a foamy virus vector to correct canine SCID-X1.

scientific article

Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies

scientific article

NUDT9, a member of the Nudix hydrolase family, is an evolutionarily conserved mitochondrial ADP-ribose pyrophosphatase.

scientific article

Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks

scientific article published on 10 October 2013

Novel reporter systems for facile evaluation of I-SceI-mediated genome editing

scientific article published on 21 November 2011

Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation

scientific article

Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus

scientific article

Receptor-mediated regulation of the TRPM7 channel through its endogenous protein kinase domain

scholarly article

Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome

scientific article

Structure/function analysis of PARP-1 in oxidative and nitrosative stress-induced monomeric ADPR formation

scientific article

Successful Targeting and Disruption of an Integrated Reporter Lentivirus Using the Engineered Homing Endonuclease Y2 I-AniI ⬇️

scientific article published on February 9, 2011

TRPM2 Ca2+ permeable cation channels: from gene to biological function

scientific article

TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors

scientific article

TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization

scientific journal article

TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions

scientific article

Tapping natural reservoirs of homing endonucleases for targeted gene modification

scientific article

The B. subtilis MgtE Magnesium Transporter Can Functionally Compensate TRPM7-Deficiency in Vertebrate B-Cells ⬇️

scientific article published on September 6, 2012

The BRCT domain of PARP-1 is required for immunoglobulin gene conversion ⬇️

scientific article

The SLC41 family of MgtE-like magnesium transporters ⬇️

scientific article published on April 1, 2013

Tracking genome engineering outcome at individual DNA breakpoints ⬇️

scientific article published on July 10, 2011

Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation

scientific article

Zinc-finger nucleases: a powerful tool for genetic engineering of animals

scientific article published on 26 September 2009

megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering

scientific article

pEVL: A Linear Plasmid for Generating mRNA IVT Templates With Extended Encoded Poly(A) Sequences.

scientific article published on 19 April 2016

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