List of works - Iwan J P de Esch

4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling

scientific article

4-(3-Aminoazetidin-1-yl)pyrimidin-2-amines as High-Affinity Non-imidazole Histamine H3 Receptor Agonists with in Vivo Central Nervous System Activity

scientific article published on 20 November 2019

A Photoswitchable Agonist for the Histamine H3 Receptor, a Prototypic Family A G-Protein-Coupled Receptor

scientific article published on 27 February 2019

A Structural Framework for GPCR Chemogenomics: What's In a Residue Number?

scientific article published in January 2018

A fluorescent approach for identifying P2X1 ligands

scientific article published on 28 May 2015

A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design ⬇️

scientific article published on September 1, 2013

A toolbox of molecular photoswitches to modulate the CXCR3 chemokine receptor with light

scientific article published on 23 October 2019

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors

scientific article published on 18 June 2019

Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2)

scientific article published on 05 July 2019

Aminergic GPCR-ligand interactions: A chemical and structural map of receptor mutation data

scientific article published on 27 November 2018

C(X)CR in silico: Computer-aided prediction of chemokine receptor-ligand interactions

scientific article published on January 2012

Covalent Inhibition of the Histamine H3 Receptor

scientific article published on 11 December 2019

Design, Synthesis, and Structure–Activity Relationships of Highly Potent 5-HT3 Receptor Ligands ⬇️

scientific article published on October 12, 2012

EPHA4 is overexpressed but not functionally active in Sézary syndrome

scientific article published on 10 September 2015

Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi

scientific article published on 01 April 2020

Fragment-to-Lead Medicinal Chemistry Publications in 2017

scientific article published on 21 November 2018

Fragment-to-Lead Medicinal Chemistry Publications in 2019

scientific article published on 23 November 2020

Identification of Phenylphthalazinones as a New Class of Leishmania infantum Inhibitors

scientific article published on 09 December 2019

Identification of Phenylpyrazolone Dimers as a New Class of Anti-Trypanosoma cruzi Agents

scientific article published on 23 August 2019

Interrogating the Essential Bacterial Cell Division Protein FtsQ with Fragments Using Target Immobilized NMR Screening (TINS)

scientific article published on 27 July 2019

KLIFS: a structural kinase-ligand interaction database

scientific article published on 22 October 2015

Ligand based design of novel histamine H4 receptor antagonists; fragment optimization and analysis of binding kinetics ⬇️

scientific article published on November 11, 2011

Pharmacological characterization of a small‐molecule agonist for the chemokine receptor CXCR3 ⬇️

scientific article published on June 1, 2012

Photoswitching the Efficacy of a Small-Molecule Ligand for a Peptidergic GPCR: from Antagonism to Agonism

scientific article published on 06 August 2018

Regiochemistry of the Condensation of 2-Aroyl-cyclohexanones and 2-Cyanoacetamide: 13C-Labeling Studies and Semiempirical MO Calculations ⬇️

scientific article published on August 16, 2012

Route to Prolonged Residence Time at the Histamine H1 Receptor: Growing from Desloratadine to Rupatadine

scientific article published on 05 July 2019

Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity

scientific article published on 14 January 2019

Selective histamine H3 and H4 receptor agonists exert opposite effects against the gastric lesions induced by HCl in the rat stomach ⬇️

scientific article published on 05 August 2011

Several down, a few to go: histamine H3receptor ligands making the final push towards the market? ⬇️

scientific article published on October 13, 2011

Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists

scientific article published on 30 October 2018

Surface plasmon resonance biosensor assay for the analysis of small-molecule inhibitor binding to human and parasitic phosphodiesterases.