List of works - Lorna W Harries

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

scientific article

A common variant of the p16(INK4a) genetic region is associated with physical function in older people

scientific article

Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations

scientific article published on 16 July 2012

Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association

scientific article

Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer

scientific article

An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes ⬇️

scientific article published on September 14, 2011

Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline

scientific article published on 25 October 2019

Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults

scientific article

CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength

scientific article

Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions.

scientific article

Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD

scientific article published on 23 July 2021

Gene expression markers of age-related inflammation in two human cohorts

scientific article

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

scientific article

Identifying likely causal connections between gene expression levels using a Mendelian randomization approach

article

Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL)

scientific article

Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood

scientific article published on 20 April 2020

Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults

scientific article

Long non-coding RNAs and human disease ⬇️

scientific article published on August 1, 2012

Messenger RNA processing and its role in diabetes ⬇️

scientific article published on September 1, 2011

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

scientific article

Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation

scientific article published on 11 January 2020

Obesity impacts the regulation of miR-10b and its targets in primary breast tumors

scientific article published on 18 January 2019

Oxidative Metabolism Genes Are Not Responsive to Oxidative Stress in Rodent Beta Cell Lines ⬇️

scientific article published on February 20, 2012

Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations

scientific article

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

scientific article

Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

scientific article published on 28 September 2017

Septic arthritis of unilateral lumbar facet joint with contiguous abscess, without prior intervention ⬇️

scientific article published on April 2, 2012

Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans

scientific article published on 23 January 2014

The VEGFA165b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease

scientific article published on 12 January 2018

Towards a gene expression biomarker set for human biological age.

scientific article

circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan

scientific article published on 06 December 2019

List of works by Lorna W Harries

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

A common variant of the p16(INK4a) genetic region is associated with physical function in older people

Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations

Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association

Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer

An alternative polyadenylation signal in TCF7L2 generates isoforms that inhibit T cell factor/lymphoid-enhancer factor (TCF/LEF)-dependent target genes ⬇️

Astrocyte senescence may drive alterations in GFAPα, CDKN2A p14ARF, and TAU3 transcript expression and contribute to cognitive decline

Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults

CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength

Changes in inflammatory gene expression induced by hyperbaric oxygen treatment in human endothelial cells under chronic wound conditions.

Changes to the identity of EndoC-βH1 beta cells may be mediated by stress-induced depletion of HNRNPD

Gene expression markers of age-related inflammation in two human cohorts

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

Identifying likely causal connections between gene expression levels using a Mendelian randomization approach

Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL)

Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood

Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults

Long non-coding RNAs and human disease ⬇️

Messenger RNA processing and its role in diabetes ⬇️

Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease

Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation

Obesity impacts the regulation of miR-10b and its targets in primary breast tumors

Oxidative Metabolism Genes Are Not Responsive to Oxidative Stress in Rodent Beta Cell Lines ⬇️

Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

Septic arthritis of unilateral lumbar facet joint with contiguous abscess, without prior intervention ⬇️

Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans

The VEGFA165b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease

Towards a gene expression biomarker set for human biological age.

circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan