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List of works by Richard Longnecker

A Functional Interaction between Herpes Simplex Virus 1 Glycoprotein gH/gL Domains I and II and gD Is Defined by Using Alphaherpesvirus gH and gL Chimeras

scientific article published on 29 April 2015

A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells

scientific article

A nonimprinted Prader-Willi Syndrome (PWS)-region gene regulates a different chromosomal domain in trans but the imprinted pws loci do not alter genome-wide mRNA levels

scientific article published in May 2005

A shared gene expression signature in mouse models of EBV-associated and non–EBV-associated Burkitt lymphoma ⬇️

scientific article published on October 28, 2011

A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion

scientific article published on 29 November 2012

Absence of the Epstein-Barr virus genome in breast cancer-derived cell lines.

scientific article published in August 2003

An auto-regulatory loop for EBV LMP2A involves activation of Notch

scientific article published on 5 November 2007

Analysis of Epstein-Barr virus glycoprotein B functional domains via linker insertion mutagenesis

scientific article

Analysis of fusion using a virus-free cell fusion assay.

scientific article published in January 2005

Assembly and architecture of the EBV B cell entry triggering complex

scientific article (publication date: August 2014)

Binding-site interactions between Epstein-Barr virus fusion proteins gp42 and gH/gL reveal a peptide that inhibits both epithelial and B-cell membrane fusion.

scientific article

Bruton's tyrosine kinase regulates B cell antigen receptor-mediated JNK1 response through Rac1 and phospholipase C-gamma2 activation

scientific article published on March 2002

Cell-surface expression of a mutated Epstein-Barr virus glycoprotein B allows fusion independent of other viral proteins

scholarly article

Characteristics of Epstein-Barr virus envelope protein gp42.

scientific article

Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins

scientific article

Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice

scientific article published on 27 March 2019

Cholesterol is critical for Epstein-Barr virus latent membrane protein 2A trafficking and protein stability

scientific article published on 5 December 2006

Cholesterol-dependent infection of Burkitt's lymphoma cell lines by Epstein–Barr virus ⬇️

scientific article published on November 1, 2003

Cleavage and secretion of Epstein-Barr virus glycoprotein 42 promote membrane fusion with B lymphocytes

scientific article published on 15 April 2009

Cleavage of Epstein-Barr virus glycoprotein B is required for full function in cell-cell fusion with both epithelial and B cells

scientific article published on March 2009

Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function

scientific article published on 9 December 2015

Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex

scientific article

Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A ⬇️

scientific article published on May 16, 2012

Differential reliance on autophagy for protection from HSV encephalitis between newborns and adults

scientific article

Drosophila Schneider 2 (S2) cells: a novel tool for studying HSV-induced membrane fusion

scientific article published on 9 February 2013

EBV LMP-2A employs a novel mechanism to transactivate the HERV-K18 superantigen through its ITAM.

scientific article

EBV LMP2A provides a surrogate pre-B cell receptor signal through constitutive activation of the ERK/MAPK pathway

scientific article

EBV gH/gL and KSHV gH/gL bind to different sites on EphA2 to trigger fusion

scientific article published on 26 August 2020

EBV germinates lymphoma from the germinal center in a battle with T and NK cells

scientific article published on 25 April 2017

EBV latent membrane protein 2A orchestrates p27kip1 degradation via Cks1 to accelerate MYC-driven lymphoma in mice

scientific article

Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor

scientific article published on 19 February 2019

Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.

scientific article published in January 2018

Ephrin receptor A4 (EphA4) is a new Kaposi's sarcoma-associated herpesvirus virus entry receptor

Epithelial cell infection by Epstein-Barr virus

scientific article published on 01 November 2019

Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma

scientific article published on 7 August 2003

Epstein-Barr virus (EBV) LMP2A alters normal transcriptional regulation following B-cell receptor activation

scientific article

Epstein-Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway

scientific article

Epstein-Barr virus (EBV) latent membrane protein 2A regulates B-cell receptor-induced apoptosis and EBV reactivation through tyrosine phosphorylation

scientific article

Epstein-Barr virus LMP2A alters in vivo and in vitro models of B-cell anergy, but not deletion, in response to autoantigen

scientific article

Epstein-Barr virus LMP2A bypasses p53 inactivation in a MYC model of lymphomagenesis

scientific article published on 07 October 2009

Epstein-Barr virus LMP2A enhances B-cell responses in vivo and in vitro

scientific article

Epstein-Barr virus LMP2A imposes sensitivity to apoptosis

scientific article

Epstein-Barr virus LMP2A interferes with global transcription factor regulation when expressed during B-lymphocyte development

scientific article

Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice

scientific article (publication date: 2012)

Epstein-Barr virus LMP2A: regulating cellular ubiquitination processes for maintenance of viral latency?

scientific article published in August 2004

Epstein-Barr virus fusion with epithelial cells triggered by gB is restricted by a gL glycosylation site.

scientific article published on 27 September 2017

Epstein-Barr virus in Burkitt's lymphoma: a role for latent membrane protein 2A

scientific article

Epstein-Barr virus latent membrane protein 2A and autoimmunity

scientific article published on 29 March 2007

Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma

scientific article published on 30 October 2013

Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function

scientific article

Epstein-Barr virus latent membrane protein 2A exploits Notch1 to alter B-cell identity in vivo

scientific article published on 24 September 2008

Epstein-Barr virus latent membrane protein 2A mediates transformation through constitutive activation of the Ras/PI3-K/Akt Pathway

scientific article

Epstein-Barr virus latent membrane protein 2A preferentially signals through the Src family kinase Lyn

scientific article published on 25 June 2008

Epstein-barr virus latent membrane protein 2B (LMP2B) modulates LMP2A activity

scientific article published on 11 October 2006

Erratum for Riccio et al., "Characterization of Sex Differences in Ocular Herpes Simplex Virus 1 Infection and Herpes Stromal Keratitis Pathogenesis of Wild-Type and Herpesvirus Entry Mediator Knockout Mice"

scientific article published on 15 May 2019

Expression and characterization of N-terminal domain of Epstein-Barr virus latent membrane protein 2A in Escherichia coli

scientific article

Functional analysis of glycoprotein L (gL) from rhesus lymphocryptovirus in Epstein-Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion

scientific article published on 20 May 2009

Functional homology of gHs and gLs from EBV-related gamma-herpesviruses for EBV-induced membrane fusion

scientific article published on 02 May 2007

Fusing structure and function: a structural view of the herpesvirus entry machinery

scientific article published on 11 April 2011

Gammaherpesvirus entry and fusion: A tale how two human pathogenic viruses enter their host cells

scientific article published on 17 July 2019

Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes

scientific article

HSV targeting of the host phosphatase PP1α is required for disseminated disease in the neonate and contributes to pathogenesis in the brain.

scientific article

Herpes B Virus Utilizes Human Nectin-1 but Not HVEM or PILRα for Cell-Cell Fusion and Virus Entry ⬇️

scientific article published on February 15, 2012

Herpesvirus Entry Mediator Binding Partners Mediate Immunopathogenesis of Ocular Herpes Simplex Virus 1 Infection

scientific article published on 12 May 2020

Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the Eye.

scientific article published on 12 April 2017

Herpesvirus entry mediator and nectin-1 mediate herpes simplex virus 1 infection of the murine cornea.

scientific article

Herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpes.

scientific article

Herpesvirus entry mediator on radiation-resistant cell lineages promotes ocular herpes simplex virus 1 pathogenesis in an entry-independent manner

scientific article

Herpesvirus entry: an update

scientific article

Hydrophobic residues that form putative fusion loops of Epstein-Barr virus glycoprotein B are critical for fusion activity

scientific article

Icacinlactone H and Icacintrichantholide from the Tuber of Icacina trichantha

scientific article published on 17 July 2015

Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein-Barr virus (EBV)-associated diseases

scientific article

Inability of simian virus 40 to establish productive infection of lymphoblastic cell lines

scientific article published on May 2004

Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies.

scientific article published on 22 September 2017

Inhibition of host kinase activity altered by the LMP2A signalosome-a therapeutic target for Epstein-Barr virus latency and associated disease

scientific article published in December 2002

Insertion mutations in herpes simplex virus 1 glycoprotein H reduce cell surface expression, slow the rate of cell fusion, or abrogate functions in cell fusion and viral entry

scientific article

Interference with T cell receptor–HLA-DR interactions by Epstein–Barr virus gp42 results in reduced T helper cell recognition ⬇️

scientific article published on September 22, 2003

Introduction to the human γ-herpesviruses

Investigation of the function of the putative self-association site of Epstein-Barr virus (EBV) glycoprotein 42 (gp42).

scientific article

Is nectin-1 the “master” receptor for deadly herpes B virus infection? ⬇️

scientific article published on June 22, 2012

Itchy, a Nedd4 Ubiquitin Ligase, Downregulates Latent Membrane Protein 2A Activity in B-Cell Signaling ⬇️

scientific article published on May 1, 2003

LMP2A does not require palmitoylation to localize to buoyant complexes or for function

scientific article published on October 2004

Latent Membrane Protein 2 (LMP2).

scientific article published on January 2015

Latent membrane protein 2A inhibits transforming growth factor-beta 1-induced apoptosis through the phosphatidylinositol 3-kinase/Akt pathway

scientific article published on February 2004

Latent membrane protein 2A, a viral B cell receptor homologue, induces CD5+ B-1 cell development

scientific article published on May 2004

Latent membrane protein 2B regulates susceptibility to induction of lytic Epstein-Barr virus infection

scientific article

Lysine-independent ubiquitination of Epstein-Barr virus LMP2A.

scientific article

Mapping regions of Epstein-Barr virus (EBV) glycoprotein B (gB) important for fusion function with gH/gL.

scientific article

Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage.

scientific article published on 3 March 2017

Mapping the N-terminal residues of Epstein-Barr virus gp42 that bind gH/gL by using fluorescence polarization and cell-based fusion assays

scientific article

Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers

scientific article

Modulation of Epstein-Barr Virus Glycoprotein B (gB) Fusion Activity by the gB Cytoplasmic Tail Domain ⬇️

scientific article published on January 22, 2013

Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein–Barr virus BARF1 ⬇️

scientific article published on July 23, 2012

Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy

scientific article published on January 2017

Mutational analyses of Epstein-Barr virus glycoprotein 42 reveal functional domains not involved in receptor binding but required for membrane fusion

scientific article

Mutational analysis of the HLA class II interaction with Epstein-Barr virus glycoprotein 42.

scientific article

Natural Selection of Glycoprotein B Mutations That Rescue the Small-Plaque Phenotype of a Fusion-Impaired Herpes Simplex Virus Mutant

article

Off-targeting oft-targeted CD20 in cHL

scientific article published on 01 May 2012

Pre-B-cell colony formation assay

scientific article published in January 2005

Rapamycin Reverses Splenomegaly and Inhibits Tumor Development in a Transgenic Model of Epstein-Barr Virus–Related Burkitt's Lymphoma ⬇️

scientific article published on January 31, 2011

Rational Targeting of Cellular Cholesterol in Diffuse Large B-Cell Lymphoma (DLBCL) Enabled by Functional Lipoprotein Nanoparticles: A Therapeutic Strategy Dependent on Cell of Origin

scientific article published on 21 September 2017

Reevaluating Herpes Simplex Virus Hemifusion ⬇️

scientific article published on September 15, 2010

Residues within the C-Terminal Arm of the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Contribute to Its Refolding during the Fusion Step of Virus Entry ⬇️

scientific article published on April 4, 2012

Rewiring of B cell receptor signaling by Epstein-Barr virus LMP2A

scientific article published on 05 October 2020

Signal transduction through the B cell antigen receptor is normal in ataxia-telangiectasia B lymphocytes

scientific article published in 2001

Soluble Epstein-Barr virus glycoproteins gH, gL, and gp42 form a 1:1:1 stable complex that acts like soluble gp42 in B-cell fusion but not in epithelial cell fusion

scientific article

Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma

article

Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus

scientific article

Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins.

scientific article published on 08 December 2016

Structure of Epstein-Barr Virus Glycoprotein 42 Suggests a Mechanism for Triggering Receptor-Activated Virus Entry

scientific article

Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B

scientific article

Structure of the Epstein-Barr virus gp42 protein bound to the MHC class II receptor HLA-DR1

scientific article

Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype.

scientific article published on 16 May 2017

Substitution of herpes simplex virus 1 entry glycoproteins with those of saimiriine herpesvirus 1 reveals a gD-gH/gL functional interaction and a region within the gD profusion domain that is critical for fusion

scientific article published on 26 March 2014

Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells

scientific article published on 23 January 2006

The COMPLEXity in herpesvirus entry

scientific article

The Cytoplasmic Tail Domain of Epstein-Barr Virus gH Regulates Membrane Fusion Activity through Altering gH Binding to gp42 and Epithelial Cell Attachment

scientific article

The Epstein-Barr virus (EBV) glycoprotein B cytoplasmic C-terminal tail domain regulates the energy requirement for EBV-induced membrane fusion

scientific article

The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus-Host Interactions

scientific article

The Ig-like v-type domain of paired Ig-like type 2 receptor alpha is critical for herpes simplex virus type 1-mediated membrane fusion

scientific article published on 23 June 2010

The Innate Immune Response to Herpes Simplex Virus 1 Infection Is Dampened in the Newborn Brain and Can Be Modulated by Exogenous Interferon Beta To Improve Survival

scientific article published on 26 May 2020

The KGD motif of Epstein-Barr virus gH/gL is bifunctional, orchestrating infection of B cells and epithelial cells

scientific article published on 3 January 2012

The LMP2A signalosome--a therapeutic target for Epstein-Barr virus latency and associated disease

scientific article

The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis

scientific article published on 12 April 2016

The Type I Interferon Response and Age-Dependent Susceptibility to Herpes Simplex Virus Infection

scientific article published on 9 March 2017

The amino terminus of Epstein-Barr virus glycoprotein gH is important for fusion with epithelial and B cells

scientific article

The c-Cbl proto-oncoprotein downregulates EBV LMP2A signaling

scientific article published on 10 December 2008

The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells

scientific article

The fusion loops and membrane proximal region of Epstein-Barr virus glycoprotein B (gB) can function in the context of herpes simplex virus 1 gB when substituted individually but not in combination ⬇️

scientific article published on October 23, 2012

The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion

scientific article published on 16 January 2013

The structural basis of herpesvirus entry

scientific article published on 21 October 2020

Two Pathways of p27 Degradation Are Required for Murine Lymphoma Driven by Myc and EBV Latent Membrane Protein 2A

scientific article published on 16 April 2019

Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor

scientific article

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