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List of works by Channing Der

14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain ⬇️

scientific article (publication date: 22 August 1997)

33 Targeting proteins to membranes using signal sequences for lipid modification

scientific article published on January 1, 1995

A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells ⬇️

scientific article published on July 25, 1997

A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma

scientific article

A tumor-specific membrane phosphoprotein marker in human cell hybrids ⬇️

scientific article published on 01 November 1981

Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms

scientific article

Activation and Involvement of Ral GTPases in Colorectal Cancer ⬇️

scientific article published on January 1, 2011

Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders

scientific article published on 18 May 2020

Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer

scientific article published on 16 July 2019

Are all KRAS mutations created equal? ⬇️

scientific article published on July 22, 2011

Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase

scientific article

Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

scientific article published on 01 June 2020

CD45 and Src-Related Protein Tyrosine Kinases Regulate the T Cell Response to Phorbol Esters ⬇️

scientific article published on February 13, 1998

CDC42 and FGD1 Cause Distinct Signaling and Transforming Activities ⬇️

scientific article published on August 1, 1998

CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth

scientific article

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K ⬇️

scientific article published on December 11, 1997

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

scientific article published on 04 March 2019

Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation

scientific article

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

scientific article

Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells ⬇️

scientific article published on 01 June 1998

Drug for an 'undruggable' protein ⬇️

scientific article published on May 22, 2013

Drugging RAS: Know the enemy

scientific article published on 16 March 2017

Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration

scientific article

Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies.

scientific article published on 26 September 2017

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras? ⬇️

scientific article published on August 8, 1997

GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex ⬇️

scientific article published on November 1, 1992

Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells

scientific article

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth

scientific article

Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo

scientific article (publication date: 12 September 2003)

Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization

scientific article

Identification of a Novel Actin-Binding Domain within the Rho Guanine Nucleotide Exchange Factor TEM4 ⬇️

scientific article published on July 24, 2012

Identity of HeLa Cell Determinants Acquired by Vesicular Stomatitis Virus with a Tumor Antigen ⬇️

scientific article published on June 3, 1983

Increasing Complexity of the Ras Signaling Pathway ⬇️

scientific article published on August 7, 1998

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

scientific article

Inhibition of Ras for Cancer Treatment: The Search Continues ⬇️

scientific article published on October 1, 2011

Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation

scientific article (publication date: 22 March 2002)

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity ⬇️

scientific article published on July 15, 1992

Isoprenoid modification of rab proteins terminating in CC or CXC motifs ⬇️

scientific article published on July 15, 1991

K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways

scientific article

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

scientific article

Lack of correlation between the decreased expression of cell surface LETS protein and tumorigenicity in human cell hybrids

scientific article published on December 1, 1978

Ligand-dependent dynamics and intramolecular signaling in a PDZ domain

scientific article

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

scientific article

Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways

scientific article (publication date: 22 March 2002)

Mas Oncogene Signaling and Transformation Require the Small GTP-Binding Protein Rac ⬇️

scientific article published on March 1, 1998

Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers

scientific article

Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity

scientific article

Mutant and Wild-type Ras: Co-conspirators in Cancer ⬇️

scientific article published on January 1, 2013

Oncogenic Activity of Ect2 Is Regulated through Protein Kinase Cι-mediated Phosphorylation ⬇️

scientific article published on December 28, 2010

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation ⬇️

scientific article published on September 26, 1997

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

scientific article

Personalized Medicine in Non–Small-Cell Lung Cancer: Is KRAS a Useful Marker in Selecting Patients for Epidermal Growth Factor Receptor–Targeted Therapy? ⬇️

scientific article published on 04 October 2010

Phosphorylation by Protein Kinase Cα Regulates RalB Small GTPase Protein Activation, Subcellular Localization, and Effector Utilization ⬇️

scientific article published on March 5, 2012

Protein prenylation: more than just glue?

scientific article published on December 1, 1992

RAS isoforms and mutations in cancer at a glance

scientific article

RAS, wanted dead or alive: Advances in targeting RAS mutant cancers

scientific article published on 24 March 2020

ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix ⬇️

scientific article published on November 10, 2003

ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion

scientific article

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes ⬇️

scientific article published on November 10, 1995

Ras effector switching promotes divergent cell fates in C. elegans vulval patterning

scientific article

Ras history: The saga continues

scientific article

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? ⬇️

scientific article published on November 24, 2010

Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade ⬇️

scientific article published on May 1, 1998

RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia

scientific article

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation

scientific article

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector

scientific journal article

Regulators and effectors of small GTPases: Ras family. Preface

preface for a new series of Methods in Enzymology

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

scientific article

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras ⬇️

scientific article published on December 5, 1997

RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress

retracted scientific article

RhoG signals in parallel with Rac1 and Cdc42

scientific article

Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

scientific article (publication date: July 2003)

Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5

scientific journal article

Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation

scientific article

SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis

scientific article

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein ⬇️

scientific article published on June 1, 1992

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

scientific article

Structure and biological effects of lipid modifications on proteins

scientific article published on August 1, 1992

TEM4 is a junctional RhoGEF required for cell-cell adhesion, monolayer integrity, and barrier function ⬇️

scientific article published on May 31, 2013

TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling ⬇️

scientific article published on November 2, 2010

The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity

scientific article

The RAF Inhibitor Paradox Revisited ⬇️

scientific article published on February 14, 2012

The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector ⬇️

scientific article published on February 13, 2012

The Ras superfamily at a glance

scientific article (publication date: March 2005)

The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility

scientific article (publication date: 2013)

The Src Homology 2 and Phosphotyrosine Binding Domains of the ShcC Adaptor Protein Function as Inhibitors of Mitogenic Signaling by the Epidermal Growth Factor Receptor ⬇️

scientific article published on August 7, 1998

The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration

scientific article

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

scientific article

Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways

scientific article

Transforming Potential of Dbl Family Proteins Correlates with Transcription from the Cyclin D1 Promoter but Not with Activation of Jun NH2-terminal Kinase, p38/Mpk2, Serum Response Factor, or c-Jun ⬇️

scientific article published on July 3, 1998

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

scientific article (publication date: 8 November 2002)

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