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List of works by Channing Der

14-3-3 ζ Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain ⬇️

scientific article (publication date: 22 August 1997)

33 Targeting proteins to membranes using signal sequences for lipid modification

scientific article published on January 1, 1995

A Raf-independent Epidermal Growth Factor Receptor Autocrine Loop Is Necessary for Ras Transformation of Rat Intestinal Epithelial Cells ⬇️

scientific article published on July 25, 1997

A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma

scientific article

A tumor-specific membrane phosphoprotein marker in human cell hybrids ⬇️

scientific article published on 01 November 1981

Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms

scientific article

Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders

scientific article published on 18 May 2020

Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer

scientific article published on 16 July 2019

Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase

scientific article

Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

scientific article published on 01 June 2020

CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth

scientific article

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

scientific article published on 04 March 2019

Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation

scientific article

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

scientific article

Drugging RAS: Know the enemy

scientific article published on 16 March 2017

Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration

scientific article

Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies.

scientific article published on 26 September 2017

Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras? ⬇️

scientific article published on August 8, 1997

GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex ⬇️

scientific article published on November 1, 1992

Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells

scientific article

Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth

scientific article

Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo

scientific article (publication date: 12 September 2003)

Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization

scientific article

Identity of HeLa Cell Determinants Acquired by Vesicular Stomatitis Virus with a Tumor Antigen ⬇️

scientific article published on June 3, 1983

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

scientific article

Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation

scientific article (publication date: 22 March 2002)

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity ⬇️

scientific article published on July 15, 1992

Isoprenoid modification of rab proteins terminating in CC or CXC motifs ⬇️

scientific article published on July 15, 1991

K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways

scientific article

KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment

scientific article

Lack of correlation between the decreased expression of cell surface LETS protein and tumorigenicity in human cell hybrids

scientific article published on December 1, 1978

Ligand-dependent dynamics and intramolecular signaling in a PDZ domain

scientific article

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

scientific article

Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways

scientific article (publication date: 22 March 2002)

Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers

scientific article

Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity

scientific article

Oncogenic Ha-Ras-induced Signaling Activates NF-κB Transcriptional Activity, Which Is Required for Cellular Transformation ⬇️

scientific article published on September 26, 1997

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

scientific article

Personalized Medicine in Non–Small-Cell Lung Cancer: Is KRAS a Useful Marker in Selecting Patients for Epidermal Growth Factor Receptor–Targeted Therapy? ⬇️

scientific article published on 04 October 2010

Protein prenylation: more than just glue?

scientific article published on December 1, 1992

RAS isoforms and mutations in cancer at a glance

scientific article

RAS, wanted dead or alive: Advances in targeting RAS mutant cancers

scientific article published on 24 March 2020

ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix ⬇️

scientific article published on November 10, 2003

ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion

scientific article

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes ⬇️

scientific article published on November 10, 1995

Ras effector switching promotes divergent cell fates in C. elegans vulval patterning

scientific article

Ras history: The saga continues

scientific article

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? ⬇️

scientific article published on November 24, 2010

RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia

scientific article

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation

scientific article

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector

scientific journal article

Regulators and effectors of small GTPases: Ras family. Preface

preface for a new series of Methods in Enzymology

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression

scientific article

RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress

retracted scientific article

RhoG signals in parallel with Rac1 and Cdc42

scientific article

Rnd proteins function as RhoA antagonists by activating p190 RhoGAP

scientific article (publication date: July 2003)

Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5

scientific journal article

Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation

scientific article

SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis

scientific article

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein ⬇️

scientific article published on June 1, 1992

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

scientific article

Structure and biological effects of lipid modifications on proteins

scientific article published on August 1, 1992

TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling ⬇️

scientific article published on November 2, 2010

The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity

scientific article

The Ras superfamily at a glance

scientific article (publication date: March 2005)

The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility

scientific article (publication date: 2013)

The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration

scientific article

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism

scientific article

Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways

scientific article

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

scientific article (publication date: 8 November 2002)

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