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List of works by Jeff W Barclay

A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action

article by Shi Quan Wong et al published 1 November 2018 in Journal of Neuroscience Methods

A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3

scientific article published on 01 January 2008

A random mutagenesis approach to isolate dominant-negative yeast sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins

scientific article

Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans

scientific article published in February 2009

Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.

scientific article

Caenorhabditis elegans: a useful tool to decipher neurodegenerative pathways

scientific article published on April 2010

Calcium-dependent regulation of exocytosis

scientific article

Ethanol Stimulates Locomotion via a Gαs-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans.

scientific article published on 26 September 2017

Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression

scientific article

Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components

scientific article

Functional analysis of epilepsy-associated variants in STXBP1/Munc18-1 using humanized Caenorhabditis elegans

scientific article published on 29 February 2020

Functional validity, role, and implications of heavy alcohol consumption genetic loci

scientific article published on 15 January 2020

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions

scientific article

Neurotransmitter release mechanisms studied in Caenorhabditis elegans

scientific article published on 20 April 2012

PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion.

scientific article

Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis

scientific article

Presynaptic targets for acute ethanol sensitivity

scientific article published on February 2010

Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size.

scientific article published on 21 October 2005

Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension

scientific article published in 2021

Regulation of the fusion pore conductance during exocytosis by cyclin-dependent kinase 5.

scientific article

S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding

scientific article

Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans

scientific article published on 15 January 2016

Structure-function study of mammalian Munc18-1 and C. elegans UNC-18 implicates domain 3b in the regulation of exocytosis

scientific article

The functions of Munc18-1 in regulated exocytosis

scientific article

UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans

scientific article published on 15 October 2008

Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

scientific article

α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy

article

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