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List of works by Galina I. Lepesheva

A requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysis

scientific article published on 03 June 2020

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

scientific article published in Journal of Biological Chemistry

Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents

scientific article

Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

scientific article

Rational modification of a candidate cancer drug for use against Chagas disease

scientific article published on March 2009

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallogr

scientific article published on 25 June 2018

Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae

scientific article published on 30 November 2018

Successful Aspects of the Coadministration of Sterol 14α-Demethylase Inhibitor VFV and Benznidazole in Experimental Mouse Models of Chagas Disease Caused by the Drug-Resistant Strain of Trypanosoma cruzi

scientific article published on 23 January 2019

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

scientific article published on 11 November 2019

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