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List of works by Giulio F Draetta

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

A mechanism for inhibiting the SUMO pathway

scientific article

Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells

scientific article published on 01 August 2020

Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib

scientific article published on 14 September 2020

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

scientific article published on 11 June 2018

Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.

scientific article published on February 2007

Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies

scientific article published on 30 November 2021

Cancer Drug Discovery Faces the FACT ⬇️

scientific article published on August 10, 2011

Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis

scientific article published on March 2004

Characterization of the BUD31 gene of Saccharomyces cerevisiae

scientific article

Collapsing the Tumor Ecosystem: Preventing Adaptive Response to Treatment by Inhibiting Transcription.

scientific article published in January 2018

Commentary on "A new cancer diagnostic system based on a CDK profiling technology" [Biochim. Biophys. Acta Molecular Basis of Disease 1741 (2005) 226-233]

scientific article published on 01 September 2005

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference

article

Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research

scientific article published on 06 September 2019

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

scientific article (publication date: 6 November 2003)

Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery

scientific article

Discovery of IACS-9439, a potent, exquisitely selective and orally bioavailable inhibitor of CSF1R

scientific article published on 29 July 2020

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties

scientific article published on 29 October 2020

Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

scientific article published on 2 March 2010

Dual mode of degradation of Cdc25 A phosphatase

scientific article

EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes

scientific article

EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming

scientific article

Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation.

scientific article

FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

scientific article

Frequent alterations in the expression of serine/threonine kinases in human cancers

scientific article

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

scientific article published on 01 January 2019

Future cancer research priorities in the USA: a Lancet Oncology Commission

scientific article published on 31 October 2017

GE-38IDENTIFYING THE TREATMENT-RESISTANT MESENCHYMAL SIGNATURE BY COMPARATIVE ANALYSES BETWEEN GLIOMA SPHERE-FORMING CELLS AND THEIR GLIOBLASTOMAS OF ORIGIN

scientific article published in November 2014

GE-39VALIDATION OF GLIOMA SPHERE-FORMING CELLS AS MODELS OF GLIOBLASTOMA AND IDENTIFICATION OF NOVEL DRIVERS OF TUMORIGENESIS THROUGH COMPREHENSIVE GENOMIC CHARACTERIZATION.

scientific article published in November 2014

GENO-36GLIOMA SPHERE-FORMING CELLS REVEAL INTRINSIC GLOBAL HYPERMETHYLATION ASSOCIATED WITH GBM RADIATION RESISTANCE.

scientific article

Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer

scientific article published on 3 March 2015

Genetics and biology of pancreatic ductal adenocarcinoma

scientific article

Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

scientific article

Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation

scientific article published in April 2004

High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

scientific article published in Nature Communications

Histone deacetylase 1 inactivation by an adenovirus early gene product.

scientific article

How Much Longer Will We Put Up With $100,000 Cancer Drugs?

scientific article published in February 2017

ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma

scientific article published on 9 June 2017

Identification of potent and selective MTH1 inhibitors

scientific article

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

scientific article

Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

scientific article published on 24 March 2009

Lineage-coupled clonal capture identifies clonal evolution mechanisms and vulnerabilities of BRAFV600E inhibition resistance in melanoma

scientific article published in 2022

Loss of ARID1A promotes epithelial-mesenchymal transition and sensitizes pancreatic tumors to proteotoxic stress

scientific article published on 06 November 2020

Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

scientific article published on 26 May 2021

Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis

scientific article

Metabolic Features of Cancer Treatment Resistance

scientific article

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

scientific article published on 01 May 2019

Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein ⬇️

scientific article published on May 1, 2003

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

scientific article

Oncology drug discovery: planning a turnaround

scientific article published on April 2014

PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models

scientific article published in April 2011

PRKCI promotes immune suppression in ovarian cancer

scientific article published on 11 July 2017

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

scientific article published on 30 July 2021

Pooled library screening with multiplexed Cpf1 library

scientific article published on 17 July 2019

Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair

scientific article

Predictive Signatures Inform the Effective Repurposing of Decitabine to Treat KRAS-Dependent Pancreatic Ductal Adenocarcinoma

scientific article published on 05 September 2019

Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer

scientific article published on 27 May 2015

Regulating mammalian checkpoints through Cdc25 inactivation

scientific article

Role for histone deacetylase 1 in human tumor cell proliferation

scientific article

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

scientific article

Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor

scientific article published on 10 June 2015

Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells

scientific article published in October 2015

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

scientific article published on 27 March 2019

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

scientific article published on 8 February 2017

THE TREATMENT-RESISTANT MESENCHYMAL SIGNATURE IN GLIOBLASTOMA DERIVES FROM TUMOR CELLS INDEPENDENT OF STROMA.

scientific article published in July 2014

TMOD-04. A COMPREHENSIVE GENOMIC LANDSCAPE OF GLIOMA SPHEROID CULTURES RECAPITULATES THE HETEROGENEITY OF GLIOBLASTOMA AND IDENTIFIES DNA METHYLATION PREDICTORS OF RADIOTHERAPY RESPONSE

Targeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma

scientific article published on 11 November 2021

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

scientific article published on 2 July 2015

The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1.

scientific article published on 22 October 2002

Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner

scientific article

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma

scientific article published on 01 November 2019

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

scientific article published on 01 November 2019

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer

scientific article

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

scientific article published on 01 February 2019

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