List of works - Xianming Deng

A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC

scientific article published on 30 November 2021

A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant BtkC481S mutation in B-cell malignancies

scientific article published on 09 December 2019

An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit ⬇️

scientific article published on June 6, 2012

Biosynthesis and Chemical Diversification of Verucopeptin Leads to Structural and Functional Versatility

scientific article published on 27 May 2020

Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression

scientific article published on 21 October 2020

Brain Penetrant LRRK2 Inhibitor

scientific article

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

scientific article

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

scientific article published on January 2014

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

scientific article published on 6 March 2011

Correction to "Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold"

scientific article published on 13 August 2020

Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities

scientific article published on 19 June 2018

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors ⬇️

scientific article published on March 15, 2011

Expanding the Diversity of Allosteric Bcr-Abl Inhibitors ⬇️

scientific article published on October 14, 2010

GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

scientific article

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors

scientific article

Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 – 2011) ⬇️

scientific article published on November 6, 2012

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

scientific article published on 23 February 2022

Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors

scientific article published on 23 August 2018

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein ⬇️

scientific article published on September 14, 2010

Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase

scientific article

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains

scientific article published on 31 August 2018

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

scientific article published on 29 October 2013

Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis

scientific article published on 15 May 2020

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor

scientific article

List of works by Xianming Deng

A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC

A non-covalent inhibitor XMU-MP-3 overrides ibrutinib-resistant BtkC481S mutation in B-cell malignancies

An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit ⬇️

Biosynthesis and Chemical Diversification of Verucopeptin Leads to Structural and Functional Versatility

Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression

Brain Penetrant LRRK2 Inhibitor

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

Correction to "Synthesis and Structure-Activity Relationships of DCLK1 Kinase Inhibitors Based on a 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one Scaffold"

Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors ⬇️

Expanding the Diversity of Allosteric Bcr-Abl Inhibitors ⬇️

GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors

Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 – 2011) ⬇️

Low-dose metformin targets the lysosomal AMPK pathway through PEN2

Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors

Pharmacological Inhibition of BMK1 Suppresses Tumor Growth through Promyelocytic Leukemia Protein ⬇️

Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis

X-ray Crystal Structure of ERK5 (MAPK7) in Complex with a Specific Inhibitor