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List of works by Klaus F. Ley

'Slings' enable neutrophil rolling at high shear

scientific article

A clinically applicable adjuvant for an atherosclerosis vaccine in mice

scientific article published on 12 August 2018

A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense

scientific article

ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis

scientific article published on 30 March 2017

Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase

scientific article

Adam17-dependent shedding limits early neutrophil influx but does not alter early monocyte recruitment to inflammatory sites ⬇️

scientific article published on May 31, 2011

Analysis of leukocyte rolling in vivo and in vitro.

scientific article published in January 2006

Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis

scientific article

Arterial macrophages and regenerating endothelial cells express P-selectin in atherosclerosis-prone apolipoprotein E-deficient mice

scientific article

Atheroprotective Vaccination with MHC-II Restricted Peptides from ApoB-100.

scientific article published on 27 December 2013

Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells

scientific article published on 13 January 2017

Atherosclerosis

scientific article published on 01 October 2018

Atherosclerosis in the single-cell era

scientific article published on 01 October 2018

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.

scientific article published on 15 March 2018

Autoperfused mouse flow chamber reveals synergistic neutrophil accumulation through P-selectin and E-selectin

scientific article

B-Cell Aortic Homing and Atheroprotection Depend on Id3 ⬇️

scientific article published on October 27, 2011

Bench-to-bedside review: acute respiratory distress syndrome - how neutrophils migrate into the lung

scientific article

Beyond vascular inflammation--recent advances in understanding atherosclerosis

scientific article

Blocking p21-activated kinase reduces lipopolysaccharide-induced acute lung injury by preventing polymorphonuclear leukocyte infiltration

scientific article

CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis

scientific article published on 28 March 2016

CD40 ligand promotes Mac-1 expression, leukocyte recruitment, and neointima formation after vascular injury

scientific article

CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice

scientific article published on 02 December 2018

CXCL4 downregulates the atheroprotective hemoglobin receptor CD163 in human macrophages

scientific article

CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo

scientific article

CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wall

scientific article

Cell protrusions and tethers: a unified approach

scientific article

Chapter 11. Intravital microscopic investigation of leukocyte interactions with the blood vessel wall

scientific article

Chemokine Receptor Activation Enhances Memory B Cell Class Switching Linked to IgE Sensitization to Alpha Gal and Cardiovascular Disease

scientific article published on 01 January 2021

Chemokines and chemokine receptors in leukocyte trafficking

scientific article

Circulating T cell-monocyte complexes are markers of immune perturbations.

scientific article

Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E.

scientific article

Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation

scientific article

Corrigendum: Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages

scientific article published on 25 February 2020

Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung ⬇️

scientific article

Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis

scientific article

Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice

scientific article

Critical role of platelet P-selectin in the response to arterial injury in apolipoprotein-E-deficient mice

scientific article

Dances with leukocytes: how tetraspanin-enriched microdomains assemble to form endothelial adhesive platforms

scientific article published on November 2008

Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury

scientific article published on September 2002

Developing Neutrophils Must Eat…Themselves!

scientific article

Development of monocytes, macrophages, and dendritic cells

scientific article (publication date: 5 February 2010)

Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues

scientific article

Double jeopardy: how soluble P-selectin activates leukocytes in peripheral arterial occlusive disease

scientific article published on 01 January 2006

Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation

scientific article published in December 2017

Effects of native and modified low-density lipoproteins on monocyte recruitment in atherosclerosis

scientific article

Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis

scientific article published on 01 March 2021

Endothelial Heparan Sulfate Mediates Hepatic Neutrophil Trafficking and Injury during Staphylococcus aureus Sepsis

scientific article published on 21 September 2021

Endothelial Protective Monocyte Patrolling in Large Arteries Intensified by Western Diet and Atherosclerosis

scientific article

Epsin-mediated degradation of IP3R1 fuels atherosclerosis

scientific article published on 07 August 2020

Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease

scientific article

Flow Cytometry Analysis of Immune Cells Within Murine Aortas ⬇️

scientific article published on July 1, 2011

Frontline Science: A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling

scientific article published on 01 September 2019

Galphai2 is required for chemokine-induced neutrophil arrest

scientific article

Getting to the site of inflammation: the leukocyte adhesion cascade updated

scientific article (publication date: September 2007)

Glycosylation in immune cell trafficking

scientific article published on July 2009

Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

Gαi2 and Gαi3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils

scientific article published on 14 March 2016

HGF Guides T Cells into the Heart.

scientific article published in June 2015

High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis

scientific article published on 01 January 2019

Hold on to your endothelium: postarrest steps of the leukocyte adhesion cascade

scientific article

How Mouse Macrophages Sense What Is Going On.

scientific article

How dendritic cells shape atherosclerosis ⬇️

scientific article published on August 10, 2011

IL-17A controls IL-17F production and maintains blood neutrophil counts in mice

scientific article

IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor

scientific article

IL-17A-producing neutrophil-regulatory Tn lymphocytes

scientific article

IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice

scientific article

IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.

scientific article

Imaging of the immune system - towards a subcellular and molecular understanding

scientific article published on 05 March 2020

Immune and inflammatory mechanisms of atherosclerosis (*)

scientific article published on January 2009

Immunity and Inflammation in Atherosclerosis

scientific article published on 01 January 2019

Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation

scientific article

Induction of dendritic cell-like phenotype in macrophages during foam cell formation

scientific article

Induction of vascular permeability: beta PIX and GIT1 scaffold the activation of extracellular signal-regulated kinase by PAK.

scientific article

Inflammatory Pathways Regulated By Tumor-Necrosis Receptor Associated Factor 1 Protect From Metabolic Consequences In Diet-Induced Obesity

scientific article published on 22 January 2018

Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity

scientific article

Interleukin 17 in vascular inflammation ⬇️

scientific article published on November 12, 2010

Intravital live cell triggered imaging system reveals monocyte patrolling and macrophage migration in atherosclerotic arteries.

scientific article

Kindlin-3 is essential for patrolling and phagocytosis functions of nonclassical monocytes during metastatic cancer surveillance

scientific article published on 09 May 2020

Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling

scientific article published on 10 August 2020

L-selectin is required for fMLP- but not C5a-induced margination of neutrophils in pulmonary circulation

scientific article

Leaking chemokines confuse neutrophils

scientific article published on 23 March 2020

Leukocyte Adhesion Deficiency IV. Monocyte Integrin Activation Deficiency in Cystic Fibrosis

scientific article published on May 2016

Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation

scientific article published on 16 December 2015

Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow

scientific article

Leukocyte phosphoinositide-3 kinase {gamma} is required for chemokine-induced, sustained adhesion under flow in vivo

scientific article

Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis

scientific article

Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays

scientific article

Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent

scientific article

M1 Means Kill; M2 Means Heal.

scientific article published in October 2017

MISTICA: Minimum Spanning Tree-Based Coarse Image Alignment for Microscopy Image Sequences.

scientific article

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages

scientific article published on 24 May 2019

Macrophage differentiation to foam cells

scientific article

Macrophages at the fork in the road to health or disease

scientific article

Mechanisms and consequences of neutrophil interaction with the endothelium

scientific article

Mechanisms by which diabetes increases cardiovascular disease

scientific article

Meta-Analysis of Leukocyte Diversity in Atherosclerotic Mouse Aortas

scientific article published on 16 July 2020

Microfluidics-based side view flow chamber reveals tether-to-sling transition in rolling neutrophils

scientific article

Microviscometry reveals reduced blood viscosity and altered shear rate and shear stress profiles in microvessels after hemodilution

scientific article

Migratory and Dancing Macrophage Subsets in Atherosclerotic Lesions

scientific article published on 09 October 2019

Monocyte-endothelial cell interactions in the development of atherosclerosis

scientific article published on August 2008

Multi-cell 3D tracking with adaptive acceptance gates

NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis

scientific article published on 22 December 2011

Natural Killer Cells at Ease: Atherosclerosis Is Not Affected by Genetic Depletion or Hyperactivation of Natural Killer Cells.

scientific article published in January 2018

Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival

scientific article

Near-wall micro-PIV reveals a hydrodynamically relevant endothelial surface layer in venules in vivo

scientific article

Neutrophil Recruitment: From Model Systems to Tissue-Specific Patterns

scientific article published on 04 June 2019

Neutrophil arrest by LFA-1 activation ⬇️

scientific article published on June 12, 2012

Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis.

scientific article

Neutrophils: New insights and open questions

scientific article published on 07 December 2018

New insights into leukocyte recruitment by intravital microscopy

scientific article published on January 2009

Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production

scientific article published on 14 January 2022

Opportunities for an atherosclerosis vaccine: From mice to humans

scientific article published on 18 January 2020

Oxidative modification of leukocyte adhesion

scientific article

Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice

scientific article published in Nature

P-selectin glycoprotein ligand-1 mediates L-selectin-dependent leukocyte rolling in venules

scientific article

P-selectin glycoprotein ligand-1-deficient mice have impaired leukocyte tethering to E-selectin under flow

scientific article

Pathogenic Autoimmunity in Atherosclerosis Evolves from Initially Protective ApoB-Reactive CD4+ T-Regulatory Cells

scientific article published on 24 July 2020

Patrolling Mechanics of Non-Classical Monocytes in Vascular Inflammation

scientific article published on 19 December 2017

Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17.

scientific article

Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation

scientific article published on 01 February 2019

Platelet chemokines in vascular disease

scientific article published on 21 August 2008

Platelet-neutrophil-interactions: linking hemostasis and inflammation

scientific article

Prevention, but not cure, of autoimmune diabetes in a NOD.scid transfer model by FTY720 despite effective modulation of blood T cells

scientific article

Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules.

scientific article

Protective effects of isoflurane pretreatment in endotoxin-induced lung injury

scientific article

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem

scientific article published on 15 April 2019

Regulatory CD4+ T Cells Recognize MHC-II-Restricted Peptide Epitopes of Apolipoprotein B.

scientific article published on 27 March 2018

Regulatory T Cell Stability and Plasticity in Atherosclerosis

scientific article published on 11 December 2020

Role of the endothelial surface layer in neutrophil recruitment

scientific article

Rolling neutrophils form tethers and slings under physiologic conditions in vivo.

scientific article

Rosiglitazone reduces the accelerated neointima formation after arterial injury in a mouse injury model of type 2 diabetes

scientific article

SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration

scientific article published on 22 January 2015

Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis

scientific article published on 21 September 2017

Selectins in T-cell recruitment to non-lymphoid tissues and sites of inflammation

scientific article

Sequential recruitment of neutrophils into lung and bronchoalveolar lavage fluid in LPS-induced acute lung injury

scientific article

Severely reduced neutrophil adhesion and impaired host defense against fecal and commensal bacteria in CD18-/-P-selectin-/- double null mice

scientific article

Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation

scientific article

Sialyltransferase specificity in selectin ligand formation

scientific article published on 25 July 2002

Single Cell RNA Sequencing in Atherosclerosis Research

scientific article published on 23 April 2020

Single injection of P-selectin or P-selectin glycoprotein ligand-1 monoclonal antibody blocks neointima formation after arterial injury in apolipoprotein E-deficient mice

scientific article

Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis

scientific article published on 15 March 2018

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

scientific journal article

Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor

scientific article

Spleen tyrosine kinase Syk is necessary for E-selectin-induced alpha(L)beta(2) integrin-mediated rolling on intercellular adhesion molecule-1.

scientific article

Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.

scientific article published on 9 November 2017

Super-STORM: Molecular Modeling to Achieve Single-molecule Localization with STORM Microscopy

scientific article published on 03 June 2020

T cell requirement for development of chronic ulcerative dermatitis in E- and P-selectin-deficient mice

scientific article

T cell subsets and functions in atherosclerosis

scientific article published on 16 March 2020

Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response

scientific article

The chemokine KC, but not monocyte chemoattractant protein-1, triggers monocyte arrest on early atherosclerotic endothelium

The primary defect in experimental ileitis originates from a nonhematopoietic source

scientific article

The role of platelets in acute lung injury (ALI)

scientific article

The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration

scientific article published on 12 February 2019

Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury

scientific article

Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720.

scientific article

Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development

scientific article published on 13 March 2018

Vaccination against atherosclerosis

scientific article published on 29 March 2019

Vaccination to modulate atherosclerosis

scientific article published on 16 February 2015

Vascular adhesion molecules in atherosclerosis

scientific article

Vascular protection by estrogen in ischemia-reperfusion injury requires endothelial nitric oxide synthase

scientific article

Viscosity-independent velocity of neutrophils rolling on p-selectin in vitro or in vivo

scientific article

Waking up the stem cell niche: how hematopoietic stem cells generate inflammatory monocytes after stroke.

scientific article published on January 2015

α2,3-Sialyltransferase-IV is essential for L-selectin ligand function in inflammation

scholarly article by Markus Sperandio et al published December 2006 in European Journal of Immunology

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