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List of works by Roy S. Herbst

"Companion diagnostics": has their time come and gone?

scientific article

"Quitting smoking will benefit your health": the evolution of clinician messaging to encourage tobacco cessation

scientific article published on 16 January 2014

A First-in-Human Study of Conatumumab in Adult Patients with Advanced Solid Tumors ⬇️

scientific article published on October 14, 2010

A Multicenter Phase I Trial of PX-866, an Oral Irreversible Phosphatidylinositol 3-Kinase Inhibitor, in Patients with Advanced Solid Tumors ⬇️

scientific article published on June 12, 2012

A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress

scientific article

A RAS renaissance: emerging targeted therapies for KRAS-mutated non-small cell lung cancer

scientific article published on 03 June 2014

A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers

scientific article published in Nature Communications

A multicenter, phase 2 study of vascular endothelial growth factor trap (Aflibercept) in platinum- and erlotinib-resistant adenocarcinoma of the lung.

scientific article published in July 2010

A phase 2 study of cetuximab in combination with docetaxel in chemotherapy-refractory/resistant patients with advanced nonsmall cell lung cancer

scientific article published on April 2009

A phase I safety and pharmacokinetic study of the death receptor 5 agonistic antibody PRO95780 in patients with advanced malignancies

scientific article published on 09 February 2010

A phase I surrogate endpoint study of SU6668 in patients with solid tumors

scientific article

A phase I/IIA trial of continuous five-day infusion of squalamine lactate (MSI-1256F) plus carboplatin and paclitaxel in patients with advanced non-small cell lung cancer ⬇️

scientific article published on September 15, 2003

A phase II study of STEALTH cisplatin (SPI-77) in patients with advanced non-small cell lung cancer

scientific article

A retrospective analysis of RET translocation, gene copy number gain and expression in NSCLC patients treated with vandetanib in four randomized Phase III studies

scientific article published on 23 March 2015

A retrospective analysis of the outcome of patients who have received two prior chemotherapy regimens including platinum and docetaxel for recurrent non-small-cell lung cancer.

scientific article

A step towards treating KRAS-mutant NSCLC ⬇️

scientific article published on November 28, 2012

AACR Celebrates 50 Years of Tobacco Research and Policy

scientific article published on 31 March 2014

ADAURA: Phase III, Double-blind, Randomized Study of Osimertinib Versus Placebo in EGFR Mutation-positive Early-stage NSCLC After Complete Surgical Resection

scientific article

Acute in vivo resistance in high-dose therapy ⬇️

scientific article published on February 1, 1998

Addressing Tobacco Use in Patients With Cancer: A Survey of American Society of Clinical Oncology Members ⬇️

scientific article published on July 29, 2013

American Society of Clinical Oncology perspective: Raising the bar for clinical trials by defining clinically meaningful outcomes

scientific article

An Open-Label, Multicenter, Three-Stage, Phase II Study of S-1 in Combination with Cisplatin as First-Line Therapy for Patients with Advanced Non-small Cell Lung Cancer ⬇️

scientific article published on 01 August 2011

An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance

scientific article published on 22 October 2012

Angiogenesis and lung cancer: implications for prognosis and treatment

scientific article published on 01 June 2007

Angiogenesis and lung cancer: potential for therapy

scientific article published on 01 December 2000

Angiogenesis and lung cancer: prognostic and therapeutic implications

scientific article

Angiogenesis as a target for cancer therapy

scientific article

Angiogenesis inhibition and lung-cancer therapy

scientific article published on 01 February 2014

Angiogenesis inhibition in the treatment of lung cancer.

scientific article published on November 2006

Angiogenesis inhibitors in clinical development for lung cancer

scientific article

Angiogenesis inhibitors in lung cancer

scientific article

Angiogenesis pathway inhibitors.

scientific article

Angiogenesis, metastasis, and lung cancer. An overview.

scientific article

Anti-vascular endothelial growth factor monoclonals in non-small cell lung cancer

scientific article published in June 2004

Antiangiogenic tumor therapy

scientific article

Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor-independent urokinase-type plasminogen activator inhibition

scientific article published on November 2006

Asian ethnicity as a predictor of response in patients with non-small-cell lung cancer treated with gefitinib on an expanded access program

scientific article

Assessing Tobacco Use by Cancer Patients and Facilitating Cessation: An American Association for Cancer Research Policy Statement ⬇️

scientific article published on 09 April 2013

Assessment of antiangiogenic effect using 99mTc-EC-endostatin

scientific article published in April 2002

Association of Broad-Based Genomic Sequencing With Survival Among Patients With Advanced Non-Small Cell Lung Cancer in the Community Oncology Setting

scientific article published on 01 August 2018

Association of Delayed Adjuvant Chemotherapy With Survival After Lung Cancer Surgery

scientific article published on 5 January 2017

B7-H1/PD-1 blockade therapy in non-small cell lung cancer: current status and future direction

scientific article published on July 2014

B7-H3 Expression in NSCLC and Its Association with B7-H4, PD-L1 and Tumor-Infiltrating Lymphocytes

scientific article published on 24 May 2017

Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer.

scientific article published on 15 May 2009

Bayesian Two-stage Biomarker-based Adaptive Design for Targeted Therapy Development

scientific article published on 04 December 2014

Bayesian adaptive design for targeted therapy development in lung cancer--a step toward personalized medicine

scientific article

Bevacizumab and erlotinib: a promising new approach to the treatment of advanced NSCLC.

scientific article

Bevacizumab/chemotherapy in non-small-cell lung cancer: looking for a few good men?

scientific article published on 01 March 2008

Beyond doublet chemotherapy for advanced non-small-cell lung cancer: combination of targeted agents with first-line chemotherapy

scientific article published on January 2009

Biomarkers associated with beneficial PD-1 checkpoint blockade in non-small-cell lung cancer (NSCLC) identified using high-plex digital spatial profiling

scientific article published on 06 April 2020

CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma

scientific article published on 30 November 2012

Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells.

scientific article published on 23 January 2013

Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study

scientific article

Cetuximab therapy for patients with advanced squamous cell carcinomas of the head and neck

scientific article

Challenges and approaches to implementing master/basket trials in oncology

scientific article published on 01 July 2019

Chemoradiotherapy with or without AE-941 in stage III non-small cell lung cancer: a randomized phase III trial

scientific article

Chemotherapy for advanced non-small cell lung cancer

scientific article published on 01 June 1997

Circulating and tumor-based biomarkers predict clinical activity in cancer patients treated with the engineered anti-PD-L1 antibody MPDL3280A

Cis effect of the type 5 adenovirus E1A gene enhancer element on cellular transformation

scientific article published in January 1990

Classification by mass spectrometry can accurately and reliably predict outcome in patients with non-small cell lung cancer treated with erlotinib-containing regimen

scientific article

Clinical Cancer Advances 2005: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology

scientific article

Clinical Features and Management of Acquired Resistance to PD-1 Axis Inhibitors in 26 Patients With Advanced Non-Small Cell Lung Cancer.

scientific article published on 22 March 2018

Clinical Outcomes and Biomarker Profiles of Elderly Pretreated NSCLC Patients from the BATTLE Trial ⬇️

scientific article published on November 1, 2012

Clinical and biomarker outcomes of the phase II vandetanib study from the BATTLE trial

scientific article published on May 2013

Clinical and pharmacokinetic study of TNP-470, an angiogenesis inhibitor, in combination with paclitaxel and carboplatin in patients with solid tumors

scientific article published on 04 June 2004

Clinical cancer advances 2006: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology

scientific article published on 8 December 2006

Clinical significance of PD-L1 protein expression on tumor-associated macrophages in lung cancer.

scientific article published on 4 November 2015

Clinically meaningful improvement in symptoms and quality of life for patients with non-small-cell lung cancer receiving gefitinib in a randomized controlled trial

scientific article published on 7 February 2005

Clinician Perspectives on Current Issues in Lung Cancer Drug Development.

scientific article

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

scientific article

Combination Treatment with MEK and AKT Inhibitors Is More Effective than Each Drug Alone in Human Non-Small Cell Lung Cancer In Vitro and In Vivo ⬇️

scientific article published on November 29, 2010

Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis

scientific article published on 24 January 2012

Combining targeted agents: blocking the epidermal growth factor and vascular endothelial growth factor pathways

scientific article published on July 2006

Comment on "Treatment of non-small cell lung cancer stage IIIA: ACCP evidence-based clinical practice guidelines (2nd edition)"

scientific article published on 01 December 2008

Comparison of outcomes for patients with unresectable, locally advanced non-small-cell lung cancer treated with induction chemotherapy followed by concurrent chemoradiation vs. concurrent chemoradiation alone

scientific article published on 06 April 2007

Comparison of patient outcomes according to histology among pemetrexed-treated patients with stage IIIB/IV non-small-cell lung cancer in two phase II trials

scientific article

Comprehensive T cell repertoire characterization of non-small cell lung cancer

scientific article published on 30 January 2020

Comprehensive biomarker analysis and final efficacy results of sorafenib in the BATTLE trial

scientific article published on 28 October 2013

Concomitant targeting of the mTOR/MAPK pathways: novel therapeutic strategy in subsets of -altered non-small cell lung cancer

Convergent Identification and Interrogation of Tumor-Intrinsic Factors that Modulate Cancer Immunity In Vivo

scientific article published on 20 February 2019

Current and Future Strategies for Antiangiogenic Agents in Non–Small-Cell Lung Cancer ⬇️

scientific article published on 01 March 2008

Current management of advanced non-small cell lung cancer: targeted therapy

scientific article

Defining and Understanding Adaptive Resistance in Cancer Immunotherapy

scholarly article by Tae Kon Kim et al published August 2018 in Trends in Immunology

Dermatologic Side Effects Associated with Gefitinib Therapy: Clinical Experience and Management ⬇️

scientific article published on May 1, 2003

Design of a Phase III Clinical Trial with Prospective Biomarker Validation: SWOG S0819 ⬇️

scientific article published on May 16, 2012

Development and validation of a drug activity biomarker that shows target inhibition in cancer patients receiving enzastaurin, a novel protein kinase C-beta inhibitor

scientific article published on June 2006

Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice.

scientific article published on November 2003

Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin

scientific article

Differential Expression and Significance of PD-L1, IDO-1, and B7-H4 in Human Lung Cancer

scientific article published on 20 July 2016

Differential expression of E-cadherin and type IV collagenase genes predicts outcome in patients with stage I non-small cell lung carcinoma

scientific article published on March 2000

Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells.

scientific article

Diminished but not dead: chemotherapy for the treatment of NSCLC

scientific article published on 01 November 2016

Disparities in broad-based genomic sequencing for patients with advanced non-small cell lung cancer

scientific article published on 02 February 2019

Dose escalation of gemcitabine is possible with concurrent chest three-dimensional rather than two-dimensional radiotherapy: a phase I trial in patients with stage III non-small-cell lung cancer

scientific article published on 14 June 2008

Dose-comparative monotherapy trials of ZD1839 in previously treated non-small cell lung cancer patients

scientific article

Dynamic contrast-enhanced magnetic resonance imaging as a pharmacodynamic measure of response after acute dosing of AG-013736, an oral angiogenesis inhibitor, in patients with advanced solid tumors: results from a phase I study

scientific article

E2F8 as a Novel Therapeutic Target for Lung Cancer

scientific article

EGFR Mutations in Non-Small-Cell Lung Cancer: Find, Divide, and Conquer.

scientific article

EGFR biomarkers predict benefit from vandetanib in combination with docetaxel in a randomized phase III study of second-line treatment of patients with advanced non-small cell lung cancer

scientific article

EGFR expression and the flexibility of FLEX ⬇️

scientific article published on 04 November 2011

EGFR inhibition in NSCLC: the emerging role of cetuximab.

scientific article published on September 2004

EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small cell lung cancer

scientific article published on 01 August 2019

EGFR tyrosine kinase inhibitors in squamous cell lung cancer.

scientific article published on 5 July 2015

Early Assessment of Lung Cancer Immunotherapy Response via Circulating Tumor DNA.

scientific article published on 12 January 2018

Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome

scientific article

Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer: report of a randomized comparative trial

scientific article published on April 2004

Efficacy and safety of gefitinib in chemonaive patients with advanced non-small cell lung cancer treated in an Expanded Access Program

scientific article published on 23 June 2006

Efficacy and safety of single-agent pertuzumab, a human epidermal receptor dimerization inhibitor, in patients with non small cell lung cancer

scientific article published in October 2007

Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial ⬇️

scientific article published on May 28, 2011

Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial

scientific article

Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology

scientific article

Electronic nicotine delivery systems: a policy statement from the American Association for Cancer Research and the American Society of Clinical Oncology

scientific article published on 8 January 2015

Emerging science and therapies in non-small-cell lung cancer: targeting the MET pathway

scientific article published in November 2014

Emerging therapies in non-small-cell lung cancer

scientific article

Endostatin improves radioresponse and blocks tumor revascularization after radiation therapy for A431 xenografts in mice

scientific article published on March 2007

Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report.

scientific article published on 21 April 2017

Enzastaurin, a protein kinase Cbeta- selective inhibitor, and its potential application as an anticancer agent in lung cancer

scientific article published on August 2007

Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer

scientific article

Epidermal growth factor receptor expression analysis in chemotherapy-naive patients with advanced non-small-cell lung cancer treated with gefitinib or placebo in combination with platinum-based chemotherapy

scientific article

Epidermal growth factor receptor inhibitors in development for the treatment of non-small cell lung cancer

scientific article published on July 2006

Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials

scientific article

Epidermal growth factor receptor tyrosine kinase inhibitor does not improve paclitaxel effect in an orthotopic mouse model of lung cancer

scientific article published in December 2004

Epidermal growth factor receptors as a target for cancer treatment: the emerging role of IMC-C225 in the treatment of lung and head and neck cancers

scientific article

Erlotinib (Tarceva): an update on the clinical trial program

scientific article

Erlotinib.

scientific article

Evaluation of Novel Orthotopic Nude Mouse Models for Human Small-Cell Lung Cancer ⬇️

scientific article published on February 1, 2013

Evolving Treatment Options for Lung Cancer

scientific article published in February 2017

Evolving treatment algorithms for advanced non-small-cell lung cancer: 2009 looking toward 2012 ⬇️

scientific article published on March 1, 2010

Evolving treatment algorithms for advanced non-small-cell lung cancer: 2009 looking toward 2012.

scientific article published in November 2009

Expression Analysis and Significance of PD-1, LAG-3, and TIM-3 in Human Non-Small Cell Lung Cancer Using Spatially Resolved and Multiparametric Single-Cell Analysis

scientific article published on 03 May 2019

Expression and clinical significance of PD-L1, B7-H3, B7-H4 and TILs in human small cell lung Cancer (SCLC)

scholarly article by Daniel Carvajal-Hausdorf et al published 8 March 2019 in Journal for Immunotherapy of Cancer

Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice

scientific article published on 3 October 2007

Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis

scientific article published in September 2000

Extracellular Matrix Receptor Expression in Subtypes of Lung Adenocarcinoma Potentiates Outgrowth of Micrometastases

scientific article published on 14 February 2017

From the Guest Editors: Progress and Future Directions for the Treatment of Advanced Lung Cancer

scientific article published in September 2015

Frontline immunotherapy for NSCLC - the tale of the tail

scientific article published on 01 February 2020

Future directions of monoclonal antibody use in personalized lung cancer therapy

scientific article published on November 30, 2010

GSK-3α Is a Novel Target of CREB and CREB-GSK-3α Signaling Participates in Cell Viability in Lung Cancer

scientific article

Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 1.

scientific article

Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial--INTACT 2.

scientific article

Gefitinib--a novel targeted approach to treating cancer

scientific article published in December 2004

Gefitinib: current and future status in cancer therapy.

scientific article

Gemcitabine and vinorelbine combinations in the treatment of non-small cell lung cancer.

scientific article

Gemcitabine and vinorelbine in patients with advanced lung cancer: preclinical studies and report of a phase I trial

scientific article

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma

scientific article published on 01 April 2016

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.

scientific article

Guillain-Barré syndrome following allogeneic bone marrow transplantation ⬇️

scientific article published on December 1, 1997

Health-Related Quality of Life in KEYNOTE-010: a Phase II/III Study of Pembrolizumab Versus Docetaxel in Patients With Previously Treated Advanced, Programmed Death Ligand 1-Expressing NSCLC

scientific article published on 31 January 2019

High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor

scientific article published in December 2005

Highlights in NSCLC From the IASLC (International Association for the Study of Lung Cancer) 14th World Conference on Lung Cancer

scientific article published on 01 September 2011

IMC-C225, an anti-epidermal growth factor receptor monoclonal antibody for treatment of head and neck cancer

scientific article

Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma

scientific article

Imaging in drug development.

scientific article published in May 2004

Immune Cell PD-L1 Colocalizes with Macrophages and Is Associated with Outcome in PD-1 Pathway Blockade Therapy

scientific article published on 15 October 2019

Immune Checkpoint Inhibitor-Associated Pericarditis

scientific article published on 07 March 2019

Immune checkpoint inhibitors in thoracic malignancies: Review of the existing evidence by an IASLC expert panel and recommendations

scientific article published on 13 March 2020

Immune checkpoint therapy for non-small-cell lung cancer: an update

scientific article published on 09 February 2016

Immuno-thermal ablations - boosting the anticancer immune response

scientific article published on 17 October 2017

Immunotherapy in Lung Cancer

scientific article published on 01 February 2017

Immunotherapy in Non-Small Cell Lung Cancer: Facts and Hopes

scientific article published on 01 March 2019

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

scientific article published on 12 October 2017

Improvements in quality of life and disease-related symptoms in phase I trials of the selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in non-small cell lung cancer and other solid tumors

scientific article

In Reply

In vitro and in vivo assays for the proliferative and vascular permeabilization activities of vascular endothelial growth factor (VEGF) and its receptor

scientific article published in January 2003

Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy

scientific article

Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy

scientific article

Induction docetaxel and carboplatin followed by weekly docetaxel and carboplatin with concurrent radiotherapy, then surgery in stage III non-small cell lung cancer: a Phase I study.

scientific article published in May 2003

Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy.

scientific article published in January 2003

Innovative Clinical Trials: The LUNG-MAP Study

scientific article

Integration of Molecular Profiling into the Lung Cancer Clinic

scientific article published on 25 August 2009

Integration of Targeted Therapies in Gemcitabine Chemotherapy Regimens ⬇️

scientific article published on January 1, 2003

Interobserver and intraobserver variability in measurement of non-small-cell carcinoma lung lesions: implications for assessment of tumor response

scientific article published in July 2003

JAK1/STAT3 activation through a proinflammatory cytokine pathway leads to resistance to molecularly targeted therapy in non-small cell lung cancer

scientific article published on 20 July 2017

KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib

scientific article published on 17 November 2015

KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer

scientific article published on May 2007

Larotrectinib in NTRK-Rearranged Solid TumorsPublished as part of the Biochemistry series "Biochemistry to Bedside"

scientific article published on 13 March 2019

Limited-stage small-cell lung cancer (stages I-III): observations from the National Cancer Data Base

scientific article

Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Statement Paper from the IASLC

article

Long-Term Outcomes and Retreatment Among Patients With Previously Treated, Programmed Death-Ligand 1‒Positive, Advanced Non‒Small-Cell Lung Cancer in the KEYNOTE-010 Study

scientific article published on 20 February 2020

Lung Endothelial MicroRNA-1 Regulates Tumor Growth and Angiogenesis

scientific article published on 30 August 2017

Lung Master Protocol (Lung-MAP)-A Biomarker-Driven Protocol for Accelerating Development of Therapies for Squamous Cell Lung Cancer: SWOG S1400.

scientific article

Lung cancer

scientific article (publication date: 25 September 2008)

Lung cancer in patients under age 40.

scientific article

Lung cancer in the era of precision medicine

scientific article published in May 2015

Lung-MAP--framework, overview, and design principles

scientific article

Measurement of conatumumab-induced apoptotic activity in tumors by fine needle aspirate sampling

scientific article

Methodological and practical challenges for personalized cancer therapies ⬇️

scientific article published on March 1, 2011

Miscellaneous Agents ⬇️

scientific article published on December 1, 2012

Mode of action of docetaxel - a basis for combination with novel anticancer agents

scientific article

Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib

scientific article

Molecular origins of lung cancer: prospects for personalized prevention and therapy.

scientific article published in June 2010

Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor

scientific article

Molecular signatures of lung cancer--toward personalized therapy

scientific article published on 01 January 2007

Molecular targeted therapy for lung cancer

scientific article published in October 2005

Molecularly targeted therapies in non-small-cell lung cancer annual update 2014

scientific article

Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy

scientific article published on 01 March 2002

Multitargeted Tyrosine Kinase Inhibitors in Unselected Patients With Advanced Non–Small-Cell Lung Cancer (NSCLC): Impressions From MONET (the Motesanib NSCLC Efficacy and Tolerability Study) ⬇️

scientific article published on July 2, 2012

Multitargeted inhibitors in lung cancer: new clinical data

scientific article

Mutation profiles in early-stage lung squamous cell carcinoma with clinical follow-up and correlation with markers of immune function.

scientific article published in January 2017

Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

scientific article published on 25 July 2005

New strategies in personalized medicine for solid tumors: molecular markers and clinical trial designs

scientific article published on September 2014

New targets for the treatment of advanced non-small cell lung cancer

scientific article published on January 1, 2002

Nivolumab and Pembrolizumab for Non-Small Cell Lung Cancer

scientific article published on June 2016

Non-small cell lung cancer and antiangiogenic therapy: what can be expected of bevacizumab?

scientific article published on January 2004

Non-small cell lung cancer clinical trials with trastuzumab: their foundation and preliminary results

scientific article

Novel agents in the treatment of lung cancer: Fourth Cambridge Conference

scientific article published in August 2007

Novel agents in the treatment of lung cancer: conference summary statement

scientific article published on 01 June 2004

Novel therapeutics for head and neck cancer

scientific article

Objective measurement and clinical significance of TILs in non-small cell lung cancer

scientific article

Oblimersen sodium (Genasense bcl-2 antisense oligonucleotide): a rational therapeutic to enhance apoptosis in therapy of lung cancer

scientific article published in June 2004

Opening Up to Precompetitive Collaboration ⬇️

scientific article published on 01 October 2010

Overview of the current status of human epidermal growth factor receptor inhibitors in lung cancer.

scientific article

Overview of the efficacy of cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum-based therapies

scientific article published in June 2008

P2.41 (also presented as PD1.06): Pembrolizumab vs Docetaxel for Previously Treated NSCLC (KEYNOTE-010): Archival vs New Tumor Samples for PD-L1 Assessment: Track: Immunotherapy

scientific article published on 22 September 2016

PD-1/PD-L1 blockers in NSCLC brain metastases: challenging paradigms and clinical practice

scientific article published on 30 April 2020

PD1.06 (also presented as P2.41): Pembrolizumab vs Docetaxel for Previously Treated NSCLC (KEYNOTE-010): Archival vs New Tumor Samples for PD-L1 Assessment

scientific article published on 22 September 2016

PS01.56: IMpower110: Phase III Trial Comparing 1L Atezolizumab with Chemotherapy in PD-L1-Selected Chemotherapy-Naive NSCLC Patients: Topic: Medical Oncology

scientific article

PS01.62: Long-Term Safety and Clinical Activity of Atezolizumab Monotherapy in Metastatic NSCLC: Final Results from a Phase Ia Study: Topic: Medical Oncology

scientific article

Paclitaxel/carboplatin administration along with antiangiogenic therapy in non-small-cell lung and breast carcinoma models ⬇️

scientific article published on 01 January 1998

Patient selection criteria and the FLEX Study

scientific article published in May 2009

Pembrolizumab for management of patients with NSCLC and brain metastases: long-term results and biomarker analysis from a non-randomised, open-label, phase 2 trial

scientific article published on 03 April 2020

Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, phase 2 trial

scientific article

Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial

scientific article

Pemetrexed in advanced NSCLC: a review of the clinical data.

scientific article

Pemetrexed in the treatment of advanced non-small-cell lung cancer: a review of the clinical data

scientific article

Personalized Therapy ⬇️

scientific article published on December 1, 2012

Pharmacodynamic analysis of target inhibition and endothelial cell death in tumors treated with the vascular endothelial growth factor receptor antagonists SU5416 or SU6668.

scientific article published in January 2005

Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition

scientific article published in January 2002

Pharmacokinetic study of the phase III, randomized, double-blind, multicenter trial (TRIBUTE) of paclitaxel and carboplatin combined with erlotinib or placebo in patients with advanced Non-small Cell Lung Cancer (NSCLC)

scientific article published on 22 January 2010

Phase I dose escalation and pharmacokinetic study of enzastaurin, an oral protein kinase C beta inhibitor, in patients with advanced cancer

scientific article published on 01 September 2006

Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer

scientific article published on 10 May 2010

Phase I participants' views of quality of life and trial participation burdens

scientific article published in July 2007

Phase I study of recombinant human endostatin in patients with advanced solid tumors

scientific article published on 01 September 2002

Phase I study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in solid tumors

scientific article published on May 2004

Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results

scientific article

Phase I-IIa study of BMS-690514, an EGFR, HER-2 and -4 and VEGFR-1 to -3 oral tyrosine kinase inhibitor, in patients with advanced or metastatic solid tumours

scientific article published on 13 March 2013

Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lun

scientific article

Phase I/IIa study of cetuximab with gemcitabine plus carboplatin in patients with chemotherapy-naive advanced non-small-cell lung cancer

scientific article

Phase II Study of Cetuximab in Combination With Chemoradiation in Patients With Stage IIIA/B Non–Small-Cell Lung Cancer: RTOG 0324 ⬇️

scientific article published on May 9, 2011

Phase II Trial of S-1 as Second-Line Therapy in Patients with Advanced Non-small Cell Lung Cancer ⬇️

scientific article published on April 1, 2011

Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck

scientific article published on 11 July 2005

Phase II selection design trial of concurrent chemotherapy and cetuximab versus chemotherapy followed by cetuximab in advanced-stage non-small-cell lung cancer: Southwest Oncology Group study S0342

scientific article

Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer

scientific article published in October 2007

Phase II study of pemetrexed in combination with carboplatin in the first-line treatment of advanced nonsmall cell lung cancer

scientific article

Phase II study of the antiangiogenesis agent thalidomide in recurrent or metastatic squamous cell carcinoma of the head and neck ⬇️

scientific article published on November 1, 2001

Phase II study of vinorelbine and docetaxel in the treatment of advanced non-small-cell lung cancer as frontline and second-line therapy

scientific article published on April 2010

Phase II trial of carboplatin, paclitaxel, cetuximab, and bevacizumab followed by cetuximab and bevacizumab in advanced nonsquamous non-small-cell lung cancer: SWOG S0536

scientific article

Potential of the aminosterol, squalamine in combination therapy in the rat 13,762 mammary carcinoma and the murine Lewis lung carcinoma

scientific article published on 01 July 1998

Potential role of molecularly targeted therapy in the management of advanced nonsmall cell lung carcinoma in the elderly

scientific article published in October 2004

Practice Patterns and Perceptions of Thoracic Oncology Providers on Tobacco Use and Cessation in Cancer Patients ⬇️

scientific article published on May 1, 2013

Predictive Biomarkers for PD-1 Axis Therapies: The Hidden Treasure or a Call for Research

scientific article published on 08 March 2016

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

scientific article (publication date: 27 November 2014)

Production of experimental malignant pleural effusions is dependent on invasion of the pleura and expression of vascular endothelial growth factor/vascular permeability factor by human lung cancer cells

scientific article published in December 2000

Programmed death ligand-1 expression in non-small cell lung cancer

scientific article

Prostate carcinoma response to cytotoxic therapy: in vivo resistance

scientific article published on November 1, 1997

Quantitative Assessment of CMTM6 in the Tumor Microenvironment and Association with Response to PD-1 Pathway Blockade in Advanced-Stage Non-Small Cell Lung Cancer

scientific article published on 09 October 2019

Quantitative Assessment of the Heterogeneity of PD-L1 Expression in Non-Small-Cell Lung Cancer

scientific article

Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors

scientific article published in January 2004

Ramucirumab Plus Pembrolizumab in Patients with Previously Treated Advanced or Metastatic Biliary Tract Cancer: Nonrandomized, Open-Label, Phase I Trial (JVDF)

scientific article published on 31 May 2018

Ramucirumab plus pembrolizumab in patients with previously treated advanced non-small-cell lung cancer, gastro-oesophageal cancer, or urothelial carcinomas (JVDF): a multicohort, non-randomised, open-label, phase 1a/b trial

scientific article published on 10 July 2019

Ramucirumab plus pembrolizumab in previously treated advanced or metastatic biliary tract cancer: A multi-disease phase 1 study

scientific article published on 01 June 2017

Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer

scientific article

Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer

scientific article

Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer

scientific article published on September 2007

Reducing tobacco-related cancer incidence and mortality: summary of an institute of medicine workshop.

scientific article published on 4 December 2013

Report from the society for biological therapy and vascular biology faculty of the NCI workshop on angiogenesis monitoring

scientific article published in March 2004

Reports from the 2010 Clinical and Translational Cancer Research Think Tank meeting: design strategies for personalized therapy trials

scientific article

Research Priorities, Measures, and Recommendations for Assessment of Tobacco Use in Clinical Cancer Research

scientific article published on 17 February 2016

Review of epidermal growth factor receptor biology

scientific article

Role of chitinase 3-like-1 and semaphorin 7a in pulmonary melanoma metastasis

scientific article published on 15 December 2014

SWOG S1400B (NCT02785913), a Phase II Study of GDC-0032 (Taselisib) for Previously Treated PI3K-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Sub-Study)

scientific article published on 31 May 2019

SWOG S1400C (NCT02154490)-A Phase II Study of Palbociclib for Previously Treated Cell Cycle Gene Alteration-Positive Patients with Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy)

scientific article published on 11 July 2019

SWOG S1400D (NCT02965378), a Phase II Study of the Fibroblast Growth Factor Receptor Inhibitor AZD4547 in Previously Treated Patients With Fibroblast Growth Factor Pathway-Activated Stage IV Squamous Cell Lung Cancer (Lung-MAP Substudy)

scientific article published on 11 June 2019

Safety and clinical activity of atezolizumab monotherapy in metastatic non-small-cell lung cancer: final results from a phase I study

scientific article published on 01 August 2018

Safety and pharmacokinetic effects of TNP-470, an angiogenesis inhibitor, combined with paclitaxel in patients with solid tumors: evidence for activity in non-small-cell lung cancer

scientific article published on 01 November 2002

Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors

scientific article published on 22 June 2009

Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors

scientific article

Scientific Advances in Lung Cancer 2015.

scientific article published on 21 March 2016

Selective oral epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 is generally well-tolerated and has activity in non-small-cell lung cancer and other solid tumors: results of a phase I trial

scientific article published in September 2002

Should chemotherapy plus immune checkpoint inhibition be the standard front-line therapy for patients with metastatic non-small cell lung cancer?

scientific article published in November 2018

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

scientific article published on 04 March 2019

Small molecule combats cancer-causing KRAS protein at last

scientific article published on 01 November 2019

Small-cell lung cancer: prognostic factors and changing treatment over 15 years

scientific article

Smoking Cessation, Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

scientific article published in November 2016

Spatially resolved and quantitative analysis of VISTA/PD-1H as a novel immunotherapy target in human non-small cell lung cancer

scientific article published on 4 December 2017

Study of the media's potential influence on prospective research participants' understanding of and motivations for participation in a high-profile phase I trial

scientific article published in September 2002

Summary of selected presentations from the 8th annual targeted therapy in lung cancer symposium

scientific article

Summary report 7th Annual Targeted Therapies of the Treatment of Lung Cancer

scientific article

Surgery: Future directions in multimodality therapy for NSCLC.

scientific article

Synchronous overexpression of epidermal growth factor receptor and HER2-neu protein is a predictor of poor outcome in patients with stage I non-small cell lung cancer

scientific article published in January 2004

Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

scientific article published on 01 August 2019

TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer.

scientific article

Targeted drug delivery strategies to treat lung metastasis

scientific article published on October 2009

Targeted therapy against VEGFR and EGFR with ZD6474 enhances the therapeutic efficacy of irradiation in an orthotopic model of human non-small-cell lung cancer

scientific article

Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin

scientific article published in June 2002

Targeted therapy in non-small-cell lung cancer.

scientific article

Targeted therapy of orthotopic human lung cancer by combined vascular endothelial growth factor and epidermal growth factor receptor signaling blockade

scientific article published on February 2007

Targeted therapy using novel agents in the treatment of non-small-cell lung cancer

scientific article published in March 2002

Targeting Vascular Endothelial Growth Factor in Patients With Squamous Cell Lung Cancer ⬇️

scientific article published on February 21, 2012

Targeting the Apoptotic Pathway in Chondrosarcoma Using Recombinant Human Apo2L/TRAIL (Dulanermin), a Dual Proapoptotic Receptor (DR4/DR5) Agonist ⬇️

scientific article published on August 20, 2012

Targeting the epidermal growth factor receptor in non-small cell lung cancer.

scientific article published on December 2003

Thalidomide, cyclooxygenase-2, and angiogenesis: potential for therapy ⬇️

scientific article published on November 1, 2001

The BATTLE trial: personalizing therapy for lung cancer

scientific article

The BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer

scientific article published on August 2016

The Combination of MEK Inhibitor With Immunomodulatory Antibodies Targeting Programmed Death 1 and Programmed Death Ligand 1 Results in Prolonged Survival in Kras/p53-Driven Lung Cancer

article by Jong Woo Lee et al published June 2019 in Journal of Thoracic Oncology

The HGF/c-MET Pathway Is a Driver and Biomarker of VEGFR-inhibitor Resistance and Vascular Remodeling in Non-Small Cell Lung Cancer

scientific article

The International Association for the Study of Lung Cancer Consensus Statement on Optimizing Management of EGFR Mutation-Positive Non-Small Cell Lung Cancer: Status in 2016.

scientific article published on 20 May 2016

The PD-1 pathway as a therapeutic target to overcome immune escape mechanisms in cancer

scientific article

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC).

scientific article published on 17 July 2018

The Value of Cancer Immunotherapy Summit at the 2016 Society for Immunotherapy of Cancer 31st anniversary annual meeting.

scientific article published on 18 April 2017

The biology and management of non-small cell lung cancer

scientific article published in January 2018

The changing face of phase 1 cancer clinical trials: new challenges in study requirements

scientific article published on April 2009

The fork in the road: Waun Ki Hong, John Mendelsohn, and the reinvigoration of The University of Texas MD Anderson Cancer Center

scientific article published on 02 March 2019

The microculture-kinetic (MiCK) assay: the role of a drug-induced apoptosis assay in drug development and clinical care

scientific article

The novel and effective nonplatinum, nontaxane combination of gemcitabine and vinorelbine in advanced nonsmall cell lung carcinoma: potential for decreased toxicity and combination with biological therapy

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The rationale and potential of combining novel biologic therapies with radiotherapy: focus on non-small cell lung cancer

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The role of growth factor signaling in malignancy

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The role of the epidermal growth factor receptor in the treatment of colorectal carcinoma

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Therapeutic Strategies for Combined-Modality Therapy of Locally Advanced-Stage Non–Small-Cell Lung Cancer: Rationale for Consolidation Docetaxel Therapy

Therapeutic options to target angiogenesis in human malignancies

scientific article published on November 2006

Therapeutic strategies for combined-modality therapy of locally advanced non-small-cell lung cancer: rationale for consolidation docetaxel therapy

scientific article

To kill a tumor cell: the potential of proapoptotic receptor agonists

scientific article published on June 2008

Tobacco Assessment in Actively Accruing National Cancer Institute Cooperative Group Program Clinical Trials ⬇️

scientific article published on June 11, 2012

Tobacco and cancer: an American Association for Cancer Research policy statement

scientific article published on 13 April 2010

Toxicities of antiangiogenic therapy in non-small-cell lung cancer.

scientific article published on December 2006

Transforming growth factor-beta 1 overexpression produces drug resistance in vivo: reversal by decorin

scientific article published on November 1, 1997

Trastuzumab in combination with cisplatin and gemcitabine in patients with Her2-overexpressing, untreated, advanced non-small cell lung cancer: report of a phase II trial and findings regarding optimal identification of patients with Her2-overexpres

scientific article published in April 2004

Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation.

scientific article

Treatment of Advanced Non-Small Cell Lung Cancer in 2018.

scientific article published in March 2018

Treatment with HIF-1alpha antagonist PX-478 inhibits progression and spread of orthotopic human small cell lung cancer and lung adenocarcinoma in mice

scientific article published on July 2010

Tumor blood flow measured by PET dynamic imaging of first-pass 18F-FDG uptake: a comparison with 15O-labeled water-measured blood flow

scientific article

Tumor blood flow measured by perfusion computed tomography and 15O-labeled water positron emission tomography: a comparison study

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Tumor cavitation during therapy with antiangiogenesis agents in patients with lung cancer

scientific article

Tumor cavitation in stage I non-small cell lung cancer: epidermal growth factor receptor expression and prediction of poor outcome

scientific article

Tumor-Infiltrating Lymphocytes-Location for Prognostic Evaluation

scientific article published on 19 December 2018

Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor-resistant human lung adenocarcinoma

scientific article published on 23 March 2011

Use of archival versus newly collected tumor samples for assessing PD-L1 expression and overall survival: an updated analysis of KEYNOTE-010 trial

scientific article published on 01 February 2019

Use of novel second-line targeted therapies in non-small cell lung cancer

scientific article

Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis

scientific article published on February 2007

Vandetanib and indwelling pleural catheter for non-small-cell lung cancer with recurrent malignant pleural effusion

scientific article

Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small-cell lung cancer (ZODIAC): a double-blind, randomised, phase 3 trial

scientific article published on July 2010

VeriStrat classifier for survival and time to progression in non-small cell lung cancer (NSCLC) patients treated with erlotinib and bevacizumab ⬇️

scientific article

Vinorelbine and gemcitabine combinations in advanced non small-cell lung cancer

scientific article published on 01 November 2000

What is the best way to manage patients treated with gefitinib for non-small-cell lung cancer?

scientific article published in June 2005

Who should go first in trials with scarce agents? The views of potential participants

scientific article published in July 2007

Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up

scientific article published on 01 April 2018

ZD1839 (Iressa) in non-small cell lung cancer

scientific article

ZD1839 (Iressa) in non-small-cell lung cancer

scientific article published on 01 August 2001

ZD1839: targeting the epidermal growth factor receptor in cancer therapy

scientific article

[18F]fluorodeoxyglucose uptake by positron emission tomography predicts outcome of non-small-cell lung cancer

scientific article

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