List of works - Ah-Ng Kong

"Curcumin, the King of Spices": Epigenetic Regulatory Mechanisms in the Prevention of Cancer, Neurological, and Inflammatory Diseases

scientific article

3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo

scientific article

A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics

scientific article

A validated HPLC assay for the determination of R-(−)-gossypol in human plasma and its application in clinical pharmacokinetic studies ⬇️

scientific article published on March 24, 2012

A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation.

scientific article published on 28 March 2012

An Update on Current Therapeutic Drugs Treating COVID-19

scientific article published on 11 May 2020

Anti-inflammatory/Anti-oxidative Stress Activities and Differential Regulation of Nrf2-Mediated Genes by Non-Polar Fractions of Tea Chrysanthemum zawadskii and Licorice Glycyrrhiza uralensis ⬇️

scientific article published on October 22, 2010

Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal

scientific article published on 28 November 2012

Anticarcinogenesis by dietary phytochemicals: cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-kappa B and AP-1 in abnormal cancer cells

scientific article published on 15 September 2007

Antioxidant defense and hepatoprotection by procyanidins from almond (Prunus amygdalus) skins.

scientific article published on 13 August 2014

Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications

scientific article

Association of aberrant DNA methylation in Apc(min/+) mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq

scientific article published on 27 May 2015

Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway

scientific article

Blocking of JB6 cell transformation by tanshinone IIA: epigenetic reactivation of Nrf2 antioxidative stress pathway

scientific article

Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells.

scientific article published on November 2006

Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models

scientific article published on September 2007

Cancer chemoprevention by traditional chinese herbal medicine and dietary phytochemicals: targeting nrf2-mediated oxidative stress/anti-inflammatory responses, epigenetics, and cancer stem cells.

scientific article published on January 2013

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable

scientific article published on 04 May 2006

Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.

scientific article published in October 2007

Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC).

scientific article published in May 2008

Chemopreventive functions of isothiocyanates

scientific article

Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice

scientific article published in January 2006

Correction to: In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

scientific article published on 6 February 2018

Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.

scientific article published on 11 December 2017

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

scientific article published on September 2008

Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1

scientific article published on 29 January 2015

Current Perspectives on Epigenetic Modifications by Dietary Chemopreventive and Herbal Phytochemicals

scientific article

DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment.

scientific article published on 30 November 2017

DNA Methylome and Transcriptome Alterations in High Glucose-Induced Diabetic Nephropathy Cellular Model and Identification of Novel Targets for Treatment by Tanshinone IIA

scientific article published on 17 September 2019

DNA methylome and transcriptome alterations and cancer prevention by triterpenoid ursolic acid in UVB-induced skin tumor in mice

scientific article published on 25 June 2019

Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers.

scientific article published on 24 December 2013

Dietary Administration of δ- and γ-Tocopherol Inhibits Tumorigenesis in the Animal Model of Estrogen Receptor–Positive, but not HER-2 Breast Cancer ⬇️

scientific article published on September 10, 2012

Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3'-Diindolylmethane: Anti-Oxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy

scientific article

Dietary Phytochemicals and Cancer Chemoprevention: A Perspective on Oxidative Stress, Inflammation, and Epigenetics.

scientific article

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression.

scientific article published on 03 October 2012

Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia

scientific article

Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

scientific article published in March 2005

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction

scientific article

Does Vitamin E Prevent or Promote Cancer? ⬇️

scientific article published on April 3, 2012

ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

scientific article published on 4 November 2005

Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice

scientific article published on June 2006

Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation

scientific article published on 23 May 2013

Emerging roles for clinical pharmacometrics in cancer precision medicine

scientific article published on 20 April 2018

Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells ⬇️

scientific article published on September 22, 2011

Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer

scientific article

Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer

scientific article published on 01 March 2019

Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors.

scientific article published on 09 May 2013

Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells.

scientific article published on 28 September 2015

Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.

scientific article published on 8 March 2013

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells.

scientific article published on 3 November 2016

Epigenetic regulation of Keap1-Nrf2 signaling

scientific article

Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer

scientific article published on 09 December 2019

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice

scientific article published on 3 March 2006

Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models

scientific article published on 2 August 2014

Hot Topic Commentary on COVID-19

scientific article published on 11 May 2020

Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2.

scientific article published on 17 September 2012

Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray

scientific article published on 20 June 2006

Identification of novel nuclear targets of human thioredoxin 1

scientific article

In vitro and in vivo anti-inflammatory effects of a novel 4,6-bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione

scientific article published on 17 December 2013

In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice.

scientific article published in October 2006

Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin

scientific article published on 15 July 2015

Induction of phase I, II and III drug metabolism/transport by xenobiotics

scientific article

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

scientific article published in August 2006

Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.

scientific article

Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells

scientific article

Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance

scientific article published on 31 October 2011

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

scientific article published on 01 August 2006

Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells

scientific article published on September 2006

Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq.

scientific article published on 3 March 2017

MicroRNAs: New players in cancer prevention targeting Nrf2, oxidative stress and inflammatory pathways

scientific article

Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line

scientific article published on April 2004

Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.

scientific article published on August 2006

Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

scientific article published in January 2006

Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway

scientific article

Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate

scientific article

Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers

scientific article published on 26 August 2015

Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells.

scientific article published on April 2007

Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin

scientific article

Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation.

scientific article published on 21 August 2012

Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages

scientific article

Nrf2: a potential molecular target for cancer chemoprevention by natural compounds

scientific article

Nrf2‐mediated induction of phase 2 detoxifying enzymes by glyceollins derived from soybean exposed to Aspergillus sojae ⬇️

scientific article published on May 1, 2011

Nuclear factor-erythroid 2-related factor 2 as a chemopreventive target in colorectal cancer.

scientific article

Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction.

scientific article published on 7 December 2011

PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function

scientific article published on 13 February 2012

PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway

scientific article published on 13 May 2008

Perspective on Nrf2, Epigenomics and Cancer Stem Cells in Cancer Chemoprevention Using Dietary Phytochemicals and Traditional Chinese Medicines

article published in 2013

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation.

scientific article published on 20 July 2011

Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates.

scientific article published on 8 June 2011

Pharmacodynamics of fish oil: protective effects against prostate cancer in TRAMP mice fed with a high fat western diet

scientific article published on 01 January 2011

Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations.

scientific article published on 9 August 2012

Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.

scientific article published in December 2006

Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice.

scientific article

Pharmacokinetics and Pharmacodynamics of Curcumin in regulating anti-inflammatory and epigenetic gene expression

scientific article published on 01 June 2018

Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes

scientific article published on 16 October 2017

Pharmacokinetics and pharmacodynamics of 3,3'-diindolylmethane (DIM) in regulating gene expression of phase II drug metabolizing enzymes.

scientific article published on 3 July 2015

Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes.

scientific article published on 11 September 2012

Pharmacokinetics and pharmacodynamics of three oral formulations of curcumin in rats

scientific article published on 04 February 2020

Pharmacokinetics, Pharmacodynamics, and PKPD Modeling of Curcumin in Regulating Antioxidant and Epigenetic Gene Expression in Healthy Human Volunteers

scientific article published on 28 March 2019

Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194.

scientific article

Phytochemical Analysis and Anti-Inflammatory Activity of the Extracts of the African Medicinal Plant Ximenia caffra ⬇️

scientific article

Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability ⬇️

scientific article published on December 1, 2012

Potent inhibitory effect of δ-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo

scientific article

Regulation of Keap1-Nrf2 signaling: The role of epigenetics

scientific article published on 05 November 2016

Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory

scientific article published on 17 August 2010

Regulation of Nrf2 transactivation domain activity by p160 RAC3/SRC3 and other nuclear co-regulators

scientific article published on May 2006

Regulation of Nrf2, NF-kappaB, and AP-1 signaling pathways by chemopreventive agents

scientific article

Requirement and epigenetics reprogramming of Nrf2 in suppression of tumor promoter TPA-induced mouse skin cell transformation by sulforaphane

scientific article published on 17 January 2014

Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway.

scientific article published on 17 March 2016

Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid and eicosapentaenoic acid

scientific article published on 6 October 2010

Structural influence of isothiocyanates on the antioxidant response element (ARE)-mediated heme oxygenase-1 (HO-1) expression

scientific article

Sulforaphane enhances Nrf2 expression in prostate cancer TRAMP C1 cells through epigenetic regulation.

scientific article published on 14 February 2013

Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

scientific article

Synergistic activation of the Nrf2-signaling pathway by glyceollins under oxidative stress induced by glutathione depletion

scientific article published on 19 April 2013

Targeting epigenetics for cancer prevention by dietary cancer preventive compounds--the case of miRNA.

scientific article published on 17 June 2013

The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway.

scientific article published on 20 June 2013

The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway

scientific article published on 8 August 2014

The complexity of the Nrf2 pathway: beyond the antioxidant response

scientific article

The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells.

scientific article published on 16 December 2017

Toxicogenomics in drug discovery and drug development: potential applications and future challenges

scientific article published on August 2006

Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice

scientific article published on 10 November 2006

p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1.

scientific article published on 17 September 2005

tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1.

scientific article published on 5 April 2011

List of works by Ah-Ng Kong

"Curcumin, the King of Spices": Epigenetic Regulatory Mechanisms in the Prevention of Cancer, Neurological, and Inflammatory Diseases

3-Morpholinopropyl isothiocyanate is a novel synthetic isothiocyanate that strongly induces the antioxidant response element-dependent Nrf2-mediated detoxifying/antioxidant enzymes in vitro and in vivo

A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics

A validated HPLC assay for the determination of R-(−)-gossypol in human plasma and its application in clinical pharmacokinetic studies ⬇️

A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation.

An Update on Current Therapeutic Drugs Treating COVID-19

Anti-inflammatory/Anti-oxidative Stress Activities and Differential Regulation of Nrf2-Mediated Genes by Non-Polar Fractions of Tea Chrysanthemum zawadskii and Licorice Glycyrrhiza uralensis ⬇️

Anti-oxidative stress regulator NF-E2-related factor 2 mediates the adaptive induction of antioxidant and detoxifying enzymes by lipid peroxidation metabolite 4-hydroxynonenal

Anticarcinogenesis by dietary phytochemicals: cytoprotection by Nrf2 in normal cells and cytotoxicity by modulation of transcription factors NF-kappa B and AP-1 in abnormal cancer cells

Antioxidant defense and hepatoprotection by procyanidins from almond (Prunus amygdalus) skins.

Apigenin reactivates Nrf2 anti-oxidative stress signaling in mouse skin epidermal JB6 P + cells through epigenetics modifications

Association of aberrant DNA methylation in Apc(min/+) mice with the epithelial-mesenchymal transition and Wnt/β-catenin pathways: genome-wide analysis using MeDIP-seq

Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway

Blocking of JB6 cell transformation by tanshinone IIA: epigenetic reactivation of Nrf2 antioxidative stress pathway

Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells.

Cancer chemoprevention by phytochemicals: potential molecular targets, biomarkers and animal models

Cancer chemoprevention by traditional chinese herbal medicine and dietary phytochemicals: targeting nrf2-mediated oxidative stress/anti-inflammatory responses, epigenetics, and cancer stem cells.

Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable

Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse.

Chemoprevention of familial adenomatous polyposis in Apc(Min/+) mice by phenethyl isothiocyanate (PEITC).

Chemopreventive functions of isothiocyanates

Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice

Correction to: In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

Curcumin inhibits anchorage-independent growth of HT29 human colon cancer cells by targeting epigenetic restoration of the tumor suppressor gene DLEC1

Current Perspectives on Epigenetic Modifications by Dietary Chemopreventive and Herbal Phytochemicals

DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment.

DNA Methylome and Transcriptome Alterations in High Glucose-Induced Diabetic Nephropathy Cellular Model and Identification of Novel Targets for Treatment by Tanshinone IIA

DNA methylome and transcriptome alterations and cancer prevention by triterpenoid ursolic acid in UVB-induced skin tumor in mice

Design and synthesis of novel iminothiazinylbutadienols and divinylpyrimidinethiones as ARE inducers.

Dietary Administration of δ- and γ-Tocopherol Inhibits Tumorigenesis in the Animal Model of Estrogen Receptor–Positive, but not HER-2 Breast Cancer ⬇️

Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3'-Diindolylmethane: Anti-Oxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy

Dietary Phytochemicals and Cancer Chemoprevention: A Perspective on Oxidative Stress, Inflammation, and Epigenetics.

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression.

Dietary tocopherols inhibit cell proliferation, regulate expression of ERα, PPARγ, and Nrf2, and decrease serum inflammatory markers during the development of mammary hyperplasia

Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells.

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction

Does Vitamin E Prevent or Promote Cancer? ⬇️

ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells.

Effects of 12-O-tetradecanoylphorbol-13-acetate (TPA) in combination with paclitaxel (Taxol) on prostate Cancer LNCaP cells cultured in vitro or grown as xenograft tumors in immunodeficient mice

Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation

Emerging roles for clinical pharmacometrics in cancer precision medicine

Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells ⬇️

Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer

Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer

Epigenetic modifications of Nrf2 by 3,3'-diindolylmethane in vitro in TRAMP C1 cell line and in vivo TRAMP prostate tumors.

Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells.

Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells.

Epigenetic regulation of Keap1-Nrf2 signaling

Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory-driven colon cancer

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice

Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models

Hot Topic Commentary on COVID-19

Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2.

Identification of Nrf2-regulated genes induced by chemopreventive isothiocyanate PEITC by oligonucleotide microarray

Identification of novel nuclear targets of human thioredoxin 1

In vitro and in vivo anti-inflammatory effects of a novel 4,6-bis ((E)-4-hydroxy-3-methoxystyryl)-1-phenethylpyrimidine-2(1H)-thione

In vivo pharmacokinetics, activation of MAPK signaling and induction of phase II/III drug metabolizing enzymes/transporters by cancer chemopreventive compound BHA in the mice.

Induction of NRF2-mediated gene expression by dietary phytochemical flavones apigenin and luteolin

Induction of phase I, II and III drug metabolism/transport by xenobiotics

Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2.

Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin.

Inhibition of NF-kappaB by (E)3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile (BAY11-7082; BAY) is associated with enhanced 12-O-tetradecanoylphorbol-13-acetate-induced growth suppression and apoptosis in human prostate cancer PC-3 cells

Kinetic analyses of Keap1-Nrf2 interaction and determination of the minimal Nrf2 peptide sequence required for Keap1 binding using surface plasmon resonance

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells

Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq.

MicroRNAs: New players in cancer prevention targeting Nrf2, oxidative stress and inflammatory pathways

Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line

Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.

Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway

Murine prostate cancer inhibition by dietary phytochemicals--curcumin and phenyethylisothiocyanate

Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers

Natural dietary anti-cancer chemopreventive compounds: redox-mediated differential signaling mechanisms in cytoprotection of normal cells versus cytotoxicity in tumor cells.

Nrf2 knockout attenuates the anti-inflammatory effects of phenethyl isothiocyanate and curcumin

Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation.