List of works - Klaus Müller

50 Years in the sun of Bürgenstock--on the success factors of a famous conference

scientific article published on 20 March 2015

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions

scientific article published on 14 April 2004

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions

scientific article

An Efficient Strategy to Orthogonally Protected (R)- and (S)-α-Methyl(alkyl)serine-Containing Peptides via a Novel Azlactone/Oxazoline Interconversion Reaction ⬇️

scientific article published on June 14, 1996

Aqueous Instability of δ-Fluorobutylpiperidines.

scientific article

Bicyclo[3.2.0]heptane as a Core Structure for Conformational Locking of 1,3-Bis-Pharmacophores, Exemplified by GABA.

scientific article

Cover Picture: Aqueous Instability of δ-Fluorobutylpiperidines (ChemMedChem 6/2017)

Design of Libraries Targeting Protein–Protein Interfaces ⬇️

scientific article published on February 21, 2013

Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties

scientific article published on 15 September 2016

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

scientific article published on 2 November 2015

Fluorine in medicinal chemistry

scientific article published on May 2004

Fluorine in pharmaceuticals: looking beyond intuition

scientific article

Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles

scientific article

Formal [3 + 2] Cycloaddition Reaction of [1,4]Oxazin-2-ones and α-Alkynyl Ketones via a Tandem Mukaiyama-Aldol Addition/Aza-Cope Rearrangement ⬇️

scientific article published on 01 September 1999

Hit and lead generation: beyond high-throughput screening ⬇️

scientific article (publication date: May 2003)

Modulation of Pharmacologically Relevant Properties of Piperidine Derivatives by Functional Groups in an Equatorial or Axial β-Position to the Amino Group

scientific article published on 23 October 2019

Multinuclear solid-state-NMR and FT-IR-absorption investigations on lipid/trichogin bilayers.

scientific article published in June 2007

On the polarity of partially fluorinated methyl groups

Organic Fluorine: The Mighty Mite

scientific article published on 01 May 2019

Orthogonal multipolar interactions in structural chemistry and biology

scientific article

Oxetanes as Promising Modules in Drug Discovery

scientific article published on 01 November 2006

Oxetanes as versatile elements in drug discovery and synthesis

scientific article

Oxetanes in drug discovery: structural and synthetic insights

scientific article published in April 2010

Predicting and tuning physicochemical properties in lead optimization: amine basicities

scientific article published on August 2007

Remote modulation of amine basicity by a phenylsulfone and a phenylthio group

scientific article published on 01 March 2007

Simple vector considerations to assess the polarity of partially fluorinated alkyl and alkoxy groups

scientific article published on 01 January 2014

Spirocyclic oxetanes: synthesis and properties

scientific article published in January 2008

Structural and Conformational Aspects of Equatorial and Axial Trifluoromethyl, Difluoromethyl, and Monofluoromethyl Groups

scientific article published on 12 October 2016

Synthesis of Azaspirocycles and their Evaluation in Drug Discovery

scientific article published on 01 May 2010

The Power of MMPA and a Teaching Lesson in Medicinal Chemistry ⬇️

scientific article published on February 15, 2012

The State of the Art of Chemical Biology

scientific article published on 01 January 2009

Three decades of structure- and property-based molecular design

scientific article

Two distinct conformations of GABA locked by embedding in the bicyclo[3.1.0]hexane core structure

scientific article published on 01 August 2011

List of works by Klaus Müller

50 Years in the sun of Bürgenstock--on the success factors of a famous conference

A fluorine scan of the phenylamidinium needle of tricyclic thrombin inhibitors: effects of fluorine substitution on pKa and binding affinity and evidence for intermolecular C-F...CN interactions

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions

An Efficient Strategy to Orthogonally Protected (R)- and (S)-α-Methyl(alkyl)serine-Containing Peptides via a Novel Azlactone/Oxazoline Interconversion Reaction ⬇️

Aqueous Instability of δ-Fluorobutylpiperidines.

Bicyclo[3.2.0]heptane as a Core Structure for Conformational Locking of 1,3-Bis-Pharmacophores, Exemplified by GABA.

Cover Picture: Aqueous Instability of δ-Fluorobutylpiperidines (ChemMedChem 6/2017)

Design of Libraries Targeting Protein–Protein Interfaces ⬇️

Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties

Fluorination Patterning: A Study of Structural Motifs That Impact Physicochemical Properties of Relevance to Drug Discovery

Fluorine in medicinal chemistry

Fluorine in pharmaceuticals: looking beyond intuition

Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophiles

Formal [3 + 2] Cycloaddition Reaction of [1,4]Oxazin-2-ones and α-Alkynyl Ketones via a Tandem Mukaiyama-Aldol Addition/Aza-Cope Rearrangement ⬇️

Hit and lead generation: beyond high-throughput screening ⬇️

Modulation of Pharmacologically Relevant Properties of Piperidine Derivatives by Functional Groups in an Equatorial or Axial β-Position to the Amino Group

Multinuclear solid-state-NMR and FT-IR-absorption investigations on lipid/trichogin bilayers.

On the polarity of partially fluorinated methyl groups

Organic Fluorine: The Mighty Mite

Orthogonal multipolar interactions in structural chemistry and biology

Oxetanes as Promising Modules in Drug Discovery

Oxetanes as versatile elements in drug discovery and synthesis

Oxetanes in drug discovery: structural and synthetic insights

Predicting and tuning physicochemical properties in lead optimization: amine basicities

Remote modulation of amine basicity by a phenylsulfone and a phenylthio group

Simple vector considerations to assess the polarity of partially fluorinated alkyl and alkoxy groups

Spirocyclic oxetanes: synthesis and properties

Structural and Conformational Aspects of Equatorial and Axial Trifluoromethyl, Difluoromethyl, and Monofluoromethyl Groups

Synthesis of Azaspirocycles and their Evaluation in Drug Discovery

The Power of MMPA and a Teaching Lesson in Medicinal Chemistry ⬇️

The State of the Art of Chemical Biology

Three decades of structure- and property-based molecular design

Two distinct conformations of GABA locked by embedding in the bicyclo[3.1.0]hexane core structure