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List of works by Richard J. Youle

A Systematic Search for Endoplasmic Reticulum (ER) Membrane-associated RING Finger Proteins Identifies Nixin/ZNRF4 as a Regulator of Calnexin Stability and ER Homeostasis ⬇️

scientific article published on January 4, 2011

A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis

scientific article published in February 2008

Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration

scientific article

Atypical mitochondrial fission upon bacterial infection

scientific article published on 16 September 2013

Bax activates endophilin B1 oligomerization and lipid membrane vesiculation

scientific article

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

scientific article

Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

scientific article

Bid, but not Bax, regulates VDAC channels

scientific article published on 16 January 2004

Cell biology: Form follows function for mitochondria.

scientific article

Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL.

scientific article

Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter

scientific article published on 26 February 2015

Conformation of BCL-XL upon Membrane Integration

scientific article

Control of mitochondrial permeability by Bcl-2 family members

scientific article published on March 2004

Coupling mitochondrial and cell division ⬇️

scientific article published on September 2, 2011

Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria

scientific article

Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins

scientific article published on 16 April 2008

Endophilin B1 is required for the maintenance of mitochondrial morphology

scientific article

Endosomal Rab cycles regulate Parkin-mediated mitophagy.

scientific article published on 23 January 2018

Endosome fusion induced by diphtheria toxin translocation domain

scholarly article

Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins.

scientific article published on 27 December 2016

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

scientific article

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy

scientific article

IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation

scientific article

Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae

scientific article

Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy

scientific article published on January 2013

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

scientific article

Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

scientific article

Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

scientific article published on 12 November 2020

Make or break for mitochondria ⬇️

scientific article published on May 14, 2013

Mechanisms of mitophagy

scientific article

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells ⬇️

scientific article

MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

scientific article published in August 2015

Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

scientific article published on 25 February 2014

Mitochondrial fission and fusion and their roles in the heart ⬇️

scientific article published on September 14, 2010

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

scientific article

Mitochondrial fission facilitates the selective mitophagy of protein aggregates.

scientific article published on 11 September 2017

Mitochondrial fission in apoptosis

scientific article

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

scientific article (publication date: 29 November 2010)

Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism.

scientific article

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

scientific article

Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis

scientific article published on 04 February 2019

Mutations in Fis1 disrupt orderly disposal of defective mitochondria

scientific article

Neurodegeneration: Trouble in the cell's powerhouse

scientific article published on 7 March 2012

Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density

scientific article

Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo

scientific article published on 07 June 2019

Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.

scientific article

Outer mitochondrial membrane protein degradation by the proteasome

scientific article published on January 2007

PINK1 and Parkin Flag Miro to Direct Mitochondrial Traffic ⬇️

scientific article published on November 11, 2011

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

scientific article

PINK1 is degraded through the N-end rule pathway

scientific article

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

scientific article

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

scientific article (publication date: 28 April 2014)

PINK1 rendered temperature sensitive by disease-associated and engineered mutations.

scientific article published on 3 March 2013

PINK1- and Parkin-mediated mitophagy at a glance ⬇️

scientific article published on February 15, 2012

PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

scientific article published on 01 October 2019

Parkin and PINK1 mitigate STING-induced inflammation

scientific article published in Nature

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

scientific article

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

scientific article

Parkin-induced mitophagy in the pathogenesis of Parkinson disease

scientific article published on 22 July 2009

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

scientific article published on 30 March 2016

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

scientific article

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1

scientific article published on 04 February 2019

Role of Bax and Bak in mitochondrial morphogenesis

scientific journal article

Role of Membrane Association and Atg14-Dependent Phosphorylation in Beclin-1-Mediated Autophagy ⬇️

scientific article published on July 22, 2013

Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin

scientific article published on 25 January 2012

Role of the ubiquitin conjugation system in the maintenance of mitochondrial homeostasis.

scientific article published on December 2008

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

scientific article

SLP-2 is required for stress-induced mitochondrial hyperfusion

scientific article

STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain

scientific article published on 01 December 2020

Sequestration and autophagy of mitochondria do not cut proteins across the board

scientific article published on 8 April 2013

Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy

scientific article published on 07 March 2019

Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA ⬇️

scientific article published on December 3, 2012

Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control ⬇️

scientific article published on March 3, 2011

The Mitochondrial Basis of Aging

scientific article published on March 2016

The Soluble Form of Bax Regulates Mitochondrial Fusion via MFN2 Homotypic Complexes ⬇️

scientific article published on January 21, 2011

The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

scientific article

The cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF), can deliver Bcl-XL as an extracellular fusion protein to protect cells from apoptosis and retain differentiation induction

scientific article published on 20 February 2007

The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division

scientific article

The role of mitochondria in apoptosis*.

scientific article published on January 2009

The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle

scientific article

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

scientific article published on 12 August 2015

ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer

scientific article published on 01 July 2020

Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission

scientific article

Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance.

scientific article published on 30 December 2017

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

scientific article

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