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List of works by Lawrence R Dick

A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.

scientific article published on 15 January 2018

Absolute Quantification of E1, Ubiquitin-Like Proteins and Nedd8–MLN4924 Adduct by Mass Spectrometry ⬇️

scientific article published on September 1, 2013

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

scientific article published in Nature Communications

Identification and localization of a cysteinyl residue critical for the trypsin-like catalytic activity of the proteasome

scientific article published on August 18, 1992

Kinetic Studies of the Branched Chain Amino Acid Preferring Peptidase Activity of the 20S Proteasome: Development of a Continuous Assay and Inhibition by Tripeptide Aldehydes and clasto-Lactacystin β-Lactone ⬇️

scientific article published on May 26, 1998

Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues ⬇️

scientific article published on October 3, 2011

Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6 ⬇️

scientific article published on March 15, 2012

N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets ⬇️

scientific article published on June 25, 2013

Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome ⬇️

scientific article published on September 15, 2010

Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor.

scientific article published on 11 September 2017

Quantifiable analysis of cellular pathway inhibition of a Nedd8-activating enzyme inhibitor, MLN4924, using AlphaScreen ⬇️

scientific article published on April 25, 2013

The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy ⬇️

scientific article published on July 1, 2010

Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 ⬇️

scientific article published on March 20, 2012

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