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List of works by E. John Wherry

A brief history of CD8 T cells.

scientific article published on November 2007

A mouse model of vitiligo with focused epidermal depigmentation requires IFN-γ for autoreactive CD8⁺ T-cell accumulation in the skin

scientific article published on 2 February 2012

A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours

scientific article published on 15 October 2018

A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection

scientific article

A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection.

scientific article published on 6 August 2009

A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma

scientific article published on 25 February 2019

AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells.

scientific article published on 19 June 2013

Acetyl CoA Carboxylase 2 Is Dispensable for CD8+ T Cell Responses

scientific article

Acquired transcriptional programming in functional and exhausted virus-specific CD8 T cells.

scientific article published in January 2012

Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines.

scientific article

Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin.

scientific article published on July 2008

Antigen exposure shapes the ratio between antigen-specific Tregs and conventional T cells in human peripheral blood

scientific article published on 28 September 2016

Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues

scientific article

Antigen-independent memory CD8 T cells do not develop during chronic viral infection

scholarly article

Antiviral memory CD8 T-cell differentiation, maintenance, and secondary expansion occur independently of MyD88.

scientific article

Awakening the immune system with radiation: Optimal dose and fractionation

scientific article published on 20 March 2015

B cell antigen presentation in the initiation of follicular helper T cell and germinal center differentiation

scientific article published on 19 March 2014

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8<sup>+</sup> T cells

scientific article published on 11 February 2021

Behavior of parasite-specific effector CD8+ T cells in the brain and visualization of a kinesis-associated system of reticular fibers

scientific article published on 22 January 2009

Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion

scientific article published on 2 August 2016

Bone marrow is a preferred site for homeostatic proliferation of memory CD8 T cells

scientific article published in February 2005

Bystander chronic infection negatively impacts development of CD8(+) T cell memory.

scientific article published on May 2014

CD39 Expression Identifies Terminally Exhausted CD8+ T Cells

scientific article published on 20 October 2015

CD4+ T Cell Differentiation in Chronic Viral Infections: The Tfh Perspective.

scientific article published on 11 November 2017

CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study

scientific article published on 01 January 2021

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

scientific article published on 24 January 2019

CD8 T Cell Memory Increases Immunopathology in the Perforin-Deficient Model of Hemophagocytic Lymphohistiocytosis Secondary to TNF-α

scientific article published on 01 February 2018

CD8 T cell dysfunction during chronic viral infection.

scientific article published on 25 July 2007

CD8+ T cell exhaustion during persistent viral infection is regulated independently of the virus-specific T cell receptor.

scientific article published on 5 March 2013

Cell-intrinsic defects in the proliferative response of antiviral memory CD8 T cells in aged mice upon secondary infection

scientific article published on 5 April 2010

Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy

scientific article published on 14 September 2021

Changing immunodominance patterns in antiviral CD8 T-cell responses after loss of epitope presentation or chronic antigenic stimulation ⬇️

scientific article published on October 10, 2003

Chronic Bystander Infections and Immunity to Unrelated Antigens ⬇️

scientific article published on October 18, 2012

Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults

scientific article

Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

scientific article

Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling

scientific article published on April 2016

Combining Radiation with Immunotherapy: The University of Pennsylvania Experience

scientific article published on 01 April 2020

Commensal bacteria calibrate the activation threshold of innate antiviral immunity

scientific article published on 14 June 2012

Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage

scientific article published on 22 August 2019

Comprehensive mapping of immune perturbations associated with severe COVID-19

scientific article published on 01 July 2020

Cooperativity between CD8+ T cells, non-neutralizing antibodies, and alveolar macrophages is important for heterosubtypic influenza virus immunity

scientific article

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

scientific article

Correction: Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity

scientific article published on 17 February 2017

Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease

scientific article published on May 2016

Current Opinion in Immunology. Editorial overview

scientific article

Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection

scientific article published on 18 July 2016

Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation

scientific article published on 01 December 2006

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells.

scientific article published on 18 July 2016

Cutting Edge: Persistently Open Chromatin at Effector Gene Loci in Resting Memory CD8+ T Cells Independent of Transcriptional Status ⬇️

scientific article published on January 28, 2011

Cutting edge: CXCR4 is critical for CD8+ memory T cell homeostatic self-renewal but not rechallenge self-renewal

scientific article published on 27 June 2014

Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche.

scientific article

Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection

scientific article published on 4 November 2011

Cutting edge: gut microenvironment promotes differentiation of a unique memory CD8 T cell population

scientific article published in February 2006

Cutting edge: rapid in vivo killing by memory CD8 T cells

scientific article published in July 2003

Cytosolic delivery of viral nucleoprotein by listeriolysin O-liposome induces enhanced specific cytotoxic T lymphocyte response and protective immunity

scientific article published on 01 January 2004

De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute.

scientific article published on April 2016

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

scientific article published on 2 February 2022

Deconstructing development ⬇️

scientific article published on June 1, 2013

Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19

scientific article published on 27 September 2020

Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns.

scientific article published on 17 March 2017

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

scientific article published on 15 July 2020

Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions

scientific article published on 23 May 2020

Defective CD8 T Cell Responses in Aged Mice Are Due to Quantitative and Qualitative Changes in Virus-Specific Precursors ⬇️

scientific article published on January 13, 2012

Defective Central Memory CD8+ T Cell Differentiation in the Absence of Eomesodermin. ⬇️

scholarly article

Defining 'T cell exhaustion'

scientific article published on 30 September 2019

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

scientific article published on 30 April 2018

Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

scientific article published on 08 May 2020

Differential induction of TLR3-dependent innate immune signaling by closely related parasite species

scientific article

Differential localization of T-bet and Eomes in CD8 T cell memory populations.

scientific article published on March 2013

Differential sensitivity of naive and memory CD8+ T cells to apoptosis in vivo

scientific article published in October 2002

Differentiation and Protective Capacity of Virus-Specific CD8+ T Cells Suggest Murine Norovirus Persistence in an Immune-Privileged Enteric Niche

scientific article published on 10 October 2017

Diminished primary CD8 T cell response to viral infection during protein energy malnutrition in mice is due to changes in microenvironment and low numbers of viral-specific CD8 T cell precursors

scientific article

Dynamic T cell migration program provides resident memory within intestinal epithelium

scientific article

Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell development in acute self-limited hepatitis B patients

scientific article

Dynamic programmed death 1 expression by virus-specific CD8 T cells correlates with the outcome of acute hepatitis B.

scientific article published on 22 March 2008

Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis

scientific article published on 8 December 2014

Editorial: Therapeutic potential of targeting BTLA

scientific article published on 01 July 2009

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

scientific article

Effector and memory T-cell differentiation: implications for vaccine development

scientific article

Efficient and qualitatively distinct MHC class I-restricted presentation of antigen targeted to the endoplasmic reticulum

scientific article published on March 2002

Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine

scientific article published on 08 April 2022

Elevated Expression of CD160 and 2B4 Defines a Cytolytic HIV-Specific CD8+ T-Cell Population in Elite Controllers

scientific article

Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection

scientific article

Enhanced T cell function in a mouse model of human glycosylation.

scientific article published on 24 May 2013

Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection

scientific article

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

scientific article published on 26 July 2021

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

scientific article

Epigenomic-Guided Mass Cytometry Profiling Reveals Disease-Specific Features of Exhausted CD8 T Cells

scientific article published on 01 May 2018

Erythrocytes Reveal Complement Activation in Patients with COVID-19

scientific article published on 22 May 2020

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

scientific article published in Nature

Exploration of T-Cell Diversity Using Mass Cytometry

scientific article published on 01 January 2020

Functional Restoration of HCV-Specific CD8 T Cells by PD-1 Blockade Is Defined by PD-1 Expression and Compartmentalization

scientific article

Generation and maintenance of immunological memory

scientific article

Generation of CD8(+) T cell memory in response to low, high, and excessive levels of epitope

scientific article

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells

scientific article published in June 2015

Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis.

scientific article published on 10 January 2014

Genomic Circuitry Underlying Immunological Response to Pediatric Acute Respiratory Infection

scientific article published in January 2018

Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals

scientific article published on 02 February 2022

Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

scientific article

HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis-Specific CD4+ T Cells.

scientific article published on 29 February 2016

HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory

scientific article published on 24 July 2006

Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection

scientific article

Heterologous immunity provides a potent barrier to transplantation tolerance

scientific article

Hidden Caveat of Inducible Cre Recombinase

scientific article published on 01 October 2019

Homeostatic proliferation but not the generation of virus specific memory CD8 T cells is impaired in the absence of IL-15 or IL-15Ralpha.

scientific article published in January 2002

Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease

scientific article

IL-10, T cell exhaustion and viral persistence

scientific article published on March 2007

IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells ⬇️

scientific article published on August 19, 2013

Identification and characterization of HIV-specific resident memory CD8 + T cells in human lymphoid tissue

article

Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells

scientific article published on August 2008

Immune Memory and Exhaustion: Clinically Relevant Lessons from the LCMV Model

scientific article published on January 2015

Immune Stimulation With Recombinant Human Granulocyte Colony-Stimulating Factor for Coronavirus Disease 2019 (COVID-19)-Beware of Blind Spots

scientific article published on 10 September 2020

Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection

preprint article published on 19 May 2020

Immunology. An interferon paradox

scientific article published on April 2013

Immunosurveillance by antiangiogenesis: tumor growth arrest by T cell-derived thrombospondin-1.

scientific article

Impact of epitope escape on PD-1 expression and CD8 T-cell exhaustion during chronic infection

scientific article published on 11 February 2009

Increased T-bet is associated with senescence of influenza virus-specific CD8 T cells in aged humans

scientific article

Increased programmed death-1 expression on CD4+ T cells in cutaneous T-cell lymphoma: implications for immune suppression

scientific article published on 16 August 2010

Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma

scientific article

Influenza virus specific CD8⁺ T cells exacerbate infection following high dose influenza challenge of aged mice

scientific article published on 26 September 2013

Inhibitory Receptors on Lymphocytes: Insights from Infections ⬇️

scientific article published on April 1, 2012

Inhibitory receptors: whose side are they on?

article

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

scientific article published in November 2011

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

scientific article published on 22 May 2013

Integrating genomic signatures for immunologic discovery

scientific article published in February 2010

Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

scientific article

In vivo CD8<sup>+</sup> T cell CRISPR screening reveals control by Fli1 in infection and cancer

scientific article published on 25 February 2021

Janus kinase inhibition lessens inflammation and ameliorates disease in murine models of hemophagocytic lymphohistiocytosis

scientific article

K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation ⬇️

scientific article published on December 19, 2011

Limited immune surveillance in lymphoid tissue by cytolytic CD4+ T cells during health and HIV disease.

scientific article published on 13 April 2018

Lineage relationship and protective immunity of memory CD8 T cell subsets

scientific article (publication date: March 2003)

Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells.

scientific article

Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors

scientific article published on 19 October 2013

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

scientific article

Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155.

scientific article

Long-term outcomes of a phase I study of agonist CD40 antibody and CTLA-4 blockade in patients with metastatic melanoma

scholarly article by David L Bajor et al published 2018 in OncoImmunology

Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells

scientific article

Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination

scientific article

Lung niches for the generation and maintenance of tissue-resident memory T cells.

scientific article published on 25 September 2013

Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major

scientific article

Memory CD8 T-cell differentiation during viral infection

scientific article

Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes

scientific article published on 15 June 2020

Molecular Basis of T-Cell Exhaustion ⬇️

scholarly article

Molecular and cellular insights into T cell exhaustion

scientific article

Molecular and transcriptional basis of CD4⁺ T cell dysfunction during chronic infection

scientific article published on 13 February 2014

Molecular regulation of effector and memory T cell differentiation

scientific article

Molecular signature of CD8+ T cell exhaustion during chronic viral infection

scientific article published on 18 October 2007

Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors

scientific article

MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection

scientific article

Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory.

scientific article

Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity

scientific article published on 13 July 2020

New-Onset IgG Autoantibodies in Hospitalized Patients with COVID-19

scientific article

Non-conventional Inhibitory CD4Foxp3PD-1 T Cells as a Biomarker of Immune Checkpoint Blockade Activity

scientific article published on 01 June 2018

Non-conventional Inhibitory CD4Foxp3PD-1 T Cells as a Biomarker of Immune Checkpoint Blockade Activity

scientific article published on 01 October 2018

Not-so-great expectations: re-assessing the essence of T-cell memory.

scientific article published on June 2006

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

scientific article published on 01 August 2019

Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function

scientific article published on 31 August 2017

Overcoming T cell exhaustion in infection and cancer

scientific article

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

scientific article (publication date: 21 September 2006)

PPT1 Inhibition enhances the anti-tumor activity of anti-PD-1 antibody in melanoma

scientific article published on 11 August 2020

Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells

scientific article

Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses

scientific article published on 17 April 2013

Plasmacytoid dendritic cells are dispensable during primary influenza virus infection

scientific article

Pregnancy promotes tolerance to future offspring by programming selective dysfunction in long-lived maternal T cells

scientific article published on 3 November 2016

Priority COVID-19 vaccination for patients with cancer while vaccine supply is limited

scientific article published on 19 December 2020

Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

scientific article published on November 2012

Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection.

scientific article published on 23 May 2012

Protein Energy Malnutrition Impairs Homeostatic Proliferation of Memory CD8 T Cells ⬇️

scientific article published on November 23, 2011

Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction

scientific article published on 10 December 2021

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

scientific article

Rapid induction of antigen-specific CD4<sup>+</sup> T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

scientific article published on 13 August 2021

Re-evaluating the generation of a "proteasome-independent" MHC class I-restricted CD8 T cell epitope

scientific article published in February 2006

Redefining chronic viral infection

scientific article

Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity

scientific article

Reinvigorating NIH Grant Peer Review

scientific article published on 01 January 2020

Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade

scientific article

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells.

scientific article

Restoring function in exhausted CD8 T cells during chronic viral infection

scientific article

Role of PD-1 in regulating acute infections.

scientific article

Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells

scientific article published on 01 May 2021

SARS-CoV-2 Seroprevalence Among Parturient Women

scientific article published on 10 July 2020

SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19

scientific article published on 18 August 2020

SARS-CoV-2 antibody responses in children with MIS-C and mild and severe COVID-19

scientific article published on 02 December 2020

SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

scientific article published in 2023

SARS-CoV-2 seroprevalence among parturient women in Philadelphia

scientific article published on 01 July 2020

SARS-CoV-2 vaccination enhances the effector qualities of spike-specific T cells induced by COVID-19

scientific article published on 8 December 2023

ST2 contributes to T-cell hyperactivation and fatal hemophagocytic lymphohistiocytosis in mice

scientific article published on 30 October 2015

Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection

scientific article published on 10 November 2020

Selective expansion of a subset of exhausted CD8 T cells by alphaPD-L1 blockade

scholarly article

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

scientific article published on 16 November 2003

Single-cell RNA-seq reveals TOX as a key regulator of CD8+ T cell persistence in chronic infection

scientific article published on 17 June 2019

SnapShot: T Cell Exhaustion

scientific article published in November 2015

Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial

scientific article published on 03 June 2022

Spatial distribution and function of T follicular regulatory cells in human lymph nodes

scientific article published on 16 May 2018

Strength of stimulus and clonal competition impact the rate of memory CD8 T cell differentiation

scientific article published in November 2007

Su.66. Memory T-Cells in Mice and Humans Share a Common Molecular Program of Differentiation Regardless of Phenotype, Lineage Or Species

scientific article published on 17 May 2006

Successive annual influenza vaccination induces a recurrent oligoclonotypic memory response in circulating T follicular helper cells

scientific article

Survival of effector CD8+ T cells during influenza infection is dependent on autophagy

scientific article published on April 2015

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

scientific article (publication date: February 2009)

T cell exhaustion during persistent viral infections

scientific article published on 22 January 2015

T cell immunity to COVID-19 vaccines

scientific article published on 19 August 2022

T cell responses in patients with COVID-19

scientific article published on 29 July 2020

T follicular helper cells in human efferent lymph retain lymphoid characteristics

scientific article published on 02 July 2019

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response.

scientific article published on 10 April 2017

T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool

scientific article

TCF-1 flips the switch on Eomes

scientific article published in August 2010

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

scientific article published on 09 October 2019

TCR signal transduction in antigen-specific memory CD8 T cells

scientific article published in June 2003

TIGIT and CD226: tipping the balance between costimulatory and coinhibitory molecules to augment the cancer immunotherapy toolkit

scientific article published on 01 December 2014

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

scientific article published on 17 June 2019

TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation ⬇️

scientific article published on August 14, 2011

Targeting of antigen to the herpesvirus entry mediator augments primary adaptive immune responses

scientific article published on 13 January 2008

Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes.

scientific article published on 27 November 2012

The Identity of Human Tissue-Emigrant CD8<sup>+</sup> T Cells

scientific article published on 04 December 2020

The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation

scientific article published on 17 November 2017

The Methylcytosine Dioxygenase TET2 Regulates CD8+ T Cell Memory Differentiation ⬇️

scholarly article

The Orphan Nuclear Receptor TLX Is an Enhancer of STAT1-Mediated Transcription and Immunity to Toxoplasma gondii

scientific article published on 21 July 2015

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

scientific article published on 01 June 2020

The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1.

scientific article published on 6 December 2017

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

scientific article published on 22 April 2020

The contribution of epigenetic memory to immunologic memory ⬇️

scientific article published on February 15, 2011

The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses.

scientific article published on 04 March 2009

The epigenetic landscape of T cell exhaustion.

scientific article

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

scientific article published on March 2007

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

scientific article published on 01 June 2019

The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation

scientific article published on 01 July 2021

The importance of cooperation: partnerless NFAT induces T cell exhaustion

scientific article published on 01 February 2015

The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan.

scientific article published on 15 August 2016

The long noncoding RNA Morrbid regulates CD8 T cells in response to viral infection

scientific article published on 28 May 2019

The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.

scientific article

The role of programming in memory T-cell development

scientific article published on April 2004

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

scientific article published on 02 March 2014

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo

scientific article published on 14 April 2003

Tissue-specific differences in PD-1 and PD-L1 expression during chronic viral infection: implications for CD8 T-cell exhaustion

scientific article

Toll-like Receptor 7 Is Required for Effective Adaptive Immune Responses that Prevent Persistent Virus Infection ⬇️

scientific article published on June 14, 2012

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

scientific article published on 29 May 2011

Transcription factor regulation of CD8+ T-cell memory and exhaustion

scientific article published on July 2010

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

scientific article published on 3 October 2010

Transient expression of ZBTB32 in anti-viral CD8+ T cells limits the magnitude of the effector response and the generation of memory

scientific article

Trib1 regulates T cell differentiation during chronic infection by restraining the effector program

scientific article published on 01 May 2020

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

scientific article published on 26 June 2018

Tumor interferon signaling regulates a multigenic resistance program to immune checkpoint blockade

scientific article published on December 2016

Turning on the off switch: regulation of anti-viral T cell responses in the liver by the PD-1/PD-L1 pathway

scientific article published on 25 July 2006

Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity

scientific article

Unique challenges for glioblastoma immunotherapy - Discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology ⬇️

scientific article published on 24 December 2020

Universal Principled Review: A Community-Driven Method to Improve Peer Review

scientific article published on 01 December 2019

Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection

scientific article

Vaccine-induced ICOS<sup>+</sup>CD38<sup>+</sup> circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways

scientific article published on 07 May 2021

Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans

scientific article

Viral Antigen Induces Differentiation of Foxp3+ Natural Regulatory T Cells in Influenza Virus–Infected Mice ⬇️

scientific article published on May 10, 2013

Viral FLIP impairs survival of activated T cells and generation of CD8+ T cell memory.

scientific article published on May 2004

Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

scientific article

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

scientific article

What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? Consideration of Strategies to Improve the Value of Animal Models.

scientific article published on 27 March 2017

miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb

scientific article published on September 2017

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