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List of works by Debby Van Dam

"Hypodense Holes" and the Ocular Glymphatic System: Author Response: "Black Holes" and the Ocular Glymphatic System.

scientific article

A General Decline in Cerebrospinal Fluid Flow: An Overlooked Risk Factor for Glaucoma?

scientific article

A behavioural study of neuroglobin-overexpressing mice under normoxic and hypoxic conditions

scientific article

A general decline in cerebrospinal fluid flow and optic nerve compartmentation: are these sequential steps leading to toxicity in normal-tension glaucoma?

scientific article published on 4 February 2016

A multidisciplinary approach unravels early and persistent effects of X-ray exposure at the onset of prenatal neurogenesis

scientific article

A new glaucoma hypothesis: a role of glymphatic system dysfunction

scientific article published on 29 June 2015

APP-Based Transgenic Models: The APP23 Model

scientific article published on 22 October 2010

APP23 mice as a model of Alzheimer's disease: an example of a transgenic approach to modeling a CNS disorder

scientific article

APP23 mice display working memory impairment in the plus-shaped water maze

scientific article published on 7 September 2006

Accelerated high-frequency repetitive transcranial magnetic stimulation enhances motor activity in rats.

scientific article published on 09 February 2017

Actigraphic measurement of agitated behaviour in dementia

scientific article

Acute modulation of the cholinergic system in the mouse brain detected by pharmacological resting-state functional MRI.

scientific article published on 9 January 2015

Adapted Morris Water Maze protocol to prevent interference from confounding motor deficits on cognitive functioning.

scientific article published on 10 September 2017

Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease

scientific article

Age-dependent changes in noradrenergic locus coeruleus system in wild-type and APP23 transgenic mice.

scientific article published on 23 July 2009

Age-dependent cognitive decline in the APP23 model precedes amyloid deposition

scientific article published in January 2003

Age-related macular degeneration, glaucoma and Alzheimer's disease: amyloidogenic diseases with the same glymphatic background?

scientific article published on 29 August 2016

Aggressive male APP23 mice modeling behavioral alterations in dementia

scientific article published on 01 December 2006

Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models

scientific article published on 14 June 2017

Aging, microglia and cytoskeletal regulation are key factors in the pathological evolution of the APP23 mouse model for Alzheimer's disease.

scientific article published on 9 November 2016

Altered circadian locomotor activity in APP23 mice: a model for BPSD disturbances

scientific article published on 01 November 2004

Altered ingestive behavior, weight changes, and intact olfactory sense in an APP overexpression model

scientific article published in June 2008

Alzheimer's disease and glaucoma: Look-alike neurodegenerative diseases

scientific article published on 31 January 2019

Alzheimer's disease and glaucoma: can glymphatic system dysfunction underlie their comorbidity?

scientific article published on 29 April 2016

Alzheimer's disease: Neurotransmitters of the sleep-wake cycle

scientific article published on 01 August 2019

Analysis of cholinergic markers, biogenic amines, and amino acids in the CNS of two APP overexpression mouse models

scientific article published on 17 January 2005

Animal models in the drug discovery pipeline for Alzheimer's disease

scientific article published on October 2011

Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo

scientific article published on 01 January 2018

Antigen-specific age-related memory CD8 T cells induce and track Alzheimer's-like neurodegeneration

scientific article published on 16 July 2024

Aripiprazole in the treatment of Alzheimer's disease

scientific article published on 28 January 2013

Behavioral Validation in Animal Models of Dementia

scientific article published on 22 October 2010

Behavioral and Neuropathological Phenotyping of the Tau58/2 and Tau58/4 Transgenic Mouse Models for FTDP-17

scientific article published on 20 October 2023

Behavioural and psychological symptoms of dementia in Down syndrome: Early indicators of clinical Alzheimer's disease?

scientific article published on 13 August 2015

Biochemical and behavioural phenotyping of a mouse model for GAMT deficiency

scientific article published in April 2005

Biogenic amines and their metabolites in mouse brain tissue: Development, optimization and validation of an analytical HPLC method ⬇️

scientific article published on September 29, 2010

Brain Kynurenine Pathway Metabolite Levels May Reflect Extent of Neuroinflammation in ALS, FTD and Early Onset AD

scientific article published on 19 April 2023

Brain Serotonergic and Noradrenergic Deficiencies in Behavioral Variant Frontotemporal Dementia Compared to Early-Onset Alzheimer's Disease.

scientific article published on 15 June 2016

Brain inflammation in a chronic epilepsy model: Evolving pattern of the translocator protein during epileptogenesis

scientific article published on 17 September 2015

Brain region-specific monoaminergic correlates of neuropsychiatric symptoms in Alzheimer's disease

scientific article published in January 2014

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice

scientific article published on 25 June 2012

Central administration of obestatin fails to show inhibitory effects on food and water intake in mice.

scientific article published on 5 May 2009

Cerebral and cerebellar language organization in a right-handed subject with a left temporal porencephalic cyst: An fMRI study

scientific article published in February 2016

Cerebrospinal fluid and serum MHPG improve Alzheimer's disease versus dementia with Lewy bodies differential diagnosis

scientific article published on 6 February 2018

Chronic Inhibition of Nitric Oxide Synthases Impairs Spatiotemporal Learning and Memory to a Similar Extent in C57BL/6 and hAPP23+/− Mice

scientific article published on 14 December 2023

Cognitive decline, neuromotor and behavioural disturbances in a mouse model for fragile-X-associated tremor/ataxia syndrome (FXTAS).

scientific article

Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease

scientific article published on 16 November 2007

Comparison of extraction methods for peptidomics analysis of mouse brain tissue.

scientific article

Comparison of size distribution and (Pro249-Ser258) epitope exposure in in vitro and in vivo derived Tau fibrils

scientific article published on 12 November 2020

Decreased expression of the GABAA receptor in fragile X syndrome

scientific article published on 16 October 2006

Dilated Virchow-Robin spaces in primary open-angle glaucoma: a biomarker of glymphatic waste clearance dysfunction?

scientific article published on 10 August 2016

Do repetitive Valsalva maneuvers reduce glymphatic clearance?

scientific article published on 26 December 2016

Drug discovery in dementia: the role of rodent models

scientific article published on November 2006

Evaluating the applicability of mouse SINEs as an alternative normalization approach for RT-qPCR in brain tissue of the APP23 model for Alzheimer's disease

scientific article published on 05 March 2019

Evaluation of the APP23-model for Alzheimer's disease in the odour paired-associate test for hippocampus-dependent memory

scientific article published on 16 February 2008

Everolimus depletes plaque macrophages, abolishes intraplaque neovascularization and improves survival in mice with advanced atherosclerosis

scientific article published on 24 December 2018

Evidence for the existence of a communication between the eye and the brain?

scientific article

Excitatory amino acids and monoaminergic neurotransmitters in cerebrospinal fluid of acute ischemic stroke patients

scientific article published on 29 December 2009

Fast circulation of cerebrospinal fluid: an alternative perspective on the protective role of high intracranial pressure in ocular hypertension

scientific article published on 21 December 2015

Fibromyalgia as a glymphatic overload syndrome

scientific article published on 26 March 2018

GSA: behavioral, histological, electrophysiological and neurochemical effects

scientific article published on 8 January 2005

General Introduction to Animal Models of Human Conditions

scientific article published on 22 October 2010

Genes involved in cerebrospinal fluid production as candidate genes for late-onset Alzheimer's disease: a hypothesis

scientific article published on 24 October 2011

Glaucoma and the Role of Cerebrospinal Fluid Dynamics

scientific article

Glaucoma considered as an imbalance between production and clearance of neurotoxins

scientific article published on 26 August 2014

How does a researcher choose the best rodent model for their Alzheimer's disease drug discovery study?

scientific article published on 08 October 2019

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

scientific article

Impaired gait pattern as a sensitive tool to assess hypoxic brain damage in a novel mouse model of atherosclerotic plaque rupture

scientific article published on 20 November 2014

Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels

scientific article published on 9 April 2017

Increased Cerebrospinal Fluid Production as a Possible Mechanism Underlying Caffeine's Protective Effect against Alzheimer's Disease

scientific article

Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain

scientific article

Inflammation, Nitro-Oxidative Stress, Impaired Autophagy, and Insulin Resistance as a Mechanistic Convergence Between Arterial Stiffness and Alzheimer’s Disease

scientific article published on 29 March 2021

Intracerebral adeno-associated virus-mediated gene transfer in rapidly progressive forms of metachromatic leukodystrophy.

scientific article

Intracranial pressure and glaucoma: Is there a new therapeutic perspective on the horizon?

scientific article published on 28 June 2018

Intracranial pressure fluctuations: a potential risk factor for glaucoma?

scientific article published on 24 December 2013

Intraneuronal amyloid beta and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.

scientific article published on 16 November 2006

Intrathecal cerebrospinal fluid infusion as a potential therapeutic strategy for Alzheimer's disease

scientific article published on 22 October 2018

Late age increase in soluble amyloid-beta levels in the APP23 mouse model despite steady-state levels of amyloid-beta-producing proteins

scientific article published on 2 November 2015

Letter to the Editor. Low ICP and normal tension glaucoma: optic nerve damage due to barotraumatic factors, failure of CSF dynamics, or both?

scientific article published on 04 May 2018

Long-Term Pharmacological Inhibition of the Activity of All NOS Isoforms Rather Than Genetic Knock-Out of Endothelial NOS Leads to Impaired Spatial Learning and Memory in C57BL/6 Mice

scientific article published on 14 December 2021

Monoaminergic Markers Across the Cognitive Spectrum of Lewy Body Disease.

scientific article published in January 2018

Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease.

scientific article published on 23 November 2017

Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's disease

scientific article

Mood and male sexual behaviour in the APP23 model of Alzheimer's disease

scientific article published on 12 March 2007

Neuroimaging of Subacute Brain Inflammation and Microstructural Changes Predicts Long-Term Functional Outcome after Experimental Traumatic Brain Injury

scientific article published on 03 October 2018

Neuropeptides in Alzheimer's disease: from pathophysiological mechanisms to therapeutic opportunities

scientific article published on June 2013

Neuropsychiatric Disturbances in Alzheimer's Disease: What Have We Learned from Neuropathological Studies?

scientific article

Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer's Disease (AD) Brain Regions: Differential Findings in AD with and without Depression

scientific article published on 05 October 2016

Nitric oxide donor molsidomine favors features of atherosclerotic plaque stability and reduces myocardial infarction in mice

scientific article published on 11 May 2019

Non human primate models for Alzheimer's disease-related research and drug discovery

scientific article published on 14 December 2016

Novel and sensitive reversed-phase high-pressure liquid chromatography method with electrochemical detection for the simultaneous and fast determination of eight biogenic amines and metabolites in human brain tissue.

scientific article

PTZ-induced seizures in mice require a revised Racine scale

scientific article published on 24 April 2019

Pentylenetetrazole-induced Seizure Susceptibility in the Tau58/4 Transgenic Mouse Model of Tauopathy

scientific article published on 27 November 2019

Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model

scientific article

Prevalence and incidence of dementia among 75–80-year-old community-dwelling elderly in different districts of Antwerp, Belgium: The Antwerp Cognition (ANCOG) Study ⬇️

scientific article published on August 20, 2011

Progressive Motor Deficit is Mediated by the Denervation of Neuromuscular Junctions and Axonal Degeneration in Transgenic Mice Expressing Mutant (P301S) Tau Protein

scientific article published on 10 February 2017

Progressive tau aggregation does not alter functional brain network connectivity in seeded hTau.P301L mice

scientific article published on 09 July 2020

Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease

scientific article published in January 2011

Senescent changes in cerebrospinal fluid circulatory physiology and their role in the pathogenesis of normal-tension glaucoma.

scientific article published on 19 April 2013

Serotonergic Dysfunction in Amyotrophic Lateral Sclerosis and Parkinson's Disease: Similar Mechanisms, Dissimilar Outcomes.

scientific article published on 20 March 2018

Serum MHPG strongly predicts conversion to Alzheimer's disease in behaviorally characterized subjects with Down syndrome.

scientific article

Serum NGAL is Associated with Distinct Plasma Amyloid-β Peptides According to the Clinical Diagnosis of Dementia in Down Syndrome

scientific article published in January 2015

Signal loss due to oligomerization in ELISA analysis of amyloid-beta can be recovered by a novel sample pre-treatment method

scientific article published on 27 February 2015

Sleep and Alzheimer's disease: A pivotal role for the suprachiasmatic nucleus

scientific article

Sleep architecture changes in the APP23 mouse model manifest at onset of cognitive deficits

scientific article published on 17 July 2019

Specific Triazine Herbicides Induce Amyloid-β42 Production

scientific article

Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.

scientific article published on 15 January 2005

The First Histologic Evidence of a Paravascular Pathway Within the Optic Nerve

scientific article published in April 2018

The GABAA receptor is an FMRP target with therapeutic potential in fragile X syndrome.

scientific article

The Glymphatic Hypothesis of Glaucoma: A Unifying Concept Incorporating Vascular, Biomechanical, and Biochemical Aspects of the Disease

scientific article published on 29 August 2017

The Glymphatic System: A New Player in Ocular Diseases?

scientific article published in October 2016

The monoaminergic footprint of depression and psychosis in dementia with Lewy bodies compared to Alzheimer's disease

scientific article

The role of low intracranial pressure in the development of glaucoma in patients with Alzheimer's disease

scientific article

The two faces of the translaminar pressure difference: the biomechanical one and the biochemical one.

scientific article published on 25 October 2016

The validation of Short Interspersed Nuclear Elements (SINEs) as a RT-qPCR normalization strategy in a rodent model for temporal lobe epilepsy

scientific article published in PLoS ONE

Validation of the APP23 transgenic mouse model of Alzheimer's disease through evaluation of risperidone treatment on aggressive behaviour

scientific article

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