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List of works by Denis T. Akan

Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

scientific article published on 28 September 2018

Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.

scientific article published in June 2018

Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS

scientific article published on 08 August 2018

Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses

scientific article published on 18 February 2019

Small molecule-mediated activation of RAS elicits biphasic modulation of phospho ERK levels that are regulated through negative feedback on SOS1.

scientific article published on 13 February 2018

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