List of works - Ezio Ghigo

A consensus on criteria for cure of acromegaly.

scientific article published on 21 April 2010

A novel likely pathogenetic variant p.(Cys235Arg) of the MEN1 gene in multiple endocrine neoplasia type 1 with multifocal glucagonomas

scientific article published in 2024

Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B

scientific journal article

Adrenocorticotropin and cortisol hyperresponsiveness to hexarelin in patients with Cushing's disease bearing a pituitary microadenoma, but not in those with macroadenoma

scientific article

Assessment of the awareness and management of cardiovascular complications of acromegaly in Italy. The COM.E.T.A. (COMorbidities Evaluation and Treatment in Acromegaly) Study

scientific article

Assessment of the awareness and management of sleep apnea syndrome in acromegaly. The COM.E.TA (Comorbidities Evaluation and Treatment in Acromegaly) Italian Study Group ⬇️

scientific article published on January 1, 2011

Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin

scientific article published on June 2004

Brain-gut communication: cortistatin, somatostatin and ghrelin.

scientific article published on 13 July 2007

Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin.

scientific article

Consensus statement: medical management of acromegaly

scientific article

Consuming more of daily caloric intake at dinner predisposes to obesity. A 6-year population-based prospective cohort study.

scientific article

Correction to: Pegvisomant in acromegaly: an update.

scientific article published on 28 December 2017

Current management practices for acromegaly: an international survey.

scientific article

Development of ACRODAT®, a new software medical device to assess disease activity in patients with acromegaly.

scientific article published on 8 September 2017

Diagnosis of GH deficiency in the transition period: accuracy of insulin tolerance test and insulin-like growth factor-I measurement

scientific article (publication date: April 2005)

Dual effects of IGFBP-3 on endothelial cell apoptosis and survival: involvement of the sphingolipid signaling pathways

scientific article

Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans

scientific article

Endocrine and non-endocrine actions of ghrelin.

scientific article

Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours.

scientific article

Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines

scientific article published on February 2004

Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors

scientific article published on 01 March 2002

GHRH and GH secretagogues: clinical perspectives and safety.

scientific article

GPR103b functions in the peripheral regulation of adipogenesis.

scientific article

Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study.

scientific article

Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor

scientific article published in September 2004

Ghrelin and synthetic GH secretagogues

scientific article

Ghrelin and synthetic growth hormone secretagogues are cardioactive molecules with identities and differences.

scientific article published in May 2004

Ghrelin and the endocrine pancreas.

scientific article published on October 2003

Ghrelin in fetal thyroid and follicular tumors and cell lines: expression and effects on tumor growth

scientific article published on February 2003

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

scientific article

Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes

scientific article

Ghrelin, hypothalamus-pituitary-adrenal (HPA) axis and Cushing's syndrome

scientific article

Ghrelin: a new hormone with endocrine and non-endocrine activities.

scientific article

Ghrelin: endocrine and non-endocrine actions.

scientific article

Ghrelin: much more than a natural growth hormone secretagogue

scientific article

Growth hormone levels in the diagnosis of growth hormone deficiency in adulthood.

scientific article published on January 2007

Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart

scientific journal article

Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults

scientific article published on September 2008

Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors.

scientific article published on 2 July 2007

How to improve effectiveness of pegvisomant treatment in acromegalic patients.

scientific article

Hypopituitarism is a common neuro-endocrine disease: how manage to inform the medical community

scientific article

Hypothalamic-Pituitary Autoimmunity and Traumatic Brain Injury

scientific article (publication date: 2015)

Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review

scientific article

IGFs and IGFBPs in adult growth hormone deficiency

scientific article

Insulin-like growth factor I levels and the diagnosis of adult growth hormone deficiency.

scientific article

Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs

scientific article

Managing patients with hypopituitarism after traumatic brain injury

scientific article published on August 2007

Neuroendocrine alterations in obese patients with sleep apnea syndrome

scientific article

Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity

scientific article

Obestatin Enhances In Vitro Generation of Pancreatic Islets through Regulation of Developmental Pathways ⬇️

scientific article published on May 31, 2013

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

scientific article published on 31 January 2014

Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation.

scientific article published on 17 May 2012

Obestatin: a new metabolic player in the pancreas and white adipose tissue

scientific article

Pegvisomant in acromegaly: an update

scientific article

Pegvisomant in acromegaly: why, when, how.

scientific article published on September 2007

Plasma total and acylated Ghrelin concentrations in patients with clinical and subclinical thyroid dysfunction

scientific article

Preliminary data on biochemical remission of acromegaly after somatostatin analogs withdrawal

scientific article

Primary empty sella: Why and when to investigate hypothalamic-pituitary function

scientific article published on 05 March 2010

Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitor cells

scientific article published on 24 January 2008

Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia

scientific article

Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement.

scientific article

Short ghrelin peptides neither displace ghrelin binding in vitro nor stimulate GH release in vivo

scientific article published in May 2002

Systemic steroids in patients with COVID-19: pros and contras, an endocrinological point of view

scientific article published on 08 June 2020

Targeting the ghrelin receptor: orally active GHS and cortistatin analogs.

scientific article published on October 2003

Testing pituitary function in aging individuals

scientific article

The antiproliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells

scientific article published on February 2002

The growth hormone-releasing hormone (GHRH) antagonist JV-1-36 inhibits proliferation and survival of human ectopic endometriotic stromal cells (ESCs) and the T HESC cell line.

scientific article

The management of the patient with acromegaly and headache: a still open clinical challenge

scientific article published on October 2008

Traumatic brain injury and hypopituitarism in children and adolescents: is the problem under-estimated?

scientific article published on March 2007

Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats.

scientific article published on 09 April 2010

Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor.

scientific article

Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes

scientific article

List of works by Ezio Ghigo

A consensus on criteria for cure of acromegaly.

A novel likely pathogenetic variant p.(Cys235Arg) of the MEN1 gene in multiple endocrine neoplasia type 1 with multifocal glucagonomas

Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B

Adrenocorticotropin and cortisol hyperresponsiveness to hexarelin in patients with Cushing's disease bearing a pituitary microadenoma, but not in those with macroadenoma

Assessment of the awareness and management of cardiovascular complications of acromegaly in Italy. The COM.E.T.A. (COMorbidities Evaluation and Treatment in Acromegaly) Study

Assessment of the awareness and management of sleep apnea syndrome in acromegaly. The COM.E.TA (Comorbidities Evaluation and Treatment in Acromegaly) Italian Study Group ⬇️

Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin

Brain-gut communication: cortistatin, somatostatin and ghrelin.

Cardiac effects of ghrelin and its endogenous derivatives des-octanoyl ghrelin and des-Gln14-ghrelin.

Consensus statement: medical management of acromegaly

Consuming more of daily caloric intake at dinner predisposes to obesity. A 6-year population-based prospective cohort study.

Correction to: Pegvisomant in acromegaly: an update.

Current management practices for acromegaly: an international survey.

Development of ACRODAT®, a new software medical device to assess disease activity in patients with acromegaly.

Diagnosis of GH deficiency in the transition period: accuracy of insulin tolerance test and insulin-like growth factor-I measurement

Dual effects of IGFBP-3 on endothelial cell apoptosis and survival: involvement of the sphingolipid signaling pathways

Endocrine activities of cortistatin-14 and its interaction with GHRH and ghrelin in humans

Endocrine and non-endocrine actions of ghrelin.

Expression of cortistatin and MrgX2, a specific cortistatin receptor, in human neuroendocrine tissues and related tumours.

Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines

Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors

GHRH and GH secretagogues: clinical perspectives and safety.

GPR103b functions in the peripheral regulation of adipogenesis.

Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study.

Ghrelin and des-acyl ghrelin both inhibit isoproterenol-induced lipolysis in rat adipocytes via a non-type 1a growth hormone secretagogue receptor

Ghrelin and synthetic GH secretagogues

Ghrelin and synthetic growth hormone secretagogues are cardioactive molecules with identities and differences.

Ghrelin and the endocrine pancreas.

Ghrelin in fetal thyroid and follicular tumors and cell lines: expression and effects on tumor growth

Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotropin and cortisol responses

Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes

Ghrelin, hypothalamus-pituitary-adrenal (HPA) axis and Cushing's syndrome

Ghrelin: a new hormone with endocrine and non-endocrine activities.

Ghrelin: endocrine and non-endocrine actions.

Ghrelin: much more than a natural growth hormone secretagogue

Growth hormone levels in the diagnosis of growth hormone deficiency in adulthood.

Growth hormone-releasing hormone promotes survival of cardiac myocytes in vitro and protects against ischaemia-reperfusion injury in rat heart

Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults

Heterogeneity of ghrelin/growth hormone secretagogue receptors. Toward the understanding of the molecular identity of novel ghrelin/GHS receptors.

How to improve effectiveness of pegvisomant treatment in acromegalic patients.

Hypopituitarism is a common neuro-endocrine disease: how manage to inform the medical community

Hypothalamic-Pituitary Autoimmunity and Traumatic Brain Injury

Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: a systematic review

IGFs and IGFBPs in adult growth hormone deficiency

Insulin-like growth factor I levels and the diagnosis of adult growth hormone deficiency.

Intracoronary ghrelin infusion decreases coronary blood flow in anesthetized pigs

Managing patients with hypopituitarism after traumatic brain injury

Neuroendocrine alterations in obese patients with sleep apnea syndrome

Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity

Obestatin Enhances In Vitro Generation of Pancreatic Islets through Regulation of Developmental Pathways ⬇️

Obestatin plays an opposite role in the regulation of pituitary somatotrope and corticotrope function in female primates and male/female mice.

Obestatin regulates adipocyte function and protects against diet-induced insulin resistance and inflammation.

Obestatin: a new metabolic player in the pancreas and white adipose tissue

Pegvisomant in acromegaly: an update

Pegvisomant in acromegaly: why, when, how.

Plasma total and acylated Ghrelin concentrations in patients with clinical and subclinical thyroid dysfunction

Preliminary data on biochemical remission of acromegaly after somatostatin analogs withdrawal

Primary empty sella: Why and when to investigate hypothalamic-pituitary function

Proliferative and protective effects of growth hormone secretagogues on adult rat hippocampal progenitor cells

Pyroglutamylated RF-amide peptide (QRFP) gene is regulated by metabolic endotoxemia

Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement.

Short ghrelin peptides neither displace ghrelin binding in vitro nor stimulate GH release in vivo

Systemic steroids in patients with COVID-19: pros and contras, an endocrinological point of view

Targeting the ghrelin receptor: orally active GHS and cortistatin analogs.

Testing pituitary function in aging individuals

The antiproliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells

The growth hormone-releasing hormone (GHRH) antagonist JV-1-36 inhibits proliferation and survival of human ectopic endometriotic stromal cells (ESCs) and the T HESC cell line.

The management of the patient with acromegaly and headache: a still open clinical challenge

Traumatic brain injury and hypopituitarism in children and adolescents: is the problem under-estimated?

Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats.

Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor.

Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes