List of works - Barbara Nawrot

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

scientific article

2-Thiouracil deprived of thiocarbonyl function preferentially base pairs with guanine rather than adenine in RNA and DNA duplexes

scientific article

5-Ethynyl-1-β-D-ribofuranosyl-1H-[1,2,3]triazole-4-carboxylic acid amide (ETCAR) and its analogues: synthesis and cytotoxic properties.

scientific article published on 30 May 2011

A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5′-monophosphate at 1.38 Å resolution

scientific article

A novel class of DNA analogs bearing 5'-C-phosphonothymidine units: synthesis and physicochemical and biochemical properties

scientific article

A single nuclease-resistant linkage in DNA as a versatile tool for the characterization of DNA lesions: application to the guanine oxidative lesion "G+34" generated by metalloporphyrin/KHSO(5) reagent

An efficient approach for conversion of 5-substituted 2-thiouridines built in RNA oligomers into corresponding desulfured 4-pyrimidinone products.

scientific article

An oxathiaphospholane approach to one-pot phosphorothioylation of isoprenoid alcohols

scientific article

Analogues of acyclic nucleosides derived from tris-(hydroxymethyl)phosphine oxide or bis-(hydroxymethyl)phosphinic acid coupled to DNA nucleobases.

scientific article

Biological evaluation of novel Pt(II) and Pd(II) complexes with pyrazole-containing ligands

scientific article

Boron clusters as a platform for new materials: composites of nucleic acids and oligofunctionalized carboranes (C2B10H12) and their assembly into functional nanoparticles

scientific article published on 25 November 2019

C5-Substituted 2-Selenouridines Ensure Efficient Base Pairing with Guanosine; Consequences for Reading the NNG-3' Synonymous mRNA Codons

scientific article published on 20 April 2020

C5-substituents of uridines and 2-thiouridines present at the wobble position of tRNA determine the formation of their keto-enol or zwitterionic forms - a factor important for accuracy of reading of guanosine at the 3΄-end of the mRNA codons.

scientific article

Catalytic DNA--deoxyribozymes

scientific article published in January 2002

Catalytic phosphoryl interactions of topoisomerase IB.

scientific article

Chemical and Structural Diversity of siRNA Molecules

scientific article published on 01 January 2006

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity

scientific article published on 19 April 2018

Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A

scientific article

Cytochrome C catalyzes the hydrogen peroxide-assisted oxidative desulfuration of 2-thiouridines in transfer RNAs.

scientific article

DNA Modified with Boron⁻Metal Cluster Complexes [M(C₂B₉H)₂]-Synthesis, Properties, and Applications ⬇️

scientific article published on 07 November 2018

DNA oligonucleotides containing stereodefined phosphorothioate linkages in selected positions

scientific article published in March 2009

Desulfuration of 2-thiouridine with hydrogen peroxide in the physiological pH range 6.6-7.6 is pH-dependent and results in two distinct products

scientific article published on 8 September 2013

Different Oxidation Pathways of 2-Selenouracil and 2-Thiouracil, Natural Components of Transfer RNA

scientific article published on 19 August 2020

Discrimination in metal-ion binding to RNA dinucleotides with a non-bridging oxygen or sulfur in the phosphate diester link.

scientific article

Effect of Helicobacter pylori eradication on the expression level of SATB1 and c-Myc genes in gastric mucosa of patients with family history of gastric cancer

scientific article published in May 2013

Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA.

scientific article

Efficient inhibition of β‐secretase gene expression in HEK293 cells by tRNAVal‐driven and CTE‐helicase associated hammerhead ribozymes ⬇️

scientific article published on October 1, 2003

Escherichia coli tRNA 2-Selenouridine Synthase (SelU): Elucidation of Substrate Specificity to Understand the Role of S-Geranyl-tRNA in the Conversion of 2-Thio- into 2-Selenouridines in Bacterial tRNA

scientific article published in 2022

Escherichia coli tRNA 2-selenouridine synthase (SelU) converts S2U-RNA to Se2U-RNA via S-geranylated-intermediate

scientific article published on 19 June 2018

Escherichia coli tRNA 2-selenouridine synthase SelU selects its prenyl substrate to accomplish its enzymatic function

scientific article published in 2022

Evaluation of BACE1 Silencing in Cellular Models

scientific article

Evaluation of influence of Ap4A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis

scientific article

Evoking picomolar binding in RNA by a single phosphorodithioate linkage.

scientific article published on 26 August 2016

Expression of somatostatin receptor subtype 3 in the gastric mucosa of dyspeptic patients in relation to Helicobacter pylori infection and a family history of gastric cancer

scientific article published on 07 August 2007

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human histidine triad nucleotide-binding protein 2 (hHINT2).

scientific article published on 28 June 2013

Family history of gastric cancer correlates with decreased expression of HINT1 tumor suppressor gene in gastric mucosa of dyspeptic patients ⬇️

scientific article published on October 21, 2011

Formation of an RNA Quadruplex-Duplex Hybrid in Living Cells between mRNA of the Epidermal Growth Factor Receptor (EGFR) and a G-Rich Antisense Oligoribonucleotide

scientific article published on 29 October 2020

Gastric ghrelin in relation to gender, stomach topography and Helicobacter pylori in dyspeptic patients

scientific article

Gene silencing activity of siRNA molecules containing phosphorodithioate substitutions

scientific article

Guanosine in a single stranded region of anticodon stem-loop tRNA models is prone to oxidatively generated damage resulting in dehydroguanidinohydantoin and spiroiminodihydantoin lesions

scientific article published on 13 March 2015

Helicobacter pylori infection and family history of gastric cancer decrease expression of FHIT tumor suppressor gene in gastric mucosa of dyspeptic patients

scientific article published in October 2009

High Boron-loaded DNA-Oligomers as Potential Boron Neutron Capture Therapy and Antisense Oligonucleotide Dual-Action Anticancer Agents

scientific article published on 23 August 2017

High Cytotoxic Activity of Phosphonium Salts and Their Complementary Selectivity towards HeLa and K562 Cancer Cells: Identification of Tri-n-butyl-n-hexadecylphosphonium bromide as a Highly Potent Anti-HeLa Phosphonium Salt

scientific article published on 17 February 2012

High-resolution X-ray structure of the rabbit histidine triad nucleotide-binding protein 1 (rHINT1)-adenosine complex at 1.10 Å resolution

scientific article

Longer 19-base pair short interfering RNA duplexes rather than shorter duplexes trigger RNA interference

scientific article published in August 2010

Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection

scientific article

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

scientific article published on 22 May 2020

Mapping of the functional phosphate groups in the catalytic core of deoxyribozyme 10-23.

scientific article published on 22 January 2007

Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase

scientific article published on 05 May 2020

Modulation of beta-secretase gene expression by action of catalytic nucleic acids

scientific article published on 01 January 2002

N-Acyl-phosphoramidates as potential novel form of gemcitabine prodrugs

scientific article

New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities

scientific article published on 04 September 2019

New, Substituted Derivatives of Dicarboximides and their Cytotoxic Properties.

scientific article published on 22 February 2016

Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M Phase

scientific article published on 01 January 2019

Novel Dicarboximide BK124.1 Breaks Multidrug Resistance and Shows Anticancer Efficacy in Chronic Myeloid Leukemia Preclinical Models and Patients' CD34/CD38 Leukemia Stem Cells

scientific article published on 27 July 2022

Nucleoside modifications in the regulation of gene expression: focus on tRNA

scientific article

Phosphorothioate analogs of P1,P3-di(nucleosid-5'-yl) triphosphates: Synthesis, assignment of the absolute configuration at P-atoms and P-stereodependent recognition by Fhit hydrolase

scientific article published on 20 August 2016

Phytotoxicity and Cytotoxicity of Imidazolium Ionic Liquids Containing Sulfur Atom

Polycationic phosphorus dendrimers: synthesis, characterization, study of cytotoxicity, complexation of DNA, and transfection experiments

Preparation of short interfering RNA containing the modified nucleosides 2-thiouridine, pseudouridine, or dihydrouridine.

scientific article published in June 2009

RNA interference in silencing of genes of Alzheimer's disease in cellular and rat brain models.

scientific article published on January 2008

RNAi mediated silencing of cyclin-dependent kinases of G1 phase slows down the cell-cycle progression and reduces apoptosis

scientific article

Reaction of S-geranyl-2-thiouracil modified oligonucleotides with alkyl amines leads to the N2-alkyl isocytosine derivatives.

scientific article published on 15 June 2017

Rhodium(III) and iridium(III) complexes with 1,2-naphthoquinone-1-oximate as a bidentate ligand: synthesis, structure, and biological activity.

scientific article

S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterization

scientific article (publication date: 15 December 2016)

S100A6 binds p53 and affects its activity

scientific article

Selenium-containing polysaccharides from Lentinula edodes-Biological activity

scientific article published on 13 July 2019

Significance of stereochemistry of 3'-terminal phosphorothioate-modified primer in DNA polymerase-mediated chain extension

scientific article

Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference

scientific article published on 7 April 2011

Synthesis and cytotoxic properties of halogen and aryl-/heteroarylpiperazinyl derivatives of benzofurans

scientific article

Synthesis and structure of highly substituted pyrazole ligands and their complexes with platinum(II) and palladium(II) metal ions

Synthesis of New Derivatives of Benzofuran as Potential Anticancer Agents

scientific article published on 18 April 2019

Synthesis of a fluorescent cationic phosphorus dendrimer and preliminary biological studies of its interaction with DNA.

scientific article published on March 2010

Synthesis of dinucleoside (N3'-->MeP5') methanephosphonamidates

scientific article published on 01 May 2002

Synthesis, crystallization and preliminary crystallographic analysis of a 52-nucleotide DNA/2'-OMe-RNA oligomer mimicking 10-23 DNAzyme in the complex with a substrate

scientific article

Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?

scientific article published in January 2004

The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions ⬇️

scientific article published on March 24, 2011

The differences in the relationship between diastolic dysfunction, selected biomarkers and collagen turn-over in heart failure patients with preserved and reduced ejection fraction.

scientific article published on 17 October 2016

The influence of Helicobacter pylori eradication on the expression and methylation status of the FHIT gene in non-cancerous gastric mucosa of dyspeptic patients

scientific article

The influence of the C5 substituent on the 2-thiouridine desulfuration pathway and the conformational analysis of the resulting 4-pyrimidinone products

scientific article

The role of selected adipokines and ghrelin in the prognosis after myocardial infarction in a 12-month follow-up in the presence of metabolic syndrome

scientific article

The α-thio and/or β-γ-hypophosphate analogs of ATP as cofactors of T4 DNA ligase

scholarly article by Roza Pawlowska published in August 2016

Transformation of a wobble 2-thiouridine to 2-selenouridine via S-geranyl-2-thiouridine as a possible cellular pathway.

scientific article

Understanding the chemical mechanisms of life

scientific article published in December 2007

Versatile Method for the Site-Specific Modification of DNA with Boron Clusters: Anti-Epidermal Growth Factor Receptor (EGFR) Antisense Oligonucleotide Case.

scientific article published on 7 September 2017

Water-soluble polycationic dendrimers with a phosphoramidothioate backbone: preliminary studies of cytotoxicity and oligonucleotide/plasmid delivery in human cell culture

scientific article published in January 2003

Wheat (Triticum vulgare) chloroplast nuclease ChSI exhibits 5' flap structure-specific endonuclease activity

scientific article

[FHIT--tumor suppressor protein involved in induction of apoptosis and cell cycle regulation].

scientific article

[Somatostatin receptor subtype 3 (SSTR3) mRNA level in gastric mucosa of patients with dyspepsia]

scientific article published on 01 May 2007

[The clinical significance of GastroPanel in diagnostics of Helicobacter pylori eradication efficiency in patients with dyspepsia with correlation of family history of gastric cancer]

siRNAs modified with boron cluster and their physicochemical and biological characterization

scientific article published on 29 May 2013

tRNA structural and functional changes induced by oxidative stress

scientific article published on 11 August 2011

List of works by Barbara Nawrot

2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

2-Thiouracil deprived of thiocarbonyl function preferentially base pairs with guanine rather than adenine in RNA and DNA duplexes

5-Ethynyl-1-β-D-ribofuranosyl-1H-[1,2,3]triazole-4-carboxylic acid amide (ETCAR) and its analogues: synthesis and cytotoxic properties.

A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5′-monophosphate at 1.38 Å resolution

A novel class of DNA analogs bearing 5'-C-phosphonothymidine units: synthesis and physicochemical and biochemical properties

A single nuclease-resistant linkage in DNA as a versatile tool for the characterization of DNA lesions: application to the guanine oxidative lesion "G+34" generated by metalloporphyrin/KHSO(5) reagent

An efficient approach for conversion of 5-substituted 2-thiouridines built in RNA oligomers into corresponding desulfured 4-pyrimidinone products.

An oxathiaphospholane approach to one-pot phosphorothioylation of isoprenoid alcohols

Analogues of acyclic nucleosides derived from tris-(hydroxymethyl)phosphine oxide or bis-(hydroxymethyl)phosphinic acid coupled to DNA nucleobases.

Biological evaluation of novel Pt(II) and Pd(II) complexes with pyrazole-containing ligands

Boron clusters as a platform for new materials: composites of nucleic acids and oligofunctionalized carboranes (C2B10H12) and their assembly into functional nanoparticles

C5-Substituted 2-Selenouridines Ensure Efficient Base Pairing with Guanosine; Consequences for Reading the NNG-3' Synonymous mRNA Codons

C5-substituents of uridines and 2-thiouridines present at the wobble position of tRNA determine the formation of their keto-enol or zwitterionic forms - a factor important for accuracy of reading of guanosine at the 3΄-end of the mRNA codons.

Catalytic DNA--deoxyribozymes

Catalytic phosphoryl interactions of topoisomerase IB.

Chemical and Structural Diversity of siRNA Molecules

Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity

Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A

Cytochrome C catalyzes the hydrogen peroxide-assisted oxidative desulfuration of 2-thiouridines in transfer RNAs.

DNA Modified with Boron⁻Metal Cluster Complexes [M(C₂B₉H)₂]-Synthesis, Properties, and Applications ⬇️

DNA oligonucleotides containing stereodefined phosphorothioate linkages in selected positions

Desulfuration of 2-thiouridine with hydrogen peroxide in the physiological pH range 6.6-7.6 is pH-dependent and results in two distinct products

Different Oxidation Pathways of 2-Selenouracil and 2-Thiouracil, Natural Components of Transfer RNA

Discrimination in metal-ion binding to RNA dinucleotides with a non-bridging oxygen or sulfur in the phosphate diester link.

Effect of Helicobacter pylori eradication on the expression level of SATB1 and c-Myc genes in gastric mucosa of patients with family history of gastric cancer

Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA.

Efficient inhibition of β‐secretase gene expression in HEK293 cells by tRNAVal‐driven and CTE‐helicase associated hammerhead ribozymes ⬇️

Escherichia coli tRNA 2-Selenouridine Synthase (SelU): Elucidation of Substrate Specificity to Understand the Role of S-Geranyl-tRNA in the Conversion of 2-Thio- into 2-Selenouridines in Bacterial tRNA

Escherichia coli tRNA 2-selenouridine synthase (SelU) converts S2U-RNA to Se2U-RNA via S-geranylated-intermediate

Escherichia coli tRNA 2-selenouridine synthase SelU selects its prenyl substrate to accomplish its enzymatic function

Evaluation of BACE1 Silencing in Cellular Models

Evaluation of influence of Ap4A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis

Evoking picomolar binding in RNA by a single phosphorodithioate linkage.

Expression of somatostatin receptor subtype 3 in the gastric mucosa of dyspeptic patients in relation to Helicobacter pylori infection and a family history of gastric cancer

Expression, purification, crystallization and preliminary X-ray crystallographic analysis of human histidine triad nucleotide-binding protein 2 (hHINT2).

Family history of gastric cancer correlates with decreased expression of HINT1 tumor suppressor gene in gastric mucosa of dyspeptic patients ⬇️

Formation of an RNA Quadruplex-Duplex Hybrid in Living Cells between mRNA of the Epidermal Growth Factor Receptor (EGFR) and a G-Rich Antisense Oligoribonucleotide

Gastric ghrelin in relation to gender, stomach topography and Helicobacter pylori in dyspeptic patients

Gene silencing activity of siRNA molecules containing phosphorodithioate substitutions

Guanosine in a single stranded region of anticodon stem-loop tRNA models is prone to oxidatively generated damage resulting in dehydroguanidinohydantoin and spiroiminodihydantoin lesions

Helicobacter pylori infection and family history of gastric cancer decrease expression of FHIT tumor suppressor gene in gastric mucosa of dyspeptic patients

High Boron-loaded DNA-Oligomers as Potential Boron Neutron Capture Therapy and Antisense Oligonucleotide Dual-Action Anticancer Agents

High Cytotoxic Activity of Phosphonium Salts and Their Complementary Selectivity towards HeLa and K562 Cancer Cells: Identification of Tri-n-butyl-n-hexadecylphosphonium bromide as a Highly Potent Anti-HeLa Phosphonium Salt

High-resolution X-ray structure of the rabbit histidine triad nucleotide-binding protein 1 (rHINT1)-adenosine complex at 1.10 Å resolution

Longer 19-base pair short interfering RNA duplexes rather than shorter duplexes trigger RNA interference

Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

Mapping of the functional phosphate groups in the catalytic core of deoxyribozyme 10-23.

Metallacarborane Complex Boosts the Rate of DNA Oligonucleotide Hydrolysis in the Reaction Catalyzed by Snake Venom Phosphodiesterase

Modulation of beta-secretase gene expression by action of catalytic nucleic acids

N-Acyl-phosphoramidates as potential novel form of gemcitabine prodrugs

New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities

New, Substituted Derivatives of Dicarboximides and their Cytotoxic Properties.

Novel Benzo[B]Furans with Anti-Microtubule Activity Upregulate Expression of Apoptotic Genes and Arrest Leukemia Cells in G2/M Phase

Novel Dicarboximide BK124.1 Breaks Multidrug Resistance and Shows Anticancer Efficacy in Chronic Myeloid Leukemia Preclinical Models and Patients' CD34/CD38 Leukemia Stem Cells

Nucleoside modifications in the regulation of gene expression: focus on tRNA

Phosphorothioate analogs of P1,P3-di(nucleosid-5'-yl) triphosphates: Synthesis, assignment of the absolute configuration at P-atoms and P-stereodependent recognition by Fhit hydrolase

Phytotoxicity and Cytotoxicity of Imidazolium Ionic Liquids Containing Sulfur Atom

Polycationic phosphorus dendrimers: synthesis, characterization, study of cytotoxicity, complexation of DNA, and transfection experiments

Preparation of short interfering RNA containing the modified nucleosides 2-thiouridine, pseudouridine, or dihydrouridine.

RNA interference in silencing of genes of Alzheimer's disease in cellular and rat brain models.

RNAi mediated silencing of cyclin-dependent kinases of G1 phase slows down the cell-cycle progression and reduces apoptosis

Reaction of S-geranyl-2-thiouracil modified oligonucleotides with alkyl amines leads to the N2-alkyl isocytosine derivatives.

Rhodium(III) and iridium(III) complexes with 1,2-naphthoquinone-1-oximate as a bidentate ligand: synthesis, structure, and biological activity.

S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterization

S100A6 binds p53 and affects its activity

Selenium-containing polysaccharides from Lentinula edodes-Biological activity

Significance of stereochemistry of 3'-terminal phosphorothioate-modified primer in DNA polymerase-mediated chain extension

Specific Silencing of L392V PSEN1 Mutant Allele by RNA Interference

Synthesis and cytotoxic properties of halogen and aryl-/heteroarylpiperazinyl derivatives of benzofurans

Synthesis and structure of highly substituted pyrazole ligands and their complexes with platinum(II) and palladium(II) metal ions

Synthesis of New Derivatives of Benzofuran as Potential Anticancer Agents

Synthesis of a fluorescent cationic phosphorus dendrimer and preliminary biological studies of its interaction with DNA.

Synthesis of dinucleoside (N3'-->MeP5') methanephosphonamidates

Synthesis, crystallization and preliminary crystallographic analysis of a 52-nucleotide DNA/2'-OMe-RNA oligomer mimicking 10-23 DNAzyme in the complex with a substrate

Targeting BACE with small inhibitory nucleic acids - a future for Alzheimer's disease therapy?

The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions ⬇️

The differences in the relationship between diastolic dysfunction, selected biomarkers and collagen turn-over in heart failure patients with preserved and reduced ejection fraction.

The influence of Helicobacter pylori eradication on the expression and methylation status of the FHIT gene in non-cancerous gastric mucosa of dyspeptic patients