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List of works by David R Kaplan

A Glo1-Methylglyoxal Pathway that Is Perturbed in Maternal Diabetes Regulates Embryonic and Adult Neural Stem Cell Pools in Murine Offspring

scientific article published in October 2016

A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis

scientific article published on 29 November 2016

A Smaug2-Based Translational Repression Complex Determines the Balance between Precursor Maintenance versus Differentiation during Mammalian Neurogenesis

scientific journal article

A Translational Repression Complex in Developing Mammalian Neural Stem Cells that Regulates Neuronal Specification

scientific article published on 26 January 2018

A dermal niche for multipotent adult skin-derived precursor cells.

scientific article published in November 2004

A neuroprotective agent that inactivates prodegenerative TrkA and preserves mitochondria.

scientific article

A novel neurofibromin (NF1) interaction with the leucine‐rich pentatricopeptide repeat motif‐containing protein links neurofibromatosis type 1 and the french canadian variant of leigh's syndrome in a common molecular complex ⬇️

scientific article published on January 30, 2013

A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines.

scientific article published on December 2013

ABT-888 restores sensitivity in temozolomide resistant glioma cells and xenografts

scientific article published in PLoS ONE

AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans

scientific article published in February 2007

APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction

scientific article published on 25 September 2006

ATPS-28COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS.

scientific article published on 9 November 2015

Acquisition of a Unique Mesenchymal Precursor-like Blastema State Underlies Successful Adult Mammalian Digit Tip Regeneration

scientific article published on 02 January 2020

An asymmetrically localized Staufen2-dependent RNA complex regulates maintenance of mammalian neural stem cells.

scientific article published on 16 August 2012

An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program

scientific journal article

An essential role for the integrin-linked kinase-glycogen synthase kinase-3 beta pathway during dendrite initiation and growth

scientific journal article

Analysis of the neurogenic potential of multipotent skin-derived precursors

scientific article published on 5 May 2006

Ankrd11 is a chromatin regulator involved in autism that is essential for neural development

scientific article published on 31 December 2014

Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma.

scientific article published on January 2014

Axon growth inhibition: signals from the p75 neurotrophin receptor ⬇️

scientific article (publication date: May 2003)

BMI1 is a therapeutic target in recurrent medulloblastoma

scientific article published on 22 October 2018

BRAIN TUMOUR INITIATING CELLS AND TARGETING STAT3 ONCOGENIC SIGNALLING IN GBM.

scientific article published in July 2014

Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway.

scientific article published in November 2002

CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain

scientific article

CBP regulates the differentiation of interneurons from ventral forebrain neural precursors during murine development

scientific article

CCM2 mediates death signaling by the TrkA receptor tyrosine kinase

scientific article published on September 2009

COMBINED DRUG SCREENING AND PHOSPHOPROTEOMICS IDENTIFIES CANDIDATE BRAIN TUMOR THERAPEUTICS AND NOVEL TARGETS IN PRIMARY HUMAN BRAIN TUMOR-INITIATING CELLS.

scientific article published in July 2014

Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1.

scientific article published in March 2003

Coffin-Lowry syndrome: a role for RSK2 in mammalian neurogenesis

scientific article published on 8 September 2010

Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments

scientific article published on 30 August 2019

Conditional ablation of p63 indicates that it is essential for embryonic development of the central nervous system

scientific article published on 11 September 2015

Control of CNS cell-fate decisions by SHP-2 and its dysregulation in Noonan syndrome

scientific article

Costello syndrome H-Ras alleles regulate cortical development

scientific article published on 14 April 2009

Cotargeting Ephrin Receptor Tyrosine Kinases A2 and A3 in Cancer Stem Cells Reduces Growth of Recurrent Glioblastoma

scientific article published on 26 June 2018

Dedifferentiated Schwann Cell Precursors Secreting Paracrine Factors Are Required for Regeneration of the Mammalian Digit Tip.

scientific article published in July 2016

Developing with BDNF: a moving experience

scientific article

Developmental Emergence of Adult Neural Stem Cells as Revealed by Single-Cell Transcriptional Profiling

scientific article published in December 2017

Direct genesis of functional rodent and human schwann cells from skin mesenchymal precursors

scientific article published on 19 June 2014

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

scientific article published on 22 March 2016

Endogenous microglia regulate development of embryonic cortical precursor cells

scientific article published on 6 January 2011

Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1.

scientific article published in October 2005

FoxP2 Regulates Neurogenesis during Embryonic Cortical Development ⬇️

scientific article published on January 2, 2013

Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression

scientific article published on 05 October 2020

HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells

scientific article published on 16 September 2009

High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model

scientific article published in August 2006

Identification of Drugs that Regulate Dermal Stem Cells and Enhance Skin Repair.

scientific article published on 23 December 2015

In vivo antitumor and antimetastatic activity of sunitinib in preclinical neuroblastoma mouse model

scientific article published on May 2009

Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma

article by Risa Torkin et al published 1 January 2005 in Molecular Cancer Therapeutics

Interleukin-6 Regulates Adult Neural Stem Cell Numbers during Normal and Abnormal Post-natal Development.

scientific article

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

scientific article published in March 2010

LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex

scientific article published on 01 October 2020

Lfc and Tctex-1 regulate the genesis of neurons from cortical precursor cells

scientific journal article

Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration

scientific article published on 29 November 2018

Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation

scientific article published on 19 November 2015

Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation

scientific article

Methylglyoxal couples metabolic and translational control of Notch signalling in mammalian neural stem cells

scientific article published on 24 April 2020

Mice lacking both mixed-lineage kinase genes Mlk1 and Mlk2 retain a wild type phenotype

scientific article published on 11 January 2008

Migrating Interneurons Secrete Fractalkine to Promote Oligodendrocyte Formation in the Developing Mammalian Brain

scientific article published on May 2017

Mobilizing Endogenous Stem Cells for Repair and Regeneration: Are We There Yet? ⬇️

scientific article published on June 14, 2012

N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons.

scientific article published in February 2002

Neural tumor-initiating cells have distinct telomere maintenance and can be safely targeted for telomerase inhibition

scientific article published in January 2011

Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell

scientific article published on 01 December 2007

Neurofibromin interacts with the cytoplasmic Dynein Heavy Chain 1 in melanosomes of human melanocytes ⬇️

scientific article published on April 10, 2013

Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex

scientific article published in January 2014

Neuronal MEK is important for normal fear conditioning in mice.

scientific article published on March 2004

Peripheral Nerve Single Cell Analysis Identifies Mesenchymal Ligands that Promote Axonal Growth

scientific article published on 29 April 2020

Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma

scientific article

Proneurogenic Ligands Defined by Modeling Developing Cortex Growth Factor Communication Networks

scientific article published on 17 August 2016

RNAi screen identifies essential regulators of human brain metastasis-initiating cells.

scientific article published in August 2017

SATB2 augments ΔNp63α in head and neck squamous cell carcinoma

scientific article

Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens

scientific article

Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse.

scientific article

Single-Cell Profiling Shows Murine Forebrain Neural Stem Cells Reacquire a Developmental State when Activated for Adult Neurogenesis

scientific article published on 01 August 2020

Skin-derived precursors differentiate into skeletogenic cell types and contribute to bone repair

scientific article published in July 2009

Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells.

scientific article published on 18 July 2016

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells

scientific article

Snail coordinately regulates downstream pathways to control multiple aspects of mammalian neural precursor development

scientific article published on April 2014

Sox2-mediated regulation of adult neural crest precursors and skin repair

scientific article published on 4 June 2013

Special AT-rich Binding Protein-2 (SATB2) Differentially Affects Disease-causing p63 Mutant Proteins ⬇️

scientific article published on September 29, 2011

Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes.

scientific article published in April 2002

System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma.

scientific article

TAp73 acts via the bHLH Hey2 to promote long-term maintenance of neural precursors.

scientific article published on 11 November 2010

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

scientific article published on 19 September 2008

The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis

scientific article published on 01 January 2020

The Snail transcription factor regulates the numbers of neural precursor cells and newborn neurons throughout mammalian life

scientific article

The invulnerability of adult neurons: a critical role for p73.

scientific article published in October 2004

To die or not to die: neurons and p63.

scientific article published on 3 February 2007

Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway.

scientific article published on November 2013

Translating neural stem cells to neurons in the mammalian brain

scientific article published on 24 September 2019

Trk signaling regulates neural precursor cell proliferation and differentiation during cortical development.

scientific article

TrkA induces apoptosis of neuroblastoma cells and does so via a p53-dependent mechanism

scientific article published on 16 June 2005

p63 Regulates Adult Neural Precursor and Newly Born Neuron Survival to Control Hippocampal-Dependent Behavior ⬇️

scientific article published on July 31, 2013

p63 antagonizes p53 to promote the survival of embryonic neural precursor cells

scientific article published on May 2009

p63 is an essential proapoptotic protein during neural development

scientific journal article

p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease

scientific article

p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease

scientific article

p75NTR is an obligate signaling receptor required for cues that cause sympathetic neuron growth cone collapse

scientific article published on 17 June 2010

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

scientific article published on 28 March 2010

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