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List of works by Camilo Rojas

A novel and potent brain penetrant inhibitor of extracellular vesicle release

scientific article published on 04 September 2019

Bioanalysis of 6-diazo-5-oxo-l-norleucine in plasma and brain by ultra-performance liquid chromatography mass spectrometry

scientific article published on 10 January 2015

Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties

scientific article

Correction: JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress.

scientific article published on 13 March 2019

D-Amino acid oxidase inhibitors based on the 5-hydroxy-1,2,4-triazin-6(1H)-one scaffold.

scientific article published on 23 February 2016

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation

scientific article published in Scientific Reports

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.

scientific article published on 30 November 2012

Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase

scientific article published on 24 February 2014

Development of a High-Throughput Fluorescence Polarization Assay to Identify Novel Ligands of Glutamate Carboxypeptidase II ⬇️

scientific article published on June 29, 2012

Development of a high-throughput method for the determination of pharmacological levels of plasma D-serine.

scientific article published on 16 August 2011

Development of a primary microglia screening assay and its use to characterize inhibition of system xc- by erastin and its analogs

scientific article published on 17 January 2017

Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma

scientific article published on 25 August 2016

Enhanced Brain Delivery of 2-(Phosphonomethyl)pentanedioic Acid Following Intranasal Administration of Its γ-Substituted Ester Prodrugs

scientific article

Glutamate carboxypeptidase II is not an amyloid peptide‐degrading enzyme ⬇️

scientific article published on March 23, 2013

Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis

scientific article

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

scientific article published on 13 August 2018

Mutant disrupted-in-schizophrenia 1 in astrocytes: focus on glutamate metabolism

scientific article published on 8 August 2014

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine

scientific article

Oral administration of D-alanine in monkeys robustly increases plasma and cerebrospinal fluid levels but experimental D-amino acid oxidase inhibitors had minimal effect

scientific article published on 10 June 2016

Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor

scientific article

Palonosetron triggers 5-HT(3) receptor internalization and causes prolonged inhibition of receptor function

scientific article published on 15 October 2009

Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors.

scientific article

Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3

scientific article

Reversible Disulfide Formation of the Glutamate Carboxypeptidase II Inhibitor E2072 Results in Prolonged Systemic Exposures In Vivo ⬇️

scientific article published on September 4, 2012

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

scientific article published on 7 July 2015

Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.

scientific article

Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase

scientific article published on May 2013

Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders ⬇️

scientific article published on April 4, 2013

The Antiemetic 5-HT3 Receptor Antagonist Palonosetron Inhibits Substance P-Mediated Responses In Vitro and In Vivo ⬇️

scientific article published on August 19, 2010

The Low-Affinity Binding of Second Generation Radiotracers Targeting TSPO is Associated with a Unique Allosteric Binding Site.

scientific article

δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors

scientific article published on 27 December 2013

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