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List of works by David J. Greenblatt

"Dingelling"

scientific article published on 01 December 1989

"Look-alikes" and generics

scientific article published on 01 April 1986

'GABA shift' in vivo: enhancement of benzodiazepine binding in vivo by modulation of endogenous GABA.

scientific article

A benzodiazepine mood effect scale: reliability and validity determined for alcohol-dependent subjects and adults with a parental history of alcoholism

scientific article published in May 2001

A comparative pharmacokinetic and dynamic evaluation of alprazolam sustained-release, bromazepam, and lorazepam

scientific article published in December 2000

A controlled trial of amantadine in drug-induced extrapyramidal disorders

scientific article published on July 1977

A large-sample study of diazepam pharmacokinetics

scientific article

A method for estimating the probability of adverse drug reactions

scientific article (publication date: August 1981)

A pharmacokinetic study of CGS-8216, a benzodiazepine receptor ligand, in the rat ⬇️

scientific article published on January 1, 1984

A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis

scientific article

A possible new approach to the treatment of neuroleptic malignant syndrome

scientific article published on 01 June 1992

A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression

scientific article published on 24 February 2016

A reevaluation of intravenous quinidine

scientific article published on 01 December 1978

A soft benzodiazepine

scientific article published on 01 March 2015

A tribute to Dr. Hermann R. Ochs, 1943-2013.

scientific article published in December 2014

Absence of interaction of cimetidine and ranitidine with intravenous and oral midazolam

scientific article published in February 1986

Absolute and relative bioavailability of oral acetaminophen preparations.

scientific article

Absolute bioavailability and effect of food and antacid on diazepam absorption from a slow-release preparation

scientific article published in May 1984

Absolute bioavailability of imipramine: influence of food

scientific article published in January 1984

Absolute bioavailability of oral and intramuscular diazepam: effects of age and sex.

scientific article published in January 1983

Absorption and disposition of chlordiazepoxide in young and elderly male volunteers

scientific article published on 01 November 1977

Absorption and disposition of ibuprofen in the elderly

scientific article published on 01 September 1984

Absorption of oral and intramuscular chlordiazepoxide

scientific article published on 01 June 1978

Absorption of oral tetracycline in patients with Billroth-II gastrectomy

scientific article published on 01 August 1978

Absorption rate, blood concentrations, and early response to oral chlordiazepoxide ⬇️

scientific article published on May 1, 1977

Abstracts from the ASENT 2010 annual meeting March 4–6, 2010.

scientific article published in July 2010

Abuse liability and clinical pharmacokinetics of alprazolam in alcoholic men

scientific article published on September 1, 1988

Accelerated benzodiazepine receptor recovery after lorazepam discontinuation ⬇️

scientific article published on 01 January 1991

Accidental Poisoning With Psychotropic Drugs in Children

scientific article published on May 1, 1976

Accidental iron poisoning in childhood. Six cases including one fatality

scientific article published on 01 September 1976

Acetaminophen kinetics in the elderly

scientific article published on 01 February 1982

Acetaminophen pharmacokinetics in women receiving conjugated estrogen

scientific article published on 01 January 1990

Actual versus reported benzodiazepine usage by medical outpatients

scientific article published on 01 January 1987

Acute barbiturate administration increases benzodiazepine receptor binding in vivo

scientific article

Acute overdosage with benzodiazepine derivatives ⬇️

scientific article published on April 1, 1977

Acute zolpidem administration produces pharmacodynamic and receptor occupancy changes at similar doses

scientific article published on 24 January 2006

Adverse effects of LSD: a current perspective

scientific article published on December 1, 1970

Adverse effects of single therapeutic doses of diazepam on performance in normal geriatric subjects: relationship to plasma concentrations

scientific article published in January 1984

Adverse performance effects of acute lorazepam administration in elderly long-term users: pharmacokinetic and clinical predictors

scientific article

Adverse reactions to beta-adrenergic receptor blocking drugs: a report from the Boston collaborative drug surveillance program

scientific article published on January 1974

Adverse reactions to intravenous diazepam: a report from the Boston Collaborative Drug Surveillance Program

scientific article published on October 1973

Adverse reactions to practolol in hospitalized patients: a report from the Boston Collaborative Drug Surveillance Program

scientific article published on November 14, 1977

Adverse reactions to propranolol in hospitalized medical patients: A report from the Boston Collaborative Drug Surveillance Program ⬇️

scientific article published on 01 October 1973

Adverse reactions to spironolactone. A report from the Boston Collaborative Drug Surveillance Program

scientific article published on July 2, 1973

Adverse reactions to triazolam, flurazepam, and placebo in controlled clinical trials

scientific article published on May 1, 1984

Aerodynamic factors affecting rebreathing in infants

scientific article published on 03 January 2019

Age and gender effects on chlordiazepoxide kinetics: relation to antipyrine disposition

scientific article published on 01 January 1989

Age and gender effects on the pharmacokinetics and pharmacodynamics of ramelteon, a hypnotic agent acting via melatonin receptors MT1 and MT2

scientific article published on 01 April 2007

Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate

scientific article published in November 2004

Age does not alter acetaminophen absorption

scientific article published on 01 April 1982

Age, sex, and nitrazepam kinetics: relation to antipyrine disposition

scientific article

Age-related changes in the pharmacokinetic disposition of diazepam in foals

scientific article published on August 1, 1997

Age-related differences in CYP3A expression and activity in the rat liver, intestine, and kidney

scientific article published on 23 January 2004

Alcohol Does Not Enhance Diazepam Absorption ⬇️

scientific article published on January 1, 1981

Alprazolam hydroxylation by mouse liver microsomes in vitro: the effect of age and phenobarbital induction

Alprazolam is another substrate for human cytochrome P450-3A isoforms.

scientific article published in June 1998

Alprazolam kinetics following sublingual and oral administration

scientific article published in October 1987

Alprazolam kinetics in patients with renal insufficiency

scientific article published on 01 October 1986

Alprazolam kinetics in the elderly. Relation to antipyrine disposition

scientific article published on 01 March 1983

Alprazolam metabolism in vitro: studies of human, monkey, mouse, and rat liver microsomes

scientific article published on 01 October 1993

Alprazolam pharmacokinetics in women on low-dose oral contraceptives

scientific article published on 01 May 1988

Alprazolam pharmacokinetics, metabolism, and plasma levels: clinical implications.

scientific article

Alprazolam, panic disorder, and the new 2 mg tablet.

scientific article published in June 1991

Alprazolam-ritonavir interaction: implications for product labeling

scientific article published on 01 April 2000

Alteration by burn injury of the pharmacokinetics and pharmacodynamics of cimetidine in children

scientific article published in January 1989

Alterations in drug distribution and clearance due to obesity ⬇️

scientific article published on June 1, 1981

Alterations in pharmacodynamics of anxiolytics in abstinent alcoholic men: subjective responses, abuse liability, and electroencephalographic effects of alprazolam, diazepam, and buspirone

scientific article published in January 1997

Altered drug disposition following bariatric surgery: a research challenge

scientific article published on June 2015

American College of Clinical Pharmacology commentary on the Strategic Plan 2010-2014 Progress Report from the Office of Dietary Supplements, National Institutes of Health

scientific article published on 13 May 2015

Amoxapine, an observation, and a perspective on MAOIs and their safety

scientific article published on 01 September 1981

An interactive model for panic disorders.

scientific article published in August 1984

Analysis of Zolpidem in Human Plasma by High-Performance Liquid Chromatography with Fluorescence Detection: Application to Single-Dose Pharmacokinetic Studies ⬇️

scientific article published on 01 September 1997

Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides

scientific article published on 29 September 2009

Analysis of generic antiretroviral formulations manufactured in India

scientific article published on 01 July 2004

Analysis of lorazepam and its glucuronide metabolite by electron-capture gas--liquid chromatography. Use in pharmacokinetic studies of lorazepam

scientific article published on 01 September 1978

Analysis of ritonavir in plasma/serum and tissues by high-performance liquid chromatography

scientific article published in November 1998

Antidepressant-Associated Hyponatremia in the Elderly

scientific article published on 01 December 2016

Antidepressants: The Second Harvest and DSM-III ⬇️

scientific article published on 01 March 1981

Antipyretic analgesic drugs as models for studies of drug disposition in old age

scientific article published on 01 November 1983

Antipyrine Absorption and Disposition in the Elderly ⬇️

scientific article published on January 1, 1988

Antipyrine Pharmacokinetics in Women Receiving Conjugated Estrogens ⬇️

scientific article published on 01 May 1988

Antipyrine and lidocaine are cleared faster in horses than in humans: acetaminophen may be handled similarly

scientific article published in January 1987

Antipyrine kinetics in patients with primary biliary cirrhosis

scientific article published on 01 January 1993

Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity

scientific article published on 01 January 1982

Antiretroviral boosting by cobicistat, a structural analog of ritonavir

scientific article published on 01 September 2014

Anxiolytic drug therapy in patients with medical disease: clinical importance of pharmacokinetic drug interactions

scientific article published on January 1, 1984

ApoE-epsilon 4 allele and susceptibility to drug-induced memory impairment in the elderly

scientific article published in April 1998

Apolipoprotein E epsilon4 allele and lorazepam effects on memory in high-functioning older adults

scientific article published in February 2005

Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers

scientific article published on July 2006

Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: comparison with fluoxetine and quinidine

scientific article published in March 2003

Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir ⬇️

scientific article published on March 1, 2003

Appetite suppressant drugs as inhibitors of human cytochromes P450: in vitro inhibition of P450-2D6 by D- and L-fenfluramine, but not phentermine

scientific article published on 01 August 1998

Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.

scientific article published in April 2001

Appropriate Use and Regulatory Control of Benzodiazepines ⬇️

scientific article published on September 1, 1991

Arithmetic versus harmonic mean values of elimination half-life: a study of triazolam

scientific article published in July 1989

Aspartame - Is there new information?

scientific article

Assessing and managing drug-nutrient interactions

scientific article published on 01 September 2002

Assessment of methodology in single-dose studies of digoxin bioavailability

scientific article published in January 1976

Atazanavir: effects on P-glycoprotein transport and CYP3A metabolism in vitro.

scientific article

Atropine overdose in three children

scientific article published in July 1972

Augmentation of GABAA receptor function by chronic exposure to GABA-neutral and GABA-negative benzodiazepine ligands in cultured cortical neurons

scientific article published on 01 September 1990

Automated Electron-Capture Gas Chromatographic Analysis of Flunitrazepam in Plasma ⬇️

scientific article published on 01 January 1982

Automated gas chromatographic determination of plasma alprazolam concentrations

scientific article published on 01 December 1983

Automated gas chromatography for studies of midazolam pharmacokinetics.

scientific article published in August 1981

Automated high-performance liquid chromatographic analysis of tetracycline in urine

scientific article published on 01 May 1989

Back to basics--diagnosis before treatment: homelessness, hypothyroidism, aging, and lithium

scientific article published on 01 December 1987

Balancing efficacy and safety in the use of oral sedation in dental outpatients

scientific article

Baseline plasma GABA: its relationship to the adverse effects of acute lorazepam administration on cognition in the elderly

scientific article published in December 2004

Bees, ginseng and MAOIs revisited

scientific article published on 01 August 1988

Behavioural reactions to triazolam

scientific article published on 01 November 1979

Benzodiazepine discontinuation syndromes

scientific article published on January 1990

Benzodiazepine drug-drug interactions commonly occurring in clinical practice

scientific article published on 01 January 1984

Benzodiazepine hypnotic metabolism: drug interactions and clinical implications

scientific article published in January 1986

Benzodiazepine hypnotics.

scientific article published in August 1990

Benzodiazepine hypnotics: kinetic and therapeutic options.

scientific article published in January 1982

Benzodiazepine kinetics: implications for therapeutics and pharmacogeriatrics

scientific article published on January 1983

Benzodiazepine overdosage: plasma concentrations and clinical outcome

scientific article published in January 1981

Benzodiazepine overuse-misuse

scientific article published on 01 June 1984

Benzodiazepine receptor binding of benzodiazepine hypnotics: receptor and ligand specificity

scientific article (publication date: October 1992)

Benzodiazepine receptor binding of triazolobenzodiazepines in vivo: increased receptor number with low-dose alprazolam

scientific article

Benzodiazepine receptor binding response to acute and chronic stress is increased in aging animals

scientific article published in January 1991

Benzodiazepine receptor binding: influence of physiologic and pharmacologic factors

scientific article published on March 1987

Benzodiazepine receptor occupancy in vivo: correlation with brain concentrations and pharmacodynamic actions.

scientific article published in February 1987

Benzodiazepine receptors mediate regional blood flow changes in the living human brain

scientific article

Benzodiazepine response and receptor binding after chronic ethanol ingestion in a mouse model

scientific article published in September 1991

Benzodiazepine sensitivity in normal human subjects

scientific article published in June 1986

Benzodiazepines and pregnancy--more to say and more to learn

scientific article published on 01 August 1989

Benzodiazepines during early pregnancy.

scientific article published in April 1984

Benzodiazepines: Safety and toxicity

scientific article published on May 1, 1975

Benzodiazepines: Some Aspects of Their Clinical Pharmacology ⬇️

scientific article published on January 1, 1979

Benzodiazepines: a summary of pharmacokinetic properties ⬇️

scientific article published on January 1, 1981

Binding of diazepam and desmethyldiazepam to plasma protein: concentration-dependence and interactions

scientific article published in January 1981

Bioavailability of digoxin tablets and elixir in the fasting and postprandial states

scientific article published in September 1974

Bioavailability of digoxin: what the clinician needs to know

scientific article published on 01 May 1974

Bioavailability of drugs: the digoxin dilemma

scientific article published on January 1, 1976

Bioavailability studies of drugs with nonlinear pharmacokinetics: I. Tracer dose AUC varies directly with serum concentration ⬇️

scientific article published on December 1, 1992

Biochemical Basis for Deficient Paracetamol Glucuronidation in Cats: an Interspecies Comparison of Enzyme Constraint in Liver Microsomes ⬇️

scientific article published on 01 April 1997

Bioequivalence of generic drugs in clinical psychopharmacology

scientific article published on 01 February 1987

Bioequivalence studies in the elderly: a pilot study of two oxazepam dosage forms

scientific article published on 01 June 1987

Bioinequivalence of a generic brand of diazepam

scientific article published in November 1989

Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species

scientific article published on 01 April 1997

Biotransformation of mestranol to ethinyl estradiol in vitro: the role of cytochrome P-450 2C9 and metabolic inhibitors

scientific article published on 01 March 1997

Body Size Changes Among National Collegiate Athletic Association New England Division III Football Players, 1956-2014: Comparison With Age-Matched Population Controls

scientific article

Bromazepam pharmacokinetics: influence of age, gender, oral contraceptives, cimetidine, and propranolol

scientific article

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

scientific article

CYP2C9 is a principal low-affinity phenacetin O-deethylase: fluvoxamine is not a specific CYP1A2 inhibitor

scientific article published on 01 December 1999

CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.

scientific article

Caffeine treatment and withdrawal in mice: relationships between dosage, concentrations, locomotor activity and A1 adenosine receptor binding

scientific article published on 01 September 1993

Caffeine-induced behavioral stimulation is dose-dependent and associated with A1 adenosine receptor occupancy

scientific article published on May 1, 1992

Caffeine-induced behavioural stimulation is dose- and concentration-dependent

scientific article published on July 1990

Can you provide a table of equivalences for benzodiazepines and other marketed benzodiazepine receptor agonists?

scientific article published on 01 August 1997

Candidate gene polymorphisms in patients with acetaminophen-induced acute liver failure

scientific article published on 08 October 2013

Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance ⬇️

scientific article published on 01 July 1988

Carbamazepine-induced reduction of plasma alprazolam concentrations: a clinical case report

scientific article published in November 1988

Cerebrospinal Fluid Digoxin Concentrations in Humans ⬇️

scientific article published on January 1, 1978

Cerebrospinal fluid uptake and peripheral distribution of centrally acting drugs: relation to lipid solubility

scientific article published on 01 June 1985

Changes in salivary antipyrine pharmacokinetics during adolescence, correlated with age, hormonal levels and Tanner stage.

scientific article published in January 1991

Characterization of cognitive dysfunction in Sjögren's syndrome patients

scientific article published on 15 December 2013

Characterization of six in vitro reactions mediated by human cytochrome P450: application to the testing of cytochrome P450-directed antibodies

scientific article published on 01 February 1996

Chlordiazepoxide Metabolism in Mice following Hepatic Irradiation ⬇️

scientific article published on 01 January 1975

Chlordiazepoxide and oxazepam disposition in cirrhosis ⬇️

scientific article published on August 1, 1979

Chronic administration of benzodiazepines--V. Rapid onset of behavioral and neurochemical alterations after discontinuation of alprazolam

scientific article

Chronic benzodiazepine administration. I. Tolerance is associated with benzodiazepine receptor downregulation and decreased gamma-aminobutyric acidA receptor function

scientific article

Chronic benzodiazepine administration. II. Discontinuation syndrome is associated with upregulation of gamma-aminobutyric acidA receptor complex binding and function

scientific article

Chronic benzodiazepine administration. III. Upregulation of gamma-aminobutyric acidA receptor binding and function associated with chronic benzodiazepine antagonist administration

scientific article

Chronic benzodiazepine administration. IV. Rapid development of tolerance and receptor downregulation associated with alprazolam administration

scientific article

Chronic benzodiazepine administration. IX. Attenuation of alprazolam discontinuation effects by carbamazepine

scientific article published in December 1991

Chronic benzodiazepine administration. VI. A partial agonist produces behavioral effects without tolerance or receptor alterations

scientific article published on July 1990

Chronic benzodiazepine administration. VII. Behavioral tolerance and withdrawal and receptor alterations associated with clonazepam administration

scientific article published in January 1991

Chronic benzodiazepine administration. X. Concurrent administration of the peripheral-type benzodiazepine ligand PK11195 attenuates chronic effects of lorazepam ⬇️

scientific article published on April 1, 1992

Chronic benzodiazepine administration. XI. Concurrent administration of PK11195 attenuates lorazepam discontinuation effects

scientific article

Chronic benzodiazepine administration. XII. Anticonvulsant cross-tolerance but distinct neurochemical effects of alprazolam and lorazepam

scientific article published in January 1993

Chronic benzodiazepine administration: effects in vivo and in vitro

scientific article published on January 1990

Chronic low-dose alprazolam augments gamma-aminobutyric acid(A) receptor function

scientific article published on April 1, 1992

Chronic morphine administration augments benzodiazepine binding and GABAA receptor function

scientific article published on 01 January 1990

Chronic treatment with Ro 15-1788 distinguishes between its benzodiazepine antagonist, agonist and inverse agonist properties

scientific article published in January 1986

Chronic treatment with fluvoxamine, clovoxamine, and placebo: interaction with digoxin and effects on sleep and alertness

scientific article published in January 1989

Cimetidine disposition in obesity

scientific article published on 01 February 1984

Cimetidine impairs clearance of antipyrine and desmethyldiazepam in the elderly

scientific article published on 01 November 1982

Cimetidine impairs nitrazepam clearance

scientific article

Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects.

scientific article published on September 1999

Clearance of the antihistamine doxylamine. Reduced in elderly men but not in elderly women

scientific article published on 01 May 1989

Clinical Pharmacokinetics of Chlordiazepoxide

scientific article published on September 1, 1978

Clinical Pharmacokinetics of Lorazepam. III. Intravenous Injection. Preliminary Results ⬇️

scientific article published on August 1, 1977

Clinical Pharmacokinetics of Lorazepam. IV. Long-Term Oral Administration ⬇️

scientific article published on August 1, 1977

Clinical Pharmacokinetics of the Newer Benzodiazepines

scientific article published on May 1, 1983

Clinical Pharmacology and Therapeuticsof Antidepressants

scholarly article published 25 October 2010

Clinical Pharmacology in Drug Development

scientific article published on 01 January 2012

Clinical Pharmacology in Drug Development: Five Years in the Books

scientific article published on 01 November 2016

Clinical implications of benzodiazepine pharmacokinetics ⬇️

scientific article published on June 1, 1977

Clinical implications of serum digoxin concentrations ⬇️

scientific article published on May 15, 1981

Clinical importance of the interaction of diazepam and cimetidine

scientific article published in June 1984

Clinical importance of the interaction of phenytoin and isoniazid: a report from the Boston Collaborative Drug Surveillance Program

scientific article published on March 1979

Clinical indications for plasma level monitoring of psychotropic drugs ⬇️

scientific article published on December 1, 1979

Clinical pharmacokinetics (second of two parts).

scientific article

Clinical pharmacokinetics of alprazolam. Therapeutic implications

scientific article

Clinical pharmacokinetics of antidepressants in the elderly. Therapeutic implications

scientific article

Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part I).

scientific article published on September 1991

Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).

scientific article published on October 1991

Clinical pharmacokinetics of chlordiazepoxide

scientific article published on 01 October 1975

Clinical pharmacokinetics of lorazepam. I. Absorption and disposition of oral 14C-lorazepam

scientific article published on September 1, 1976

Clinical pharmacokinetics of lorazepam: a review

scientific article published on October 1, 1978

Clinical pharmacokinetics of lorazepam; II. Intramuscular injection ⬇️

scientific article published on February 1, 1977

Clinical pharmacokinetics of quinidine

scientific article published on March 1980

Clinical pharmacokinetics of some antiarrhythmic drugs

scientific article published on August 1, 1979

Clinical pharmacology in drug development - an update

scientific article published on 01 July 2015

Clinical toxicity of chloridazepoxide and diazepam in relation to serum albumin concentration: A report from the Boston collaborative drug surveillance Program ⬇️

scientific article published on July 26, 1974

Clinical toxicity of furosemide in hospitalized patients. A report from the Boston Collaborative Drug Surveillance Program

scientific article published on 01 July 1977

Clinical use and toxicity of intravenous lidocaine. A report from the Boston Collaborative Drug Surveillance Program

scientific article published in August 1976

Clinical use of the benzodiazepines

scientific article published in October 1981

Clinically Important Drug Interactions with Zopiclone, Zolpidem and Zaleplon

scientific article published on January 1, 2003

Clobazam kinetics in the elderly ⬇️

scientific article published on November 1, 1981

Clobazam kinetics: intrasubject variability and effect of food on adsorption

scientific article published in January 1982

Clonazepam pharmacokinetics, brain uptake, and receptor interactions.

scientific article

Clonazepam pharmacokinetics: comparison of subcutaneous microsphere injection with multiple-dose oral administration

scientific article published in November 2005

Clorazepate Dipotassium and Diazepam in Renal Insufficiency: Serum Concentrations and Protein Binding of Diazepam and Desmethyldiazepam ⬇️

scientific article published on 01 January 1984

Close correlation of acetaminophen clearance with that of conjugated benzodiazepines but not oxidized benzodiazepines

scientific article published on 01 January 1983

Clozapine and fluvoxamine, a curious complexity

scientific article published on 01 April 1998

Cocaine augments peripheral benzodiazepine binding in humans

scientific article published in October 1990

Cognitive effects of beta-adrenergic antagonists after single doses: pharmacokinetics and pharmacodynamics of propranolol, atenolol, lorazepam, and placebo

scientific article published in May 1993

Cognitive toxicity of drugs used in the elderly ⬇️

scientific article published on September 1, 2001

Comment on the Next Chapter of the Journal of Clinical Psychopharmacology

scientific article published on 14 October 2020

Comparative Single-Dose Kinetics of Oxazolam, Prazepam, and Clorazepate: Three Precursors of Desmethyldiazepam ⬇️

scientific article published on October 1, 1984

Comparative abuse liability and pharmacological effects of meprobamate, triazolam, and butabarbital

scientific article

Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo

scientific article published in November 1998

Comparative kinetics and response to the benzodiazepine agonists triazolam and zolpidem: evaluation of sex-dependent differences

scientific article published in May 2000

Comparative pharmacokinetics of alprazolam and lorazepam in humans and in African Green Monkeys

scientific article published in January 1991

Comparative protein binding of diazepam and desmethyldiazepam

scientific article published in May 1981

Comparative protein binding of diazepam and desmethyldiazepam

scientific article published on 01 November 1980

Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo

scientific article

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches

scientific article published in December 2000

Comparison of Pharmacokinetic Profiles of Zolpidem Buffered Sublingual Tablet and Zolpidem Oral Immediate-Release Tablet: Results from a Single-Center, Single-Dose, Randomized, Open-Label Crossover Study in Healthy Adults ⬇️

scientific article published on March 28, 2013

Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers.

scientific article

Comparison of one- and six-day urinary digoxin excretion in single-dose bioavailability studies.

scientific article

Concentration-independent plasma protein binding of benzodiazepines ⬇️

scientific article published on 01 March 1983

Conflicts of interest, redundant publication, and identification of authorship: a plea for trust instead of suspicion

scientific article published in June 1998

Contribution of the gastrointestinal tract to lorazepam conjugation and clonazepam nitroreduction

scientific article published on 01 January 1991

Correlates of outcome following acute glutethimide overdosage

scientific article published on January 1, 1979

Correlating pharmacokinetics and pharmacodynamics of benzodiazepines: problems and assumptions.

scientific article published in January 1987

Cortisol response to diazepam: its relationship to age, dose, duration of treatment, and presence of generalized anxiety disorder

scientific article published on 27 August 2004

Cyclosporine blood concentrations determined by specific versus nonspecific assay methods

scientific article published on 01 May 1986

Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes

scientific article

Cytochromes in psychopharmacology

scientific article published on 01 February 1994

Decline in chlordiazepoxide plasma levels during fixed-dose therapy of alcohol withdrawal ⬇️

scientific article published on October 1, 1978

Decreased EEG Sensitivity to Alprazolam in Subjects with a Parental History of Alcoholism

scientific article published on 01 January 2000

Dependence, Tolerance, and Addiction to Benzodiazepines: Clinical and Pharmacokinetic Considerations ⬇️

scientific article published on January 1, 1978

Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis

scientific article

Designer Benzodiazepines: A Review of Published Data and Public Health Significance

scientific article published on 07 February 2019

Desipramine Pharmacokinetics When Coadministered With Paroxetine or Sertraline in Extensive Metabolizers ⬇️

scientific article published on 01 August 1997

Desmethyldiazepam kinetics after intravenous, intramuscular, and oral administration of clorazepate dipotassium

scientific article published in April 1982

Desmethyldiazepam kinetics in the elderly after oral prazepam

scientific article

Desmethyldiazepam pharmacokinetics: studies following intravenous and oral desmethyldiazepam, oral clorazepate, and intravenous diazepam

scientific article published in September 1988

Determinants of benzodiazepine brain uptake: lipophilicity versus binding affinity

scientific article

Determination of Ro 15-1788, a benzodiazepine antagonist, in human plasma by gas-liquid chromatography with nitrogen-phosphorus detection. Application to single-dose pharmacokinetic studies

scientific article published on 01 January 1983

Determination of atenolol in plasma by high-performance liquid chromatography with application to single-dose pharmacokinetics

scientific article published on 01 August 1986

Determination of the in vivo Km and Vmax of a drug with tracer studies

scientific article published in April 1987

Determination of zopiclone in plasma by liquid chromatography with application to steady-state monitoring

scientific article published on 01 July 1986

Diazepam Kinetics in Relation to Age and Sex ⬇️

scientific article published on January 1, 1981

Diazepam absorption: effect of antacids and food

scientific article published on November 1978

Diazepam absorption: effects of age, sex, and Billroth gastrectomy

scientific article published in March 1982

Diazepam disposition determinants

scientific article published in March 1980

Diazepam impairs performance in normal elderly subjects

scientific article published in January 1984

Diazepam in the Elderly: Looking Back, Ahead, and at the Evidence

scientific article published on 01 May 2020

Diazepam interaction with antituberculosis drugs

scientific article published in May 1981

Diazepam kinetics in patients with renal insufficiency or hyperthyroidism ⬇️

scientific article published on December 1, 1981

Diazepam kinetics in patients with severe burns

scientific article published in March 1983

Diazepam pharmacokinetics after intravenous administration in alcohol withdrawal

scientific article

Diazepam versus lorazepam: relationship of drug distribution to duration of clinical action

scientific article published on January 1, 1983

Dietary choline intake modulates benzodiazepine receptor binding and gamma-aminobutyric acidA receptor function in mouse brain

scientific article (publication date: 1989)

Differences in pharmacodynamics but not pharmacokinetics between subjects with panic disorder and healthy subjects after treatment with a single dose of alprazolam

scientific article published on 01 June 2000

Differential effect of central versus parenteral administration of morphine sulfate on regional concentrations of reduced glutathione in rat brain

scientific article published in February 1997

Differential effect of cigarette smoking on antipyrine oxidation versus acetaminophen conjugation

scientific article published in January 1990

Differential effect of cimetidine on drug oxidation (antipyrine and diazepam) vs. conjugation (acetaminophen and lorazepam): prevention of acetaminophen toxicity by cimetidine

scientific article published in March 1983

Differential effect of isoniazid on triazolam oxidation and oxazepam conjugation

scientific article

Differential effects of benzodiazepine disposition by disulfiram and ethanol

scientific article published on 01 January 1980

Differential effects of chronic lorazepam and alprazolam on benzodiazepine binding and GABAA-receptor function

scientific article published on December 1990

Differential effects of isoniazid and oral contraceptive steroids on antipyrine oxidation and acetaminophen conjugation

scientific article published on 01 January 1984

Differential impairment of triazolam and zolpidem clearance by ritonavir

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Differential metabolism of midazolam in mouse liver and intestine microsomes: a comparison of cytochrome P450 activity and expression

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Differential modulation of P-glycoprotein expression and activity by non-nucleoside HIV-1 reverse transcriptase inhibitors in cell culture

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Differential modulation of benzodiazepine receptor binding by ethanol in LS and SS mice

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Differential side effect profile of triazolam versus flurazepam in elderly patients undergoing rehabilitation therapy

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Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole

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Digoxin disposition in obesity: Clinical pharmacokinetic investigation ⬇️

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Diltiazem, verapamil, and quinidine in patients with chronic atrial fibrillation

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Diphenhydramine determination in human plasma by gas-liquid chromatography using nitrogen-phosphorus detection: application to single low-dose pharmacokinetic studies

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Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration

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Disease-related alterations in cardiac glycoside disposition

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Disposition of clotiazepam: influence of age, sex, oral contraceptives, cimetidine, isoniazid and ethanol

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Disposition of intravenous diazepam in young men and women

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Disposition of oxazepam in patients on maintenance hemodialysis

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Disposition of oxazepam in relation to age, sex, and cigarette smoking ⬇️

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Distinguishing a benzodiazepine agonist (triazolam) from a nonagonist anxiolytic (buspirone) by electroencephalography: kinetic-dynamic studies

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Does carbamazepine-induced reduction of plasma haloperidol levels worsen psychotic symptoms?

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Dose-dependent retrograde facilitation of verbal memory in healthy elderly after acute oral lorazepam administration

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Dose-independent pharmacokinetics of digoxin in humans ⬇️

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Dose-independent pharmacokinetics of intravenous lidocaine in humans

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Dose‐Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans ⬇️

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Doxylamine and diphenhydramine pharmacokinetics in women on low-dose estrogen oral contraceptives

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Draft legislation: the Science Research Protection Act of 1990

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Drug Interaction Studies With CYP3A Substrates: How Much Inhibitor Pre-exposure Is Needed?

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Drug Metabolism and Drug Interactions: Application and Clinical Value of In Vitro Models ⬇️

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Drug abuse and the emergency room physician.

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Drug disposition in obese humans. An update

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Drug interactions in clinical perspective

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Drug interactions involving psychotropic drugs

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Drug interactions with grapefruit juice: an update

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Drug interactions with methadone: Time to revise the product label.

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Drug interactions with newer antidepressants: role of human cytochromes P450

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Drug therapy reviews: rational use of psychotropic drugs. III. Major tranquilizers.

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Drug therapy. Anticholinergics

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Drug therapy. Benzodiazepines (first of two parts).

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Drug therapy. Benzodiazepines (second of two parts).

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Drug therapy. Current status of benzodiazepines

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Drug therapy. Current status of benzodiazepines

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Drug therapy: drug disposition in old age.

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Drug transporters in psychopharmacology--are they important?

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Drug transporters revisited

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Drug-drug noninteractions

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Drugs in cardiac transplantation

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Dynamics and kinetics of a modified-release formulation of zolpidem: comparison with immediate-release standard zolpidem and placebo

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Editorial: Peripheral vasodilators

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Editors' note: New Board of International Consulting Editors (BICE)

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Editors' note: retraction notice

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Effect of 7-day exposure to midazolam on electroencephalogram pharmacodynamics in rats: a model to study multiple pharmacokinetic-pharmacodynamic relationships in individual animals

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Effect of Abdominal Radiation Therapy on Drug Absorption in Humans ⬇️

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Effect of First-Line Antituberculosis Therapy on Nevirapine Pharmacokinetics in Children Younger than Three Years Old

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Effect of a cocktail on diazepam absorption ⬇️

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Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers ⬇️

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Effect of age and Billroth gastrectomy on absorption of desmethyldiazepam from clorazepate ⬇️

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Effect of age and gender on disposition of temazepam ⬇️

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Effect of age and sex on disposition of desmethyldiazepam formed from its precursor clorazepate

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Effect of age and sex on lorazepam protein binding ⬇️

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Effect of age on in vitro triazolam biotransformation in male human liver microsomes

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Effect of age, body composition, and lipid solubility on benzodiazepine tissue distribution in rats.

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Effect of age, gender, and obesity on midazolam kinetics.

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Effect of alprazolam on digoxin kinetics and creatinine clearance

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Effect of antipyrine coadministration on the kinetics of acetaminophen and lidocaine

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Effect of blood collection tubes on antidepressant concentrations

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Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers

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Effect of bupropion on CYP2B6 and CYP3A4 catalytic activity, immunoreactive protein and mRNA levels in primary human hepatocytes: comparison with rifampicin

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Effect of cirrhosis and renal failure on the kinetics of clotiazepam

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Effect of diazepam on plasma gamma-aminobutyric acid in sons of alcoholic fathers

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Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir

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Effect of food on acetaminophen absorption in young and elderly subjects.

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Effect of food on enteral absorption of quinidine

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Effect of obesity on the pharmacokinetics of drugs in humans

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Effect of propranolol on pharmacokinetics and acute electrocardiographic changes following intravenous quinidine in humans

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Effect of rifampin/isoniazid-containing antituberculosis therapy on efavirenz pharmacokinetics in HIV-infected children aged 3 to 14 years old

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Effect of subject age and gender on the pharmacokinetics of oral triazolam and temazepam

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Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein

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Effects of Flibanserin on the Pharmacokinetics of a Combined Ethinylestradiol/Levonorgestrel Oral Contraceptive in Healthy Premenopausal Women: A Randomized Crossover Study

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Effects of acute lorazepam administration on aminergic activity in normal elderly subjects: relationship to performance effects and apolipoprotein genotype

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Effects of age and other drugs on benzodiazepine kinetics

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Effects of desmethyldiazepam on diazepam kinetics: a study of effects of a metabolite on parent drug disposition

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Effects of diazepam on recall memory: relationship to aging, dose, and duration of treatment

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Effects of ketoconazole on triazolam pharmacokinetics, pharmacodynamics and benzodiazepine receptor binding in mice ⬇️

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Electron capture GLC analysis of the thienodiazepine clotiazepam. Preliminary pharmacokinetic studies

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Electron-capture gas chromatographic analysis of the triazolobenzodiazepines alprazolam and triazolam ⬇️

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Elements of a Good Scientific Paper

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Enhanced bioavailability of triazolam following sublingual versus oral administration

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Enhanced glucuronide conjugation of drugs in obesity: studies of lorazepam, oxazepam, and acetaminophen

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Enterohepatic circulation of lorazepam and acetaminophen conjugates in ponies

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Entry of diazepam and its major matabolite into cerebrospinal fluid

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Entry of lorazepam into cerebrospinal fluid

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Entry of quinidine into cerebrospinal fluid

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Enzyme kinetic modelling as a tool to analyse the behaviour of cytochrome P450 catalysed reactions: application to amitriptyline N-demethylation

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Epiphenomenal, causal, or correlational--more on the mechanism(s) of action of antidepressants

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Equivalent Bioavailability From Digoxin Elixir and Rapid-Dissolution Tablets ⬇️

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Errors in science versus scientific fraud

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Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity

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Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram

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Estimation of the elimination half-life of a drug at any serum concentration when the Km and Vmax of the drug are known: calculations and validation with phenytoin

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Ethanol inhibits in-vitro metabolism of nifedipine, triazolam and testosterone in human liver microsomes

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Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism

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Evaluation of Digoxin Bioavailability in Single-Dose Studies ⬇️

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Evaluation of Supermix as an in vitro model of human liver microsomal drug metabolism

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Evaluation of the hypothalamic-pituitary effects of digoxin

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Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion

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Evidence for propofol hydroxylation by cytochrome P4502B11 in canine liver microsomes: breed and gender differences

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Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers

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Evidence for systematic temporal variation in 24-hour urinary creatinine excretion

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Evidence-based choice of ritonavir as index CYP3A inhibitor in drug-drug interaction studies

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Explaining Some Journal Requirements

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Extensive impairment of triazolam and alprazolam clearance by short-term low-dose ritonavir: the clinical dilemma of concurrent inhibition and induction

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Extrapyramidal side effects of psychotropic drugs

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Eye movement effects of diazepam in sons of alcoholic fathers and male control subjects

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Factors influencing blood concentrations of chlordiazepoxide: a use of multiple regression analysis

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Factors influencing diazepam pharmacokinetics: age, sex, and liver disease

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Factors influencing midazolam hydroxylation activity in human liver microsomes

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Falling off the straight line: some hazards of correlation and regression

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Fatal hyperthermia following haloperidol therapy of sedative-hypnotic withdrawal

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Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen

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Fentanyl clearance and volume of distribution are increased in patients with major burns

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Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavir

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Five Distinct Human Cytochromes Mediate Amitriptyline N‐Demethylation In Vitro: Dominance of CYP 2C19 and 3A4 ⬇️

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Fluoxetine impairs clearance of alprazolam but not of clonazepam

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Fluoxetine inhibition of phenytoin metabolism

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Flurazepam hydrochloride ⬇️

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Flurazepam hydrochloride, a benzodiazepine hypnotic

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Fluvoxamine impairs single-dose caffeine clearance without altering caffeine pharmacodynamics

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From disordered eating to addiction: the "food drug" in bulimia nervosa.

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Fruit juices and pharmacology

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Functional tolerance to lorazepam in the rat.

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Gabapentin and Pregabalin for the Treatment of Anxiety Disorders

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Gas chromatographic analysis of alprazolam in plasma: replicability, stability and specificity

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Gas chromatographic analysis of underivatized tocainide

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Gender differences in pharmacokinetics and pharmacodynamics of zolpidem following sublingual administration

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Gender has a small but statistically significant effect on clearance of CYP3A substrate drugs

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Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivo

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Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects

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Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate

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Grapefruit-medication interactions

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Gynecomastia and Impotence Complications of Spironolactone Therapy ⬇️

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Halazepam as a precursor of desmethyldiazepam: quantitation by electron-capture gas-liquid chromatography

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Halazepam, another precursor of desmethyldiazepam ⬇️

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Haloperidol determination in serum and cerebrospinal fluid using gas--liquid chromatography with nitrogen--phosphorus detection: application to pharmacokinetic studies

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Hepatic Clearance of Drugs in Patients With Renal Insufficiency

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Hepatic vs. gastrointestinal presystemic extraction of oral midazolam and flurazepam

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Herpes and clinical psychopharmacology.

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High-affinity benzodiazepine binding sites on rat peritoneal mast cells and RBL-1 cells: binding characteristics and effects on granule secretion

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High-performance liquid chromatographic determination of acetaminophen in plasma: single-dose pharmacokinetic studies

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Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models ⬇️

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Human cytochromes P450 mediating phenacetin O-deethylation in vitro: validation of the high affinity component as an index of CYP1A2 activity

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Human cytochromes and some newer antidepressants: kinetics, metabolism, and drug interactions.

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Human cytochromes mediating N-demethylation of fluoxetine in vitro

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Human cytochromes mediating gepirone biotransformation at low substrate concentrations

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Human cytochromes mediating sertraline biotransformation: seeking attribution

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Human pregnane X receptor: genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity

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Hyperforin plasma level as a marker of treatment adherence in the National Institutes of Health Hypericum Depression Trial

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IN VITRO QUANTITATION OF BENZODIAZEPINE LIPOPHILICITY: RELATION TO IN VIVO DISTRIBUTION

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Ibuprofen disposition in obese individuals

Ibuprofen does not impair antipyrine clearance

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Ibuprofen kinetics in patients with renal insufficiency who are receiving maintenance hemodialysis

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Identification of 7-chloro-5-(2'-fluorophenyl)-2,3-dihydro-2-oxo-1H-1, 4-benzodiazepine-1-acetaldehyde, a new metabolite of flurazepam in man

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Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

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Identification of polymorphisms in the 3'-untranslated region of the human pregnane X receptor (PXR) gene associated with variability in cytochrome P450 3A (CYP3A) metabolism

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Imipramine and Buspirone in Patients With Panic Disorder Who Are Discontinuing Long-term Benzodiazepine Therapy ⬇️

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Imipramine and desipramine disposition in the elderly

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Imipramine disposition in users of oral contraceptive steroids

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Imipramine-cimetidine interaction: impairment of clearance and enhanced absolute bioavailability

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Impaired Rivaroxaban Clearance in Mild Renal Insufficiency With Verapamil Coadministration: Potential Implications for Bleeding Risk and Dose Selection.

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Impaired absorption of desmethyldiazepam from clorazepate by magnesium aluminum hydroxide ⬇️

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Impaired absorption of tetracycline by colestipol is not reversed by orange juice

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Impairment of Digoxin Clearance by Coadministration of Quinidine ⬇️

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Impairment of Lidocaine Clearance in Elderly Male Subjects ⬇️

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Impairment of antipyrine metabolism by low-dose oral contraceptive steroids

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Impairment of diazepam metabolism by low-dose estrogen-containing oral-contraceptive steroids

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Impairment of hepatic drug oxidation by propoxyphene

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Implications of altered drug disposition in the elderly: studies of benzodiazepines

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Importance of protein binding for the interpretation of serum or plasma drug concentrations

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Improved high-performance liquid chromatographic assay of antipyrine, hydroxymethylantipyrine, 4-hydroxyantipyrine and norantipyrine in urine

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Improved liquid chromatographic analysis of phenytoin and salicylate using radial compression separation

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In Memoriam: Darrell R. Abernethy 1949-2017.

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In Memoriam: Darrell R. Abernethy, 1949-2017.

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In Memoriam: David A. Flockhart, 1952-2015

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In memoriam: Louis Lasagna, MD 1923-2003.

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In situ hybridization histochemistry as a method to assess GABA(A) receptor subunit mRNA expression following chronic alprazolam administration

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In vitro approaches to predicting drug interactions in vivo.

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In vitro biotransformation of sildenafil (Viagra) in the male rat: the role of CYP2C11.

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In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions

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In vitro correlates of benzodiazepine cerebrospinal fluid uptake, pharmacodynamic action and peripheral distribution

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In vitro inhibition of human UGT isoforms by ritonavir and cobicistat

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In vitro interactions of water-soluble garlic components with human cytochromes p450

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In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.

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In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors.

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In vitro prediction of the terfenadine-ketoconazole pharmacokinetic interaction

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In vitro, pharmacokinetic, and pharmacodynamic interactions of ketoconazole and midazolam in the rat.

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Increased cimetidine clearance in burn patients

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Increased clearance of digoxin in rabbits during repeated administration ⬇️

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Increased metabolic clearance of acetaminophen with oral contraceptive use

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Increased sensitivity of the elderly to the central depressant effects of diazepam.

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Induction of P-glycoprotein expression and activity by ritonavir in bovine brain microvessel endothelial cells

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Induction of P-glycoprotein expression by HIV protease inhibitors in cell culture

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Influence of age, gender, and obesity on salicylate kinetics following single doses of aspirin

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Influence of beta-blocker coadministration on the kinetics of isosorbide mononitrate and dinitrate

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Influence of food on pharmacokinetics of zolpidem from fast dissolving sublingual zolpidem tartrate tablets ⬇️

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Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies

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Influence of magnesium and aluminum hydroxide mixture on chlordiazepoxide absorption

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Influence of oral contraceptive use and cigarette smoking, alone and together, on antipyrine pharmacokinetics

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Influence of polyethylene glycol and acetone on the in vitro biotransformation of tamoxifen and alprazolam by human liver microsomes

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Influence of propranolol coadministration or cigarette smoking on the kinetics of desmethyldiazepam following intravenous clorazepate

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Influence of serum digoxin concentration measurements on frequency of digitoxicity

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Inhibition of 2-methoxyestradiol glucuronidation by probenecid

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Inhibition of CYP2C9 by selective serotonin reuptake inhibitors in vitro: studies of phenytoin p‐hydroxylation ⬇️

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Inhibition of acetaminophen and lorazepam glucuronidation in vitro by probenecid

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Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants

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Inhibition of cytochrome P450 by nefazodone in vitro: studies of dextromethorphan O- and N-demethylation

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Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo

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Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo

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Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors

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Inhibition of human cytochrome P450 isoforms in vitro by zafirlukast

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Inhibition of human cytochrome P450-3A isoforms by fluoxetine and norfluoxetine: in vitro and in vivo studies

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Inhibition of human cytochromes P450 by components of Ginkgo biloba ⬇️

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Inhibition of human cytochromes P450 in vitro by ritonavir and cobicistat.

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Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase

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Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo

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Inhibition of triazolam clearance by macrolide antimicrobial agents: in vitro correlates and dynamic consequences

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Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine

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Inhibitory Effects of Selected Antituberculosis Drugs on Common Human Hepatic Cytochrome P450 and UDP-glucuronosyltransferase Enzymes

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Inhibitory Effects of Sulfonylureas and Non-Steroidal Anti-Inflammatory Drugs on In-Vitro Metabolism of Canagliflozin in Human Liver Microsomes

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Interaction of Cimetidine with Oxazepam, Lorazepam, and Flurazepam ⬇️

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Interaction of caffeine with the GABAA receptor complex: alterations in receptor function but not ligand binding

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Interaction of cimetidine with the triazolobenzodiazepines alprazolam and triazolam

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Interaction of diazepam with famotidine and cimetidine, two H2-receptor antagonists

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Interaction of disulfiram with benzodiazepines ⬇️

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Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies

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Interaction of ibuprofen with the H-2 receptor antagonists ranitidine and cimetidine

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Interaction of oxaprozin with acetaminophen, cimetidine, and ranitidine

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Interaction of propoxyphene with diazepam, alprazolam and lorazepam

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Interaction of triazolam and ketoconazole

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Interaction of triazolam and ketoconazole in P-glycoprotein-deficient mice

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Interaction of warfarin with drugs, natural substances, and foods

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Interactions of tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen with P-glycoprotein and CYP3A.

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Interdose elevation in plasma cortisol during chronic treatment with alprazolam but not lorazepam in the elderly

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Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms ⬇️

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International Task Force on Benzodiazepines

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Into the Second Year

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Intramuscular haloperidol or lorazepam and QT intervals in schizophrenia

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Intramuscular injection of drugs

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Intramuscular injection-site complications

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Intravenous digoxin as a bioavailability standard: slow infusion and rapid injection

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Intravenous quinidine in congestive cardiomyopathy

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Intravenous quinidine: pharmacokinetic properties and effects on left ventricular performance in humans

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Is Temazepam an Accumulating Hypnotic? ⬇️

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Is There Always a Right or Wrong?: Comments on the FDA Warnings About Triptans and the Serotonin Syndrome

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Is Volume of Distribution at Steady State a Meaningful Kinetic Variable? ⬇️

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Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6.

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It's in the bag: drug absorption by drug-delivery systems

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Ketoconazole and Liver Injury: A Five-Year Update

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Ketoconazole does not impair antipyrine clearance in humans

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Ketoconazole inhibition of triazolam and alprazolam clearance: differential kinetic and dynamic consequences

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Ketoconazole-Associated Liver Injury in Drug-Drug Interaction Studies in Healthy Volunteers

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Kinetic Characterization and Identification of the Enzymes Responsible for the Hepatic Biotransformation of Adinazolam and N-Desmethyladinazolam in Man ⬇️

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Kinetic and dynamic components of increased benzodiazepine sensitivity in aging animals

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Kinetic and dynamic interaction of brotizolam and ethanol

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Kinetic and dynamic interaction study of zolpidem with ketoconazole, itraconazole, and fluconazole

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Kinetic and dynamic study of intravenous lorazepam: comparison with intravenous diazepam

scientific article published in July 1989

Kinetic equivalence of stable-isotope-labeled and unlabeled phenytoin

Kinetic-dynamic modeling in clinical psychopharmacology

scientific article published on 01 August 1993

Kinetics and EEG effects of midazolam during and after 1-minute, 1-hour, and 3-hour intravenous infusions.

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Kinetics and cardiac effects of propranolol in humans

scientific article published on 01 May 1982

Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs

scientific article published on October 1, 1981

Kinetics and dynamics of intravenous adinazolam, N-desmethyl adinazolam, and alprazolam in healthy volunteers

scientific article published in May 2005

Kinetics and dynamics of lorazepam during and after continuous intravenous infusion

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Kinetics and dynamics of single doses of oxazepam in the elderly: implications of absorption rate

scientific article published in October 1986

Kinetics of 1,2-dinitroglycerin following sustained release nitroglycerin: influence of propranolol and metoprolol

scientific article published on 01 November 1985

Kinetics of Oxazepam and Lorazepam in Two Subjects with Gilbert Syndrome* ⬇️

scientific article published on 01 November 1981

Kinetics of diazepam, midazolam, and lorazepam in cigarette smokers

scientific article published in February 1985

Kinetics of high-dose i.v. diazepam

scientific article published in August 1982

Kinetics of high‐dose intravenous morphine in cardiac surgery patients ⬇️

scientific article published on 01 June 1976

Kinetics of intravenous and intramuscular morphine

scientific article published on July 1, 1978

Kinetics of intravenous chlordiazepoxide: sex differences in drug distribution

scientific article published on December 1, 1977

Kinetics of low-dose intravenous antipyrine: use of liquid chromatography

scientific article published on 01 February 1983

Kinetics, brain uptake, and receptor binding characteristics of flurazepam and its metabolites

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Kinetics, brain uptake, and receptor binding of tandospirone and its metabolite 1-(2-pyrimidinyl)-piperazine

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Lack of effect of influenza vaccine on the pharmacokinetics of antipyrine, alprazolam, paracetamol (acetaminophen) and lorazepam

scientific article published on 01 March 1989

Lack of effect of sertraline on the pharmacokinetics of alprazolam

scientific article published on 01 October 2000

Lack of influence of cigarette smoking on triazolam pharmacokinetics

scientific article published in June 1987

Large theophylline requirements due to high theophylline clearance: verification by the antipyrine test

scientific article published on 01 January 1986

Letter: Safety of nitrazepam

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Levothyroxine up-regulates P-glycoprotein independent of the pregnane X receptor

scientific article published on August 2004

Liability to alprazolam abuse in daughters of alcoholics

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Lidocaine determination in human plasma with application to single low-dose pharmacokinetic studies

scientific article published on 01 October 1982

Lidocaine disposition in obesity

scientific article published in April 1984

Lidocaine plasma concentrations following administration of intraoral lidocaine solution

scientific article published in May 1985

Limited sampling strategy to predict AUC of the CYP3A phenotyping probe midazolam in adults: application to various assay techniques

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Liquid chromatographic determination of chlordiazepoxide and metabolites in plasma

scientific article published on 01 January 1982

Liquid chromatographic retention of beta-adrenoceptor antagonists: an index of lipid solubility

scientific article published on 01 June 1984

Lithium and the newborn heart

scientific article published on 01 October 1990

Lithium nephropathy and antipyretic analgesics--an uncontrolled variable

scientific article published on 01 October 1989

Liver injury associated with ketoconazole: review of the published evidence

scientific article published on October 2014

Long v short half-life benzodiazepines in the elderly. Kinetics and clinical effects of diazepam and oxazepam

scientific article published in March 1983

Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy

scientific article published in January 1985

Long-term administration of benzodiazepines: pharmacokinetic versus pharmacodynamic tolerance

scientific article published on 01 January 1986

Lopinavir: acute exposure inhibits P-glycoprotein; extended exposure induces P-glycoprotein ⬇️

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Lorazepam and oxazepam kinetics in women on low-dose oral contraceptives

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Lorazepam attenuates the behavioral effects of dizocilpine

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Lorazepam discontinuation promotes 'inverse agonist' effects of benzodiazepines

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Lorazepam kinetics in the elderly ⬇️

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Lorazepam: a review of its clinical pharmacological properties and therapeutic uses

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Low-dose alprazolam augments motor activity in mice

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MAOIs and drug interactions--a proposal for a clearinghouse

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MAOIs and hypertension

scientific article published on 01 February 1992

Magnesium pemoline and job performance in mentally handicapped workers

scientific article published in July 1969

Management of anxiety in the elderly: the balance between therapeutic and adverse effects.

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Mass units or molar units for drug concentration?

scientific article published on 01 February 1999

Massive benzodiazepine requirements during acute alcohol withdrawal ⬇️

scientific article published on June 1, 1979

Measurement of clonazepam by electron-capture gas-liquid chromatography with application to single-dose pharmacokinetics

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Mechanism of cytochrome P450-3A inhibition by ketoconazole ⬇️

scientific article published on February 1, 2011

Mechanism of in-vitro inhibition of UGT1A1 by paritaprevir

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Mechanism-based inhibition of human Cytochrome P450-3A activity by grapefruit hybrids having low furanocoumarin content ⬇️

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Mechanisms and Consequences of Drug-Drug Interactions

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MedWatch, the new FDA adverse effects reporting system

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Medication dependence and anxiety ⬇️

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Meldonium (Mildronate): A Performance-Enhancing Drug?

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Mental illness, pharmacotherapy, and automobile operation: what is the risk?

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Meprobamate Overdosage: A Continuing Problem ⬇️

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Meprobamate: A Study of Irrational Drug Use ⬇️

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Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies.

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Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.

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Metabolism of drugs by cytochrome P450 3A isoforms. Implications for drug interactions in psychopharmacology.

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Metabolism of haloperidol: clinical implications and unanswered questions

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Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P-450 1A2, 2D6, and 3A4

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Methadone Disposition: Implementing Lessons Learned

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Methadone inhibits rhodamine123 transport in Caco-2 cells

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Methodologic factors influencing plasma binding of alpha-1-acid glycoprotein-bound and albumin-bound drugs

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Methodologies to study the induction of rat hepatic and intestinal cytochrome P450 3A at the mRNA, protein, and catalytic activity level

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Methods for the determination of lorazepam and chlordiazepoxide and metabolites in brain tissue. A comparison with plasma concentrations in the rat

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Methsuximide for complex partial seizures: efficacy, toxicity, clinical pharmacology, and drug interactions

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Metoprolol or Propranolol Does Not Alter the Kinetics of Procainamide ⬇️

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Metronidazole Impairs Clearance of Phenytoin but Not of Alprazolam or Lorazepam ⬇️

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Microsomal binding of amitriptyline: effect on estimation of enzyme kinetic parameters in vitro

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Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors

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Midazolam

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Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.

scientific article published in February 2000

Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents

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Midazolam: pharmacology and uses

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Misconduct in science and misconduct against scientists

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Modest but variable effect of rifampin on steady-state plasma pharmacokinetics of efavirenz in healthy African-American and Caucasian volunteers

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Modification of gamma-aminobutyric acidA receptor binding and function by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline in vitro and in vivo: effects of aging

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Modulation of benzodiazepine receptor binding in mouse brain by adrenalectomy and steroid replacement

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Molecular and Pharmacokinetic Evaluation of Rat Hepatic and Gastrointestinal Cytochrome P450 Induction by Tamoxifen ⬇️

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Molecular basis for deficient acetaminophen glucuronidation in cats. An interspecies comparison of enzyme kinetics in liver microsomes

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Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms

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More on drugs and pregnancy

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More on oral contraceptives, drug interactions, herbal medicines, and hormone replacement therapy

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More on potassium, the heart, and antipsychotic agents

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Multiple complications and death following protriptyline overdose

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Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A

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Multiple-dose kinetics and dialyzability of oxazepam in renal insufficiency

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N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors

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Nefazodone treatment of cocaine dependence with comorbid depressive symptoms

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Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions

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Neurochemical and pharmacokinetic correlates of the clinical action of benzodiazepine hypnotic drugs

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Neuroendocrine effects of diazepam in panic and generalized anxiety disorders ⬇️

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Neuropsychiatric Sequelae of Pharmacotherapy of Cardiac Arrhythmias and Hypertension ⬇️

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Neurotoxicity and tretinoin

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New anxiolytics: are they really new?

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New pharmacokinetic methods. III. Two simple test for "deep pool effect".

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New pharmacokinetic methods: I. Estimation of mean serum concentration from trough serum concentration

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Newer antidepressants: further reflections.

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Newer antidepressants: hypotheses and evidence

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Newly marketed medications: ABCs and mind your Qs

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Nifedipine: Kinetics and dynamics after single oral doses ⬇️

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Nitrazepam clearance unimpaired in patients with renal insufficiency

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Nomifensine--a farewell and future concerns

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Noninteraction of digitoxin and quinidine

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Noninteraction of temazepam and cimetidine

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Norcocaine and N-hydroxynorcocaine formation in human liver microsomes: role of cytochrome P-450 3A4.

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Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs

scientific article published on 01 June 1999

O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants

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Obesity effects on nitrazepam disposition

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Obesity, sex, and acetaminophen disposition

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On the psychopharmacology of beta adrenergic blockade

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Opioid Prescribing: What Are the Numbers?

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Opportunistic Journals in the Clinical Pharmacology Space: A Policy Statement From the Publications and Public Policy Committees of the American College of Clinical Pharmacology

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Opportunistic Journals in the Clinical Pharmacology Space: A Policy Statement From the Publications and Public Policy Committees of the American College of Clinical Pharmacology

scholarly article by David J Greenblatt & Joseph S Bertino published 1 May 2018 in The Journal of Clinical Pharmacology

Outliers ??? Noise, Nuisance, or Opportunity? ⬇️

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Overdosage with Pentobarbital and Secobarbital: Assessment of Factors Related to Outcome ⬇️

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Overdosage with antipsychotic agents

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Oxaprozin pharmacokinetics in patients with congestive heart failure.

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Oxaprozin pharmacokinetics in the elderly

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Oxazepam kinetics: effects of age and sex.

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Oxidative versus conjugative biotransformation of temazepam

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P-glycoprotein interactions of nefazodone and trazodone in cell culture

scientific article published in July 2001

Pain and CPX elevation after intramuscular digoxin

scientific article published on March 1973

Paracetamol absorption from a feeding jejunostomy

scientific article published in July 1986

Parental alcoholism as a risk factor in benzodiazepine abuse: a pilot study

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Persistence of a Posaconazole-Mediated Drug-Drug Interaction With Ranolazine After Cessation of Posaconazole Administration: Impact of Obesity and Implications for Patient Safety

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Personality and benzodiazepine sensitivity in anxious patients and control subjects

scientific article published in May 1993

Pharmacodynamic and receptor binding changes during chronic lorazepam administration

scientific article published in May 2001

Pharmacodynamic comparison of L-bunolol with propranolol, metoprolol, and placebo

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Pharmacodynamics of Benzodiazepines After Single Oral Doses: Kinetic and Physiochemical Correlates ⬇️

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Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes

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Pharmacokinetic Aspects of Anxiolytic Drug Therapy ⬇️

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Pharmacokinetic Comparison of Sublingual Lorazepam with Intravenous, Intramuscular, and Oral Lorazepam ⬇️

scientific article published on February 1, 1982

Pharmacokinetic Noninteraction of Triazolam and Ethanol ⬇️

scientific article published on 01 April 1984

Pharmacokinetic Understanding of Antianxiety Drug Therapy

scientific article published on August 1, 1978

Pharmacokinetic and Clinical Implications of Quinidine Protein Binding ⬇️

scientific article published on April 1, 1979

Pharmacokinetic and electroencephalographic study of intravenous diazepam, midazolam, and placebo

scientific article published in April 1989

Pharmacokinetic and pharmacodynamic interactions between zolpidem and caffeine

scientific article published on 18 April 2007

Pharmacokinetic approach to the clinical use of lidocaine intravenously

scientific article published in July 1976

Pharmacokinetic aspects of drug therapy in the elderly

scientific article published on 01 January 1986

Pharmacokinetic determinants of dynamic differences among three benzodiazepine hypnotics. Flurazepam, temazepam, and triazolam

scientific article published in April 1989

Pharmacokinetic determinants of the response to single doses of chlordiazepoxide

scientific article published on 01 December 1974

Pharmacokinetic equivalence of stable-isotope-labeled and unlabeled drugs. Phenobarbital in man

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Pharmacokinetic evaluation of eszopiclone: clinical and therapeutic implications ⬇️

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Pharmacokinetic profile of SKP-1041, a modified release formulation of zaleplon

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Pharmacokinetic properties of benzodiazepine hypnotics

scientific article published on April 1, 1983

Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men.

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Pharmacokinetic studies on Ro 15-1788, a benzodiazepine receptor ligand, in the brain of the rat.

scientific article published in January 1984

Pharmacokinetic study of lorazepam overdosage ⬇️

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Pharmacokinetics and Bioavailability of Intravenous, Intramuscular, and Oral Lorazepam in Humans ⬇️

scientific article published on January 1, 1979

Pharmacokinetics and CSF Entry of Flurazepam in Dogs ⬇️

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Pharmacokinetics and Clinical Effects of Amantadine in Drug-Induced Extrapyramidal Symptoms ⬇️

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Pharmacokinetics and Pharmacodynamics for Medical Students: A Proposed Course Outline

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Pharmacokinetics and Pharmacodynamics of Diphenhydramine 25 mg in Young and Elderly Volunteers ⬇️

scientific article published on July 1, 1998

Pharmacokinetics and bioavailability of digoxin capsules, solution and tablets after single and multiple doses

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Pharmacokinetics and clinical drug effects in the elderly [proceedings]

scientific article published on April 1, 1979

Pharmacokinetics and clinical effects of alprazolam following single and multiple oral doses in patients with panic disorder

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Pharmacokinetics and dynamics of penbutolol in humans: evidence for pathway-specific stereoselective clearance

scientific article published in July 1986

Pharmacokinetics and electroencephalographic effects of ketoconazole in the rat.

scientific article published in January 1999

Pharmacokinetics and pharmacodynamics of intravenous digoxin and digitoxin ⬇️

scientific article published on August 17, 1981

Pharmacokinetics and pharmacodynamics of multiple sublingual buprenorphine tablets in dose-escalation trials

scientific article published in February 2006

Pharmacokinetics and pharmacodynamics of oral diazepam: effect of dose, plasma concentration, and time

scientific article published on August 1, 1992

Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy

scientific article published in February 2001

Pharmacokinetics and preliminary observations of behavioral changes following administration of midazolam to dogs

scientific article published in December 1992

Pharmacokinetics cannot explain the increased effective dose requirement for morphine and midazolam in rats during their extended administration alone or in combination.

scientific article published on 28 November 2016

Pharmacokinetics in clinical medicine: oxazepam versus other benzodiazepines

scientific article published on May 1, 1975

Pharmacokinetics of Benzodiazepine Hypnotics ⬇️

scientific article published on January 1, 1983

Pharmacokinetics of alprazolam

scientific article published on 01 August 1983

Pharmacokinetics of antipyrine, acetaminophen and lidocaine in fed and fasted horses

scientific article published on March 1987

Pharmacokinetics of benzodiazepine hypnotics

scientific article published on January 1, 1982

Pharmacokinetics of benzodiazepines and psychostimulants in children

scientific article published on August 1, 1983

Pharmacokinetics of chlordiazepoxide and metabolites following single and multiple oral doses

scientific article published on 01 October 1978

Pharmacokinetics of d-tubocurarine in patients with thermal injury

scientific article published on 01 March 1982

Pharmacokinetics of dezocine, a new analgesic: effect of dose and route of administration

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Pharmacokinetics of digoxin in normal subjects after intravenous bolus and infusion doses ⬇️

scientific article published on 01 June 1975

Pharmacokinetics of diphenhydramine and a demethylated metabolite following intravenous and oral administration

scientific article published in September 1986

Pharmacokinetics of drugs in obesity

scientific article published on March 1982

Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: Pharmacogenetic effect of CYP2B6 variation

scientific article published on September 2008

Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects ⬇️

scientific article published on February 4, 2012

Pharmacokinetics of intravenous caffeine: comparison of high-performance liquid chromatographic and gas chromatographic methods

scientific article published on 01 November 1987

Pharmacokinetics of oxaprozin in women receiving conjugated estrogen

scientific article published on 01 January 1988

Pharmacokinetics of quinidine in humans after intravenous, intramuscular and oral administration ⬇️

scientific article published on 01 August 1977

Pharmacokinetics of zolpidem from sublingual zolpidem tartrate tablets in healthy elderly versus non-elderly subjects

scientific article published on 01 October 2014

Pharmacokinetics, Central Nervous System Uptake, and Lipid Solubility of Propranolol, Acebutolol, and Sotalol ⬇️

scientific article published on January 1, 1984

Pharmacokinetics, bioavailability and effects on electrocardiographic parameters of oral fludarabine phosphate

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Pharmacokinetics: dose-dependent changes

scientific article published on 01 July 1986

Pharmacologic consideration for the use of antiretroviral agents in the elderly

scientific article published on October 2008

Pharmacologic management of dental anxiety: conscious versus unconscious sedation

scientific article published in February 2006

Pharmacologic properties of acebutolol: relationship of hydrophilicity to central nervous system penetration

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Pharmacotherapy of cardiopulmonary arrest

scientific article published in June 1976

Pharmacotherapy of essential hypertension

scientific article published on May 1975

Pharmacotherapy of essential hypertension

scientific article published on 01 May 1975

Pharmocokinetics and pharmacodynamics of single-dose triazolam: electroencephalography compared with the Digit-Symbol Substitution Test

scientific article published on September 2005

Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors

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Phenacetin O-deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine

scientific article published on 01 December 1996

Phenacetin and chlorzoxazone biotransformation in aging male Fischer 344 rats

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Phenelzine and the dream machine--ramblings and reflections.

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Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics ⬇️

scientific article published on 01 April 1988

Phenytoin disposition in obesity. Determination of loading dose

scientific article published on 01 May 1985

Physiologic changes in old age: relation to altered drug disposition

scientific article published on 01 November 1982

Pilot pharmacokinetic study of brotizolam, a thienodiazepine hypnotic, using electron-capture gas-liquid chromatography

scientific article (publication date: 1983)

Plasma alprazolam concentrations. Relation to efficacy and side effects in the treatment of panic disorder

scientific article published on 01 September 1993

Plasma and cerebrospinal fluid concentrations of chlordiazepoxide and its metabolites in surgical patients

scientific article published in November 1976

Plasma and cerebrospinal fluid concentrations of chlordiazepoxide and its metabolites in surgical patients [proceedings]

scientific article published on January 1, 1977

Plasma concentrations and clinical effects after single oral doses of prazepam, clorazepate, and diazepam

scientific article published on October 1, 1984

Plasma concentrations of temazepam, a 3-hydroxy benzodiazepine, determined by electron-capture gas—liquid chromatography ⬇️

scientific article published on 01 January 1981

Plasma diazepam and desmethyldiazepam concentrations during long-term diazepam therapy

scientific article published on January 1981

Plasma levels of trazodone: methodology and applications

scientific article published on 01 January 1984

Plasma protein binding of drugs after severe burn injury

scientific article published in April 1984

Pomegranate Juice and Pomegranate Extract Do Not Impair Oral Clearance of Flurbiprofen in Human Volunteers: Divergence From In Vitro Results ⬇️

scientific article published on October 10, 2012

Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice

scientific article published in March 2007

Poor bioavailability of CGS 8216 in a water/tween vehicle following intraperitoneal injection

scientific article published in January 1987

Population pharmacokinetics of methylphenidate in children with attention-deficit hyperactivity disorder

scientific article published on 01 August 1999

Population study of triazolam pharmacokinetics

scientific article published in December 1986

Potassium, antipsychotic agents, arrhythmias, and sudden death

scientific article published on 01 December 1998

Potent mechanism-based inhibition of human CYP3A in vitro by amprenavir and ritonavir: comparison with ketoconazole

scientific article published on 01 June 2000

Potentially toxic serum lidocaine concentrations following spray anesthesia for bronchoscopy

scientific article published in April 1983

Prazepam and Lorazepam, Two New Benzodiazepines ⬇️

scientific article published on December 14, 1978

Prazepam, a precursor of desmethyldiazepam

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Preclinical Rodent Toxicity Studies for Long Term Use of Ceftriaxone

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Preliminary evidence of benzodiazepine subsensitivity in panic disorder

scientific article published on November 1989

Prenatal benzodiazepine administration. II. Lorazepam exposure is associated with decreases in [35S]TBPS binding but not benzodiazepine binding

scientific article published on 01 October 1991

Prenatal exposure to benzodiazepine--I. Prenatal exposure to lorazepam in mice alters open-field activity and GABAA receptor function

scientific article published in January 1991

Preparation of scientific reports on pharmacokinetic drug interaction studies

scientific article published on 01 August 2008

Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate).

scientific article published in August 1982

Prolonged accumulation of diazepam in obesity

scientific article published in August 1983

Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl

scientific article published on 21 February 2019

Propofol clearance and volume of distribution are increased in patients with major burns.

scientific article published in July 2009

Propofol hydroxylation by dog liver microsomes: assay development and dog breed differences

scientific article published in November 1999

Propranolol interactions with diazepam, lorazepam, and alprazolam

scientific article published in October 1984

Propranolol kinetics: use of automated liquid chromatography

scientific article published on 01 September 1984

Propranolol??s Psychiatric Side Effects ⬇️

scientific article published on April 1, 1983

Protease Inhibitors as Inhibitors of Human Cytochromes P450: High Risk Associated with Ritonavir ⬇️

scientific article published on 01 February 1998

Protease inhibitors and drug interactions--an alert

scientific article published on 01 October 1996

Psychopharmacologic Management of Anxiety in the Cardiac Patient ⬇️

scientific article published on January 1, 1971

Psychotropic drug prescribing in the United States: extent, costs, and expenditures

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Psychotropic drug use in the Boston area. A report from the Boston Collaborative Drug Surveillance Program

scientific article published on April 1975

Public Health Risk of Designer Psychotropic Drugs: Should PHASE Be Phased In?

scientific article published on 22 August 2019

Quantitation by gas chromatography of the 1- and 4-hydroxy metabolites of midazolam in human plasma

scientific article published in January 1984

Quantitation of flurazepam and three metabolites by electron capture gas liquid chromatography

scientific article published on 01 May 1988

Race, Gender, and Genetic Polymorphism Contribute to Variability in Acetaminophen Pharmacokinetics, Metabolism, and Protein-Adduct Concentrations in Healthy African-American and European-American Volunteers

scientific article published on 29 June 2017

Ranitidine does not impair oxidative or conjugative metabolism: noninteraction with antipyrine, diazepam, and lorazepam

scientific article published in February 1984

Rapid assessment of P-glycoprotein inhibition and induction in vitro

scientific article published on August 2003

Rapid increase in brain benzodiazepine receptor binding following defeat stress in mice

scientific article published on 01 June 1987

Rapid recovery from massive diazepam overdose

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Rational Psycho-Pharmacology for Patients with Medical Diseases ⬇️

scientific article published on January 1, 1976

Rational therapeutic drug monitoring

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Rational use of psychotropic drugs II. Antianxiety agents.

scientific article published on November 1974

Rational use of psychotropic drugs. I. Hypnotics.

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Rational use of psychotropic drugs. II. Antianxiety agents

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Rational use of psychotropic drugs. III. Major tranquilizers

scientific article published on December 1974

Rational use of psychotropic drugs. IV. Antidepressants

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Rational use of psychotropic drugs. IV. Antidepressants

scientific article published on 01 January 1975

Recent Recall of a Generic Form of Extended-Release Paliperidone

scientific article published on 01 October 2017

Reduced Clearance of Quinidine in Elderly Humans ⬇️

scientific article published on January 1, 1977

Reduced Distribution and Clearance of Acetaminophen in Patients with Congestive Heart Failure ⬇️

scientific article published on 01 July 1983

Reduced benzodiazepine sensitivity in panic disorder

scientific article published in June 1990

Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects

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Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity ⬇️

scientific article published on March 1, 1983

Reduced quinidine clearance in elderly persons ⬇️

scientific article published on September 1, 1978

Reduced single-dose clearance of clobazam in elderly men predicts increased multiple-dose accumulation

scientific article published on 01 January 1983

Reduced systemic absorption of intrabronchial lidocaine by high-frequency nebulization

scientific article published in September 1990

Reduction in lidocaine clearance during continuous infusion and by coadministration of propranolol

scientific article published in August 1980

Reduction of digoxin toxicity associated with measurement of serum levels. A report from the Boston Collaborative Drug Surveillance Program

scientific article published on 01 April 1974

Regression and Correlation

scientific article published on 01 May 2015

Regulatory and Scientific Aspects of Drug-Drug Interaction Studies

scientific article published on 01 April 2012

Relationship between plasma protease inhibitor concentrations and lipid elevations in HIV patients on a double-boosted protease inhibitor regimen (saquinavir/lopinavir/ritonavir).

scientific article published on 23 January 2010

Relationship of in vitro data on drug metabolism to in vivo pharmacokinetics and drug interactions: implications for diazepam disposition in humans

scientific article published in August 1996

Relationship of plasma and brain concentrations of caffeine and metabolites to benzodiazepine receptor binding and locomotor activity

scientific article published on 01 March 1989

Relative Quantities of Catalytically Active CYP 2C9 and 2C19 in Human Liver Microsomes: Application of the Relative Activity Factor Approach ⬇️

scientific article published on July 1, 1998

Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies

scientific article

Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine

scientific article published in April 2001

Repeated diazepam dosing in cirrhotic patients: cumulation and sedation

scientific article published in April 1983

Response to diazepam in sons of alcoholics

scientific article published on December 1, 1992

Resveratrol glucuronidation in vitro: potential implications of inhibition by probenecid

scientific article published on 12 November 2018

Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats

scientific article published in February 2004

Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis

scientific article published in December 2008

Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers

scientific article published on 01 May 2006

Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line

scientific article

Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies

scientific article

Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion

scientific article

Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice

scientific article published on 28 March 2007

Role of CYP3A enzymes in the biotransformation of triazolam in rat liver

scientific article published in May 2004

Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes

scientific article published on 06 October 2008

Role of nurse and pharmacist monitors in the Boston Collaborative Drug Surveillance Program

scientific article published on 01 December 1975

Role of the nuclear receptor pregnane X receptor in acetaminophen hepatotoxicity

scientific article

Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial

scientific article

Saint John's wort: an in vitro analysis of P-glycoprotein induction due to extended exposure

scientific article

Say "no" to drug testing

scientific article published on 01 June 1990

Scaling drug biotransformation data from cDNA-expressed cytochrome P-450 to human liver: a comparison of relative activity factors and human liver abundance in studies of mirtazapine metabolism

scientific article

Sedative effects and impaired learning and recall after single oral doses of lorazepam

scientific article published in May 1986

Selective serotonin reuptake inhibitor antidepressants: cardiovascular complications--sorting through findings.

scientific article

Self-Poisoning with Over-the-Counter Hypnotics ⬇️

scientific article published on 01 January 1979

Self-rated sedation and plasma concentrations of desmethyldiazepam following single doses of clorazepate

scientific article published on January 1979

Sensitivity to triazolam in the elderly

scientific article published in June 1991

Separate and combined effects of caffeine and alprazolam on motor activity and benzodiazepine receptor binding in vivo

scientific article published in January 1990

Serotonin (5-hydroxytryptamine) glucuronidation in vitro: assay development, human liver microsome activities and species differences

scientific article published in February 2003

Serum concentrations and clinical effects of atorvastatin in patients taking grapefruit juice daily ⬇️

scientific article published on September 1, 2011

Serum creatine phosphokinase concentrations after intramuscular chlordiazepoxide and its solvent

scientific article published on 01 February 1976

Serum digoxin concentrations and subjective manifestations of toxicity

scientific article published on 01 January 1980

Serum haloperidol concentrations and clinical response in acute psychosis

scientific article published on 01 December 1984

Sex differences in diazepam protein binding in patients with renal insufficiency

scientific article published on January 1, 1978

Sex-related elevation in cortisol during chronic treatment with alprazolam associated with enhanced cognitive performance

scientific article published on 19 October 2005

Shades of the patent medicine man.

scientific article published in August 1983

Short half-life benzodiazepines

scientific article published on April 1, 1984

Short- and long-acting oral quinidine preparations: clinical implications of pharmacokinetic differences

scientific article published on 01 March 1978

Short-term clarithromycin administration impairs clearance and enhances pharmacodynamic effects of trazodone but not of zolpidem

scientific article published on 25 February 2009

Short-term exposure to low-dose ritonavir impairs clearance and enhances adverse effects of trazodone.

scientific article published in April 2003

Simple and rapid liquid chromatography method for determination of efavirenz in plasma

scientific article published on 29 March 2006

Simplified approaches to the determination of antipyrine pharmacokinetic parameters

scientific article

Simplified gas chromatographic assay of underivatized nitrazepam in plasma

scientific article published on 01 January 1985

Simplified measurement of haloperidol by gas chromatography with nitrogen-phosphorus detection

scientific article published on 01 December 1987

Simultaneous determination of lidocaine and its deethylated metabolites using gas-liquid chromatography with nitrogen-phosphorus detection

scientific article published on 01 April 1984

Single and multiple dose kinetics of clobazam, and clinical effects during multiple dosage

scientific article published on 01 January 1984

Single and multiple dose pharmacokinetics of oral quinidine sulfate and gluconate ⬇️

scientific article published on 01 April 1978

Single- and multiple-dose kinetics of estazolam, a triazolo benzodiazepine

scientific article (publication date: 1979)

Single- and multiple-dose kinetics of intravenous digoxin

scientific article published on 01 September 1980

Single- and multiple-dose kinetics of oral lorazepam in humans: the predictability of accumulation

scientific article published on April 1979

Single-Dose Kinetics of Prazepam, a Precursor of Desmethyldiazepam ⬇️

scientific article published on August 1, 1979

Single-dose kinetics of oral propranolol, metoprolol, atenolol, and sotalol: relation to lipophilicity

scientific article published on 01 January 1985

Single‐Dose Pharmacokinetics and Pharmacodynamics of Alprazolam in Elderly and Young Subjects ⬇️

scientific article published on 01 January 1998

Sleep-promoting medications: Weighing the hazards of use versus non-use

scientific article

Slow Accumulation and Elimination of Diazepam and Its Active Metabolite With Extended Treatment in the Elderly

scientific article published on 27 August 2020

Slow absorption of intramuscular chlordiazepoxide

scientific article published on 01 November 1974

Some current treatment options for symptoms of anxiety

scientific article published on November 1, 1983

Some thoughts on a new antidepressant and a marking of the death of John Cade, MD.

scientific article published in May 1981

Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro

scientific article published on October 2010

Spectrophotometric assay of antipyrine in plasma: a reevaluation

scientific article published on 01 September 1979

Spironolactone

scientific article published on 01 September 1978

Staggered stable isotope administration technique for study of drug distribution

scientific article

Starting the Tenth Year

scientific article published on 01 January 2021

Steady-state plasma desmethyldiazepam during long-term clorazepate use: effects of antacids

scientific article published in February 1982

Stereo-Psychopharmacology: The Case of Citalopram and Escitalopram

scientific article published on 01 September 2016

Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9

scientific article (publication date: November 2002)

Studies with stable isotopes I: Changes in phenytoin pharmacokinetics and biotransformation during monotherapy

scientific article published on 01 January 1985

Studies with stable isotopes II: Phenobarbital pharmacokinetics during monotherapy

scientific article published on 01 January 1985

Studies with stable isotopes III: Pharmacokinetics of tracer doses of drug

scientific article published on 01 January 1985

Suggestions for treating drug abusers in a family practice

scientific article published on 01 September 1974

Suppression of norepinephrine appearance rate in plasma by diazepam in humans

scientific article published in January 1988

Sustained Impairment of Lurasidone Clearance After Discontinuation of Posaconazole: Impact of Obesity, and Implications for Patient Safety

scientific article published on 01 August 2018

Systemic pharmacokinetics and cerebrospinal fluid uptake of intravenous ceftriaxone in patients with amyotrophic lateral sclerosis

scientific article

THE NOVEL UGT1A9 INTRONIC I399 POLYMORPHISM APPEARS AS A PREDICTOR OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN GLUCURONIDATION LEVELS IN THE LIVER

scientific article published on 04 April 2006

Temazepam clearance unaltered in cirrhosis

scientific article published on 01 January 1986

The Bolger conference on PDE-5 inhibition and HIV risk: implications for health policy and prevention

scientific article

The Effect of CYP3A Induction and Inhibition on the Pharmacokinetics of Laquinimod, a Novel Neuroimmunomodulator

scientific article published on 01 April 2020

The Impact Non-Factor

scientific article published on 01 August 2017

The Influence of Obesity on the Pharmacokinetics of Oral Alprazolam and Triazolam

scientific article published on 01 March 1984

The Journal of Clinical Pharmacology, Clinical Pharmacology in Drug Development, and the Impact Factor

scientific article

The Journal of Clinical Pharmacology, Clinical Pharmacology in Drug Development, and the Impact Factor

scientific article published on 01 May 2017

The NMDA Receptor Competitive Antagonist CPP Modulates Benzodiazepine Tolerance and Discontinuation ⬇️

scientific article published on November 1, 1997

The Pharmacovigilance Syndrome

scientific article published on 01 August 2015

The Prescription of Benzodiazepines for Panic Disorder: Time for an Evidence-Based Educational Approach

scientific article published on 01 August 2018

The Seventy-Kilogram Fantasy

scientific article published in April 2013

The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-

scientific article published on 13 February 2013

The absence of an interaction between warfarin and cranberry juice: a randomized, double-blind trial.

scientific article published in July 2009

The acute and chronic performance effects of alprazolam and lorazepam in the elderly: relationship to duration of treatment and self-rated sedation.

scientific article published in January 1998

The admissibility of positive EMIT results as scientific evidence: counting facts, not heads

scientific article published on 01 April 1985

The archaic barbiturate hypnotics

scientific article published on 01 October 1974

The behavioural effects of Lorazepam are poorly related to its concentration in the brain ⬇️

scientific article published on April 25, 1983

The bioavailability of intranasal lignocaine

scientific article published on December 1989

The chronic patient: issues and concerns.

scientific article published in June 1985

The clinical choice of sedative-hypnotics

scientific article

The clinical use of procainamide

scientific article

The clinical use of procainamide

scientific article published on 01 June 1974

The clinician and drug interactions--an update

scientific article published on 01 June 1996

The concept of geriatric clinical pharmacology. Panel I: The ideal training program

scientific article published in December 1987

The effect of age on P-glycoprotein expression and function in the Fischer-344 rat.

scientific article published on 2 February 2004

The effect of age on sildenafil biotransformation in rat and mouse liver microsomes.

scientific article published in November 2003

The effect of benztropine on haloperidol-induced dystonia, clinical efficacy and pharmacokinetics: a prospective, double-blind trial

scientific article

The effect of chronic lorazepam administration in aging mice

scientific article published on 20 September 2006

The effect of grapefruit juice on drug disposition ⬇️

scientific article published on January 22, 2011

The importance of presystemic extraction in clinical psychopharmacology

scientific article published on 01 December 1996

The influence of age and sex on the clearance of cytochrome P450 3A substrates

scientific article

The interactions of propranolol and ketanserin

scientific article published on 01 January 1987

The ketoconazole legacy

scientific article published on 01 January 2014

The neuropsychiatric effects of aspartame in normal volunteers

scientific article published in May 1990

The pharmacokinetics and pharmacodynamics of sublingual and oral alprazolam in the post-prandial state

scientific article published on 01 January 1992

The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma

scientific article published on January 1986

The pharmacokinetics of doxylamine: use of automated gas chromatography with nitrogen-phosphorus detection

scientific article

The pharmacokinetics of midazolam in chronic renal failure patients

scientific article published in November 1983

The psychiatrist as mind sweeper

scientific article published on 01 August 1982

The reappearance of a monamine oxidase inhibitor (isocarboxazid)

scientific article published on 01 April 1999

The relationship of alprazolam dose to steady-state plasma concentrations.

scientific article

The safety of over-the-counter drugs: some reflections and unanswered questions

scientific article published on 01 April 2003

The specificity of the extraction fluorescence assay for serum or plasma quinidine

scientific article published on August 1981

The use of benzodiazepines for psychotic disorders: a literature review and preliminary clinical findings

scientific article

The use of benzodiazepines in clinical practice ⬇️

scientific article published on January 1, 1981

Therapeutic Drug Monitoring of Antidepressants

scientific article published on 01 January 2019

Therapeutic drug monitoring in cardiology: recognizing pitfalls and problems

scientific article published on 01 July 1987

Thinking while balancing: what to do about replacing dropouts

scientific article published in August 1994

Thyroid function monitoring for lithium-treated patients

scientific article published on 01 April 1988

Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice

scientific article (publication date: August 2003)

Tissue distribution of diazepam and its metabolite desmethyldiazepam: a human autopsy study

scientific article published in November 1985

Toxicity of high-dose flurazepam in the elderly ⬇️

scientific article published on March 1, 1977

Toxicity of nitrazepam in the elderly: a report from the Boston Collaborative Drug Surveillance Program

scientific article

Toxicity of nitrazepam in the elderly: a report from the Boston Collaborative Drug Surveillance Program. 1978.

scientific article published in December 2004

Translocase of Outer Mitochondrial Membrane 40 Homolog (TOMM40) Poly-T Length Modulates Lorazepam-Related Cognitive Toxicity in Healthy APOE ϵ4-Negative Elderly

article

Trazodone kinetics: effect of age, gender, and obesity

scientific article published on 01 August 1987

Treating the drug abuser in the ED

scientific article published on 01 May 1975

Treatment of Diazepam Withdrawal Syndrome with Propranolol

scientific article published on March 1, 1981

Treatment of postmenopausal osteoporosis

scientific article published in April 2005

Triazolam Kinetics: Interaction with Cimetidine, Propranolol, and the Combination ⬇️

scientific article published on March 1, 1988

Triazolam and anterograde amnesia: all is not well in the Z-zone

scientific article published on 01 October 1983

Triazolam and ethanol interaction: kinetic and dynamic consequences

scientific article published in May 1985

Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole

scientific article published on 01 February 1996

Tricyclic Antidepressant Determination in Human Plasma by Gas-Liquid Chromatography Using Nitrogen-Phosphorous Detection: Application to Single-Dose Pharmacokinetic Studies ⬇️

scientific article published on 01 January 1981

Trimipramine kinetics and absolute bioavailability: use of gas-liquid chromatography with nitrogen-phosphorus detection

scientific article published on 01 March 1984

Twice may be too many: redundant publications

scientific article published on 01 February 1996

Tyr-MIF-1 augments benzodiazepine receptor binding in vivo

scientific article

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation

scientific article

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S).

scientific article

UDP-glucuronosyltransferase (UGT) 2B15 pharmacogenetics: UGT2B15 D85Y genotype and gender are major determinants of oxazepam glucuronidation by human liver

scientific article

UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver

scientific article published in August 2005

Unchanged cytochrome P450 3A (CYP3A) expression and metabolism of midazolam, triazolam, and dexamethasone in mdr(-/-) mouse liver microsomes

scientific article published in June 1999

Underivatized measurement of bromazepam by gas chromatography-electron-capture detection with application to single-dose pharmacokinetics

scientific article published on 01 June 1986

Unusually low clearance of two CYP3A substrates, alprazolam and trazodone, in a volunteer subject with wild-type CYP3A4 promoter region

scientific article published on 01 February 2000

Update on Psychotropic Drug Prescribing in the United States: 2014-2015.

scientific article published on 6 December 2017

Urgent pharmacotherapy for drug abuse

scientific article published on January 1, 1975

Use of Antipsychotics for the Treatment of Behavioral Symptoms of Dementia

scientific article published on 7 March 2016

Use of benzodiazepines in anxiety disorders

scientific article published on May 1993

User unfriendly drugs--fillers, additives, excipients

scientific article

Uses and toxicity of belladonna alkaloids and synthetic anticholinergics

scientific article published on November 1971

Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6.

scientific article

Validity of a two-point acetaminophen pharmacokinetic study

scientific article published in January 1990

Validity of self-reports of caffeine use

scientific article published on 01 July 1991

Variability of 24-hour urinary creatinine excretion by normal subjects

scientific article published on 01 July 1976

Venlafaxine and metabolites are very weak inhibitors of human cytochrome P450-3A isoforms

scientific article published on 01 February 1997

Volume of distribution - Again

scientific article published on 01 November 2014

Vortioxetine Disposition in Obesity: Potential Implications for Patient Safety

scientific article published on 28 March 2018

Zolpidem and Gender: Are Women Really At Risk?

scientific article published on 01 May 2019

Zolpidem for insomnia

scientific article published on 19 March 2012

Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

scientific article

Zolpidem pharmacokinetic properties in young females: influence of smoking and oral contraceptive use.

scientific article published in October 2002

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