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List of works by Gerrit J Poelarends

A mutational analysis of active site residues in trans‐3‐chloroacrylic acid dehalogenase ⬇️

scientific article published on July 10, 2013

Aminocarboxylic acids related to aspergillomarasmine A (AMA) and ethylenediamine-N,N'-disuccinic acid (EDDS) are strong zinc-binders and inhibitors of the metallo-beta-lactamase NDM-1

scientific article published on 01 March 2020

An Unexpected Promiscuous Activity of 4‐Oxalocrotonate Tautomerase: The cis–trans Isomerisation of Nitrostyrene ⬇️

scientific article published on July 31, 2012

Biocatalytic Asymmetric Michael Additions of Nitromethane to α,β-Unsaturated Aldehydes via Enzyme-bound Iminium Ion Intermediates

article

Biocatalytic Michael-type additions of acetaldehyde to nitroolefins with the proline-based enzyme 4-oxalocrotonate tautomerase yielding enantioenriched γ-nitroaldehydes.

scientific article

Biochemical Properties and Crystal Structure of a  -Phenylalanine Aminotransferase from Variovorax paradoxus

scientific article

Bridging between Organocatalysis and Biocatalysis: Asymmetric Addition of Acetaldehyde to β‐Nitrostyrenes Catalyzed by a Promiscuous Proline‐Based Tautomerase ⬇️

scientific article published on December 21, 2011

Catalytic Mechanisms and Biocatalytic Applications of Aspartate and Methylaspartate Ammonia Lyases ⬇️

scientific article published on August 16, 2012

Characterization of a Newly Identified Mycobacterial Tautomerase with Promiscuous Dehalogenase and Hydratase Activities Reveals a Functional Link to a Recently Diverged cis-3-Chloroacrylic Acid Dehalogenase ⬇️

scientific article published on March 22, 2011

Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans

scientific article published on 18 October 2011

Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors.

scientific article published on 15 August 2018

Dehalogenation of an Anthropogenic Compound by an Engineered Variant of the Mouse Cytokine Macrophage Migration Inhibitory Factor ⬇️

scientific article published on May 21, 2012

Demethionylation of Pro-1 variants of 4-oxalocrotonate tautomerase in Escherichia coli by co-expression with an engineered methionine aminopeptidase

scientific article published on 9 July 2014

Discovery of an Escherichia coli Esterase with High Activity and Enantioselectivity toward 1,2- O -Isopropylideneglycerol Esters ⬇️

scientific article published on July 15, 2011

Discovery of chromenes as inhibitors of macrophage migration inhibitory factor.

scientific article published on 24 December 2017

Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions

scientific article published on 07 January 2019

Engineered C-N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners

scientific article published on 19 November 2019

Engineering a Promiscuous Tautomerase into a More Efficient Aldolase for Self-Condensations of Linear Aliphatic Aldehydes

scientific article

Enhancement of the Promiscuous Aldolase and Dehydration Activities of 4‐Oxalocrotonate Tautomerase by Protein Engineering ⬇️

scientific article published on May 21, 2012

Enzymatic synthesis of enantiopure alpha- and beta-amino acids by phenylalanine aminomutase-catalysed amination of cinnamic acid derivatives

scientific article published in January 2009

Evidence for the formation of an enamine species during aldol and Michael-type addition reactions promiscuously catalyzed by 4-oxalocrotonate tautomerase

scientific article

Facilitated Drug Influx by an Energy-uncoupled Secondary Multidrug Transporter ⬇️

scientific article published on October 14, 2003

In Situ Acetaldehyde Synthesis for Carboligation Reactions

scientific article published on 23 December 2019

Inter- and intramolecular aldol reactions promiscuously catalyzed by a proline-based tautomerase

scientific article

Kinetic, Mutational, and Structural Analysis of Malonate Semialdehyde Decarboxylase from Coryneform Bacterium Strain FG41: Mechanistic Implications for the Decarboxylase and Hydratase Activities ⬇️

scientific article published on July 2, 2013

Metabolic alkene labeling and in vitro detection of histone acylation via the aqueous oxidative Heck reaction

scientific article (publication date: 28 March 2015)

Modular Enzymatic Cascade Synthesis of Vitamin B5 and Its Derivatives

scientific article published on 30 October 2018

Mutations Closer to the Active Site Improve the Promiscuous Aldolase Activity of 4-Oxalocrotonate Tautomerase More Effectively than Distant Mutations.

scientific article

Photoaffinity labeling under non-energized conditions of a specific drug-binding site of the ABC multidrug transporter LmrA from Lactococcus lactis ⬇️

scientific article published on November 21, 2003

Promiscuous Catalysis of Asymmetric Michael‐Type Additions of Linear Aldehydes to β‐Nitrostyrene by the Proline‐Based Enzyme 4‐Oxalocrotonate Tautomerase ⬇️

scientific article published on January 9, 2013

Recent Advances in the Study of Enzyme Promiscuity in the Tautomerase Superfamily ⬇️

scientific article published on 03 May 2013

Stereochemical Control of Enzymatic Carbon-Carbon Bond-Forming Michael-Type Additions by "Substrate Engineering".

scientific article published on 25 October 2016

Structural Basis for the Catalytic Mechanism of Ethylenediamine- N, N'-disuccinic Acid Lyase, a Carbon-Nitrogen Bond-Forming Enzyme with a Broad Substrate Scope.

scientific article published on 18 May 2018

Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF)

scientific article published on 11 November 2019

Systematic Screening for Catalytic Promiscuity in 4‐Oxalocrotonate Tautomerase: Enamine Formation and Aldolase Activity ⬇️

scientific article published on 03 February 2011

The Lactococcal lmrP Gene Encodes a Proton Motive Force- dependent Drug Transporter ⬇️

scientific article published on November 3, 1995

The roles of active site residues in the catalytic mechanism of methylaspartate ammonia‐lyase ⬇️

scientific article published on July 8, 2013

Tuning Enzyme Activity for Nonaqueous Solvents: Engineering an Enantioselective "Michaelase" for Catalysis in High Concentrations of Ethanol

scientific article published on 30 December 2019

Using mutability landscapes of a promiscuous tautomerase to guide the engineering of enantioselective Michaelases

scientific article

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