List of works - Adrian Vella

A Model for the Estimation of Hepatic Insulin Extraction After a Meal

scientific article published on 4 December 2015

A concerted decline in insulin secretion and action occurs across the spectrum of fasting and postchallenge glucose concentrations

scientific article published on February 2012

A model of GLP-1 action on insulin secretion in nondiabetic subjects

scientific article

A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity

scientific article

A stable isotope breath test with a standard meal for abnormal gastric emptying of solids in the clinic and in research

scientific article published on 14 April 2008

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases

scientific article

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes

scientific article published in March 2004

Assessment of pulsatile insulin secretion derived from peripheral plasma C-peptide concentrations by nonparametric stochastic deconvolution

scientific article published on 26 February 2019

Association between thyrotropin levels and insulin sensitivity in euthyroid obese adolescents

scientific article published on 7 April 2015

Association of TCF7L2 allelic variations with gastric function, satiation, and GLP-1 levels ⬇️

scientific article published on June 1, 2011

Association of UCP-3 rs1626521 with obesity and stomach functions in humans

scientific article

Common genetic variation in GLP1R and insulin secretion in response to exogenous GLP-1 in nondiabetic subjects: a pilot study ⬇️

scientific article

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

scientific article

Contribution of endogenous glucagon-like peptide 1 to glucose metabolism after Roux-en-Y gastric bypass

scientific article published on 02 October 2013

Defects in GLP-1 response to an oral challenge do not play a significant role in the pathogenesis of prediabetes

scientific article published on 16 November 2011

Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.

scientific article published on 28 March 2012

Dipeptidyl peptidase-4 inhibition by vildagliptin and the effect on insulin secretion and action in response to meal ingestion in type 2 diabetes

scientific article published on 17 October 2008

Direct effects of exendin-(9,39) and GLP-1-(9,36)amide on insulin action, β-cell function, and glucose metabolism in nondiabetic subjects

scientific article published on April 2013

Effects of liraglutide on weight, satiation, and gastric functions in obesity: a randomised, placebo-controlled pilot trial

scientific article published on 25 September 2017

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

scientific article published on 25 September 2018

Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

scientific article published on 16 December 2019

Glucose metabolism during rotational shift-work in healthcare workers

scientific article published on 27 May 2017

Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans

scientific article published on 6 November 2017

Increased Rates of Meal Absorption Do Not Explain Elevated 1-Hour Glucose in Subjects With Normal Glucose Tolerance

scientific article published on 21 November 2018

Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes

scientific article published on April 2004

Limitations of the fasting proinsulin to insulin ratio as a measure of β-cell health in people with and without impaired glucose tolerance

scientific article published on 08 December 2020

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

scientific article

Model-Based Quantification of Glucagon-Like Peptide-1-Induced Potentiation of Insulin Secretion in Response to a Mixed Meal Challenge

scientific article

Performance of individually-measured vs population-based C-peptide kinetics to assess β-cell function in presence and absence of acute insulin resistance.

scientific article published on September 2017

Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes

scientific article

Randomized controlled phase Ib study of ghrelin agonist, RM-131, in type 2 diabetic women with delayed gastric emptying: pharmacokinetics and pharmacodynamics

scientific article

Relationship between glycemic control and gastric emptying in poorly controlled type 2 diabetes

scientific article

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus

scientific article

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

scientific article

Six and 12 Weeks of Caloric Restriction Increases β Cell Function and Lowers Fasting and Postprandial Glucose Concentrations in People with Type 2 Diabetes

scientific article

Standardized Mixed-Meal Tolerance and Arginine Stimulation Tests Provide Reproducible and Complementary Measures of β-Cell Function: Results From the Foundation for the National Institutes of Health Biomarkers Consortium Investigative Series

scientific article published on 12 July 2016

TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes

scientific article published on 2 November 2015

Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator

scientific article published on 01 January 2019

The Ghrelin Agonist RM-131 Accelerates Gastric Emptying of Solids and Reduces Symptoms in Patients With Type 1 Diabetes Mellitus ⬇️

scientific article published on April 30, 2013

The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes

scientific article

The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose

scientific article

The effect of a bile acid sequestrant on glucose metabolism in subjects with type 2 diabetes

scientific article published on 18 December 2012

The effect of vagal nerve blockade using electrical impulses on glucose metabolism in nondiabetic subjects

scientific article

The oral minimal model method

scientific article

Three hours of intermittent hypoxia increases circulating glucose levels in healthy adults

scientific article published on 13 January 2017

List of works by Adrian Vella

A Model for the Estimation of Hepatic Insulin Extraction After a Meal

A concerted decline in insulin secretion and action occurs across the spectrum of fasting and postchallenge glucose concentrations

A model of GLP-1 action on insulin secretion in nondiabetic subjects

A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity

A stable isotope breath test with a standard meal for abnormal gastric emptying of solids in the clinic and in research

Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes

Assessment of pulsatile insulin secretion derived from peripheral plasma C-peptide concentrations by nonparametric stochastic deconvolution

Association between thyrotropin levels and insulin sensitivity in euthyroid obese adolescents

Association of TCF7L2 allelic variations with gastric function, satiation, and GLP-1 levels ⬇️

Association of UCP-3 rs1626521 with obesity and stomach functions in humans

Common genetic variation in GLP1R and insulin secretion in response to exogenous GLP-1 in nondiabetic subjects: a pilot study ⬇️

Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes

Contribution of endogenous glucagon-like peptide 1 to glucose metabolism after Roux-en-Y gastric bypass

Defects in GLP-1 response to an oral challenge do not play a significant role in the pathogenesis of prediabetes

Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.

Dipeptidyl peptidase-4 inhibition by vildagliptin and the effect on insulin secretion and action in response to meal ingestion in type 2 diabetes

Direct effects of exendin-(9,39) and GLP-1-(9,36)amide on insulin action, β-cell function, and glucose metabolism in nondiabetic subjects

Effects of liraglutide on weight, satiation, and gastric functions in obesity: a randomised, placebo-controlled pilot trial

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Genetic Discrimination Between LADA and Childhood-Onset Type 1 Diabetes Within the MHC

Glucose metabolism during rotational shift-work in healthcare workers

Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans

Increased Rates of Meal Absorption Do Not Explain Elevated 1-Hour Glucose in Subjects With Normal Glucose Tolerance

Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes

Limitations of the fasting proinsulin to insulin ratio as a measure of β-cell health in people with and without impaired glucose tolerance

Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms

Model-Based Quantification of Glucagon-Like Peptide-1-Induced Potentiation of Insulin Secretion in Response to a Mixed Meal Challenge

Performance of individually-measured vs population-based C-peptide kinetics to assess β-cell function in presence and absence of acute insulin resistance.

Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes

Randomized controlled phase Ib study of ghrelin agonist, RM-131, in type 2 diabetic women with delayed gastric emptying: pharmacokinetics and pharmacodynamics

Relationship between glycemic control and gastric emptying in poorly controlled type 2 diabetes

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Six and 12 Weeks of Caloric Restriction Increases β Cell Function and Lowers Fasting and Postprandial Glucose Concentrations in People with Type 2 Diabetes

Standardized Mixed-Meal Tolerance and Arginine Stimulation Tests Provide Reproducible and Complementary Measures of β-Cell Function: Results From the Foundation for the National Institutes of Health Biomarkers Consortium Investigative Series

TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes

Targeting hepatic glucokinase to treat diabetes with TTP399, a hepatoselective glucokinase activator

The Ghrelin Agonist RM-131 Accelerates Gastric Emptying of Solids and Reduces Symptoms in Patients With Type 1 Diabetes Mellitus ⬇️

The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes

The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose

The effect of a bile acid sequestrant on glucose metabolism in subjects with type 2 diabetes

The effect of vagal nerve blockade using electrical impulses on glucose metabolism in nondiabetic subjects

The oral minimal model method

Three hours of intermittent hypoxia increases circulating glucose levels in healthy adults