List of works - Barry R O'Keefe

(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks

scientific article published on 18 January 2017

A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity

scientific article published on 06 June 2016

A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium

scientific article

Acetophenone Monomers from Acronychia trifoliolata.

scientific article

Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models

scientific article

Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge Astrosclera willeyana

scientific article published on 24 June 2021

An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis

scientific article

An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures

scientific article published on 23 November 2020

Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines

scientific article published on 04 March 2019

Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas foetus in a Mouse Vaginal Model

scientific article

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

scientific article

Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus

scientific article

Antiviral lectins: Selective inhibitors of viral entry

scientific article

Atomic-resolution crystal structure of the antiviral lectin scytovirin

scientific article

Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site

scientific article

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

scientific article published in May 2010

Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae

scientific article

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

scientific article published on 06 October 2020

Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses

scientific article published in 2021

Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors ⬇️

scientific article published on August 14, 2012

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

scientific article

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa.

scientific article published on 29 December 2017

Creating and screening natural product libraries

scientific article published on 18 March 2020

Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine

scientific article

Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin

scientific article

Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus

scientific article

Cyclonellin, a new cyclic octapeptide from the marine sponge Axinella carteri

scientific article published on 01 March 2004

Cytotoxic Metabolites from an Australian Collection of the SpongeJaspisSpecies

scientific article published on 26 July 2002

Design and initial characterization of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N.

scientific article published in February 2002

Development of a fluorescent microplate assay for determining cyanovirin-N levels in plasma

scientific article published on 27 August 2004

Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses

scientific article

Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor

scientific article published on 4 November 2015

Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. ⬇️

scientific article published on 14 October 2008

Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.

scientific article

Encoded Fiber‐Optic Microsphere Arrays for Probing Protein–Carbohydrate Interactions ⬇️

scientific article published on November 10, 2003

Engineering DNA topology with locked nucleosides: a structural study

scientific article

Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV

scientific article published on 9 January 2015

Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens

scientific article published on 10 December 2018

Gene-silencing suppressors for high-level production of the HIV-1 entry inhibitor griffithsin in Nicotiana benthamiana

scientific article published on 10 April 2018

Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge

scientific article published on 10 February 2020

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus

scientific article

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

scientific article published in Nature Communications

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

scientific article published on 23 January 2015

Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture

scientific article published on 04 November 2020

Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta

scientific article published on 29 November 2018

High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41.

scientific article published in April 2002

Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1)

article published in 2017

Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays

scientific article

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen

scientific article published on 12 February 2008

India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base.

scientific article

Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor

scientific article

Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate

scientific article (publication date: 2011)

Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea

scientific article published on June 2004

Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp

scientific article

Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia

scientific article published on 05 November 2019

Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina

scientific article published on 27 March 2017

Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

scientific article

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN.

scientific article published on 15 August 2013

Molecular Genomic Features Associated with in Vitro Response of the NCI-60 Cancer Cell Line Panel to Natural Products

scientific article published on 09 November 2020

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

scientific article

Multisite and multivalent binding between cyanovirin-N and branched oligomannosides: calorimetric and NMR characterization

scientific article

NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening

scientific article published on 13 June 2018

NMR characterization of rearranged staurosporine aglycone analogues from the marine sponge Damiria sp

scientific article published on 04 August 2019

National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library

scientific article published on 07 April 2020

Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions

scientific article

Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium

scientific article

Potent anti-HIV activity of scytovirin domain 1 peptide.

scientific article

Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin

scientific article

Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis

scientific article published on 24 September 2019

Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides

scientific article published on March 2004

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I

scientific article published on 02 December 2020

Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.

scientific article

Results of a phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel

scientific article published on 20 January 2022

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV.

scientific article published on 23 January 2016

Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea ⬇️

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

scientific article

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities

scientific article published on 02 January 2019

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

scientific article published on 6 April 2018

Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from Cryptocarya laevigata

scientific article published on 23 August 2019

Stable Vindoline Production in Transformed Cell Cultures ofCatharanthus roseus

scientific article published on 26 July 2002

Structure elucidation and absolute configuration of metabolites from the soil-derived fungus Dictyosporium digitatum using spectroscopic and computational methods

scientific article published on 17 February 2020

Structure of a lectin from the sea mussel Crenomytilus grayanus (CGL).

scientific article

Structure-activity analysis of vinylogous urea inhibitors of human immunodeficiency virus-encoded ribonuclease H.

scientific article

Structures of the complexes of a potent anti-HIV protein cyanovirin-N and high mannose oligosaccharides

scientific article

Suberitamides A-C, Aryl Alkaloids from a Pseudosuberites sp. Marine Sponge that Inhibit Cbl-b Ubiquitin Ligase Activity

scientific article published on 28 October 2020

Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii

scientific article published on 25 September 2009

Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors ⬇️

scientific article published on April 26, 2012

Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas

scientific article published on 17 December 2019

The NCI library of traditional Chinese medicinal plant extracts - Preliminary assessment of the NCI-60 activity and chemical profiling of selected species

scientific article published on 03 August 2019

The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation

scientific article published on 30 May 2019

The Novel Fold of Scytovirin Reveals a New Twist For Antiviral Entry Inhibitors

scientific article

The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites

scientific article published on 17 September 2010

The canSAR data hub for drug discovery.

scientific article

The cyanobacterial lectin scytovirin displays potent in vitro and in vivo activity against Zaire Ebola virus

scientific article

The domain-swapped dimer of cyanovirin-N is in a metastable folded state: reconciliation of X-ray and NMR structures

scientific article

The lectins griffithsin, cyanovirin-N and scytovirin inhibit HIV-1 binding to the DC-SIGN receptor and transfer to CD4(+) cells

scientific article published on 29 December 2011

Topology of the disulfide bonds in the antiviral lectin scytovirin

scientific article

Treatment of influenza A (H1N1) virus infections in mice and ferrets with cyanovirin-N.

scientific article

Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea

scientific article published on 10 July 2020

US National Cancer Institute-China Collaborative Studies on Chinese Medicine and Cancer.

scientific article published in November 2017

Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.

scientific article

Unexpected synergistic HIV neutralization by a triple microbicide produced in rice endosperm

article published in the Proceedings of the National Academy of Sciences of the United States of America

Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris

scientific article published on 27 February 2020

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity

scientific article

List of works by Barry R O'Keefe

(-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks

A Designed "Nested" Dimer of Cyanovirin-N Increases Antiviral Activity

A potent novel anti-HIV protein from the cultured cyanobacterium Scytonema varium

Acetophenone Monomers from Acronychia trifoliolata.

Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models

Agelasine Diterpenoids and Cbl-b Inhibitory Ageliferins from the Coralline Demosponge Astrosclera willeyana

An HIV RNase H inhibitory 1,3,4,5-tetragalloylapiitol from the African plant Hylodendron gabunensis

An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures

Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines

Anti-Retroviral Lectins Have Modest Effects on Adherence of Trichomonas vaginalis to Epithelial Cells In Vitro and on Recovery of Tritrichomonas foetus in a Mouse Vaginal Model

Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species.

Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus

Antiviral lectins: Selective inhibitors of viral entry

Atomic-resolution crystal structure of the antiviral lectin scytovirin

Binding of the mannose-specific lectin, griffithsin, to HIV-1 gp120 exposes the CD4-binding site

Broad-Spectrum In Vitro Activity and In Vivo Efficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the Family Coronaviridae

Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells

Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses

Correction to Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors ⬇️

Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa

Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa.

Creating and screening natural product libraries

Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine

Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin

Cyanovirin-N binds to the viral surface glycoprotein, GP1,2 and inhibits infectivity of Ebola virus

Cyclonellin, a new cyclic octapeptide from the marine sponge Axinella carteri

Cytotoxic Metabolites from an Australian Collection of the SpongeJaspisSpecies

Design and initial characterization of a circular permuted variant of the potent HIV-inactivating protein cyanovirin-N.

Development of a fluorescent microplate assay for determining cyanovirin-N levels in plasma

Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses

Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor

Discovery of new pyridoacridine alkaloids from Lissoclinum cf. badium that inhibit the ubiquitin ligase activity of Hdm2 and stabilize p53. ⬇️

Domain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.

Encoded Fiber‐Optic Microsphere Arrays for Probing Protein–Carbohydrate Interactions ⬇️

Engineering DNA topology with locked nucleosides: a structural study

Engineering soya bean seeds as a scalable platform to produce cyanovirin-N, a non-ARV microbicide against HIV

Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens

Gene-silencing suppressors for high-level production of the HIV-1 entry inhibitor griffithsin in Nicotiana benthamiana

Griffithsin Inhibits Nipah Virus Entry and Fusion and Can Protect Syrian Golden Hamsters From Lethal Nipah Virus Challenge

Griffithsin and Carrageenan Combination To Target Herpes Simplex Virus 2 and Human Papillomavirus

Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

Griffithsin tandemers: flexible and potent lectin inhibitors of the human immunodeficiency virus

Hantavirus Infection Is Inhibited by Griffithsin in Cell Culture

Harnessing Natural Product Diversity for Fluorophore Discovery: Naturally Occurring Fluorescent Hydroxyanthraquinones from the Marine Crinoid Pterometra venusta

High throughput screening for cyanovirin-N mimetics binding to HIV-1 gp41.

Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1)

Identification of biologically active, HIV TAR RNA-binding small molecules using small molecule microarrays

Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen

India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base.

Influenza A (H1N1) virus resistance to cyanovirin-N arises naturally during adaptation to mice and by passage in cell culture in the presence of the inhibitor

Investigation of griffithsin's interactions with human cells confirms its outstanding safety and efficacy profile as a microbicide candidate

Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea

Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp

Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia nymphaeifolia

Macrophilone A: Structure Elucidation, Total Synthesis, and Functional Evaluation of a Biologically Active Iminoquinone from the Marine Hydroid Macrorhynchia philippina

Mannose-rich glycosylation patterns on HIV-1 subtype C gp120 and sensitivity to the lectins, Griffithsin, Cyanovirin-N and Scytovirin

Mechanisms of HIV-1 subtype C resistance to GRFT, CV-N and SVN.

Molecular Genomic Features Associated with in Vitro Response of the NCI-60 Cancer Cell Line Panel to Natural Products

Monomerization of Viral Entry Inhibitor Griffithsin Elucidates the Relationship between Multivalent Binding to Carbohydrates and anti-HIV Activity

Multisite and multivalent binding between cyanovirin-N and branched oligomannosides: calorimetric and NMR characterization

NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening

NMR characterization of rearranged staurosporine aglycone analogues from the marine sponge Damiria sp

National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library

Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions

Overexpression and purification of scytovirin, a potent, novel anti-HIV protein from the cultured cyanobacterium Scytonema varium

Potent anti-HIV activity of scytovirin domain 1 peptide.

Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin

Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis

Probing protein-carbohydrate interactions with microarrays of synthetic oligosaccharides

Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I

Resistance of human immunodeficiency virus type 1 to the high-mannose binding agents cyanovirin N and concanavalin A.

Results of a phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel

Rice endosperm is cost-effective for the production of recombinant griffithsin with potent activity against HIV.

Roseabol A, a New Peptaibol from the Fungus Clonostachys rosea ⬇️

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

Secondary Metabolites from the Fungus Dictyosporium sp. and Their MALT1 Inhibitory Activities

Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata.

Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from Cryptocarya laevigata