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List of works by Leif Nelin

A Proactive Approach to Neonates Born at 23 Weeks of Gestation

scientific article

A multidisciplinary quality improvement effort to reduce bronchopulmonary dysplasia incidence

scientific article published on 06 January 2020

A single nucleotide polymorphism in the dimethylarginine dimethylaminohydrolase gene is associated with lower risk of pulmonary hypertension in bronchopulmonary dysplasia

scientific article published on 10 December 2015

Alterations of the thioredoxin system by hyperoxia: implications for alveolar development.

scientific article published on 24 February 2009

An arginase-1 SNP that protects against the development of pulmonary hypertension in bronchopulmonary dysplasia enhances NO-mediated apoptosis in lymphocytes

scientific article published on November 2016

Apgar Score at 5 Minutes Is Associated with Mortality in Extremely Preterm Infants Even after Transfer to an All Referral NICU.

scientific article published on 9 June 2015

Arginase II is a target of miR-17-5p and regulates miR-17-5p expression in human pulmonary artery smooth muscle cells.

scientific article published on 30 May 2014

Arginase and α-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia.

scientific article published on 20 December 2017

Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells.

scientific article published on 20 February 2004

Assessing heparin dosing in neonates on venoarterial extracorporeal membrane oxygenation

scientific article published on 01 January 2007

Asymmetric dimethylarginine does not inhibit arginase activity and is pro-proliferative in pulmonary endothelial cells

scientific article

Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia

scientific article published on 30 June 2022

Cancer in pregnancy: fetal and neonatal outcomes

scientific article published on December 2011

Cerebral Oxygenation and Autoregulation in Preterm Infants (Early NIRS Study)

scientific article published on 17 August 2020

Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine

scientific article published on 26 October 2012

Cyclooxygenase-2 in newborn hyperoxic lung injury

scientific article published on 25 April 2013

Cytokine-induced arginase activity in pulmonary endothelial cells is dependent on Src family tyrosine kinase activity

scientific article published on 11 July 2008

Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor

scientific article published on 30 June 2005

DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells.

scientific article

Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury

scientific article published on 10 January 2019

Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin

scientific article

Developmental differences in pulmonary eNOS expression in response to chronic hypoxia in the rat.

scientific article published in July 2002

Developmental outcomes of very preterm infants with tracheostomies.

scientific article

Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen

scientific article published on January 2009

Disappointing results: a call to action.

scientific article

Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine

scientific article published on 01 December 2010

Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis

article

Early extubation attempts reduce length of stay in extremely preterm infants even if re-intubation is necessary

scientific article published in July 2015

Effect of Docosahexaenoic Acid Supplementation vs Placebo on Developmental Outcomes of Toddlers Born Preterm: A Randomized Clinical Trial

scientific article published on 01 December 2018

Effects of practice change on outcomes of extremely preterm infants with patent ductus arteriosus

scientific article published on 14 June 2018

Endothelin type A receptor antagonist normalizes blood pressure in rats exposed to eucapnic intermittent hypoxia

scientific article published on 30 May 2008

Exhaled NO is reduced at an early stage of hypoxia-induced pulmonary hypertension in newborn piglets

scientific article published on 8 November 2002

Extracellular signal-regulated kinase mediates expression of arginase II but not inducible nitric-oxide synthase in lipopolysaccharide-stimulated macrophages

scientific article

Factors Associated with Neurodevelopmental Impairment in Bronchopulmonary Dysplasia

scientific article published on 08 January 2020

Factors associated with long-term mechanical ventilation in extremely preterm infants

scientific article published on 01 January 2018

Factors associated with maternal visitation and participation in skin-to-skin care in an all referral level IIIc NICU.

scientific article published on 27 November 2012

Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells

scientific article

Glutathione Reductase Facilitates Host Defense by Sustaining Phagocytic Oxidative Burst and Promoting the Development of Neutrophil Extracellular Traps ⬇️

scientific article published on January 25, 2012

Glutathione Reductase Promotes Fungal Clearance and Suppresses Inflammation during Systemic Candida albicans Infection in Mice

scientific article published on 09 September 2019

Glutathione reductase is essential for host defense against bacterial infection

scientific article published on 24 April 2013

Guyana's paediatric training program: a global health partnership for medical education

scientific article

Hospital variation in nitric oxide use for premature infants

scientific article published on 12 March 2012

How to decrease bronchopulmonary dysplasia in your neonatal intensive care unit today and "tomorrow".

scientific article

Hyperoxia increases hepatic arginase expression and ornithine production in mice

scientific article published on 22 March 2006

Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKα1 signaling

scientific article published on 17 February 2017

Hypoxia promotes human pulmonary artery smooth muscle cell proliferation through induction of arginase

scientific article published on 2 October 2009

Hypoxia-induced proliferation of HeLa cells depends on epidermal growth factor receptor-mediated arginase II induction

scientific article

Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation

scientific article

Hypoxia-induced pulmonary endothelin-1 expression is unaltered by nitric oxide

scientific article published in March 2002

Hypoxic Proliferation of Osteosarcoma Cells Depends on Arginase II.

scientific article published on August 2016

Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells

scientific article published on 10 February 2017

Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells.

scientific article published in May 2018

Immunostimulated Arginase II Expression in Intestinal Epithelial Cells Reduces Nitric Oxide Production and Apoptosis

scientific article published on March 2017

Impact of Process Optimization and Quality Improvement Measures on Neonatal Feeding Outcomes at an All-Referral Neonatal Intensive Care Unit

scientific article published on 2 March 2015

Improving publication rates in a collaborative clinical trials research network

scientific article published on 13 July 2016

In Reply

In Response to Letter from Altit, Basso, Grandi, and Yang

scientific article published on 24 May 2018

In vitro evaluation of radio-labeled aerosol delivery via a variable-flow infant CPAP system

scientific article published on 06 August 2013

Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice

scientific article

Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1.

scientific article published on 03 August 2009

Infant Pulmonary Function Testing and Phenotypes in Severe Bronchopulmonary Dysplasia

scientific article published on 05 April 2018

Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibility randomized clinical trials

scientific article published on 12 December 2014

Inhaled nitric oxide decreases leukocyte trafficking in the neonatal mouse lung during exposure to >95% oxygen

scientific article

Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response

Inhaled nitric oxide prevents 3-nitrotyrosine formation in the lungs of neonatal mice exposed to >95% oxygen

scientific article

Inhaled nitric oxide usage in preterm infants in the NICHD Neonatal Research Network: inter-site variation and propensity evaluation

scientific article

Inter-center variation in death or tracheostomy placement in infants with severe bronchopulmonary dysplasia.

scientific article

Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia

scientific article published on 28 November 2016

Intratracheal adenoviral-mediated delivery of iNOS decreases pulmonary vasoconstrictor responses in rats

scientific article published on 16 July 2004

Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria

scientific article published on 01 April 2007

Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.

scientific article

L-Arginine uptake and metabolism following in vivo silica exposure in rat lungs

scientific article published in March 2002

L-arginine infusion lowers blood pressure in children.

scientific article published in November 2001

L-lysine decreases nitric oxide production and increases vascular resistance in lungs isolated from lipopolysaccharide-treated neonatal pigs

scientific article

Lipopolysaccharide-induced cyclooxygenase-2 expression in mouse transformed Clara cells

scientific article

Lung development alterations in newborn mice after recovery from exposure to sublethal hyperoxia.

scientific article published on 8 February 2014

MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock

scientific article

MAPK phosphatases--regulating the immune response

scientific article published on March 2007

MKP-1 is a target of miR-210 and mediate the negative regulation of miR-210 inhibitor on hypoxic hPASMC proliferation

scientific article

MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.

scientific article published on 18 April 2007

Maturational changes in the regulation of pulmonary vascular tone by nitric oxide in neonatal rats

scientific article published on 7 September 2007

Mean airway pressure and response to inhaled nitric oxide in neonatal and pediatric patients.

scientific article published in November 2005

Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide

scientific article published on 30 December 2005

Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia

scientific article

Mid-term differences in right ventricular function in patients with congenital diaphragmatic hernia compared with controls

scientific article published on 15 November 2012

Milrinone in congenital diaphragmatic hernia - a randomized pilot trial: study protocol, review of literature and survey of current practices.

scientific article published on 27 November 2017

Mitogen-activated protein kinase phosphatase-1 prevents lipopolysaccharide-induced apoptosis in immature rat intestinal epithelial cells

scientific article published on 7 May 2015

Multicenter crossover study of automated control of inspired oxygen in ventilated preterm infants

scientific article published on 27 December 2010

Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells

scientific article published on 01 September 2020

Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells

scientific article

Nitric oxide-dependent pulmonary vasodilation in polycythemic rats

scientific article published on 01 November 2000

Noninvasive inhaled nitric oxide does not prevent bronchopulmonary dysplasia in premature newborns

scientific article published on 22 July 2014

Novel biomarkers of bronchopulmonary dysplasia and bronchopulmonary dysplasia-associated pulmonary hypertension

scientific article published on 18 August 2020

Outcomes following a comprehensive versus a selective approach for infants born at 22 weeks of gestation

article

Overexpression of cationic amino acid transporter-1 increases nitric oxide production in hypoxic human pulmonary microvascular endothelial cells

scientific article published on December 2011

Pharmacologic agents elevating cAMP prevent arginase II expression and proliferation of pulmonary artery smooth muscle cells

scientific article

Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension

scientific article published on 11 October 2014

Post-translational regulation of mitogen-activated protein kinase phosphatase (MKP)-1 and MKP-2 in macrophages following lipopolysaccharide stimulation: the role of the C termini of the phosphatases in determining their stability

scientific article

Predicting survival in infants born at <27 weeks gestation admitted to an all referral neonatal intensive care unit: a pilot study

scientific article published on 20 February 2020

Prediction of short-term neonatal complications in preterm infants using exome-wide genetic variation and gestational age: a pilot study

scientific article published on 05 February 2020

Preterm Birth, Bronchopulmonary Dysplasia, and Long-Term Respiratory Disease

scientific article published in August 2017

Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants

scientific article published on 30 July 2018

Pulmonary Vein Stenosis in Neonates with Severe Bronchopulmonary Dysplasia

scientific article published on 10 February 2016

Representativeness of enrollment into a perinatal research repository

scientific article published on 12 August 2014

Respiratory severity score on day of life 30 is predictive of mortality and the length of mechanical ventilation in premature infants with protracted ventilation

scientific article published on 10 March 2014

Role of endothelin in intermittent hypoxia-induced hypertension

scientific article published in February 2001

Spatiotemporal characteristics of acid refluxate and relationship to symptoms in premature and term infants with chronic lung disease

scientific article published in March 2008

The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year

scientific article published on 29 August 2018

The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells

scientific article

The effect of inhaled nitric oxide and oxygen on the hydroxylation of salicylate in rat lungs

scientific article

The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia

scientific article published on 21 September 2008

The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.

scientific article

The use of inhaled corticosteroids in chronically ventilated preterm infants

scientific article published on 30 July 2017

Therapeutic interventions and short-term outcomes for infants with severe bronchopulmonary dysplasia born at <32 weeks' gestation

scientific article published on 04 July 2013

Tissue Doppler changes in three neonates with congenital diaphragmatic hernia

scientific article published on 01 July 2009

Triptolide induces anti-inflammatory cellular responses.

scientific article published on 05 March 2009

Using clinical and genetic data to predict pulmonary hypertension in bronchopulmonary dysplasia

scientific article published on 01 December 2018

Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia

scientific article published on 30 September 2019

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