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List of works by Susan E Bates

A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days.

scientific article published in May 2005

A Phase I study of infusional vinblastine in combination with the P-glycoprotein antagonist PSC 833 (valspodar).

scientific article published on September 2001

A Serial Analysis of Gene Expression (SAGE) database analysis of chemosensitivity: comparing solid tumors with cell lines and comparing solid tumors from different tissue origins.

scientific article published in April 2004

A database study that identifies genes whose expression correlates, negatively or positively, with 5-year survival of cancer patients

scientific article published on 25 January 2007

A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax(®)).

scientific article

A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).

scientific article published in June 2001

A high-throughput cell-based assay for inhibitors of ABCG2 activity

scientific article published on 20 February 2006

A millennium goal for cancer

scientific article published on 01 February 2012

A novel approach to assess real-world efficacy of cancer therapy in metastatic prostate cancer. Analysis of national data on Veterans treated with abiraterone and enzalutamide

scientific article published on 01 August 2019

A pharmacodynamic study of docetaxel in combination with the P-glycoprotein antagonist tariquidar (XR9576) in patients with lung, ovarian, and cervical cancer.

scientific article

A pharmacodynamic study of the P-glycoprotein antagonist CBT-1® in combination with paclitaxel in solid tumors.

scientific article published on 13 March 2012

A phase I study of the P-glycoprotein antagonist tariquidar in combination with vinorelbine

scientific article

A phase I/II study of infusional vinblastine with the P-glycoprotein antagonist valspodar (PSC 833) in renal cell carcinoma

scientific article

A phase II clinical trial of ixabepilone (Ixempra; BMS-247550; NSC 710428), an epothilone B analog, in patients with metastatic renal cell carcinoma

scientific article published on 23 February 2010

A phase II trial of combination chemotherapy and surgical resection for the treatment of metastatic adrenocortical carcinoma: continuous infusion doxorubicin, vincristine, and etoposide with daily mitotane as a P-glycoprotein antagonist.

scientific article

A phase i study of DMS612, a novel bifunctional alkylating agent

scientific article

A pilot study of amiodarone with infusional doxorubicin or vinblastine in refractory breast cancer

scientific article published in January 1995

A population pharmacokinetic/toxicity model for the reduction of platelets during a 48-h continuous intravenous infusion of the histone deacetylase inhibitor belinostat

scientific article published on 27 June 2018

A sea change in melanoma

scientific article

ABC Transporters: Unvalidated Therapeutic Targets in Cancer and the CNS ⬇️

scientific article published on October 1, 2010

ABC transporters and inhibitors: new targets, new agents.

scientific article

ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates

scientific article published on September 2005

ABCG2 mediates differential resistance to SN-38 (7-ethyl-10-hydroxycamptothecin) and homocamptothecins

scientific article published on 9 April 2004

ABCG2-mediated transport of photosensitizers: potential impact on photodynamic therapy

scientific article published on 8 February 2005

ABCG2: a perspective.

scientific article

ABCG2: determining its relevance in clinical drug resistance

scientific article published on March 2007

ABCG2: structure, function and role in drug response

scientific article published on 01 January 2008

ANG1005 for breast cancer brain metastases: correlation between 18F-FLT-PET after first cycle and MRI in response assessment.

scientific article

ATM inhibition overcomes resistance to histone deacetylase inhibitor due to p21 induction and cell cycle arrest

scientific article published on 15 September 2020

Aberrant promoter methylation of the ABCG2 gene in renal carcinoma

scientific article

Accrual, Publication Bias, and the Coronavirus in 2020

scientific article published on 27 May 2020

Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.

scientific article

Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene

scientific article

Adjuvant and neoadjuvant cancer therapies: A historical review and a rational approach to understand outcomes

scientific article published on 26 January 2019

Adrenocortical Cancer: A Molecularly Complex Disease Where Surgery Matters

scientific article published on October 2016

Advancing Clinical Trials to Streamline Drug Development

scientific article published in October 2015

Altered gene expression in drug-resistant human breast cancer cells.

scientific article published in December 1997

Amplification of 4q21-q22 and the MXR gene in independently derived mitoxantrone-resistant cell lines

scientific article published on January 2000

An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding domain

scientific article

An information-intensive approach to the molecular pharmacology of cancer.

scientific article published on January 1997

Analyzing the pivotal trial that compared sunitinib and IFN-α in renal cell carcinoma, using a method that assesses tumor regression and growth.

scientific article published on 17 February 2012

Anti-epidermal growth factor receptor antibodies inhibit the autocrine-stimulated growth of MDA-468 human breast cancer cells

scientific article published in November 1989

Antibody Conjugates: The Future Is Now ⬇️

scientific article published on October 15, 2011

Application of a human multidrug transporter (ABCG2) variant as selectable marker in gene transfer to progenitor cells

scientific article published in March 2003

Arginine 383 is a crucial residue in ABCG2 biogenesis

scientific article

Arsenic trioxide (As(2)O(3)): still a mystery

scientific article published on 01 May 2002

Assessing the Eventual Publication of Clinical Trial Abstracts Submitted to a Large Annual Oncology Meeting

scientific article published on 17 February 2016

Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib

scientific article published on August 2006

Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients.

scientific article published on 29 March 2007

Autoantibody cancer biomarker: extracellular protein kinase A

scientific article published on 01 September 2006

BRCA Mutations in Pancreas Cancer: Spectrum, Current Management, Challenges and Future Prospects

scientific article published on 23 April 2020

Base Pairs to Populations

scientific article published on 01 June 2017

Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells

scientific article published on 09 January 2009

Bevacizumab reduces the growth rate constants of renal carcinomas: a novel algorithm suggests early discontinuation of bevacizumab resulted in a lack of survival advantage

scientific article published on 30 September 2008

Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras.

scientific article published on 13 September 2016

Botryllamide G is an ABCG2 inhibitor that improves lapatinib delivery in mouse brain

scientific article published on 10 November 2019

Botryllamides: natural product inhibitors of ABCG2

scientific article published in August 2009

Brain-derived neurotrophic factor protects neuroblastoma cells from vinblastine toxicity

scientific article published in August 1996

Bryostatin 1 affects P-glycoprotein phosphorylation but not function in multidrug-resistant human breast cancer cells

CCR 20th Anniversary Commentary: Expanding the Epigenetic Therapeutic Portfolio.

scientific article published in May 2015

CCR focus: breast cancer

scientific article published on 01 December 2008

Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells

scientific article

Cardiac involvement with lymphoma: a review of the literature

scientific article

Cardiac studies in patients treated with depsipeptide, FK228, in a phase II trial for T-cell lymphoma

scientific article published on 01 June 2006

Central nervous system malignancies: what next?

scientific article

Central nervous system metastasis from breast cancer

scientific article

Challenges of evaluating the cardiac effects of anticancer agents

scientific article published on 01 July 2006

Changing the paradigms of treatment in peripheral T-cell lymphoma: from biology to clinical practice.

scientific article published in October 2014

Characterization of ABCG2 gene amplification manifesting as extrachromosomal DNA in mitoxantrone-selected SF295 human glioblastoma cells.

scientific article published on July 2005

Characterization of estrogen responsive transforming activity in human breast cancer cell lines

scientific article published in April 1986

Chemoresistance in the clinic: overview 1994.

scientific article published on December 1994

Cisplatin Every 3 Weeks Versus Weekly With Definitive Concurrent Radiotherapy for Squamous Cell Carcinoma of the Head and Neck

scientific article published on 01 May 2019

Cisplatin versus cetuximab with definitive concurrent radiotherapy for head and neck squamous cell carcinoma: An analysis of veterans health affairs data

article

Clinical Reversal of Multidrug Resistance

scientific article published on 01 January 1996

Clinical Toxicities of Histone Deacetylase Inhibitors

scientific article

Clinical reversal of multidrug resistance

scientific article published on 01 January 1996

Clinical trial results: Sharing results, speeding discoveries

scientific article published in January 2013

Clinical trial results: a clinical trial bazaar!

scientific article published on 25 March 2014

Clinical trials: New drug for pancreatic cancer highlights the dual effect of regulatory approvals

scientific article published on 23 February 2016

Coexpression of TGF alpha, epidermal growth factor receptor, and P-glycoprotein in normal and benign diseased breast tissues

scientific article published on 01 June 1995

Commentary: troublesome words, linguistic precision, and medical oncology

scientific article published on April 2009

Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib

scientific article

Comparison of urinary transforming growth factor-alpha in women with disseminated breast cancer and healthy control women

scientific article published on 01 January 1991

Conflict of Interest: An Ethical Firestorm with Consequences for Cancer Research

article

Continuing a cancer treatment despite tumor growth may be valuable: sunitinib in renal cell carcinoma as example

scientific article

Contribution of glutathione and glutathione-dependent enzymes in the reversal of adriamycin resistance in colon carcinoma cell lines ⬇️

scientific article published on November 11, 1991

Controlled trial of dexverapamil, a modulator of multidrug resistance, in lymphomas refractory to EPOCH chemotherapy ⬇️

scientific article published on 01 August 1995

Current challenges in the management of breast cancer brain metastases

scientific article published in April 2017

DNA repair: a reinvigorated therapeutic target

scientific article published on 07 September 2010

Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors

scientific article published on August 2005

Detection of in vivo P-glycoprotein inhibition by PSC 833 using Tc-99m sestamibi

scientific article published on 01 April 1997

Determination of the cyclic depsipeptide FK228, a histone deacetylase inhibitor, by liquid chromatography-mass spectrometry

scientific article

Differential effects of the breast cancer resistance protein on the cellular accumulation and cytotoxicity of 9-aminocamptothecin and 9-nitrocamptothecin

scientific journal article

Differential expression of cell adhesion genes: implications for drug resistance

scientific article

Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines

scientific article

Differential modulation of P-glycoprotein transport by protein kinase inhibition ⬇️

scientific article published on September 7, 1993

Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family.

scientific article published on January 2002

Disruptive Immunology

scientific article published on 01 April 2016

Downregulation of mdr-1 expression by 8-Cl-cAMP in multidrug resistant MCF-7 human breast cancer cells

scientific article

Drug development: portals of discovery

scientific article

Drug resistance in adult lymphomas

scientific article published on January 1994

Drug resistance: Still a daunting challenge to the successful treatment of AML ⬇️

scientific article published on February 1, 2012

Drugs that target the stemness pathways

scientific article published on 08 June 2010

EPOCH chemotherapy: toxicity and efficacy in relapsed and refractory non-Hodgkin's lymphoma ⬇️

scientific article published on August 1, 1993

EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR

scientific article

Editor's Note …Clinical Trial Reports: A New Section ⬇️

scientific article published on January 1, 2012

Effect of a histone deacetylase inhibitor on human cardiac mass

scientific article published on 01 January 2005

Effect of common CYP3A4 and CYP3A5 variants on the pharmacokinetics of the cytochrome P450 3A phenotyping probe midazolam in cancer patients

scientific article published in October 2005

Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies

scientific article published on 2 February 2016

Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer.

scientific article

Effects of p53-expressing adenovirus on the chemosensitivity and differentiation of anaplastic thyroid cancer cells

scientific article

Efflux of rhodamine from CD56+ cells as a surrogate marker for reversal of P-glycoprotein-mediated drug efflux by PSC 833

scientific article published on 01 January 1999

Electrocardiographic studies of romidepsin demonstrate its safety and identify a potential role for K(ATP) channel.

scientific article published on 15 April 2013

Emerging Therapeutic Implications of STK11 Mutation: Case Series

scientific article published on 12 May 2020

Endocrine Cancers: Defying the Paradigms

scientific article

Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228.

scientific article published in September 2001

Entinostat finds a path: A new study elucidates effects of the histone deacetylase inhibitor on the immune system

scientific article published on 13 November 2018

Epidermal growth factor receptor (EGFR) inhibitor PD153035 reverses ABCG2-mediated multidrug resistance in non-small cell lung cancer: In vitro and in vivo

scientific article published on 5 March 2018

Epidermal growth factor receptor inhibitors: a moving target?

scientific article published in October 2005

Epigenetic Therapies for Cancer

scientific article published on 01 August 2020

Epigenetic modifiers: basic understanding and clinical development.

scientific article

Epigenetic therapies reach main street

scientific article published on 01 June 2009

Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2-mediated drug resistance

scientific article published on November 2007

Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2.

scientific article published on October 2009

Estimation of tumour regression and growth rates during treatment in patients with advanced prostate cancer: a retrospective analysis

scientific article published on 12 December 2016

Evidence for microtubule target engagement in tumors of patients receiving ixabepilone

scientific article published on December 2007

Exploring the Impact of Dust on North Atlantic Hurricanes in a High‐Resolution Climate Model

scientific article published in 2019

Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia.

scientific article

Expression of a drug resistance gene in human neuroblastoma cell lines: modulation by retinoic acid-induced differentiation

scientific article published on October 1989

Expression of the multidrug resistance-associated protein gene in refractory lymphoma: quantitation by a validated polymerase chain reaction assay

scientific article published on 01 May 1997

Expression of the transforming growth factor-alpha/epidermal growth factor receptor pathway in normal human breast epithelial cells

scientific article

Expression of transforming growth factor alpha and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance

scientific article published in June 1988

FR901228 causes mitotic arrest but does not alter microtubule polymerization

scientific article published on 01 July 2000

Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.

scientific article published on June 2005

Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2

scientific article published on 28 January 2011

From the Editor

scientific article published on 01 December 2009

From the editor. Bridging the gap between biostatistician and oncologist

scientific article published on 01 October 2008

From the editor. Translational Research Working Group roadmaps for cancer research

scientific article published on 01 September 2008

Future perspectives for the development of P-glycoprotein modulators

scientific article published on January 1998

Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen

scientific article

Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors ⬇️

scientific article published on March 1, 1998

Gout, genetics and ABC transporters.

scientific article published on November 2011

Histone deacetylase inhibitor FR901228 enhances adenovirus infection of hematopoietic cells

scientific article published in March 2002

Histone deacetylase inhibitor-mediated cell death is distinct from its global effect on chromatin

scientific article

Histone deacetylase inhibitors all induce p21 but differentially cause tubulin acetylation, mitotic arrest, and cytotoxicity.

scientific article published on September 2002

Histone deacetylase inhibitors and demethylating agents: clinical development of histone deacetylase inhibitors for cancer therapy

scientific article published on January 2007

Histone deacetylase inhibitors in combinations: will the preclinical promises be kept?

scientific article published on 01 March 2007

Histone deacetylase inhibitors induce CXCR4 mRNA but antagonize CXCR4 migration

scientific article published on 28 November 2012

Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter

scientific article

Histone deacetylase inhibitors modulate KATP subunit transcription in HL-1 cardiomyocytes through effects on cholesterol homeostasis

scientific article

Histone deacetylase inhibitors: emerging mechanisms of resistance.

scientific article published on 7 October 2011

Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells

scientific article published in January 2008

How Do Cancer Cells Die?

scientific article published on 01 November 2015

Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2.

scientific article

Identification of compounds that correlate with ABCG2 transporter function in the National Cancer Institute Anticancer Drug Screen

scientific article published on 24 July 2009

Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells.

scientific article

Impact of ABCB1 allelic variants on QTc interval prolongation

scientific article

Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells

scientific article

In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity.

scientific article published in July 2004

Increased 99mTc-sestamibi accumulation in normal liver and drug-resistant tumors after the administration of the glycoprotein inhibitor, XR9576.

scientific article

Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176).

scientific article published in March 2006

Increased epidermal growth factor receptor in an estrogen-responsive, adriamycin-resistant MCF-7 cell line

scientific article published on October 1993

Increased mdr-1/P-glycoprotein expression after treatment of human colon carcinoma cells with P-glycoprotein antagonists.

scientific article published on February 1993

Induction of CYP3A4 by Vinblastine: Role of the Nuclear Receptor NR1I2 ⬇️

scientific article published on October 19, 2010

Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478

scientific article

Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure.

scientific article

Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).

scientific article

Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

scientific article published in November 2001

Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.

scientific article

Initial pharmacokinetics and bioavailability of PSC 833, a P-glycoprotein antagonist

scientific article

Intractable cancers: the many faces of multidrug resistance and the many targets it presents for therapeutic attack

scientific article published on May 2004

Intrinsic drug resistance in primary and metastatic renal cell carcinoma

scientific article published on July 1999

It's all about the test: the complexity of companion diagnostic co-development in personalized medicine

scientific article published on 01 March 2014

Laboratory correlates for a phase II trial of romidepsin in cutaneous and peripheral T-cell lymphoma

scientific article

Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance.

scientific article published on 12 April 2014

Localization of the ABCG2 mitoxantrone resistance-associated protein in normal tissues.

scientific article published on 28 June 2005

Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells

scientific article published on 01 July 2000

Loss of the proteins Bak and Bax prevents apoptosis mediated by histone deacetylase inhibitors.

scientific article published on 07 August 2013

Low and high concentrations of the topo II inhibitor daunorubicin in NIH3T3 cells: reversible G2/M versus irreversible G1 and S arrest

scientific article published on March 1, 2003

Low concentrations of the histone deacetylase inhibitor, depsipeptide (FR901228), increase expression of the Na(+)/I(-) symporter and iodine accumulation in poorly differentiated thyroid carcinoma cells

scientific article published in July 2001

MAPK pathway activation leads to Bim loss and histone deacetylase inhibitor resistance: rationale to combine romidepsin with an MEK inhibitor

scientific article published on 26 March 2013

MDR1 (ABCB1) gene polymorphism C3435T is associated with P-glycoprotein activity in B-cell chronic lymphocytic leukemia

scientific article published on 01 September 2006

MS-27-275, an inhibitor of histone deacetylase, has marked in vitro and in vivo antitumor activity against pediatric solid tumors

scientific article published on November 2002

Measuring MDR-1 by Quantitative RT-PCR.

scientific article

Metabolic symbiosis in cancer and its therapeutic implication

scientific article published in June 2017

Metastatic and recurrent adrenocortical cancer is not defined by its genomic landscape

scientific article published on 04 November 2020

Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations

scientific article published on July 1996

Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells

scientific article published on 2 July 2012

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

scientific article

Mitotane Enhances Cytotoxicity of Chemotherapy in Cell Lines Expressing a Multidrug Resistance Gene (mdr-1/P-Glycoprotein) which is also Expressed by Adrenocortical Carcinomas ⬇️

scientific article (publication date: July 1991)

Modulation of EGF receptor expression by differentiating agents in human colon carcinoma cell lines.

scientific article published on January 1990

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

scientific article published on July 21, 1992

Modulation of multidrug resistance by dexverapamil in EPOCH-refractory lymphomas

scientific article published in January 1995

Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents.

scientific article published in October 1989

Molecular Diagnostics: Are We There Yet? ⬇️

scientific article published on March 15, 2012

Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes

scientific article

Molecular targets in the National Cancer Institute drug screen

scientific article published on January 1995

Multidrug resistance in cancer: role of ATP-dependent transporters

scientific article (publication date: 2002)

Multiple Myeloma: Multiplying Therapies

scientific article published on 01 November 2016

Multiple myeloma

scientific article published on 01 March 2011

Multispecificity of drug transporters: probing inhibitor selectivity for the human drug efflux transporters ABCB1 and ABCG2.

scientific article published on December 2007

Mutational analysis of ABCG2: role of the GXXXG motif

scientific article published on July 2004

Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.

scientific article

Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization

scientific article published in April 2006

Mutations at amino-acid 482 in the ABCG2 gene affect substrate and antagonist specificity.

scientific article published in November 2003

Neoadjuvant Treatment for Pancreatic Cancer

scientific article published on 28 December 2018

Neutrophil-to-lymphocyte ratio as a prognostic indicator for overall and cancer-specific survival in squamous cell carcinoma of the head and neck

scientific article published on 27 June 2020

New Strategies in Peripheral T-Cell Lymphoma: Understanding Tumor Biology and Developing Novel Therapies ⬇️

scientific article published on December 1, 2010

New cytotoxics in oncology. From the editor

scientific article published on 01 March 2008

New inhibitors of ABCG2 identified by high-throughput screening

scientific article

Normal p53 status and function despite the development of drug resistance in human breast cancer cells

scientific article published on 01 November 1995

Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters

scientific article published on December 2007

On Innovating and Inspiring the Clinical Trial Enterprise

scientific article

On drug development, chance, and the prepared mind

scientific article published on 01 January 2012

On masterpieces and breast cancer research

scientific article published in December 2013

Other paradigms: growth rate constants and tumor burden determined using computed tomography data correlate strongly with the overall survival of patients with renal cell carcinoma

scientific article

Overcoming resistance to DNA targeted agents by epigenetic activation of Schlafen 11 (SLFN11) expression with class I histone deacetylase inhibitors

scientific article

Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells

scientific article

Overlapping substrate and inhibitor specificity of human and murine ABCG2. ⬇️

scientific article published on 18 July 2013

P-glycoprotein expression and schedule dependence of adriamycin cytotoxicity in human colon carcinoma cell lines

scientific article published in November 1991

P-glycoprotein substrates and antagonists cluster into two distinct groups

P-glycoprotein--a clinical target in drug-refractory epilepsy?

scientific article

PARP inhibitors in BRCA1/BRCA2 germline mutation carriers with ovarian and breast cancer ⬇️

scientific article published on February 11, 2010

PD-1 Pandemonium at the American Association for Cancer Research Annual Meeting.

scientific article published in May 2019

PFS: The Endpoint We Love and Love to Hate ⬇️

scientific article published on May 15, 2013

Paclitaxel in doxorubicin-refractory or mitoxantrone-refractory breast cancer: a phase I/II trial of 96-hour infusion

scientific article

Pancreatic Cancer: "A Riddle Wrapped in a Mystery inside an Enigma".

scientific article published in April 2017

Pancreatic Cancer: Challenge and Inspiration

scientific article published on 01 April 2017

Pancreatic Cancer: Steps in the Right Direction ⬇️

scientific article published on August 15, 2012

Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma

scientific article

Phase I Study of ATR Inhibitor M6620 in Combination With Topotecan in Patients With Advanced Solid Tumors

scientific article published on 18 December 2017

Phase I Testing: 60 Years in the Making

scientific article

Phase I Trial of a New Schedule of Romidepsin in Patients with Advanced Cancers ⬇️

scientific article published on June 11, 2013

Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy ⬇️

scientific article published on August 1, 1995

Phase I clinical trials: overcoming barriers

scientific article published on 09 March 2010

Phase I study of infusional paclitaxel in combination with the P-glycoprotein antagonist PSC 833.

scientific article

Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days.

scientific article published on May 2003

Phase I trial of belinostat with cisplatin and etoposide in advanced solid tumors, with a focus on neuroendocrine and small cell cancers of the lung.

scientific article published on 7 February 2018

Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms

scientific article

Phase II Clinical Trial of Ixabepilone in Metastatic Cervical Carcinoma

scientific article published on 3 June 2015

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

scientific article

Phase II study of paclitaxel in relapsed non-Hodgkin's lymphomas

scientific article published on 01 February 1995

Pheophorbide a is a specific probe for ABCG2 function and inhibition.

scientific article published in February 2004

PolyHEMA spheroids are an inadequate model for the drug resistance of the intractable solid tumors.

scientific article published on 9 January 2008

Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma

scientific article published on February 2009

Potential Pitfalls of Crossover and Thoughts on Iniparib in Triple-Negative Breast Cancer ⬇️

scientific article published on December 7, 2011

Preclinical pharmacologic evaluation of pralatrexate and romidepsin confirms potent synergy of the combination in a murine model of human T-cell lymphoma

scientific article

Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs

scientific article

Prevention of Venous Thromboembolism in Pancreatic Cancer: Breaking Down a Complex Clinical Dilemma

scientific article published on 01 October 2019

Production of and responsiveness to transforming growth factor-beta in normal and oncogene-transformed human mammary epithelial cells

scientific article published in November 1989

Progress in Pediatric Cancer ⬇️

scientific article published on May 15, 2012

Prostate Cancer: Score One for Validated Targets ⬇️

scientific article published on June 15, 2011

Publish or Perish v2

scientific article published on 07 May 2019

Quit early, quit often

scientific article published on 01 May 2015

Randomized Phase III Trial of Pegvorhyaluronidase Alfa With Nab-Paclitaxel Plus Gemcitabine for Patients With Hyaluronan-High Metastatic Pancreatic Adenocarcinoma

scientific article published on 24 July 2020

Rapid detection of ABC transporter interaction: potential utility in pharmacology.

scientific article

Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy: a case series report

scientific article published on 16 July 2009

Reduced drug accumulation and multidrug resistance in human breast cancer cells without associated P-glycoprotein or MRP overexpression

scientific article published on June 1997

Reduced expression of DNA topoisomerase I in SF295 human glioblastoma cells selected for resistance to homocamptothecin and diflomotecan.

scientific article

Refining Immunotherapy Approvals

scientific article published in September 2017

Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line.

scientific article published on 23 June 2008

Reinventing Cancer Cell Metabolism ⬇️

scientific article published on October 15, 2012

Relationship of EGFR mutations, expression, amplification, and polymorphisms to epidermal growth factor receptor inhibitors in the NCI60 cell lines

scientific article published on November 2007

Resistance to paclitaxel mediated by P-glycoprotein can be modulated by changes in the schedule of administration

scientific article published on January 1997

Responses to romidepsin in patients with cutaneous T-cell lymphoma and prior treatment with systemic chemotherapy.

scientific article published on 30 August 2017

Reversal of ABCB1 mediated efflux by imatinib and nilotinib in cells expressing various transporter levels.

scientific article published on 13 June 2017

Reversal of Multidrug Resistance

scientific article published on 01 January 1994

Reversal of multidrug resistance.

scientific article

Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.

scientific article published in November 1999

Revisiting the role of ABC transporters in multidrug-resistant cancer.

scientific article published on 11 April 2018

Rhodamine efflux patterns predict P-glycoprotein substrates in the National Cancer Institute drug screen.

scientific article published on October 1994

Romidepsin (FK228/depsipeptide) controls growth and induces apoptosis in neuroblastoma tumor cells

scientific article published on 15 May 2010

Romidepsin Therapy Over 5 Years in a Clinical Setting-Real-world Experience

scientific article published on 7 April 2016

Romidepsin in peripheral and cutaneous T-cell lymphoma: mechanistic implications from clinical and correlative data

scientific article

Romidepsin is effective and well tolerated in older patients with peripheral T-cell lymphoma: analysis of two phase II trials

scientific article published on 07 March 2017

Romidepsin: A New Drug for the Treatment of Cutaneous T-Cell Lymphoma ⬇️

scientific article published on 01 April 2012

Romidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors.

scientific article

Schedule-dependent synergy of histone deacetylase inhibitors with DNA damaging agents in small cell lung cancer

scientific article published on 15 September 2011

Screening for and identification of novel agents directed at renal cell carcinoma.

scientific article published in March 2001

Side population analysis using a violet-excited cell-permeable DNA binding dye.

scientific article published on 21 December 2006

Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.

scientific article

Single nucleotide polymorphisms modify the transporter activity of ABCG2.

scientific article published on 19 April 2005

Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).

scientific article

Stable disease is not preferentially observed with targeted therapies and as currently defined has limited value in drug development.

scientific article published on September 2009

Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells

scientific article published in April 1996

Striving to improve outcomes in oncology: unmet expectations in a complex disease

scientific article published on 01 December 2010

Sunitinib (Sutent, SU11248), a small-molecule receptor tyrosine kinase inhibitor, blocks function of the ATP-binding cassette (ABC) transporters P-glycoprotein (ABCB1) and ABCG2.

scientific article published on 29 October 2008

Sunitinib Does Not Accelerate Tumor Growth in Patients with Metastatic Renal Cell Carcinoma

scientific article published on 07 February 2013

Synthesis of titanium boride (TiB)2 nanocrystallites by solution-phase processing

article

T-cell lymphoma as a model for the use of histone deacetylase inhibitors in cancer therapy: impact of depsipeptide on molecular markers, therapeutic targets, and mechanisms of resistance

scientific article published on 2 March 2004

Targeting MDR in breast and lung cancer: discriminating its potential importance from the failure of drug resistance reversal studies.

scientific article published on February 2012

Targeting Prolactin Receptor (PRLR) Signaling in PRLR-Positive Breast and Prostate Cancer

scientific article published on 22 April 2016

Targeting RAS: The Elusive Prize

scientific article published in April 2015

Targeting Translation of mRNA as a Therapeutic Strategy in Cancer

scientific article published on 01 August 2019

Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models

scientific article published on 21 December 2018

Targeting the epigenome in lung cancer: expanding approaches to epigenetic therapy

scientific article

Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor

scientific article published on April 2007

The 315-316 deletion determines the BXP-21 antibody epitope but has no effect on the function of wild type ABCG2 or the Q141K variant.

scientific article

The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6alpha-hydroxypaclitaxel, a major metabolite of paclitaxel.

scientific article published in June 2001

The Role of ABC Transporters in Clinical Practice ⬇️

scientific article published on January 1, 2003

The Roleof MDR-1in Refractory Lymphoma ⬇️

scientific article published on December 1, 1997

The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.

scientific article published on July 2006

The challenge of exploiting ABCG2 in the clinic.

scientific article

The controversial role of ABC transporters in clinical oncology.

scientific article published on September 2011

The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance.

scientific article

The extent of chromosomal aberrations induced by chemotherapy in non-human primates depends on the schedule of administration

scientific article published on June 2005

The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems

scientific article published in February 2007

The histone deacetylase inhibitor FK228 preferentially enhances adenovirus transgene expression in malignant cells ⬇️

scientific article published on November 1, 2003

The histone deacetylase inhibitor FR901228 (desipeptide) restores expression and function of pseudo-null p53.

scientific article

The language of pharmacodynamics

scientific article

The linker region of breast cancer resistance protein ABCG2 is critical for coupling of ATP-dependent drug transport.

scientific article published on 26 December 2015

The livestock photosensitizer, phytoporphyrin (phylloerythrin), is a substrate of the ATP-binding cassette transporter ABCG2.

scientific article published on 30 June 2006

The lymphoma medicine cabinet

scientific article

The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2)

scientific article published on 01 June 2000

The product of the ABC half-transporter gene ABCG2 (BCRP/MXR/ABCP) is expressed in the plasma membrane

scientific article published on 01 April 2000

The role of breast cancer resistance protein in acute lymphoblastic leukemia.

scientific article published in November 2003

The role of half-transporters in multidrug resistance

scientific article

Therapies with diverse mechanisms of action kill cells by a similar exponential process in advanced cancers.

scientific article published in September 2014

Too Many Journals

scientific article published on 10 February 2017

Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics

scientific article published on February 2007

Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: a molecular modeling study

scientific article published on 30 August 2006

Transforming growth factor alpha production and epidermal growth factor receptor expression in normal and oncogene transformed human mammary epithelial cells

scientific article published in January 1989

Transforming growth factor-beta induces platelet-derived growth factor (PDGF) messenger RNA and PDGF secretion while inhibiting growth in normal human mammary epithelial cells

scientific article published on 01 July 1990

Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.

scientific article published in July 2003

Transporter pharmacogenetics: transporter polymorphisms affect normal physiology, diseases, and pharmacotherapy ⬇️

scientific article published on January 1, 2012

Treatment of drug resistance in epilepsy: one step at a time

scientific article published on 01 May 2006

Tumor Regression and Growth Rates Determined in Five Intramural NCI Prostate Cancer Trials: The Growth Rate Constant as an Indicator of Therapeutic Efficacy ⬇️

scientific article published on November 24, 2010

Tumor growth rates derived from data for patients in a clinical trial correlate strongly with patient survival: a novel strategy for evaluation of clinical trial data

scientific article

UGT1A1 genotype-dependent dose adjustment of belinostat in patients with advanced cancers using population pharmacokinetic modeling and simulation.

scientific article published on 4 December 2015

Upregulation of ABCG2 by romidepsin via the aryl hydrocarbon receptor pathway.

scientific article published on 25 February 2011

Use of peptide antibodies to probe for the mitoxantrone resistance-associated protein MXR/BCRP/ABCP/ABCG2.

scientific article published on September 2002

Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression

scientific article published in November 1990

Using the national cancer institute anticancer drug screen to assess the effect of MRP expression on drug sensitivity profiles

scientific article published on 01 November 1998

VA Cancer Research: A Legacy and A Future

scientific article published on 01 August 2019

Various methods of analysis of mdr-1/P-glycoprotein in human colon cancer cell lines

scientific article published on May 6, 1992

Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment

scientific article published in July 2005

Waking the Immune System at Last ⬇️

scientific article published on 01 March 2013

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