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List of works by Pradipsinh K. Rathod

A call to arms: Unifying the fight against resistance

article

A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates

scientific article

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article

A membrane network for nutrient import in red cells infected with the malaria parasite

scientific article published in May 1997

A microfluidic model for single-cell capillary obstruction by Plasmodium falciparum-infected erythrocytes

scientific article

A microfluidic system to study cytoadhesion of Plasmodium falciparum infected erythrocytes to primary brain microvascularendothelial cells

scientific article

A nondiscriminating glutamyl-tRNA synthetase in the plasmodium apicoplast: the first enzyme in an indirect aminoacylation pathway

scientific article (publication date: 8 November 2013)

A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity

scientific article published on 26 May 2020

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor (DSM421) with improved drug-like properties for treatment and prevention of malaria

scientific article (publication date: 9 December 2016)

Analysis of flavin oxidation and electron-transfer inhibition in Plasmodium falciparum dihydroorotate dehydrogenase

scientific article

Anopheles subpictus carry human malaria parasites in an urban area of Western India and may facilitate perennial malaria transmission

scientific article

Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network

scientific article

Antimalarial activity of a combination of 5-fluoroorotate and uridine in mice

scientific article published on July 1990

Asexual populations of the human malaria parasite, Plasmodium falciparum, use a two-step genomic strategy to acquire accurate, beneficial DNA amplifications

scientific article

Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor

scientific article published on 20 October 2014

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

scientific article

Catalytic and ligand-binding characteristics of Plasmodium falciparum serine hydroxymethyltransferase

scientific article published on 08 July 2009

Cell-free production of functional Plasmodium falciparum dihydrofolate reductase-thymidylate synthase

scientific article published on 15 November 2006

Chemical genetics of Plasmodium falciparum

scientific article (publication date: 20 May 2010)

Clonal variants of Plasmodium falciparum exhibit a narrow range of rolling velocities to host receptor CD36 under dynamic flow conditions

scientific article

Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate

scientific article published in May 1993

DNA microarrays for malaria

scientific article published in January 2002

Decreased In Vitro Artemisinin Sensitivity of Plasmodium falciparum across India

scientific article published on 23 September 2019

Deformability limits of Plasmodium falciparum-infected red blood cells

scientific article published on 30 April 2009

Demographic and clinical profiles of Plasmodium falciparum and Plasmodium vivax patients at a tertiary care centre in southwestern India.

scientific article

Diaza-anthracene Antibiotics from a Freshwater-Derived Actinomycete with Selective Antibacterial Activity toward Mycobacterium tuberculosis ⬇️

scientific article published on 11 March 2015

Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase

scientific article published on 01 September 2005

Distinct genomic architecture of Plasmodium falciparum populations from South Asia

scientific article published on 22 July 2016

Divergent regulation of dihydrofolate reductase between malaria parasite and human host

scientific article

Dynamics of Plasmodium vivax sporogony in wild Anopheles stephensi in a malaria-endemic region of Western India

scientific article

Enhanced ex vivo Plasmodium vivax intraerythrocytic enrichment and maturation for rapid and sensitive parasite growth assays

scientific article published on 29 January 2018

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum ⬇️

scientific article published on May 1, 1982

Essential protein-protein interactions between Plasmodium falciparum thymidylate synthase and dihydrofolate reductase domains

scientific article published on December 1999

Estimating physical splenic filtration ofPlasmodium falciparum-infected red blood cells in malaria patients ⬇️

scientific article published on September 4, 2012

Expression of functional Plasmodium falciparum enzymes using a wheat germ cell-free system

scientific article published on 11 October 2013

Extra-chromosomal DNA amplicons in antimalarial resistant Plasmodium falciparum

scientific article published on 14 October 2020

Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors

scientific article

Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance.

scientific article

Gene organization of a Plasmodium falciparum serine hydroxymethyltransferase and its functional expression in Escherichia coli.

scientific article published in October 2000

Heterologous expression in reveals a topogenic signal anchor in a apicoplast protein

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

scientific article

Histone acetyltransferase inhibitor anacardic acid causes changes in global gene expression during in vitro Plasmodium falciparum development

scientific article published on 16 May 2008

Hospital-derived antibody profiles of malaria patients in Southwest India

scientific article published on 17 April 2019

Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265

scientific article published on 13 November 2018

Identification of a Plasmodium falciparum histone 2A gene

scientific article published on August 1, 1992

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

scientific article published on April 2009

Improved light microscopy counting method for accurately counting Plasmodium parasitemia and reticulocytemia

scientific article published on 13 April 2016

In vitro adaptation of Plasmodium falciparum reveal variations in cultivability.

scientific article

Independent Origin and Global Distribution of Distinct Plasmodium vivax Duffy Binding Protein Gene Duplications

scientific article

Indispensable malaria genes

scientific article published in Science

Infection of laboratory colonies of Anopheles mosquitoes with Plasmodium vivax from cryopreserved clinical isolates

scientific article published on 22 July 2016

Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach

scientific article

Isoxazolopyrimidine-Based Inhibitors of Dihydroorotate Dehydrogenase with Antimalarial Activity

Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX

scientific article

Kinetics of Plasmodium falciparum thymidylate synthase: interactions with high-affinity metabolites of 5-fluoroorotate and D1694

scientific article

Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria

scientific article published on 06 April 2020

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

scientific article

Malaria evolution in South Asia: knowledge for control and elimination

scientific article published on 14 January 2012

Malaria in India: The Need for New Targets for Diagnosis and Detection of Plasmodium vivax

scientific article published on 29 November 2017

Malaria in South Asia: prevalence and control

scientific article

Malaria-attributed death rates in India

scientific article published on March 2011

Malarial dihydroorotate dehydrogenase. Substrate and inhibitor specificity.

scientific article published on 19 August 2002

Meta-analysis of Plasmodium falciparum Signatures Contributing to Severe Malaria in African Children and Indian Adults

scientific article published on 30 April 2019

Microfluidic approaches to malaria pathogenesis

scientific article published on 27 August 2008

Microfluidic modeling of cell-cell interactions in malaria pathogenesis

scientific article (publication date: July 2007)

Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum ⬇️

scientific article published on April 1, 1992

Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo

scientific article published in 2008

Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes ⬇️

scientific article published on March 10, 1983

Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy

scientific article

Plasmodium falciparum S-adenosylhomocysteine hydrolase. cDNA identification, predicted protein sequence, and expression in Escherichia coli

scientific article published on June 1994

Plasmodium falciparum: direct cloning and expression of pyrimethamine-sensitive and pyrimethamine-resistant dihydrofolate reductase domains

scientific article published on 01 March 1997

Plasmodium falciparum:Kinetic Interactions of WR99210 with Pyrimethamine-Sensitive and Pyrimethamine-Resistant Dihydrofolate Reductase ⬇️

scientific article published on November 1, 1997

Plasmodium vivax strains use alternative pathways for invasion

scientific article published on 17 September 2020

Plasmodium yoelii: oral delivery of 5-fluoroorotate to treat malaria in mice

scientific article published in November 1991

Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparum

scientific article

Prized malaria drug target nailed ⬇️

scientific article published on May 1, 2003

Prodrug activation by Cryptosporidium thymidine kinase

scientific article

Regulatory hotspots in the malaria parasite genome dictate transcriptional variation

scientific article

Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase

scientific article

Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum

scientific article published on 20 January 2005

Reticulocyte Preference and Stage Development of Plasmodium vivax Isolates

scientific article published on 17 July 2016

Selection and characterization of 5-fluoroorotate-resistant Plasmodium falciparum ⬇️

scientific article published on December 1, 1994

Selective activity of 5-fluoroorotic acid against Plasmodium falciparum in vitro

scientific article

Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass.

scientific article published on 16 May 2016

Shotgun DNA microarrays and stage-specific gene expression in Plasmodium falciparum malaria

scientific article

Stochastic versus stable transcriptional differences on Plasmodium falciparum DNA microarrays

scientific article published in December 2002

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

scientific article

Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions

scientific article published on 21 April 2015

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

scientific article

Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase

scientific article

Susceptibility of wild and colonized Anopheles stephensi to Plasmodium vivax infection.

scientific article

Synthesis and antiproliferative activity of threo-5-fluoro-L-dihydroorotate

scientific article published on August 1990

Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity

scientific article published on 29 April 2016

The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase

scientific article

The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions

scientific article published on 21 April 2015

Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION

scientific article (publication date: 14 August 2015)

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

scientific article published on 04 June 2008

Variations in frequencies of drug resistance in Plasmodium falciparum ⬇️

scientific article published on August 19, 1997

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

scientific article

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