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List of works by George J Kontoghiorghes

A Record Of 1320 Suspect, Deferasirox-Related, Patient Deaths Reported In 2009: Insufficient Toxicity Testing, Low Efficacy And Lack Of Transparency May Endanger The Lives Of Iron Loaded Patients ⬇️

scientific article published on January 1, 2011

A new era in iron chelation therapy: the design of optimal, individually adjusted iron chelation therapies for the complete removal of iron overload in thalassemia and other chronically transfused patients

scientific article published in January 2009

A record number of fatalities in many categories of patients treated with deferasirox: loopholes in regulatory and marketing procedures undermine patient safety and misguide public funds?

article by George J Kontoghiorghes published 21 May 2013 in Expert Opinion on Drug Safety

Advances in iron overload therapies. prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NA11 and their combinations

scientific article

Advances in the prevention and treatment are changing thalassemia from a fatal to a chronic disease. experience from a Cyprus model and its use as a paradigm for future applications

scientific article published on January 2009

Advances on Chelation and Chelator Metal Complexes in Medicine

scientific article published on 03 April 2020

Antioxidant targeting by deferiprone in diseases related to oxidative damage

scientific article published on June 2014

Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine

scientific article

Characterization of the neuroprotective potential of derivatives of the iron chelating drug deferiprone

scientific article published on 6 January 2015

Chelators controlling metal metabolism and toxicity pathways: applications in cancer prevention, diagnosis and treatment

scientific article published on January 2008

Clinical use, therapeutic aspects and future potential of deferiprone in thalassemia and other conditions of iron and other metal toxicity.

scientific article published on January 2001

Deferasirox: uncertain future following renal failure fatalities, agranulocytosis and other toxicities

scientific article published in May 2007

Dietary and pharmacological factors affecting iron absorption in mice and man (Comment for a Letter to the editor).

scientific article published on March 2016

Do we need more iron-chelating drugs?

scientific article published in August 2003

EDTA chelation reappraisal following new clinical trials and regular use in millions of patients: review of preliminary findings and risk/benefit assessment ⬇️

scientific article published on October 19, 2012

Effective combination therapy of deferiprone and deferoxamine for the rapid clearance of excess cardiac IRON and the prevention of heart disease in thalassemia. The Protocol of the International Committee on Oral Chelators

scientific article published in January 2006

Effective new treatments of iron overload in thalassaemia using the ICOC combination therapy protocol of deferiprone (L1) and deferoxamine and of new chelating drugs.

scientific article published in June 2006

Effects of ICL670 (deferasirox) on cardiac iron concentrations

scientific article

Effects on Mycobacterium avium replication in normal human macrophages by deferiprone (L1) and other iron chelators. Possible implications on toxicity

scientific article published on January 2002

Efficacy and safety of iron-chelation therapy with deferoxamine, deferiprone, and deferasirox for the treatment of iron-loaded patients with non-transfusion-dependent thalassemia syndromes

scientific article

Efficacy, Compliance And Toxicity Factors Are Affecting The Rate Of Normalization Of Body Iron Stores In Thalassemia Patients Using The Deferiprone And Deferoxamine Combination Therapy ⬇️

scientific article published on January 1, 2011

Ethical issues and risk/benefit assessment of iron chelation therapy: advances with deferiprone/deferoxamine combinations and concerns about the safety, efficacy and costs of deferasirox

scientific article published on January 2008

Future challenges in the use of magnetic resonance imaging for the diagnosis of iron overload ⬇️

scientific article published on October 1, 2010

Future chelation monotherapy and combination therapy strategies in thalassemia and other conditions. comparison of deferiprone, deferoxamine, ICL670, GT56-252, L1NAll and starch deferoxamine polymers

scientific article published on January 2006

How to manage iron toxicity in post-allogeneic hematopoietic stem cell transplantation?

scientific article published on 08 February 2020

Interactions Of Hydroxycarbamide (Hydroxyurea) With Iron And Copper: Implications On Toxicity and Therapeutic Strategies ⬇️

scientific article published on January 1, 2011

Introduction of higher doses of deferasirox: better efficacy but not effective iron removal from the heart and increased risks of serious toxicities

scientific article published on July 2010

Iron and Chelation in Biochemistry and Medicine: New Approaches to Controlling Iron Metabolism and Treating Related Diseases

scientific article published on 12 June 2020

Iron chelation therapy in hereditary hemochromatosis and thalassemia intermedia: regulatory and non regulatory mechanisms of increased iron absorption

scientific article published on June 2010

Iron mobilisation from transferrin by deferiprone (L1).

scientific article published in April 2005

Iron mobilization from transferrin and non-transferrin-bound-iron by deferiprone. Implications in the treatment of thalassemia, anemia of chronic disease, cancer and other conditions

scientific article published on January 2006

Iron mobilization using chelation and phlebotomy

scientific article published on 05 May 2012

Liver iron and serum ferritin levels are misleading for estimating cardiac, pancreatic, splenic and total body iron load in thalassemia patients: factors influencing the heterogenic distribution of excess storage iron in organs as identified by MRI

scientific article published on 01 January 2013

Long term comparative studies in thalassemia patients treated with deferoxamine or a deferoxamine/deferiprone combination. Identification of effective chelation therapy protocols

scientific article

Low serum ferritin levels are misleading for detecting cardiac iron overload and increase the risk of cardiomyopathy in thalassemia patients. The importance of cardiac iron overload monitoring using magnetic resonance imaging T2 and T2*.

scientific article published in January 2006

Maintenance of normal range body iron store levels for up to 4.5 years in thalassemia major patients using deferiprone monotherapy

scientific article published in June 2010

Molecular factors and mechanisms affecting iron and other metal excretion or absorption in health and disease: the role of natural and synthetic chelators

scientific article

Myocyte damage and loss of myofibers is the potential mechanism of iron overload toxicity in congestive cardiac failure in thalassemia. Complete reversal of the cardiomyopathy and normalization of iron load by deferiprone

scientific article

New chelation therapies and emerging chelating drugs for the treatment of iron overload

scientific article published in March 2006

New developments and controversies in iron metabolism and iron chelation therapy

scientific article published on 26 March 2016

New golden era of chelation therapy in thalassaemia: the achievement and maintenance of normal range body iron stores

scientific article published on 9 May 2010

Phytochelators Intended for Clinical Use in Iron Overload, Other Diseases of Iron Imbalance and Free Radical Pathology

scientific article

Potential clinical applications of chelating drugs in diseases targeting transferrin-bound iron and other metals ⬇️

scientific article published on May 1, 2013

Prevention of Iron Overload and Long Term Maintenance of Normal Iron Stores in Thalassaemia Major Patients using Deferiprone or Deferiprone Deferoxamine Combination

scientific article published on 20 March 2017

Prophylactic use of deferiprone (L1) and magnetic resonance imaging T2* or T2 for preventing heart disease in thalassaemia

scientific article published in November 2004

Prospects for introducing deferiprone as potent pharmaceutical antioxidant

scientific article published on June 2009

Prospects for the introduction of targeted antioxidant drugs for the prevention and treatment of diseases related to free radical pathology

scientific article published on 21 June 2019

Radiation protection by deferiprone in animal models

scientific article published on 01 January 2006

Redox Interactions of Vitamin C and Iron: Inhibition of the Pro-Oxidant Activity by Deferiprone

scientific article published on 31 May 2020

Reduction of body iron stores to normal range levels in thalassaemia by using a deferiprone/deferoxamine combination and their maintenance thereafter by deferiprone monotherapy

scientific article published on November 2010

Regulatory molecules and chelators used for the control of essential and toxic metals in health and disease: from molecular interactions to clinical effects and applications

scientific article published on 01 January 2005

Report on the proceedings of the 15th International Conference on Oral Chelation (ICOC) in the Treatment of Thalassemia and Other Diseases at Taichung, Taiwan, April 22-26, 2005

scientific article published on 01 January 2006

Risk/benefit assessment, advantages over other drugs and targeting methods in the use of deferiprone as a pharmaceutical antioxidant in iron loading and non iron loading conditions

scientific article published in January 2009

The 18th ICOC Proceedings in Athens, Greece: New breakthrough in thalassemia leading to the complete treatment of iron overload and to hundreds of patients achieving and maintaining normal body iron stores. Ethical questions on chelation therapy

scientific article published in June 2010

The History of Deferiprone (L1) and the Paradigm of the Complete Treatment of Iron Overload in Thalassaemia

scientific article published on 01 January 2020

The Proceedings Of The 19Th International Conference On Chelation Held In London, United Kingdom: Major Changes In Iron Chelation Therapy In The Last 25 Years Using Deferiprone (L1) Has Resulted In The Complete Treatment Of Iron Overload ⬇️

scientific article published on January 1, 2011

The Proceedings of the 20th International Conference on Chelation held in the USA: advances on new and old chelation therapies ⬇️

scientific article published on October 19, 2012

The aim of iron chelation therapy in thalassaemia.

scientific article

The effects of bicarbonate and its combination with chelating agents used for the removal of depleted uranium in rats

scientific article

The importance of spleen, spleen iron, and splenectomy for determining total body iron load, ferrikinetics, and iron toxicity in thalassemia major patients ⬇️

scientific article published on January 1, 2013

The proceedings of the 17th International Conference on Chelation: application of effective chelation therapies in iron loading and non iron loading conditions, and the gap in the prevention and treatment policies on thalassemia between developed an

scientific article published in January 2009

The role of iron and chelators on infections in iron overload and non iron loaded conditions: prospects for the design of new antimicrobial therapies

scientific article published in June 2010

Transfusion-Related Acute Lung Injury (TRALI) in two Thalassaemia Patients Caused by the Same Multiparous Blood Donor

scientific article

Transition of Thalassaemia and Friedreich ataxia from fatal to chronic diseases

scientific article

Transparency and access to full information for the fatal or serious toxicity risks, low efficacy and high price of deferasirox, could increase the prospect of improved iron chelation therapy worldwide

scientific article

Trying to Solve the Puzzle of the Interaction of Ascorbic Acid and Iron: Redox, Chelation and Therapeutic Implications

scientific article published on 30 July 2020

Update on toxicity and efficacy aspects of treatment with deferasirox and its implication on the morbidity and mortality of transfused iron loaded patients

scientific article published on 01 November 2008

Uses and limitations of serum ferritin, magnetic resonance imaging T2 and T2* in the diagnosis of iron overload and in the ferrikinetics of normalization of the iron stores in thalassemia using the International Committee on Chelation deferiprone/de

scientific article published in January 2009

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