Search filters

List of works by Matthias G von Herrath

A Deeper Look into Type 1 Diabetes - Imaging Immune Responses during Onset of Disease

scientific article

A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes.

scientific article published on November 2004

Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes

scientific article

Alpha cells, the main source of IL-1β in human pancreas.

scientific article published on 18 March 2017

Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease.

scientific article published in December 2003

Anti-IL-21 monoclonal antibody combined with liraglutide effectively reverses established hyperglycemia in mouse models of type 1 diabetes.

scientific article

Antigen-Specific Regulatory T Cells and Low Dose of IL-2 in Treatment of Type 1 Diabetes

scientific article

Antigen-induced regulatory T cells in autoimmunity

scientific article

Autoantibodies exacerbate the severity of MHV-induced encephalitis

scientific article published on January 2006

Beta cells under attack: toward a better understanding of type 1 diabetes immunopathology ⬇️

scientific article published on December 18, 2010

Beta-cell specific production of IL6 in conjunction with a mainly intracellular but not mainly surface viral protein causes diabetes

scientific article

Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice

scientific article

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

scientific article published on 9 February 2003

CD40L blockade prevents autoimmune diabetes by induction of bitypic NK/DC regulatory cells

scientific article published in March 2002

CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors

scientific article published in April 2004

Clinical potential of antigen-specific therapies in type 1 diabetes

scientific article published on 28 December 2012

Combination therapy with InsB9-23 peptide immunization and CTLA4-IgG does not reverse diabetes in NOD mice ⬇️

scientific article published on December 23, 2011

Combination therapy with an anti-IL-1β antibody and GAD65 DNA vaccine can reverse recent-onset diabetes in the RIP-GP mouse model

scientific article

Combination therapy with anti-CD6 and oral insulin immunization reverses recent onset diabetes in non obese diabetic mice but fails to induce lasting tolerance

scientific article published on 15 August 2013

Control of graft-versus-host disease by regulatory T cells: which level of antigen specificity?

scientific article published on September 2006

Corona Pandemic: Assisted Isolation and Care to Protect Vulnerable Populations May Allow Us to Shorten the Universal Lock-Down and Gradually Re-open Society

scientific article published on 30 September 2020

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies

retracted scientific article

Cure of chronic viral infection and virus-induced type 1 diabetes by neutralizing antibodies

scientific article published on 01 June 2006

Cure of chronic viral infection by neutralizing antibody treatment

scientific article published on 12 October 2006

Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient

scientific article

Cytokines and chemokines in virus-induced autoimmunity.

scientific article

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

scientific article

Development of autoimmune diabetes in the absence of detectable IL-17A in a CD8-driven virally induced model

scientific article published on August 10, 2011

Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions

scientific article published on September 2004

Distinct Housing Conditions Reveal a Major Impact of Adaptive Immunity on the Course of Obesity-Induced Type 2 Diabetes.

scientific article

Do viral infections protect from or enhance type 1 diabetes and how can we tell the difference?

scientific article

Enterovirus infection and type 1 diabetes: closing in on a link?

scientific article

Erratum. Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes. Diabetes 2014;63:3880-3890.

scientific article published on January 2016

Essential role for TLR9 in prime but not prime-boost plasmid DNA vaccination to activate dendritic cells and protect from lethal viral infection

scientific article

Exacerbated pathology of viral encephalitis in mice with central nervous system-specific autoantibodies

scientific article published on February 2007

Expression level of a pancreatic neo-antigen in beta cells determines degree of diabetes pathogenesis

scientific article

Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic cytotoxic T lymphocytes to pancreatic islets in a virally induced autoimmune diabetes model

scientific article published on 22 February 2013

Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase

scientific article

Histopathology of type 1 diabetes: old paradigms and new insights

scientific article published on 10 August 2009

Human herpesvirus-6 is present at higher levels in the pancreatic tissues of donors with type 1 diabetes

scientific article published on 06 December 2019

IP-10 and type 1 diabetes: a question of time and location.

scientific article

Immune responsiveness, tolerance and dsRNA: implications for traditional paradigms

scientific article

Immunohistochemical assessment of glucagon-like peptide 1 receptor (GLP-1R) expression in the pancreas of patients with type 2 diabetes.

scientific article published on 17 January 2017

Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo

scientific article published on 23 August 2005

Immunoregulatory mechanisms triggered by viral infections protect from type 1 diabetes in mice

scientific article published on 26 May 2009

Immunosuppressive mechanisms during viral infectious diseases

scientific article published in January 2011

Immunotherapies and immune biomarkers in Type 1 diabetes: A partnership for success

scientific article published on 26 June 2015

Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset

scientific article

Increased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes.

scientific article

Induction, acceleration or prevention of autoimmunity by molecular mimicry

scientific article published on February 2004

Infection as a cause of type 1 diabetes?

scientific article

Infections and autoimmunity--good or bad?

scientific article

Initiation of autoimmunity.

scientific article

Interfacing dendritic and natural killer cells: a tool for targeted tolerance induction?

scientific article published on December 2003

Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets

scientific article published on 10 May 2012

Islet beta-cell death - fuel to sustain autoimmunity?

scientific article published on 01 August 2007

Islet-specific expression of CXCL10 causes spontaneous islet infiltration and accelerates diabetes development

scientific article published on 01 September 2005

Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.

scientific article published on January 2006

Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes

scientific article published on 26 June 2018

Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity

scientific article published on November 2005

Metabolic syndrome - Removing roadblocks to therapy: Antigenic immunotherapies

scientific article published on 21 January 2014

Microorganisms and autoimmunity: making the barren field fertile?

scientific article published on November 2003

Minimal impact of a de novo-expressed beta-cell autoantigen on spontaneous diabetes development in NOD mice.

scientific article published in April 2007

Molecular mimicry, bystander activation, or viral persistence: infections and autoimmune disease.

scientific article

Motifs for a deadly encounter ⬇️

scientific article published on February 16, 2012

NKG2D blockade facilitates diabetes prevention by antigen-specific Tregs in a virus-induced model of diabetes ⬇️

scientific article published on September 1, 2012

Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance

scientific article published in August 2008

Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis

scientific article

No significant CTL cross-priming by dendritic cell-derived exosomes during murine lymphocytic choriomeningitis virus infection

scientific article published in February 2009

Nonmitogenic CD3 antibody reverses virally induced (rat insulin promoter-lymphocytic choriomeningitis virus) autoimmune diabetes without impeding viral clearance

scientific article published in January 2002

Novel strategies to eliminate persistent viral infections

scientific article published on 06 February 2008

OAS1 is not associated with MHC class I hyperexpression in the islets of donors with T1D regardless of disease duration.

scientific article

OX40 Facilitates Control of a Persistent Virus Infection ⬇️

scientific article published on September 6, 2012

Pathogenesis of type 1 diabetes: a viewpoint

scientific article

Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals ⬇️

scientific article published on November 1, 2011

Potential viral pathogenic mechanism in human type 1 diabetes

scientific article

Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment

scientific article

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

scientific article published on 9 January 2017

Real-time imaging of the pancreas during development of diabetes

scientific article published on February 2008

Reduction of antiviral CD8 lymphocytes in vivo with dendritic cells expressing Fas ligand-increased survival of viral (lymphocytic choriomeningitis virus) central nervous system infection

scientific article published on November 2002

Regulatory T-cells in type 1 diabetes

scientific article published in November 2004

Resolution of a chronic viral infection after interleukin-10 receptor blockade

scientific article

Response to Comment on Rodriguez-Calvo et al. Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset. Diabetes 2017;66:1334-1345.

scientific article published in September 2017

SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.

scientific article published on 10 October 2006

Strategies to treat autoimmune diabetes

scientific article published on 01 March 2007

T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes

scientific article

TLR2 signaling improves immunoregulation to prevent type 1 diabetes ⬇️

scientific article published on May 1, 2011

The role of innate immunity in autoimmunity.

scientific article published on December 2004

The role of the activating receptor NKG2D in autoimmunity

scientific article published on 14 March 2009

The type 1 diabetes signature: hardwired to trigger inflammation?

scientific article published in November 2014

The viral paradigm in type 1 diabetes: Who are the main suspects?

scientific article

Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: a two-faced impact on autoimmunity

scientific article published on 8 August 2008

Transgenic animal models for type 1 diabetes: linking a tetracycline-inducible promoter with a virus-inducible mouse model.

scientific article

Trials in type 1 diabetes: Antigen-specific therapies

scientific article published on 15 February 2013

Type 1 diabetes: etiology, immunology, and therapeutic strategies

scientific article published on January 2011

Vaccination to prevent type 1 diabetes

scientific article

Viral infections and molecular mimicry in type 1 diabetes ⬇️

scientific article published on October 11, 2012

Viral trigger for type 1 diabetes: pros and cons

scientific article

Viral triggers for autoimmunity: is the 'glass of molecular mimicry' half full or half empty?

scientific article published on 27 August 2009

Virally induced inflammation and therapeutic avenues in type 1 diabetes.

scientific article published on March 2004

Virally induced inflammation triggers fratricide of Fas-ligand-expressing beta-cells

scientific article published in March 2004

Viruses and Cytotoxic T Lymphocytes in Type 1 Diabetes ⬇️

scientific article published on October 1, 2011

Viruses and Type 1 diabetes: a dynamic labile equilibrium

scientific article published on May 2013

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

scientific article published in March 2018

Paulina is supported by:

About Paulina

Help