List of works - Nobuhisa Ishikawa

A Comprehensive Peptidome Profiling Technology for the Identification of Early Detection Biomarkers for Lung Adenocarcinoma ⬇️

scientific article (publication date: 12 April 2011)

A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY)

scientific article published on 06 May 2019

A case of pulmonary asbestosis presenting with temporal arteritis involving multiple medium-sized vessels

scientific article

A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis

scientific article

A pharmacokinetics study of edoxaban in NSCLC patients harboring an EGFR mutation combined with venous thromboembolism ⬇️

scholarly article

ADAM8 as a novel serological and histochemical marker for lung cancer

scientific article

ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway

scientific article

Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis

scientific article published on November 2006

Ageing and long-term smoking affects KL-6 levels in the lung, induced sputum and plasma ⬇️

scientific article published on May 11, 2011

Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction

scientific article published on 19 April 2011

Airflow limitation in smokers is associated with subclinical atherosclerosis.

scientific article

Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls

scientific article

Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study

scientific article published on 24 August 2018

Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease

scientific article

Anti-tumor effect of the anti-KL-6/MUC1 monoclonal antibody through exposure of surface molecules by MUC1 capping

scientific article published on May 2006

Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes

scientific article

Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis

scientific article published on 26 April 2014

Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study

scientific article published on 01 September 2018

Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease ⬇️

scientific article published on July 26, 2011

Circulating KL-6/MUC1 mucin carrying sialyl Lewisa oligosaccharide is an independent prognostic factor in patients with lung adenocarcinoma

scientific article published on June 2007

Clinical and molecular features of rapidly progressive chronic hypersensitivity pneumonitis

scientific article published on 28 April 2017

Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis.

scientific article published on 17 May 2016

Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer ⬇️

scientific article published on April 8, 2011

Development of Serum Glycoproteomic Profiling Technique; Simultaneous Identification of Glycosylation Sites and Site-Specific Quantification of Glycan Structure Changes ⬇️

scientific article published on September 1, 2010

Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms

scientific article published on 08 January 2014

Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels

scientific article

Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas

scientific article published on March 2007

Effect of increasing respiratory rate on airway resistance and reactance in COPD patients

scientific article published on 23 September 2014

Efficacy and Safety of Re-administration of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) After EGFR-TKI-Induced Interstitial Lung Disease (CS-Lung-005)

scholarly article

Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy ⬇️

scientific article published on January 28, 2011

Expression profiles of metastatic brain tumor from lung adenocarcinomas on cDNA microarray.

scientific article published in April 2006

Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer

scientific article

First-line immune checkpoint therapy in metastatic squamous cell lung cancer harboring both EGFR mutation and high expression of PD-L1: A case report

scientific article published on 14 April 2020

Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets.

scientific article published on 18 August 2017

Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: role of IL-6.

scientific article published on 29 January 2009

Hemoglobin α and β are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD ⬇️

scientific article published on September 13, 2010

IV. Advances in the Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis

scholarly article

Identification of Epstein-Barr Virus–Induced Gene 3 as a Novel Serum and Tissue Biomarker and a Therapeutic Target for Lung Cancer ⬇️

scientific article published on August 17, 2011

Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer

scientific article published on February 2007

Impact of HER2 expression on EGFR-TKI treatment outcomes in lung tumors harboring EGFR mutations: A HER2-CS study subset analysis

scientific article published on 01 October 2020

Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer

scientific article published on January 2007

Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers

scientific article

Interferon (Alpha, Beta and Omega) Receptor 2 Is a Prognostic Biomarker for Lung Cancer ⬇️

scientific article published on January 12, 2012

Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice ⬇️

scientific article published on September 16, 2011

KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome ⬇️

scientific article published on March 22, 2011

KL-6, a human MUC1 mucin, promotes proliferation and survival of lung fibroblasts

scientific article published on 2 November 2005

Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer

scientific article

Levels of Surfactant Proteins A and D and KL-6 Are Elevated in the Induced Sputum of Chronic Obstructive Pulmonary Disease Patients: A Sequential Sputum Analysis ⬇️

scientific article published on 07 April 2011

Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers

scientific article

MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study

scientific article

MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis

scientific article published on 08 January 2015

Mass Screening of SARS-CoV-2 Variants using Sanger Sequencing Strategy in Hiroshima, Japan

scientific article published on 14 February 2022

Mucins Carrying Selectin Ligands as Predictive Biomarkers of Disseminated Intravascular Coagulation Complication in ARDS ⬇️

scientific article published on July 29, 2010

Need for a high-specificity test for confirming weakly positive result in an immunochromatographic SARS-CoV-2-specific antigen test: A case report

scientific article published on 01 December 2020

Novel prospective umbrella-type lung cancer registry study for clarifying clinical practice patterns: CS-Lung-003 study protocol

Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis.

scientific article

Pharmacokinetics of edoxaban in EGFR-mutated non-small cell lung cancer patients with venous thromboembolism

scientific article published on 30 December 2020

Phase 2 Study of Afatinib Alone or Combined With Bevacizumab in Chemonaive Patients With Advanced Non-Small-Cell Lung Cancer Harboring EGFR Mutations: AfaBev-CS Study Protocol

scientific article published on 01 November 2018

Phase I study of docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer

scientific article

Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer

scientific article published on August 2005

Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839).

scientific article published on 20 October 2004

Proteomic approaches for studying human parenchymal lung diseases

scientific article published on December 2009

Pulmonary cryptococcosis mimicking lung cancer

scientific article published on 01 September 2019

Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy

scientific article published on 01 March 2011

SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis

scientific article published on 29 August 2013

Sputum Leucine-Rich Alpha-2 Glycoprotein as a Marker of Airway Inflammation in Asthma

scientific article

Standard antifungal therapy for pulmonary cryptococcosis to improve prognosis - Authors' reply

scientific article published on 01 December 2019

Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice

scientific article published on 2 October 2008

Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis

scientific article published on April 2010

Targeted serum glycoproteomics for the discovery of lung cancer-associated glycosylation disorders using lectin-coupled ProteinChip arrays

scientific article

Treatment of ALK-positive Lung Cancer with Crizotinib-derived Complexed Renal Cysts Using Alectinib and Ceritinib: a Case Study

scholarly article

Treatment rationale and design of the PROLONG study: safety and efficacy of pembrolizumab as first-line therapy for elderly patients with non-small cell lung cancer

scientific article published on 01 March 2020

Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors.

scientific article published in June 2008

Usefulness of the modified lavage technique of Bingisser and KL-6 monitoring in a patient with pulmonary alveolar proteinosis

scientific article published on 01 May 2002

Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases ⬇️

scientific article published on 08 March 2012

Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy

scientific article published on 15 June 2010

[A Case of FMF (Familial Mediterranean Fever) with HLA-B39 and HLA-B40 as Disease-promoting Factors]

scientific article published on 01 November 2016

[Case report: A case of Hodgkin lymphoma required a differential diagnosis from sarcoidosis due to elevated serum level of angiotensin converting enzyme (ACE)]

scientific article published on 01 May 2012

[Interstitial lung disease and lung cancer]

scientific article published on 01 January 2010

[Major drug-induced lung diseases: adverse effects of newly developed molecular targeted drugs]

scientific article published on 01 June 2007

List of works by Nobuhisa Ishikawa

A Comprehensive Peptidome Profiling Technology for the Identification of Early Detection Biomarkers for Lung Adenocarcinoma ⬇️

A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY)

A case of pulmonary asbestosis presenting with temporal arteritis involving multiple medium-sized vessels

A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis

A pharmacokinetics study of edoxaban in NSCLC patients harboring an EGFR mutation combined with venous thromboembolism ⬇️

ADAM8 as a novel serological and histochemical marker for lung cancer

ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway

Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis

Ageing and long-term smoking affects KL-6 levels in the lung, induced sputum and plasma ⬇️

Ageing and smoking contribute to plasma surfactant proteins and protease imbalance with correlations to airway obstruction

Airflow limitation in smokers is associated with subclinical atherosclerosis.

Airway inflammation in Japanese COPD patients compared with smoking and nonsmoking controls

Alternate-day administration of S-1 for elderly patients with advanced non-small-cell lung carcinoma: A prospective feasibility study

Anti-inflammatory effects and clinical efficacy of theophylline and tulobuterol in mild-to-moderate chronic obstructive pulmonary disease

Anti-tumor effect of the anti-KL-6/MUC1 monoclonal antibody through exposure of surface molecules by MUC1 capping

Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes

Baseline KL-6 predicts increased risk for acute exacerbation of idiopathic pulmonary fibrosis

Bevacizumab with Single-agent Chemotherapy in Previously Treated Non-squamous Non-small-cell Lung Cancer: Phase II Study

Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease ⬇️

Circulating KL-6/MUC1 mucin carrying sialyl Lewisa oligosaccharide is an independent prognostic factor in patients with lung adenocarcinoma

Clinical and molecular features of rapidly progressive chronic hypersensitivity pneumonitis

Comparative Study of Circulating MMP-7, CCL18, KL-6, SP-A, and SP-D as Disease Markers of Idiopathic Pulmonary Fibrosis.

Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer ⬇️

Development of Serum Glycoproteomic Profiling Technique; Simultaneous Identification of Glycosylation Sites and Site-Specific Quantification of Glycan Structure Changes ⬇️

Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms

Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels

Dikkopf-1 as a novel serologic and prognostic biomarker for lung and esophageal carcinomas

Effect of increasing respiratory rate on airway resistance and reactance in COPD patients

Efficacy and Safety of Re-administration of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) After EGFR-TKI-Induced Interstitial Lung Disease (CS-Lung-005)

Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy ⬇️

Expression profiles of metastatic brain tumor from lung adenocarcinomas on cDNA microarray.

Fibroblast growth factor receptor 1 oncogene partner as a novel prognostic biomarker and therapeutic target for lung cancer

First-line immune checkpoint therapy in metastatic squamous cell lung cancer harboring both EGFR mutation and high expression of PD-L1: A case report

Gene expression profiling of idiopathic interstitial pneumonias (IIPs): identification of potential diagnostic markers and therapeutic targets.

Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: role of IL-6.

Hemoglobin α and β are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD ⬇️

IV. Advances in the Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis

Identification of Epstein-Barr Virus–Induced Gene 3 as a Novel Serum and Tissue Biomarker and a Therapeutic Target for Lung Cancer ⬇️

Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer

Impact of HER2 expression on EGFR-TKI treatment outcomes in lung tumors harboring EGFR mutations: A HER2-CS study subset analysis

Increased expression of insulin-like growth factor-II messenger RNA-binding protein 1 is associated with tumor progression in patients with lung cancer

Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers

Interferon (Alpha, Beta and Omega) Receptor 2 Is a Prognostic Biomarker for Lung Cancer ⬇️

Intra-airway administration of small interfering RNA targeting plasminogen activator inhibitor-1 attenuates allergic asthma in mice ⬇️

KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome ⬇️

KL-6, a human MUC1 mucin, promotes proliferation and survival of lung fibroblasts

Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer

Levels of Surfactant Proteins A and D and KL-6 Are Elevated in the Induced Sputum of Chronic Obstructive Pulmonary Disease Patients: A Sequential Sputum Analysis ⬇️

Long-term pulmonary complications of chemical weapons exposure in former poison gas factory workers

MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study

MUC5B promoter polymorphism in Japanese patients with idiopathic pulmonary fibrosis

Mass Screening of SARS-CoV-2 Variants using Sanger Sequencing Strategy in Hiroshima, Japan

Mucins Carrying Selectin Ligands as Predictive Biomarkers of Disseminated Intravascular Coagulation Complication in ARDS ⬇️

Need for a high-specificity test for confirming weakly positive result in an immunochromatographic SARS-CoV-2-specific antigen test: A case report

Novel prospective umbrella-type lung cancer registry study for clarifying clinical practice patterns: CS-Lung-003 study protocol

Overproduction of collagen and diminished SOCS1 expression are causally linked in fibroblasts from idiopathic pulmonary fibrosis.

Pharmacokinetics of edoxaban in EGFR-mutated non-small cell lung cancer patients with venous thromboembolism

Phase 2 Study of Afatinib Alone or Combined With Bevacizumab in Chemonaive Patients With Advanced Non-Small-Cell Lung Cancer Harboring EGFR Mutations: AfaBev-CS Study Protocol

Phase I study of docetaxel plus S-1 combination chemotherapy for recurrent non-small cell lung cancer

Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer

Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839).

Proteomic approaches for studying human parenchymal lung diseases

Pulmonary cryptococcosis mimicking lung cancer

Regression of a primary pulmonary adenocarcinoma after zoledronic acid monotherapy

SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis

Sputum Leucine-Rich Alpha-2 Glycoprotein as a Marker of Airway Inflammation in Asthma

Standard antifungal therapy for pulmonary cryptococcosis to improve prognosis - Authors' reply

Suplatast tosilate prevents bleomycin-induced pulmonary fibrosis in mice

Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis

Targeted serum glycoproteomics for the discovery of lung cancer-associated glycosylation disorders using lectin-coupled ProteinChip arrays

Treatment of ALK-positive Lung Cancer with Crizotinib-derived Complexed Renal Cysts Using Alectinib and Ceritinib: a Case Study

Treatment rationale and design of the PROLONG study: safety and efficacy of pembrolizumab as first-line therapy for elderly patients with non-small cell lung cancer

Usefulness of monitoring the circulating Krebs von den Lungen-6 levels to predict the clinical outcome of patients with advanced nonsmall cell lung cancer treated with epidermal growth factor receptor tyrosine kinase inhibitors.

Usefulness of the modified lavage technique of Bingisser and KL-6 monitoring in a patient with pulmonary alveolar proteinosis

Utility of KL-6/MUC1 in the clinical management of interstitial lung diseases ⬇️

Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy

[A Case of FMF (Familial Mediterranean Fever) with HLA-B*39 and HLA-B*40 as Disease-promoting Factors]

[Case report: A case of Hodgkin lymphoma required a differential diagnosis from sarcoidosis due to elevated serum level of angiotensin converting enzyme (ACE)]

[Interstitial lung disease and lung cancer]

[A Case of FMF (Familial Mediterranean Fever) with HLA-B39 and HLA-B40 as Disease-promoting Factors]