Search filters

List of works by Ralph R. Isberg

A 76-amino acid disulfide loop in the Yersinia pseudotuberculosis invasin protein is required for integrin receptor recognition

scientific article published on September 1993

A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death

scholarly article

A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication.

scientific article published on 22 December 2016

A bifunctional bacterial protein links GDI displacement to Rab1 activation

scientific article

A global regulatory system links virulence and antibiotic resistance to envelope homeostasis in Acinetobacter baumannii.

scientific article

A hemidominant Naip5 allele in mouse strain MOLF/Ei-derived macrophages restricts Legionella pneumophila intracellular growth.

scientific article published on 3 November 2008

A molecular strategy for the study of bacterial invasion

scientific article published on September 1987

A region of the Yersinia pseudotuberculosis invasin protein enhances integrin-mediated uptake into mammalian cells and promotes self-association

scientific article

A region of the Yersinia pseudotuberculosis invasin protein that contributes to high affinity binding to integrin receptors

scientific article published on September 1996

A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12.

scientific article published on September 1985

Acinetobacter baumannii: Envelope Determinants That Control Drug Resistance, Virulence, and Surface Variability

scientific article published on 14 June 2019

Aggravating Genetic Interactions Allow a Solution to Redundancy in a Bacterial Pathogen ⬇️

scientific article published on December 14, 2012

Altered intracellular targeting properties associated with mutations in the Legionella pneumophila dotA gene

scientific article published on November 1994

An Experimental Pipeline for Initial Characterization of Bacterial Type III Secretion System Inhibitor Mode of Action Using Enteropathogenic

scholarly article by Jessica M Morgan et al published 2018 in Frontiers in cellular and infection microbiology

An O antigen can interfere with the function of the Yersinia pseudotuberculosis invasin protein ⬇️

scientific article published on February 1, 1991

An aspartate residue of the Yersinia pseudotuberculosis invasin protein that is critical for integrin binding.

scientific article published on February 1995

An immunoglobulin superfamily-like domain unique to the Yersinia pseudotuberculosis invasin protein is required for stimulation of bacterial uptake via integrin receptors

scientific article published on May 2000

An open letter to Elias Zerhouni

scientific article published on 01 March 2005

Analysis of Legionella Infection Using RNAi in Drosophila Cells ⬇️

scientific article published on January 1, 2013

Analysis of expression and thermoregulation of the Yersinia pseudotuberculosis inv gene with hybrid proteins

scientific article published on August 1988

Analysis of the Legionella pneumophila fliI gene: intracellular growth of a defined mutant defective for flagellum biosynthesis

scientific article published on June 1997

Analysis of the intracellular fate of Legionella pneumophila mutants

scientific article published on October 1996

Analysis of the role of invasin during Yersinia pseudotuberculosis infection of mice

scientific article published on October 1996

Analyzing microbial disease at high resolution: following the fate of the bacterium during infection ⬇️

scientific article published on December 3, 2011

Antibiotic modulation of capsular exopolysaccharide and virulence in Acinetobacter baumannii

scientific article

Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope

scientific article published on 09 September 2020

Arf6 and phosphoinositol-4-phosphate-5-kinase activities permit bypass of the Rac1 requirement for beta1 integrin-mediated bacterial uptake

scientific article

Association of Legionella pneumophila with the macrophage endoplasmic reticulum

scientific article

Author Correction: Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope

scientific article published on 24 November 2020

Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density

scientific article

Bacterial pathogen manipulation of host membrane trafficking

scientific article published on 06 August 2014

Binding and internalization of microorganisms by integrin receptors

scientific article published on January 1994

Binding of cultured mammalian cells to immobilized bacteria ⬇️

scientific article published on February 1, 1992

Border patrols and secret passageways across the intestinal epithelium

scientific article published on July 2000

CD8(+) T cells restrict Yersinia pseudotuberculosis infection: bypass of anti-phagocytosis by targeting antigen-presenting cells

scientific article

CD8(+) T cells specific to a single Yersinia pseudotuberculosis epitope restrict bacterial replication in the liver but fail to provide sterilizing immunity

scientific article published on 4 June 2016

Cdc42 interacts with the exocyst complex to promote phagocytosis ⬇️

scientific article published on January 7, 2013

Cell biology of Legionella pneumophila

scientific article

Cellular internalization in the absence of invasin expression is promoted by the Yersinia pseudotuberculosis yadA product

scientific article published on September 1993

Common entry mechanisms. Bacterial pathogenesis

scientific article published on September 1996

Community behavior and spatial regulation within a bacterial microcolony in deep tissue sites serves to protect against host attack

scientific article

Comparison of the ability of enteroinvasive Escherichia coli, Salmonella typhimurium, Yersinia pseudotuberculosis, and Yersinia enterocolitica to enter and replicate within HEp-2 cells

scientific article

Compartmentalization of the proteins encoded by IS50R

scientific article published on 01 March 1985

Components of the endocytic and recycling trafficking pathways interfere with the integrity of the Legionella-containing vacuole

scientific article published on 01 April 2020

Conferral of transposable properties to a chromosomal gene in Escherichia coli ⬇️

scientific article published on August 15, 1980

Conjugative Transfer by the Virulence System of Legionella pneumophila ⬇️

scientific article published on February 6, 1998

Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses.

scientific article published in July 2018

Control of host cell phosphorylation by legionella pneumophila

scientific article published on 04 April 2011

Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: Analysis using platelet-derived growth factor and platelet-poor plasma ⬇️

scientific article published on June 1, 1979

Correction for Amyot et al., Poison Domains Block Transit of Translocated Substrates via the Legionella pneumophila Icm/Dot System.

scientific article published in October 2014

Crystal structure of invasin: a bacterial integrin-binding protein

scientific article

Cultured mammalian cells attach to the invasin protein of Yersinia pseudotuberculosis ⬇️

scientific article published on September 1, 1988

DNA gyrase is a host factor required for transposition of Tn5.

scientific article

Dancing with the host; flow-dependent bacterial adhesion

scientific article

Defining heterogeneity within bacterial populations via single cell approaches

scientific article

Delivering dangerous cargoes

scientific article published in December 2001

Determinants for thermoinducible cell binding and plasmid-encoded cellular penetration detected in the absence of the Yersinia pseudotuberculosis invasin protein

scientific article

Dictyostelium discoideum strains lacking the RtoA protein are defective for maturation of the Legionella pneumophila replication vacuole

scientific article

Differential effects of integrin alpha chain mutations on invasin and natural ligand interaction

scientific article published on November 1998

Discrimination Between Intracellular Uptake and Surface Adhesion of Bacterial Pathogens ⬇️

scientific article published on May 17, 1991

Disruption of RhoGDI and RhoA regulation by a Rac1 specificity switch mutant

scientific article published on 29 October 2006

Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction

scientific article published on 31 March 2008

Droplet Tn-Seq combines microfluidics with Tn-Seq for identifying complex single-cell phenotypes

scientific article published on 16 December 2019

E3 ubiquitin ligase activity and targeting of BAT3 by multiple Legionella pneumophila translocated substrates

scientific article

Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function

scientific article

Emerging views on integrin signaling via Rac1 during invasin-promoted bacterial uptake

scientific article

Endoplasmic Reticulum Tubule Protein Reticulon 4 Associates with the Legionella pneumophila Vacuole and with Translocated Substrate Ceg9.

scientific article

Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity

scientific article published on 31 August 2020

Evidence for pore‐forming ability by Legionella pneumophila ⬇️

scientific article published on January 1, 1998

Experimental Evolution of Legionella pneumophila in Mouse Macrophages Leads to Strains with Altered Determinants of Environmental Survival ⬇️

scientific article published on May 31, 2012

Farewell Stan Stanley Falkow: 1934-2018

scientific article published on 01 July 2018

Formation of a fibrous structure on the surface of Legionella pneumophila associated with exposure of DotH and DotO proteins after intracellular growth

scientific article published on 01 January 2001

Formation of the Legionella pneumophila replicative phagosome

scientific article published on 01 August 1993

Genetic analysis of bacterial virulence determinants in Bordetella pertussis and the pathogenetic Yersinia

scientific article published on January 1985

Genetic analysis of cell invasiveness by Yersinia pseudotuberculosis

scientific article published on 01 May 1986

Growth of Legionella pneumophila in Dictyostelium discoideum: a novel system for genetic analysis of host-pathogen interactions

scientific article

Growth of Yersinia pseudotuberculosis in mice occurs independently of Toll-like receptor 2 expression and induction of interleukin-10.

scientific article published on 9 April 2007

Host signal transduction and protein kinases implicated in Legionella infection

scientific article published on January 2013

IcmF and DotU are required for optimal effector translocation and trafficking of the Legionella pneumophila vacuole

scientific article published on October 2004

IcmR-regulated membrane insertion and efflux by the Legionella pneumophila IcmQ protein

scientific article published on 18 November 2003

Identification and Characterization of a Candidate Wolbachia pipientis Type IV Effector That Interacts with the Actin Cytoskeleton

scientific article published on 05 July 2016

Identification of Legionella pneumophila mutants that have aberrant intracellular fates.

scientific article published on July 1996

Identification of Legionella pneumophila promoters regulated by the macrophage intracellular environment

scientific article published on 01 August 1993

Identification of Linked Legionella pneumophila Genes Essential for Intracellular Growth and Evasion of the Endocytic Pathway ⬇️

scientific article published on March 1, 1998

Identification of MrtAB, an ABC transporter specifically required for Yersinia pseudotuberculosis to colonize the mesenteric lymph nodes

scientific article

Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells

scientific article

Identification of mammalian proteins that collaborate with type III secretion system function: involvement of a chemokine receptor in supporting translocon activity

scientific article

Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein ⬇️

scientific article published on June 1, 1990

Inhibition of host cell translation elongation by Legionella pneumophila blocks the host cell unfolded protein response

scientific article

Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation.

scientific article published in August 2017

Innate immune recognition of Yersinia pseudotuberculosis type III secretion

scientific article

Integrin beta1-chain residues involved in substrate recognition and specificity of binding to invasin

scientific article published on June 2000

Interplay Between Antibiotic Resistance and Virulence During Disease Promoted by Multidrug-Resistant Bacteria

scientific article

Intracellular growth of Legionella pneumophila in Dictyostelium discoideum, a system for genetic analysis of host-pathogen interactions

scientific article

Intracellular replication of Mycobacterium marinum within Dictyostelium discoideum: efficient replication in the absence of host coronin

scientific article

Intracellular survival by Legionella.

scientific article

Invasin-dependent and invasin-independent pathways for translocation of Yersinia pseudotuberculosis across the Peyer's patch intestinal epithelium ⬇️

scientific article published on August 1, 1997

Investigation of the host transcriptional response to intracellular bacterial infection using Dictyostelium discoideum as a host model

scientific article published on 10 December 2019

Involvement of focal adhesion kinase in invasin-mediated uptake

scientific article

Iron Limitation Triggers Early Egress by the Intracellular Bacterial Pathogen Legionella pneumophila

scientific article published on 16 May 2016

Iron-Sulfur Cluster Repair Contributes to Yersinia pseudotuberculosis Survival within Deep Tissues

scientific article published on 19 September 2019

Isolation and identification of eukaryotic receptors promoting bacterial internalization

scientific article published on January 1994

Large-scale identification of Legionella pneumophila Dot/Icm substrates that modulate host cell vesicle trafficking pathways

scientific article

Lasker-Koshland Award to 21st century microbe master

scientific article published in September 2008

Legionella pneumophila Dot/Icm translocated substrates: a sum of parts

scientific article published on 20 January 2009

Legionella pneumophila DotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake

scientific article published on May 1998

Legionella pneumophila EnhC is required for efficient replication in tumour necrosis factor alpha-stimulated macrophages

scientific article published on 28 June 2008

Legionella pneumophila is internalized by a macropinocytotic uptake pathway controlled by the Dot/Icm system and the mouse Lgn1 locus

scientific article

Legionella pneumophila replication vacuole formation involves rapid recruitment of proteins of the early secretory system

scientific article

Legionella pneumophila: factors involved in the route and response to an intracellular niche

scientific article published on 01 August 1993

Legionnaires' disease: the pore macrophage and the legion of terror within ⬇️

scientific article published on 01 July 1998

Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13

scientific article published on 01 April 1995

LidA, a translocated substrate of the Legionella pneumophila type IV secretion system, interferes with the early secretory pathway

scientific article published on July 2005

LnaB: a Legionella pneumophila activator of NF-kappaB.

scientific article

Macrophage-induced genes of Legionella pneumophila: protection from reactive intermediates and solute imbalance during intracellular growth

scientific article

Macrophages from mice with the restrictive Lgn1 allele exhibit multifactorial resistance to Legionella pneumophila

scientific article

Maintenance of vacuole integrity by bacterial pathogens

scientific article

Mammalian cell adhesion functions and cellular penetration of enteropathogenic Yersinia species

scientific article published on October 1989

Mapping and topographic localization of epitopes of the Yersinia pseudotuberculosis invasin protein

scientific article published on October 1991

Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets

scientific article published on January 2014

MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth

scientific article

Members of a Legionella pneumophila family of proteins with ExoU (phospholipase A) active sites are translocated to target cells

scientific article

Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion ⬇️

scientific article published on August 22, 2011

Modulation of the host innate immune and inflammatory response by translocated bacterial proteins

scientific article

Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells

scientific article published on March 1990

Multiple substrates of the Legionella pneumophila Dot/Icm system identified by interbacterial protein transfer.

scholarly article

Mutations in the cytoplasmic domain of the integrin beta1 chain indicate a role for endocytosis factors in bacterial internalization

scientific article

NF-kappaB translocation prevents host cell death after low-dose challenge by Legionella pneumophila.

scientific article

New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems

article

New gene in Escherichia coli K-12 (drpA): does its product play a role in RNA synthesis?

scientific article

Non-vertebrate hosts in the analysis of host-pathogen interactions

scientific article

One for All, but Not All for One: Social Behavior during Bacterial Diseases

scientific article published on 19 September 2018

Pathways for the penetration of enteroinvasive Yersinia into mammalian cells

scientific article published on February 1990

Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system

scientific article published on July 2009

Phagocytosis mediated by Yersinia invasin induces collagenase-1 expression in rabbit synovial fibroblasts through a proinflammatory cascade.

scientific article published on September 2001

Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants

scientific article

Plague's partners in crime

scientific article published on September 2014

Poison domains block transit of translocated substrates via the Legionella pneumophila Icm/Dot system

scientific article published on 24 June 2013

QnAs with Ralph R. Isberg ⬇️

scientific article published on January 7, 2013

RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics

scientific article

Recombinant Soluble Human α3β1Integrin: Purification, Processing, Regulation, and Specific Binding to Laminin-5 and Invasin in a Mutually Exclusive Manner ⬇️

scientific article published on August 4, 1998

Recombination genes on the Escherichia coli sex factor specific for transposable elements ⬇️

scientific article published on May 1, 1980

Regulation of Tn5 by the right-repeat proteins: Control at the level of the transposition reaction? ⬇️

scientific article published on 01 October 1982

Replicon fusions promoted by the inverted repeats of Tn5. The right repeat is an insertion sequence

scientific article published on 01 July 1981

Residues added to the carboxyl terminus of the Yersinia pseudotuberculosis invasin protein interfere with recognition by integrin receptors

scientific article

Robust bioengineered 3D functional human intestinal epithelium

scientific article

SWIM analysis allows rapid identification of residues involved in invasin-mediated bacterial uptake ⬇️

scientific article published on April 28, 1998

Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1).

scientific article

Signaling and invasin-promoted uptake via integrin receptors

scientific article

Subversion of integrins by enteropathogenic Yersinia

scientific article

Targeting of host Rab GTPase function by the intravacuolar pathogen Legionella pneumophila.

scientific article published on July 2006

The DotL protein, a member of the TraG-coupling protein family, is essential for Viability of Legionella pneumophila strain Lp02.

scientific article published on May 2005

The E Block motif is associated with Legionella pneumophila translocated substrates ⬇️

scientific article

The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication

scientific article published on 11 June 2019

The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation

scientific article

The Legionella pneumophila EnhC Protein Interferes with Immunostimulatory Muramyl Peptide Production to Evade Innate Immunity ⬇️

scientific article published on August 16, 2012

The Legionella pneumophila IcmR protein exhibits chaperone activity for IcmQ by preventing its participation in high-molecular-weight complexes

scientific article published in June 2001

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity

scientific article published on 01 April 2003

The Legionella pneumophila replication vacuole: making a cosy niche inside host cells

scientific article

The Yersinia pseudotuberculosis invasin protein and human fibronectin bind to mutually exclusive sites on the alpha 5 beta 1 integrin receptor.

scientific article published on December 1991

The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA

scientific article published on September 2009

The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines

scientific article

The integrin-binding domain of invasin is sufficient to allow bacterial entry into mammalian cells ⬇️

scientific article published on September 1, 1992

The interaction of bacteria with mammalian cells

scientific article published on January 1, 1992

The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter

scientific article published on 20 August 2019

The mechanism of phagocytic uptake promoted by invasin-integrin interaction

scientific article published on March 1995

The polybasic region of Rac1 modulates bacterial uptake independently of self-association and membrane targeting

scientific article published on 21 October 2008

The protein SdhA maintains the integrity of the Legionella-containing vacuole

scientific article

The psa locus is responsible for thermoinducible binding of Yersinia pseudotuberculosis to cultured cells.

scientific article

The vacuole guard hypothesis: how intravacuolar pathogens fight to maintain the integrity of their beloved home

scientific article published on 07 February 2020

Tn5 transposes independently of cointegrate resolution. Evidence for an alternative model for transposition

scientific article published on 01 March 1985

Topologically correct synthetic reconstruction of pathogen social behavior found during Yersinia growth in deep tissue sites

scientific article published on 16 June 2020

Topology of Legionella pneumophila DotA: an inner membrane protein required for replication in macrophages

scientific article

Towards a molecular understanding of human diseases using Dictyostelium discoideum

scientific article published on 4 August 2006

Transcriptional regulation of the Yersinia pseudotuberculosis pH6 antigen adhesin by two envelope-associated components

scientific article published on May 1997

Transposition of the kanamycin-resistance transposon Tn903.

scientific article published in January 1980

Two distinct defects in intracellular growth complemented by a single genetic locus in Legionella pneumophila

scientific article published on 01 January 1993

Two mammalian cell internalization strategies used by pathogenic bacteria

scientific article (publication date: December 1994)

Uptake of enteropathogenic Yersinia by mammalian cells

scientific article published on January 1996

Use of Staphylococcus aureus coated with invasin derivatives to assay invasin function

scientific article published on January 1994

Use of salt to isolate Legionella pneumophila mutants unable to replicate in macrophages

scientific article published on 01 October 1996

Very late antigen 4-dependent adhesion and costimulation of resting human T cells by the bacterial beta 1 integrin ligand invasin

scientific article

Vibrational spectra of cis-dimethyldiazene-d0, -1,1,1-d3, and -d6

article

Yersinia Entry into Host Cells Requires Rab5-Dependent Dephosphorylation of PI(4,5)P2 and Membrane Scission ⬇️

scientific article published on February 16, 2012

Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine

scientific article

Yersinia pseudotuberculosis spatially controls activation and misregulation of host cell Rac1.

scientific article

Yersinia pseudotuberculosis virulence determinants invasin, YopE, and YopT modulate RhoG activity and localization

scientific article published on 31 August 2009

cis-Dimethyldiazene

article

iMAD, a genetic screening strategy for dissecting complex interactions between a pathogen and its host

scientific article

Paulina is supported by:

About Paulina

Help