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List of works by Diana M Downs

Absence of MMF1 disrupts heme biosynthesis by targeting Hem1pin Saccharomyces cerevisiae

scientific article published on 10 October 2021

Amino-4-imidazolecarboxamide ribotide directly inhibits coenzyme A biosynthesis in Salmonella enterica

scientific article published on 02 December 2013

An Unexpected Role for the Periplasmic Phosphatase PhoN in the Salvage of B6 Vitamers in Salmonella enterica

scientific article published on 20 November 2020

Analyses of variants of the Ser/Thr dehydratase IlvA provide insight into 2-aminoacrylate metabolism in Salmonella enterica

scientific article published in Journal of Biological Chemistry

Analysis of ThiC Variants in the Context of the Metabolic Network of Salmonella enterica ⬇️

scientific article published on September 7, 2012

Analysis of yggX and gshA mutants provides insights into the labile iron pool in Salmonella enterica

scientific article published on 03 October 2008

Anthranilate synthase can generate sufficient phosphoribosyl amine for thiamine synthesis in Salmonella enterica

scientific article

Archaeal ApbC/Nbp35 homologs function as iron-sulfur cluster carrier proteins

scientific article published on 29 December 2008

Bacterial ApbC can bind and effectively transfer iron-sulfur clusters

scientific article published on 11 July 2008

Balancing cost and benefit: How E. coli cleverly averts disulfide stress caused by cystine

scientific article published on 28 November 2019

Bridges and chasms: summary of the IMAGE 2 meeting in Montreal, Canada, 30 April to 3 May 2007.

scientific article

Cobalt targets multiple metabolic processes in Salmonella enterica

scientific article

Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions

scientific journal article

Decreased Transport Restores Growth of a Salmonella enterica apbC Mutant on Tricarballylate ⬇️

scientific article published on November 18, 2011

Endogenous synthesis of 2-aminoacrylate contributes to cysteine sensitivity in Salmonella enterica

scientific article

FAD Binding by ApbE Protein from Salmonella enterica: a New Class of FAD-Binding Proteins

scientific article

From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species

scientific article

Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family

scientific article published on 15 May 2015

Genomics and bacterial metabolism.

scientific article

In the absence of RidA, endogenous 2-aminoacrylate inactivates alanine racemases by modifying the pyridoxal 5'-phosphate cofactor

scientific article published on 07 June 2013

Induction of the Sugar-Phosphate Stress Response Allows Saccharomyces cerevisiae 2-Methyl-4-Amino-5-Hydroxymethylpyrimidine Phosphate Synthase To Function in Salmonella enterica

scientific article

L-2,3-diaminopropionate generates diverse metabolic stresses in Salmonella enterica

scientific article published on 24 March 2016

Lack of the ApbC or ApbE protein results in a defect in Fe-S cluster metabolism in Salmonella enterica serovar Typhimurium

scientific article published in January 2003

Members of the Rid protein family have broad imine deaminase activity and can accelerate the Pseudomonas aeruginosa D-arginine dehydrogenase (DauA) reaction in vitro.

scientific article published on 28 September 2017

Members of the YjgF/YER057c/UK114 Family of Proteins Inhibit Phosphoribosylamine Synthesis in Vitro ⬇️

scientific article published on September 3, 2010

Metabolic flux in both the purine mononucleotide and histidine biosynthetic pathways can influence synthesis of the hydroxymethyl pyrimidine moiety of thiamine in Salmonella enterica

scientific article

Metabolic network structure and function in bacteria goes beyond conserved enzyme components

scientific article published on 14 April 2016

Perturbation of the metabolic network in Salmonella enterica reveals cross-talk between coenzyme A and thiamine pathways.

scientific article published on 23 May 2018

Perturbations in histidine biosynthesis uncover robustness in the metabolic network of Salmonella enterica

scientific article

Plasticity in the Purine–Thiamine Metabolic Network of Salmonella ⬇️

scientific article published on December 6, 2010

Probing the complex system of metabolic integration

scientific article

PurF-independent phosphoribosyl amine formation in yjgF mutants of Salmonella enterica utilizes the tryptophan biosynthetic enzyme complex anthranilate synthase-phosphoribosyltransferase

scientific article published on October 2006

Reaction of AdoMet with ThiC generates a backbone free radical

scientific article

Reduced transaminase B (IlvE) activity caused by the lack of yjgF is dependent on the status of threonine deaminase (IlvA) in Salmonella enterica serovar Typhimurium

scientific article published on February 2004

RidA Proteins Protect against Metabolic Damage by Reactive Intermediates

scientific article published on 15 July 2020

SNZ3 Encodes a PLP Synthase Involved in Thiamine Synthesis in Saccharomyces cerevisiae

scientific article published on 07 February 2019

Salmonella enterica requires ApbC function for growth on tricarballylate: evidence of functional redundancy between ApbC and IscU

scientific article published on 25 April 2008

Suppressor Analyses Identify Threonine as a Modulator of ridA Mutant Phenotypes in Salmonella enterica ⬇️

scientific article published on August 10, 2012

The Response to 2-Aminoacrylate Differs in Escherichia coli and Salmonella enterica, despite Shared Metabolic Components.

scientific article published on May 2017

The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase

scientific article published in 2021

The STM4195 gene product (PanS) transports coenzyme A precursors in Salmonella enterica

scientific article

The cysteine desulfhydrase CdsH is conditionally required for sulfur mobilization to the thiamine thiazole in Salmonella enterica

scientific article

The rhodanese domain of ThiI is both necessary and sufficient for synthesis of the thiazole moiety of thiamine in Salmonella enterica

scientific article

The stm4066 gene product of Salmonella enterica serovar Typhimurium has aminoimidazole riboside (AIRs) kinase activity and allows AIRs to satisfy the thiamine requirement of pur mutant strains

scientific article

The thiamine biosynthetic enzyme ThiC catalyzes multiple turnovers and is inhibited by S-adenosylmethionine (AdoMet) metabolites

scientific article published on 06 September 2013

Thiamine biosynthesis can be used to dissect metabolic integration

scientific article published on 08 April 2010

Understanding microbial metabolism

scientific article published on January 2006

YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium

scientific journal article

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