List of works - Roger A H Adan

"Eating addiction", rather than "food addiction", better captures addictive-like eating behavior

scientific article

A meta-analysis of circulating BDNF concentrations in anorexia nervosa ⬇️

scientific article published on April 12, 2011

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

scientific article

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

A novel approach to map induced activation of neuronal networks using chemogenetics and functional neuroimaging in rats: A proof-of-concept study on the mesocorticolimbic system.

scientific article published on 11 May 2017

AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior

scientific article

Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity

scientific article

Altered food-cue processing in chronically ill and recovered women with anorexia nervosa

scientific article

An Intersectional Approach to Target Neural Circuits With Cell- and Projection-Type Specificity: Validation in the Mesolimbic Dopamine System

An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector

scientific article

An overview on how components of the melanocortin system respond to different high energy diets ⬇️

scientific article published on 03 January 2011

Anatomical projections of the dorsomedial hypothalamus to the periaqueductal grey and their role in thermoregulation: a cautionary note

scientific article published on 01 July 2018

Animal models of eating disorder traits

scientific article published on January 2011

Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data

scientific article

Anti-obesity drugs and neural circuits of feeding.

scientific article

Anticipation of meals during restricted feeding increases activity in the hypothalamus in rats

scientific article published in November 2011

Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?

scientific article

Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner ⬇️

scientific article published on 03 January 2011

Cannabinoid, melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum

scientific article published on 26 March 2014

Central melanocortins regulate the motivation for sucrose reward

scientific article published on 26 March 2015

Chemogenetic Activation of Midbrain Dopamine Neurons Affects Attention, but not Impulsivity, in the Five-Choice Serial Reaction Time Task in Rats

scientific article published on 17 October 2016

Chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats

scientific article published on 3 October 2016

Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat

scientific article

Combined use of the canine adenovirus-2 and DREADD-technology to activate specific neural pathways in vivo

scientific article

Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns.

scientific article

Considerations related to the use of short neuropeptide promoters in viral vectors targeting hypothalamic neurons

scientific article published on 31 July 2019

Corticolimbic Mechanisms of Behavioral Inhibition under Threat of Punishment

scientific article published on 22 March 2019

Diet as connecting factor: Functional brain connectivity in relation to food intake and sucrose tasting, assessed with resting-state functional MRI in rats

scientific article published on 26 November 2019

Diet-induced neuropeptide expression: feasibility of quantifying extended and highly charged endogenous peptide sequences by selected reaction monitoring

scientific article published on 16 September 2015

Dietary factors affect food reward and motivation to eat.

scientific article published on 20 April 2012

Difference in susceptibility to activity-based anorexia in two inbred strains of mice

scientific article

Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making

scientific article published on 29 June 2019

Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior.

scientific article published in December 2007

Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet

scientific article published on 31 January 2014

Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event.

scientific article

Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides.

scientific article

Dopamine and serotonin release in the nucleus accumbens during starvation-induced hyperactivity.

scientific article published on 31 January 2009

Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa

scientific article

Dopaminergic contributions to behavioral control under threat of punishment in rats

scientific article published on 27 March 2020

Effects of GABA and Leptin Receptor-Expressing Neurons in the Lateral Hypothalamus on Feeding, Locomotion, and Thermogenesis

scientific article published on 14 May 2019

Enhancing excitability of dopamine neurons promotes motivational behaviour through increased action initiation.

scientific article published on 16 November 2017

Erratum: Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes

article

Exploration of large, rare copy number variants associated with psychiatric and neurodevelopmental disorders in individuals with anorexia nervosa

scientific article

FTO knockdown in rat ventromedial hypothalamus does not affect energy balance

scientific article

Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness

scientific article

Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations

scholarly article

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

scientific article

Ghrelin mediates anticipation to a palatable meal in rats

scientific article

Good taste or gut feeling? A new method in rats shows oro-sensory stimulation and gastric distention generate distinct and overlapping brain activation patterns

scientific article published on 15 July 2020

Hyperactivity in anorexia nervosa: warming up not just burning-off calories

scientific article

Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations

scientific article

Impact of Free-Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety-Like Behavior in Rats

scientific article published on 30 January 2019

Improved identification of endogenous peptides from murine nervous tissue by multiplexed peptide extraction methods and multiplexed mass spectrometric analysis

scientific article published in February 2009

Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets

scientific article published on 24 December 2015

Inverse agonism gains weight

scientific article

Is leptin resistance the cause or the consequence of diet-induced obesity?

scientific article published on 22 May 2018

Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area ⬇️

scientific article published on December 28, 2010

Limbic control over the homeostatic need for sodium

scientific article published in Scientific Reports

Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food

scientific article published on 19 February 2014

Longitudinal changes in the physical activity of adolescents with anorexia nervosa and their influence on body composition and leptin serum levels after recovery

scientific article

Low control over palatable food intake in rats is associated with habitual behavior and relapse vulnerability: individual differences.

scientific article

Mechanisms underlying current and future anti-obesity drugs ⬇️

scientific article published on January 8, 2013

Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward

scientific article

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat

scientific journal article

Melanocortin receptors as drug targets for disorders of energy balance

scientific article published on June 2006

Melanocortin system and eating disorders

scientific article

Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients

scientific article

Neurobiology of overeating and obesity: the role of melanocortins and beyond.

scientific article published on 02 February 2011

Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion.

scientific article

Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1.

scientific article published on 7 May 2012

Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference

scientific article

Olanzapine affects locomotor activity and meal size in male rats

scientific article published on 15 May 2010

Olanzapine and sibutramine have opposing effects on the motivation for palatable food ⬇️

scientific article published on April 1, 2012

Olanzapine-induced weight gain: chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution

scientific article published on 04 March 2008

Optimization of adeno-associated viral vector-mediated gene delivery to the hypothalamus

scientific article published in June 2010

Profiling of diet-induced neuropeptide changes in rat brain by quantitative mass spectrometry

scientific article published on 26 April 2013

Rats that are predisposed to excessive obesity show reduced (leptin-induced) thermoregulation even in the preobese state

scientific article published on 01 July 2019

Recombinant adeno-associated viral vectors

scientific article published on January 1, 2011

Recombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood

scientific article

Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats

scientific article

Reducing Ventral Tegmental Dopamine D2 Receptor Expression Selectively Boosts Incentive Motivation

scientific article

Refinement of behavioural traits in animals for the genetic dissection of eating disorders ⬇️

scientific article published on November 7, 2003

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

scientific article published on 16 February 2020

Sustained NPY overexpression in the PVN results in obesity via temporarily increasing food intake

scientific article published on 19 February 2009

Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups.

scientific article published in January 2005

The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis.

scientific article

The determinants of food choice.

scientific article

The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas

scientific article published on 30 July 2014

To eat or not to eat; regulation by the melanocortin system

scientific article

Towards new nutritional policies for brain health: A research perspective on future actions

scientific article published in 2022

Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes

scientific article published on May 2008

Viral mediated neuropeptide Y expression in the rat paraventricular nucleus results in obesity

scientific article published in October 2007

Zona incerta neurons projecting to the ventral tegmental area promote action initiation towards feeding

scientific article published on 09 December 2020

List of works by Roger A H Adan

"Eating addiction", rather than "food addiction", better captures addictive-like eating behavior

A meta-analysis of circulating BDNF concentrations in anorexia nervosa ⬇️

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

A novel approach to map induced activation of neuronal networks using chemogenetics and functional neuroimaging in rats: A proof-of-concept study on the mesocorticolimbic system.

AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior

Acute and chronic suppression of the central ghrelin signaling system reveals a role in food anticipatory activity

Altered food-cue processing in chronically ill and recovered women with anorexia nervosa

An Intersectional Approach to Target Neural Circuits With Cell- and Projection-Type Specificity: Validation in the Mesolimbic Dopamine System

An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector

An overview on how components of the melanocortin system respond to different high energy diets ⬇️

Anatomical projections of the dorsomedial hypothalamus to the periaqueductal grey and their role in thermoregulation: a cautionary note

Animal models of eating disorder traits

Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data

Anti-obesity drugs and neural circuits of feeding.

Anticipation of meals during restricted feeding increases activity in the hypothalamus in rats

Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?

Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner ⬇️

Cannabinoid, melanocortin and opioid receptor expression on DRD1 and DRD2 subpopulations in rat striatum

Central melanocortins regulate the motivation for sucrose reward

Chemogenetic Activation of Midbrain Dopamine Neurons Affects Attention, but not Impulsivity, in the Five-Choice Serial Reaction Time Task in Rats

Chemogenetic activation of dopamine neurons in the ventral tegmental area, but not substantia nigra, induces hyperactivity in rats

Chronic loss of melanin-concentrating hormone affects motivational aspects of feeding in the rat

Combined use of the canine adenovirus-2 and DREADD-technology to activate specific neural pathways in vivo

Common genetic variations in CCK, leptin, and leptin receptor genes are associated with specific human eating patterns.

Considerations related to the use of short neuropeptide promoters in viral vectors targeting hypothalamic neurons

Corticolimbic Mechanisms of Behavioral Inhibition under Threat of Punishment

Diet as connecting factor: Functional brain connectivity in relation to food intake and sucrose tasting, assessed with resting-state functional MRI in rats

Diet-induced neuropeptide expression: feasibility of quantifying extended and highly charged endogenous peptide sequences by selected reaction monitoring

Dietary factors affect food reward and motivation to eat.

Difference in susceptibility to activity-based anorexia in two inbred strains of mice

Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making

Differential effects of recombinant adeno-associated virus-mediated neuropeptide Y overexpression in the hypothalamic paraventricular nucleus and lateral hypothalamus on feeding behavior.

Differential modulation of arcuate nucleus and mesolimbic gene expression levels by central leptin in rats on short-term high-fat high-sugar diet

Differential regulation of agouti-related protein and neuropeptide Y in hypothalamic neurons following a stressful event.

Discovery and in vivo evaluation of new melanocortin-4 receptor-selective peptides.

Dopamine and serotonin release in the nucleus accumbens during starvation-induced hyperactivity.

Dopamine antagonism inhibits anorectic behavior in an animal model for anorexia nervosa

Dopaminergic contributions to behavioral control under threat of punishment in rats

Effects of GABA and Leptin Receptor-Expressing Neurons in the Lateral Hypothalamus on Feeding, Locomotion, and Thermogenesis

Enhancing excitability of dopamine neurons promotes motivational behaviour through increased action initiation.

Erratum: Variations in the uncoupling protein-3 gene are associated with specific obesity phenotypes

Exploration of large, rare copy number variants associated with psychiatric and neurodevelopmental disorders in individuals with anorexia nervosa

FTO knockdown in rat ventromedial hypothalamus does not affect energy balance

Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness

Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

Ghrelin mediates anticipation to a palatable meal in rats

Good taste or gut feeling? A new method in rats shows oro-sensory stimulation and gastric distention generate distinct and overlapping brain activation patterns

Hyperactivity in anorexia nervosa: warming up not just burning-off calories

Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations

Impact of Free-Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety-Like Behavior in Rats

Improved identification of endogenous peptides from murine nervous tissue by multiplexed peptide extraction methods and multiplexed mass spectrometric analysis

Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets

Inverse agonism gains weight

Is leptin resistance the cause or the consequence of diet-induced obesity?

Leptin reduces hyperactivity in an animal model for anorexia nervosa via the ventral tegmental area ⬇️

Limbic control over the homeostatic need for sodium

Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food

Longitudinal changes in the physical activity of adolescents with anorexia nervosa and their influence on body composition and leptin serum levels after recovery

Low control over palatable food intake in rats is associated with habitual behavior and relapse vulnerability: individual differences.

Mechanisms underlying current and future anti-obesity drugs ⬇️

Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward

Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat

Melanocortin receptors as drug targets for disorders of energy balance

Melanocortin system and eating disorders

Mutation analysis of the agouti related protein promoter region and the melanocortin-3 receptor in anorexia nervosa patients

Neurobiology of overeating and obesity: the role of melanocortins and beyond.

Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion.

Nutritional state affects the expression of the obesity-associated genes Etv5, Faim2, Fto, and Negr1.

Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference

Olanzapine affects locomotor activity and meal size in male rats

Olanzapine and sibutramine have opposing effects on the motivation for palatable food ⬇️

Olanzapine-induced weight gain: chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution

Optimization of adeno-associated viral vector-mediated gene delivery to the hypothalamus

Profiling of diet-induced neuropeptide changes in rat brain by quantitative mass spectrometry

Rats that are predisposed to excessive obesity show reduced (leptin-induced) thermoregulation even in the preobese state

Recombinant adeno-associated viral vectors

Recombinant adeno-associated virus: efficient transduction of the rat VMH and clearance from blood