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List of works by Timothy Palzkill

A Drug-Resistant β-lactamase Variant Changes the Conformation of Its Active Site Proton Shuttle to Alter Substrate Specificity and Inhibitor Potency

scientific article published on 26 October 2020

A Standard Numbering Scheme for Class C β-Lactamases

scientific article published on 21 February 2020

Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance

scientific article published on 16 April 2020

BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A β-Lactamases.

scientific article published on 9 February 2017

Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1

scientific article published on 16 November 2021

Development and Evaluation of a Novel Protein-Based Assay for Specific Detection of KPC β-Lactamases from Klebsiella pneumoniae Clinical Isolates

scientific article published on 08 January 2020

High-Resolution Mapping of Human Norovirus Antigens via Genomic Phage Display Library Selections and Deep Sequencing

scientific article published on 14 October 2020

Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries

scientific article published on 25 March 2020

KPC-2 β-lactamase Enables Carbapenem Antibiotic Resistance Through Fast Deacylation of the Covalent Intermediate

scientific article published on 03 December 2020

Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread

scientific article published on 25 March 2020

Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria.

scientific article published on 15 August 2017

Structural Basis for Different Substrate Profiles of Two Closely Related Class D β-Lactamases and Their Inhibition by Halogens

scientific article

Structure of the catalytic domain of the colistin resistance enzyme MCR-1.

scientific article

Synergistic effects of functionally distinct substitutions in β-lactamase variants shed light on the evolution of bacterial drug resistance

scientific article published in Journal of Biological Chemistry

Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases.

scientific article

The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation

scientific article published on 14 June 2017

Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of <i>Escherichia coli</i> Producing OXA-48

scientific article published in 2021

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