List of works - Hiroshi Kakeya

A 52-year-old male with fever and rapidly progressive dyspnea

scientific article published on 19 August 2008

A case of influenza pneumonia following pneumococcal infection in an adult patient with concurrent encephalopathy with a lesion in the splenium of the corpus callosum

scientific article published on July 2013

A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment

scientific article published in September 2008

A case series of chronic necrotizing pulmonary aspergillosis and a new proposal

scientific article published in January 2013

A clinical comparative study of piperacillin and sulbactam/ampicillin in patients with community-acquired bacterial pneumonia

scientific article

An adult case of influenza-associated encephalitis successfully treated with high dose intravenous immunoglobulins

scientific article published on May 2012

An autopsy case of Erysipelothrix rhusiopathiae endocarditis

scientific article published on August 2008

Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan

scientific article published on 24 October 2011

Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumoniae in airway epithelial cells

scientific article published on 28 August 2009

Azole Resistance in Candida Spp ⬇️

scientific article published on January 1, 2003

Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis.

scientific article

Clinical characteristics of pneumonia in the oldest old patients

scientific article

Clinical characteristics of seven patients with Aeromonas septicemia in a Japanese hospital

scientific article

Clinical characteristics of tertiary hospital patients from whom Acinetobacter calcoaceticus-Acinetobacter baumannii complex strains were isolated

scientific article published in January 2012

Clinical features of pulmonary cryptococcosis in non-HIV patients in Japan

scientific article published on 29 October 2014

Comparative mutant prevention concentration and mutant selection window of sitafloxacin versus other quinolones using strains of Haemophilus influenzae with decreasing susceptibility to levofloxacin

scientific article published on 15 January 2009

Concurrent subcutaneous candidal abscesses and pulmonary cryptococcosis in a patient with diabetes mellitus and a history of corticosteroid therapy.

scientific article

Contribution of the Slt2-regulated transcription factors to echinocandin tolerance in Candida glabrata.

scientific article published on 19 September 2014

Correlation between triazole treatment history and susceptibility in clinically isolated Aspergillus fumigatus.

scientific article

Diagnostic significance of Aspergillus species isolated from respiratory samples in an adult pneumology ward

scientific article

Diffuse alveolar hemorrhage following itraconazole injection

scientific article published in March 2010

Disseminated Mycobacterium abscessus subsp. massiliense infection in a Good's syndrome patient negative for human immunodeficiency virus and anti-interferon-γ autoantibody: a case report

scientific article published on 20 June 2020

Efficacy and Safety of Intravenous Peramivir Compared With Oseltamivir in High-Risk Patients Infected With Influenza A and B Viruses: A Multicenter Randomized Controlled Study

scientific article

Efficacy of AiiM, an N-acylhomoserine lactonase, against Pseudomonas aeruginosa in a mouse model of acute pneumonia

scientific article published on 20 May 2013

Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis

scientific article published on 25 February 2008

Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis

scientific article published on 25 February 2008

Efficacy of aerosolized liposomal amphotericin B against murine invasive pulmonary mucormycosis

scientific article

Efficacy of clarithromycin against experimentally induced pneumonia caused by clarithromycin-resistant Haemophilus influenzae in mice

scientific article

Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis

scientific article published on 15 June 2009

Efficacy of combination therapy with oseltamivir phosphate and azithromycin for influenza: a multicenter, open-label, randomized study

scientific article

Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection

scientific article published on 7 August 2009

Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome

scientific article

Elevated levels of high mobility group box chromosomal protein-1 (HMGB-1) in sera from patients with severe bacterial pneumonia coinfected with influenza virus

scientific article published in January 2008

Evaluation of a rapid immunochromatographic ODK0501 assay for detecting Streptococcus pneumoniae antigen in sputum samples from patients with lower respiratory tract infection

scientific article published on 04 March 2009

Evaluation of the Cica Fungi Test Candida, a novel serum Candida mannan antigen kit, and its comparison with Cand-Tec in candidemia patients.

scientific article published in January 2011

Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection.

scientific article published in January 2009

Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance

scientific article

Functional characterization of the regulators of calcineurin in Candida glabrata

scientific article

High-dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells

scientific article published on 21 March 2011

Imaging mass spectrometry analysis reveals an altered lipid distribution pattern in the tubular areas of hyper-IgA murine kidneys

scientific article

In vitro activity of garenoxacin against Streptococcus pneumoniae mutants with characterized resistance mechanisms

scientific article published on 18 May 2009

In vitro and in vivo antifungal activities of T-2307, a novel arylamidine, against Cryptococcus gattii: an emerging fungal pathogen

scientific article published on 13 February 2017

In vivo efficacy and pharmacokinetics of tomopenem (CS-023), a novel carbapenem, against Pseudomonas aeruginosa in a murine chronic respiratory tract infection model

scientific article published on 3 October 2008

In vivo efficacy of daptomycin against methicillin-resistant Staphylococcus aureus in a mouse model of hematogenous pulmonary infection

scientific article

In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube.

scientific article published on 24 April 2009

In vivo efficacy of sivelestat in combination with pazufloxacin againstLegionellapneumonia ⬇️

scientific article published on October 1, 2010

Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection

scientific article published in January 2011

Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis: a multicenter trial in Japan

scientific article published on 24 August 2010

Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages ⬇️

scientific article published on November 22, 2010

Lemierre's syndrome followed by acute respiratory distress syndrome successfully rescued by antibiotics and hemoperfusion with polymyxin B-immobilized fiber.

scientific article

Melting curve analysis for rapid detection of topoisomerase gene mutations in Haemophilus influenzae

scientific article published on 7 January 2009

Multilocus sequence typing of Cryptococcus neoformans in non-HIV associated cryptococcosis in Nagasaki, Japan

scientific article published on 17 August 2012

Multiplex real-time polymerase chain reaction for rapid detection of beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae

scientific article published on 20 February 2009

Necrotizing pneumonia due to femoral osteomyelitis caused by community-acquired methicillin-resistant Staphylococcus aureus

scientific article published in July 2013

Paradoxical response to disseminated non-tuberculosis mycobacteriosis treatment in a patient receiving tumor necrosis factor-α inhibitor: a case report

scientific article

Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus

scientific article

Prospective randomized comparison study of piperacillin/tazobactam and meropenem for healthcare-associated pneumonia in Japan

scientific article published on 24 January 2013

Pulmonary aspergilloma, diagnosis and treatment

scientific article published on December 2003

Pulmonary cryptococcosis in late pregnancy and review of published literature

scientific article published on 18 October 2008

Pulmonary cryptococcosis presenting as endobronchial lesions in a patient under corticosteroid treatment

scientific article published on 17 April 2007

Relapsed Pulmonary Cryptococcosis during Tumor Necrosis Factor α Inhibitor Treatment

scientific article published on October 2016

Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata

scientific article published on 3 February 2010

Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata

scientific article

Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat

scientific article

Severe pulmonary tuberculosis complicating Ileocecal intussusception due to intestinal tuberculosis: a case report

scientific article published on 13 July 2008

Skn7p is involved in oxidative stress response and virulence of Candida glabrata

scientific article published on 20 August 2009

Spontaneous pyogenic spondylitis caused by Klebsiella pneumoniae

scientific article

Study on the blood concentration and clinical efficacy of ceftazidime, a cephem antibiotic at dose of one gram q.i.d, for adult hospital-acquired pneumonia patients

scientific article published in February 2009

The clinical efficacy of fluoroquinolone and macrolide combination therapy compared with single-agent therapy against community-acquired pneumonia caused by Legionella pneumophila.

scientific article published on 21 June 2009

The effect of intravenous peramivir, compared with oral oseltamivir, on the outcome of post-influenza pneumococcal pneumonia in mice.

scientific article

Three cases of concurrent infection with Mycobacterium tuberculosis and Cryptococcus neoformans.

scientific article published on August 2014

Toll-like receptor 4 agonistic antibody promotes innate immunity against severe pneumonia induced by coinfection with influenza virus and Streptococcus pneumoniae.

scientific article published on May 2013

Two unusual cases of successful treatment of hypermucoviscous Klebsiella pneumoniae invasive syndrome

scientific article

List of works by Hiroshi Kakeya

A 52-year-old male with fever and rapidly progressive dyspnea

A case of influenza pneumonia following pneumococcal infection in an adult patient with concurrent encephalopathy with a lesion in the splenium of the corpus callosum

A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment

A case series of chronic necrotizing pulmonary aspergillosis and a new proposal

A clinical comparative study of piperacillin and sulbactam/ampicillin in patients with community-acquired bacterial pneumonia

An adult case of influenza-associated encephalitis successfully treated with high dose intravenous immunoglobulins

An autopsy case of Erysipelothrix rhusiopathiae endocarditis

Antifungal susceptibilities of Aspergillus fumigatus clinical isolates obtained in Nagasaki, Japan

Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumoniae in airway epithelial cells

Azole Resistance in Candida Spp ⬇️

Bronchoalveolar lavage galactomannan for the diagnosis of chronic pulmonary aspergillosis.

Clinical characteristics of pneumonia in the oldest old patients

Clinical characteristics of seven patients with Aeromonas septicemia in a Japanese hospital

Clinical characteristics of tertiary hospital patients from whom Acinetobacter calcoaceticus-Acinetobacter baumannii complex strains were isolated

Clinical features of pulmonary cryptococcosis in non-HIV patients in Japan

Comparative mutant prevention concentration and mutant selection window of sitafloxacin versus other quinolones using strains of Haemophilus influenzae with decreasing susceptibility to levofloxacin

Concurrent subcutaneous candidal abscesses and pulmonary cryptococcosis in a patient with diabetes mellitus and a history of corticosteroid therapy.

Contribution of the Slt2-regulated transcription factors to echinocandin tolerance in Candida glabrata.

Correlation between triazole treatment history and susceptibility in clinically isolated Aspergillus fumigatus.

Diagnostic significance of Aspergillus species isolated from respiratory samples in an adult pneumology ward

Diffuse alveolar hemorrhage following itraconazole injection

Disseminated Mycobacterium abscessus subsp. massiliense infection in a Good's syndrome patient negative for human immunodeficiency virus and anti-interferon-γ autoantibody: a case report

Efficacy and Safety of Intravenous Peramivir Compared With Oseltamivir in High-Risk Patients Infected With Influenza A and B Viruses: A Multicenter Randomized Controlled Study

Efficacy of AiiM, an N-acylhomoserine lactonase, against Pseudomonas aeruginosa in a mouse model of acute pneumonia

Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis

Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis

Efficacy of aerosolized liposomal amphotericin B against murine invasive pulmonary mucormycosis

Efficacy of clarithromycin against experimentally induced pneumonia caused by clarithromycin-resistant Haemophilus influenzae in mice

Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis

Efficacy of combination therapy with oseltamivir phosphate and azithromycin for influenza: a multicenter, open-label, randomized study

Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection

Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome

Elevated levels of high mobility group box chromosomal protein-1 (HMGB-1) in sera from patients with severe bacterial pneumonia coinfected with influenza virus

Evaluation of a rapid immunochromatographic ODK0501 assay for detecting Streptococcus pneumoniae antigen in sputum samples from patients with lower respiratory tract infection

Evaluation of the Cica Fungi Test Candida, a novel serum Candida mannan antigen kit, and its comparison with Cand-Tec in candidemia patients.

Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection.

Fluconazole treatment is effective against a Candida albicans erg3/erg3 mutant in vivo despite in vitro resistance

Functional characterization of the regulators of calcineurin in Candida glabrata

High-dose tobramycin inhibits lipopolysaccharide-induced MUC5AC production in human lung epithelial cells

Imaging mass spectrometry analysis reveals an altered lipid distribution pattern in the tubular areas of hyper-IgA murine kidneys

In vitro activity of garenoxacin against Streptococcus pneumoniae mutants with characterized resistance mechanisms

In vitro and in vivo antifungal activities of T-2307, a novel arylamidine, against Cryptococcus gattii: an emerging fungal pathogen

In vivo efficacy and pharmacokinetics of tomopenem (CS-023), a novel carbapenem, against Pseudomonas aeruginosa in a murine chronic respiratory tract infection model

In vivo efficacy of daptomycin against methicillin-resistant Staphylococcus aureus in a mouse model of hematogenous pulmonary infection

In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube.

In vivo efficacy of sivelestat in combination with pazufloxacin againstLegionellapneumonia ⬇️

Increase of apoptosis in a murine model for severe pneumococcal pneumonia during influenza A virus infection

Intravenous micafungin versus voriconazole for chronic pulmonary aspergillosis: a multicenter trial in Japan

Legionella pneumophila induces cathepsin B-dependent necrotic cell death with releasing high mobility group box1 in macrophages ⬇️

Lemierre's syndrome followed by acute respiratory distress syndrome successfully rescued by antibiotics and hemoperfusion with polymyxin B-immobilized fiber.

Melting curve analysis for rapid detection of topoisomerase gene mutations in Haemophilus influenzae

Multilocus sequence typing of Cryptococcus neoformans in non-HIV associated cryptococcosis in Nagasaki, Japan

Multiplex real-time polymerase chain reaction for rapid detection of beta-lactamase-negative, ampicillin-resistant Haemophilus influenzae

Necrotizing pneumonia due to femoral osteomyelitis caused by community-acquired methicillin-resistant Staphylococcus aureus

Paradoxical response to disseminated non-tuberculosis mycobacteriosis treatment in a patient receiving tumor necrosis factor-α inhibitor: a case report

Potency of SMP-601, a novel carbapenem, in hematogenous murine bronchopneumonia caused by methicillin-resistant and vancomycin-intermediate Staphylococcus aureus

Prospective randomized comparison study of piperacillin/tazobactam and meropenem for healthcare-associated pneumonia in Japan

Pulmonary aspergilloma, diagnosis and treatment

Pulmonary cryptococcosis in late pregnancy and review of published literature

Pulmonary cryptococcosis presenting as endobronchial lesions in a patient under corticosteroid treatment

Relapsed Pulmonary Cryptococcosis during Tumor Necrosis Factor α Inhibitor Treatment

Role of the Slt2 mitogen-activated protein kinase pathway in cell wall integrity and virulence in Candida glabrata

Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata

Severe Legionnaires' disease successfully treated using a combination of fluoroquinolone, erythromycin, corticosteroid, and sivelestat

Severe pulmonary tuberculosis complicating Ileocecal intussusception due to intestinal tuberculosis: a case report

Skn7p is involved in oxidative stress response and virulence of Candida glabrata

Spontaneous pyogenic spondylitis caused by Klebsiella pneumoniae

Study on the blood concentration and clinical efficacy of ceftazidime, a cephem antibiotic at dose of one gram q.i.d, for adult hospital-acquired pneumonia patients

The clinical efficacy of fluoroquinolone and macrolide combination therapy compared with single-agent therapy against community-acquired pneumonia caused by Legionella pneumophila.

The effect of intravenous peramivir, compared with oral oseltamivir, on the outcome of post-influenza pneumococcal pneumonia in mice.

Three cases of concurrent infection with Mycobacterium tuberculosis and Cryptococcus neoformans.

Toll-like receptor 4 agonistic antibody promotes innate immunity against severe pneumonia induced by coinfection with influenza virus and Streptococcus pneumoniae.

Two unusual cases of successful treatment of hypermucoviscous Klebsiella pneumoniae invasive syndrome