List of works - Neeltje A Kootstra

A lower viral set point but little immunological impact after early treatment during primary HIV infection

scientific article

ADAR1 Facilitates HIV-1 Replication in Primary CD4+ T Cells

scientific article published on 2 December 2015

Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells

scientific article

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

scientific article published on 23 December 2020

Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19

scientific article published on 19 May 2020

Analysis of the Temporal Relationship between Human Immunodeficiency Virus Type 1 Quasispecies in Sequential Blood Samples and Various Organs Obtained at Autopsy ⬇️

scientific article published on January 1, 1998

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population ⬇️

scientific article published on March 1, 1992

Chimeric HIV-1 envelope glycoproteins with potent intrinsic granulocyte-macrophage colony-stimulating factor (GM-CSF) activity

scientific article

Comparison of in vivo and in vitro evolution of CCR5 to CXCR4 coreceptor use of primary human immunodeficiency virus type 1 variants

scientific article published on 4 February 2011

Comparison of the hepatitis B virus core, surface and polymerase gene substitution rates in chronically infected patients ⬇️

scientific article published on August 16, 2011

DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner

scientific article published on 7 December 2015

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

scientific article published on 28 August 2017

Efficient transduction of simian cells by HIV-1-based lentiviral vectors that contain mutations in the capsid protein

scientific article published on 13 February 2007

Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

scientific article

Fetal exposure to HIV-1 alters chemokine receptor expression by CD4+T cells and increases susceptibility to HIV-1.

scientific article

G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA.

scientific article published on 29 September 2015

Gag sequence variation in a human immunodeficiency virus type 1 transmission cluster influences viral replication fitness ⬇️

scientific article published on November 7, 2012

Gene therapy with viral vectors

scientific article

Genetic composition of replication competent clonal HIV-1 variants isolated from peripheral blood mononuclear cells (PBMC), HIV-1 proviral DNA from PBMC and HIV-1 RNA in serum in the course of HIV-1 infection

scientific article published on 17 July 2010

Genome-wide association scan in HIV-1-infected individuals identifying variants influencing disease course.

scientific article

HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism.

scientific article

HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds

scientific article published on 07 July 2016

HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag

scientific article

Hepatitis B Virus Protein X Induces Degradation of Talin-1.

scientific article published on 19 October 2016

Higher Prevalence of Hypertension in HIV-1-Infected Patients on Combination Antiretroviral Therapy Is Associated With Changes in Body Composition and Prior Stavudine Exposure

scientific article published on 3 May 2016

Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity

scientific article

Identification of a new genotype of Torque Teno Mini virus

scientific article published on 30 October 2013

Identification of the HIV-1 Vif and Human APOBEC3G Protein Interface

scientific article

Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti-MicroRNA-122, RG-101.

scientific article published on 11 March 2017

Immune responses in DAA treated chronic hepatitis C patients with and without prior RG-101 dosing

scientific article published on 24 August 2017

Infection history determines the differentiation state of human CD8+ T cells

scientific article

Loss of HIV-1-derived cytotoxic T lymphocyte epitopes restricted by protective HLA-B alleles during the HIV-1 epidemic

scientific article published on September 2011

Low level of HIV-1 evolution after transmission from mother to child

scientific article published on 28 May 2014

Macrophages and HIV-1.

scientific article published on September 2011

MicroRNAs: role and therapeutic targets in viral hepatitis

scientific article published on 18 March 2014

Molecular evolution of human immunodeficiency virus type 1 upon transmission between human leukocyte antigen disparate donor-recipient pairs

scientific article

Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children

scientific article published on March 2016

Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule ⬇️

scientific article published on May 1, 1992

Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcription

scientific article

Plasma MicroRNA Levels Are Associated With Hepatitis B e Antigen Status and Treatment Response in Chronic Hepatitis B Patients

scientific article

Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages.

scientific article

Polymorphisms in the regulatory region of the Cyclophilin A gene influence the susceptibility for HIV-1 infection

scientific article

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

scientific article published on 13 May 2020

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

scientific article published on 15 June 2020

Proliferation-Dependent Replication in Primary Macrophages of Macrophage-Tropic HIV Type 1 Variants ⬇️

scientific article published on March 1, 1998

Proliferation-dependent HIV-1 infection of monocytes occurs during differentiation into macrophages ⬇️

scientific article published on April 1, 1992

Protein X of hepatitis B virus: origin and structure similarity with the central domain of DNA glycosylase

scientific article published in 2011

Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets

scientific article published on 07 December 2016

Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection

scientific article published on 11 January 2012

Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial

scientific article

Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia

scientific article

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

scientific article published on 31 March 2009

Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage.

scientific article published in July 2018

Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls

scientific article published on 14 August 2017

The Neutralizing Antibody Response in an Individual with Triple HIV-1 Infection Remains Directed at the First Infecting Subtype

scientific article

The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection

scientific article

The hepatitis B virus x protein inhibits thymine DNA glycosylase initiated base excision repair

scientific article

The presence of CXCR4-using HIV-1 prior to start of antiretroviral therapy is an independent predictor of delayed viral suppression

scientific article

Twelve-Month Antiretroviral Therapy Suppresses Plasma and Genital Viral Loads but Fails to Alter Genital Levels of Cytokines, in a Cohort of HIV-Infected Rwandan Women

scientific article published on 26 May 2015

Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients

scientific article

List of works by Neeltje A Kootstra

A lower viral set point but little immunological impact after early treatment during primary HIV infection

ADAR1 Facilitates HIV-1 Replication in Primary CD4+ T Cells

Abrogation of postentry restriction of HIV-1-based lentiviral vector transduction in simian cells

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Afucosylated immunoglobulin G responses are a hallmark of enveloped virus infections and show an exacerbated phenotype in COVID-19

Analysis of the Temporal Relationship between Human Immunodeficiency Virus Type 1 Quasispecies in Sequential Blood Samples and Various Organs Obtained at Autopsy ⬇️

Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population ⬇️

Chimeric HIV-1 envelope glycoproteins with potent intrinsic granulocyte-macrophage colony-stimulating factor (GM-CSF) activity

Comparison of in vivo and in vitro evolution of CCR5 to CXCR4 coreceptor use of primary human immunodeficiency virus type 1 variants

Comparison of the hepatitis B virus core, surface and polymerase gene substitution rates in chronically infected patients ⬇️

DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

Efficient transduction of simian cells by HIV-1-based lentiviral vectors that contain mutations in the capsid protein

Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

Fetal exposure to HIV-1 alters chemokine receptor expression by CD4+T cells and increases susceptibility to HIV-1.

G3BP1 restricts HIV-1 replication in macrophages and T-cells by sequestering viral RNA.

Gag sequence variation in a human immunodeficiency virus type 1 transmission cluster influences viral replication fitness ⬇️

Gene therapy with viral vectors

Genetic composition of replication competent clonal HIV-1 variants isolated from peripheral blood mononuclear cells (PBMC), HIV-1 proviral DNA from PBMC and HIV-1 RNA in serum in the course of HIV-1 infection

Genome-wide association scan in HIV-1-infected individuals identifying variants influencing disease course.

HIV-1 disease progression is associated with bile-salt stimulated lipase (BSSL) gene polymorphism.

HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds

HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag

Hepatitis B Virus Protein X Induces Degradation of Talin-1.

Higher Prevalence of Hypertension in HIV-1-Infected Patients on Combination Antiretroviral Therapy Is Associated With Changes in Body Composition and Prior Stavudine Exposure

Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity

Identification of a new genotype of Torque Teno Mini virus

Identification of the HIV-1 Vif and Human APOBEC3G Protein Interface

Immune phenotype and function of natural killer and T cells in chronic hepatitis C patients who received a single dose of anti-MicroRNA-122, RG-101.

Immune responses in DAA treated chronic hepatitis C patients with and without prior RG-101 dosing

Infection history determines the differentiation state of human CD8+ T cells

Loss of HIV-1-derived cytotoxic T lymphocyte epitopes restricted by protective HLA-B alleles during the HIV-1 epidemic

Low level of HIV-1 evolution after transmission from mother to child

Macrophages and HIV-1.

MicroRNAs: role and therapeutic targets in viral hepatitis

Molecular evolution of human immunodeficiency virus type 1 upon transmission between human leukocyte antigen disparate donor-recipient pairs

Neurometabolite Alterations Associated With Cognitive Performance in Perinatally HIV-Infected Children

Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule ⬇️

Phosphodiesterase 8a supports HIV-1 replication in macrophages at the level of reverse transcription

Plasma MicroRNA Levels Are Associated With Hepatitis B e Antigen Status and Treatment Response in Chronic Hepatitis B Patients

Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages.

Polymorphisms in the regulatory region of the Cyclophilin A gene influence the susceptibility for HIV-1 infection

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Proliferation-Dependent Replication in Primary Macrophages of Macrophage-Tropic HIV Type 1 Variants ⬇️

Proliferation-dependent HIV-1 infection of monocytes occurs during differentiation into macrophages ⬇️

Protein X of hepatitis B virus: origin and structure similarity with the central domain of DNA glycosylase

Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets

Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection

Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial

Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia

Storage and regulated secretion of factor VIII in blood outgrowth endothelial cells

Systemic DPP4 activity is reduced during primary HIV-1 infection and is associated with intestinal RORC+ CD4+ cell levels: a surrogate marker candidate of HIV-induced intestinal damage.

Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls

The Neutralizing Antibody Response in an Individual with Triple HIV-1 Infection Remains Directed at the First Infecting Subtype

The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection

The hepatitis B virus x protein inhibits thymine DNA glycosylase initiated base excision repair

The presence of CXCR4-using HIV-1 prior to start of antiretroviral therapy is an independent predictor of delayed viral suppression

Twelve-Month Antiretroviral Therapy Suppresses Plasma and Genital Viral Loads but Fails to Alter Genital Levels of Cytokines, in a Cohort of HIV-Infected Rwandan Women

Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients