Search filters

List of works by Govert W Somsen

A Novel Platinum(II)-Based Bifunctional ADC Linker Benchmarked Using 89Zr-Desferal and Auristatin F-Conjugated Trastuzumab

scientific article published on 21 November 2016

A single-step preparation of carbohydrate functionalized monoliths for separation and trapping of polar compounds

scientific article published on 16 August 2020

Acylation of arginine in goserelin-loaded PLGA microspheres.

scientific article published on 19 November 2015

Adduct-ion formation in trapped ion mobility spectrometry as a potential tool for studying molecular structures and conformations

article

Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing

scientific article

Analysis of recombinant human growth hormone by capillary electrophoresis with bilayer-coated capillaries using UV and MS detection

scientific article published on 13 January 2007

Analytical characterization of NOTA-modified somatropins

scientific article published on 20 March 2014

Analytics for Bioactivity Profiling of Complex Mixtures with a Focus on Venoms

scientific article published on 01 January 2020

Anionic metabolic profiling of urine from antibiotic-treated rats by capillary electrophoresis-mass spectrometry

scientific article published on 12 January 2013

Antivenom Neutralization of Coagulopathic Snake Venom Toxins Assessed by Bioactivity Profiling Using Nanofractionation Analytics

scientific article published on 16 January 2020

Asymmetrical flow field-flow fractionation to probe the dynamic association equilibria of β-D-galactosidase

scientific article published on 13 November 2020

At-Line Cellular Screening Methodology for Bioactives in Mixtures Targeting the α7-Nicotinic Acetylcholine Receptor

scientific article published on 6 January 2016

At-line coupling of LC-MS to bioaffinity and selectivity assessment for metabolic profiling of ligands towards chemokine receptors CXCR1 and CXCR2.

scientific article published on 10 August 2015

At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake venoms.

scientific article published on 18 December 2015

Atmospheric pressure photoionization for enhanced compatibility in on-line micellar electrokinetic chromatography-mass spectrometry

scientific article

Bioactivity Profiling of Small-Volume Samples by Nano Liquid Chromatography Coupled to Microarray Bioassaying Using High-Resolution Fractionation

scientific article published on 02 August 2019

CE-MS for metabolomics: Developments and applications in the period 2008-2010.

scientific article published on 03 December 2010

CE-MS for metabolomics: Developments and applications in the period 2014-2016

scientific article published on 08 October 2016

CE-MS for metabolomics: Developments and applications in the period 2016-2018

scientific article published on 01 October 2018

CE-MS for metabolomics: developments and applications in the period 2010-2012.

scientific article published on 03 December 2012

CE-MS for metabolomics: developments and applications in the period 2012-2014.

scientific article

CE-MS for the analysis of intact proteins 2010-2012.

scientific article

CE-MS in metabolomics

scientific article published on January 2009

Capillary Electrophoresis: Trends and Recent Advances

scientific article published on 3 January 2018

Capillary HILIC-MS: A New Tool for Sensitive Top-Down Proteomics.

scientific article

Capillary Zone Electrophoresis-Mass Spectrometry of Intact Proteins.

scientific article published in January 2016

Capillary electrophoresis of intact basic proteins using noncovalently triple-layer coated capillaries.

scientific article published in July 2009

Capillary electrophoresis with lamp-based wavelength-resolved fluorescence detection for the probing of protein conformational changes

scientific article published on 8 July 2011

Capillary electrophoresis-atmospheric pressure chemical ionization-mass spectrometry using an orthogonal interface: set-up and system parameters

scientific article

Capillary electrophoresis-based assessment of nanobody affinity and purity.

scientific article published on 4 February 2014

Capillary electrophoresis-mass spectrometry for the analysis of intact proteins

scientific article

Capillary electrophoresis-mass spectrometry for the analysis of intact proteins 2007-2010.

scientific article

Capillary electrophoresis-mass spectrometry of intact basic proteins using Polybrene-dextran sulfate-Polybrene-coated capillaries: system optimization and performance

scientific article published on 16 September 2010

Capillary electrophoresis-mass spectrometry of proteins at medium pH using bilayer-coated capillaries

scientific article published on 18 October 2006

Capillary electrophoresis-tandem mass spectrometry as a highly selective tool for the compositional and site-specific assessment of multiple peptide-deamidation.

scientific article published on 24 June 2017

Capillary electrophoresis-time of flight-mass spectrometry using noncovalently bilayer-coated capillaries for the analysis of amino acids in human urine

scientific article published in June 2008

Characterization of conformers and dimers of antithrombin by capillary electrophoresis-quadrupole-time-of-flight mass spectrometry

scientific article published on 14 October 2016

Chiral Discrimination of DL-Amino Acids by Trapped Ion Mobility Spectrometry after Derivatization with (+)-1-(9-Fluorenyl)ethyl Chloroformate

article

Chiral capillary electrophoresis with UV-excited fluorescence detection for the enantioselective analysis of 9-fluorenylmethoxycarbonyl-derivatized amino acids

scientific article published on 29 May 2018

Chiral separation of acidic compounds using an O-9-(tert-butylcarbamoyl)quinidine functionalized monolith in micro-liquid chromatography

scientific article published on 19 March 2016

Chromatographic preconcentration coupled on-line to capillary electrophoresis via a tee-split interface

scientific article published on 01 October 2004

Chromatographic preconcentration coupled to capillary electrophoresis via an in-line injection valve

scientific article published on 01 August 2004

Comparison of atmospheric pressure photoionization and ESI for CZE-MS of drugs

scientific article

Comparison of capillary electrophoresis-mass spectrometry and hydrophilic interaction chromatography-mass spectrometry for anionic metabolic profiling of urine.

scientific article published on 27 August 2014

Comparison of electrospray ionization and atmospheric pressure photoionization for coupling of micellar electrokinetic chromatography with ion trap mass spectrometry

scientific article

Compound Identification Using Liquid Chromatography and High-Resolution Noncontact Fraction Collection with a Solenoid Valve

scientific article published on 16 May 2019

Computer-aided gradient optimization of hydrophilic interaction liquid chromatographic separations of intact proteins and protein glycoforms

scientific article published on 03 April 2019

Continuous fraction collection of gas chromatographic separations with parallel mass spectrometric detection applied to cell-based bioactivity analysis.

scientific article published on 2 March 2017

Coupling of non-aqueous electrokinetic chromatography using cationic cyclodextrins with electrospray ionization mass spectrometry

scientific article

Coupling of sequential injection analysis and capillary electrophoresis - Laser-induced fluorescence via a valve interface for on-line derivatization and analysis of amino acids and peptides.

scientific article

Cyclodextrin-based nonaqueous electrokinetic chromatography with UV and mass spectrometric detection: application to the impurity profiling of amiodarone

scientific article published in September 2008

Design and applications of coupled SPE-CE.

scientific article published on January 2008

Detailed Characterization of Monoclonal Antibody Receptor Interaction Using Affinity Liquid Chromatography Hyphenated to Native Mass Spectrometry.

scientific article published on 11 April 2017

Determination of oversulfated chondroitin sulfate and dermatan sulfate impurities in heparin by capillary electrophoresis

scientific article published on 26 February 2009

Determination of trehalose-6-phosphate in Arabidopsis seedlings by successive extractions followed by anion exchange chromatography-mass spectrometry

scientific article published on 9 March 2009

Determination of trehalose-6-phosphate in Arabidopsis thaliana seedlings by hydrophilic-interaction liquid chromatography-mass spectrometry

scientific article published on 27 March 2012

Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms

scientific article published on 24 June 2015

Development of a generic high-throughput screening assay for profiling snake venom protease activity after high-resolution chromatographic fractionation

scientific article published on 26 February 2020

Development of an Online Cell-Based Bioactivity Screening Method by Coupling Liquid Chromatography to Flow Cytometry with Parallel Mass Spectrometry.

scientific article published on 5 April 2016

Development of high-throughput screening assays for profiling snake venom phospholipase A2 activity after chromatographic fractionation

scientific article published on 02 June 2020

Developments in coupled solid-phase extraction-capillary electrophoresis 2009-2011.

scientific article

Developments in coupled solid-phase extraction-capillary electrophoresis 2011-2013.

scientific article published on 31 October 2013

Developments in coupled solid-phase extraction-capillary electrophoresis 2013-2015.

scientific article published on 14 October 2015

Direct sample injection for capillary electrophoretic determination of organic acids in cerebrospinal fluid

scientific article published on 10 November 2006

Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays

scientific article published on 25 January 2019

Drug impurity profiling by capillary electrophoresis/mass spectrometry using various ionization techniques

scientific article

Effect of fabrication strategy on the enantioseparation performance of β-cyclodextrin-functionalized polymethacrylate monoliths: A comparative evaluation.

scientific article published on 27 July 2017

Effectiveness of charged noncovalent polymer coatings against protein adsorption to silica surfaces studied by evanescent-wave cavity ring-down spectroscopy and capillary electrophoresis.

scientific article published in December 2009

Efficient and highly reproducible capillary electrophoresis-mass spectrometry of peptides using Polybrene-poly(vinyl sulfonate)-coated capillaries

scientific article published on 01 June 2006

Efficient and reproducible analysis of peptides by capillary electrophoresis using noncovalently bilayer-coated capillaries

scientific article published in March 2004

Enantioselective analysis of proteinogenic amino acids in cerebrospinal fluid by capillary electrophoresis-mass spectrometry.

scientific article

Enantioselective micellar electrokinetic chromatography of dl-amino acids using (+)-1-(9-fluorenyl)-ethyl chloroformate derivatization and UV-induced fluorescence detection

scientific article published on 22 May 2018

Erratum to: Monitoring antigenic protein integrity during glycoconjugate vaccine synthesis using capillary electrophoresis-mass spectrometry.

scientific article published on 9 November 2016

Evaluation of CE methods for global metabolic profiling of urine

scientific article published in July 2010

Evaluation of capillary electrophoresis-mass spectrometry for the analysis of the conformational heterogeneity of intact proteins using beta2-microglobulin as model compound

scientific article

Evaluation of fritless solid-phase extraction coupled on-line with capillary electrophoresis-mass spectrometry for the analysis of opioid peptides in cerebrospinal fluid.

scientific article published in October 2014

Evaluation of the sensitivity of miniaturized liquid chromatography-electrospray ionization-mass spectrometry for pharmaceutical analysis

scientific article

Explorative analysis of urine by capillary electrophoresis-mass spectrometry in chronic patients with complex regional pain syndrome.

scientific article published in December 2009

Fast, selective and quantitative protein profiling of adenovirus-vector based vaccines by ultra-performance liquid chromatography

scientific article published on 26 October 2018

Feasibility of nonvolatile buffers in capillary electrophoresis-electrospray ionization-mass spectrometry of proteins.

scientific article

Fully compatible and ultra-sensitive micellar electrokinetic chromatography-tandem mass spectrometry using sheathless porous-tip interfacing.

scientific article

Gas chromatography fractionation platform featuring parallel flame-ionization detection and continuous high-resolution analyte collection in 384-well plates

scientific article

Growth arrest by trehalose-6-phosphate: an astonishing case of primary metabolite control over growth by way of the SnRK1 signaling pathway.

scientific article

Heterogeneity assessment of antibody-derived therapeutics at the intact and middle-up level by low-flow sheathless capillary electrophoresis-mass spectrometry

scientific article published on 15 August 2018

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

scientific article published on 01 April 2020

High-resolution glycoform profiling of intact therapeutic proteins by hydrophilic interaction chromatography-mass spectrometry.

scientific article published on 8 March 2018

Highly Selective Screening of Estrogenic Compounds in Consumer-Electronics Plastics by Liquid Chromatography in Parallel Combined with Nanofractionation-Bioactivity Detection and Mass Spectrometry

scientific article published on 2 November 2016

Hydrophilic interaction chromatography-mass spectrometry for anionic metabolic profiling of urine from antibiotic-treated rats

scientific article published on 20 January 2014

Hydrophilic interaction liquid chromatography-mass spectrometry as a new tool for the characterization of intact semi-synthetic glycoproteins.

scientific article published on 02 June 2017

Identification and Assessment of Octreotide Acylation in Polyester Microspheres by LC-MS/MS.

scientific article published on 2 April 2015

Identification of mutagenic and endocrine disrupting compounds in surface water and wastewater treatment plant effluents using high-resolution effect-directed analysis

scientific article published on 16 October 2019

Implementation of at-line capillary zone electrophoresis for fast and reliable determination of adenovirus concentrations in vaccine manufacturing

scientific article published on 15 April 2019

In-capillary derivatization with (-)-1-(9-fluorenyl)ethyl chloroformate as chiral labeling agent for the electrophoretic separation of amino acids.

scientific article

In-line solid-phase extraction–capillary electrophoresis coupled with mass spectrometry for determination of drugs of abuse in human urine

scientific article published on 29 February 2012

Increasing the Separation Capacity of Intact Histone Proteoforms Chromatography Coupling Online Weak Cation Exchange-HILIC to Reversed Phase LC UVPD-HRMS

scientific article published on 08 October 2018

Influence of the BGE composition on analyte response in CD-mediated NACE-MS.

scientific article published in April 2010

Interlaboratory study of a NACE method for the determination ofR-timolol content inS-timolol maleate: Assessment of uncertainty

scientific article published on 01 June 2006

Investigations into the stabilization of drugs by sugar glasses: III. The influence of various high-pH buffers

scientific article published on September 1, 2003

Ionization techniques in capillary electrophoresis-mass spectrometry: principles, design, and application

scientific article

Lamp-based native fluorescence detection of proteins in capillary electrophoresis

scientific article published on 2 April 2009

Lamp-based wavelength-resolved fluorescence detection for protein capillary electrophoresis: setup and detector performance

scientific article published on 01 September 2010

Linking the concentrations of itraconazole and 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids after oral intake of Sporanox®

scientific article published on 27 June 2018

Liquid chromatographic nanofractionation with parallel mass spectrometric detection for the screening of plasmin inhibitors and (metallo)proteinases in snake venoms

scientific article published on 09 August 2018

Low-flow sheathless capillary electrophoresis-mass spectrometry for sensitive glycoform profiling of intact pharmaceutical proteins

scientific article published on 30 January 2013

Low-picomolar analysis of peptides by on-line coupling of fritless solid-phase extraction to sheathless capillary electrophoresis-mass spectrometry.

scientific article

MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation

scientific article published on 21 August 2020

Metabolic analysis of body fluids by capillary electrophoresis using noncovalently coated capillaries

scientific article published on 06 June 2008

Metabolic profiling of human urine by CE-MS using a positively charged capillary coating and comparison with UPLC-MS.

scientific article

Methyleneation of peptides by N,N,N,N-tetramethylethylenediamine (TEMED) under conditions used for free radical polymerization: a mechanistic study.

scientific article published on 30 December 2014

Micellar electrokinetic chromatography-electrospray ionization mass spectrometry employing a volatile surfactant for the analysis of amino acids in human urine

scientific article published on 21 August 2013

Micellar electrokinetic chromatography-electrospray ionization mass spectrometry for the identification of drug impurities

scientific article published on 11 July 2006

Micellar electrokinetic chromatography-mass spectrometry: combining the supposedly incompatible

scientific article published on 01 January 2006

Monitoring antigenic protein integrity during glycoconjugate vaccine synthesis using capillary electrophoresis-mass spectrometry

scientific article

Nanofractionation Platform with Parallel Mass Spectrometry for Identification of CYP1A2 Inhibitors in Metabolic Mixtures

scientific article published on 21 December 2017

Native fluorescence detection of biomolecular and pharmaceutical compounds in capillary electrophoresis: detector designs, performance and applications: a review

scientific article published on 13 December 2012

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

scientific article published on 04 May 2018

Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms

scientific article published on 15 September 2020

Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic Viperinae Snake Venom Toxins

scientific article published on 20 August 2020

New capillary gel electrophoresis method for fast and accurate identification and quantification of multiple viral proteins in influenza vaccines.

scientific article

Nonaqueous electrokinetic chromatography-electrospray ionization mass spectrometry using anionic cyclodextrins

scientific article published on 18 May 2007

Noncovalently bilayer-coated capillaries for efficient and reproducible analysis of proteins by capillary electrophoresis

scientific article published in August 2005

On-line capillary electrophoresis-mass spectrometry using dopant-assisted atmospheric pressure photoionization: setup and system performance

scientific article

On-line coupling of SPE and CE-MS for peptide analysis

scientific article published on May 2007

On-line coupling of cyclodextrin mediated nonaqueous capillary electrophoresis to mass spectrometry for the determination of salbutamol enantiomers in urine

scientific article published on 13 September 2005

On-line coupling of electrokinetic chromatography and mass spectrometry

scientific article

On-line coupling of size exclusion chromatography and capillary electrophoresis via solid-phase extraction and a Tee-split interface

scientific article published on 2 March 2006

On-line coupling of solid-phase extraction and capillary electrophoresis for the determination of cefoperazone and ceftiofur in plasma

scientific article published on 02 June 2007

On-line coupling of surface plasmon resonance optical sensing to size-exclusion chromatography for affinity assessment of antibody samples

scientific article published on 9 May 2016

On-line micellar electrokinetic chromatography-mass spectrometry: feasibility of direct introduction of non-volatile buffer and surfactant into the electrospray interface

scientific article published in June 2003

One single, fast and robust capillary electrophoresis method for the direct quantification of intact adenovirus particles in upstream and downstream processing samples.

scientific article published on 12 January 2017

Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry

scientific article published on 30 May 2018

Optimization of in-line fritless solid-phase extraction for capillary electrophoresis-mass spectrometry

scientific article published on 27 August 2012

Performance of a sheathless porous tip sprayer for capillary electrophoresis-electrospray ionization-mass spectrometry of intact proteins

scientific article published on November 2010

Photon-independent gas-phase-ion formation in capillary electrophoresis-mass spectrometry using atmospheric pressure photoionization

scientific article

Platinum(II) as bifunctional linker in antibody-drug conjugate formation: coupling of a 4-nitrobenzo-2-oxa-1,3-diazole fluorophore to trastuzumab as a model

scientific article published on 25 March 2015

Potential of capillary electrophoresis with wavelength-resolved fluorescence detection for protein unfolding studies using β-lactoglobulin B as a test compound

scientific article published on 6 June 2013

Preface

scientific article published on 27 March 2017

Probing Protein Denaturation during Size-Exclusion Chromatography Using Native Mass Spectrometry

scientific article published on 06 March 2020

Profiling of erythropoietin products by capillary electrophoresis with native fluorescence detection

scientific article published on 24 September 2012

Quality of original and biosimilar epoetin products

scientific article

Rapid activity-directed screening of estrogens by parallel coupling of liquid chromatography with a functional gene reporter assay and mass spectrometry.

scientific article published on 16 June 2015

Rapid ligand fishing for identification of acetylcholinesterase-binding peptides in snake venom reveals new properties of dendrotoxins

scientific article published on 07 July 2018

Rapid screening and identification of ACE inhibitors in snake venoms using at-line nanofractionation LC-MS.

scientific article published on 11 August 2017

Recent applications of chemometrics in one- and two-dimensional chromatography

scientific article published on 25 February 2020

Recent developments in coupled SPE-CE.

scientific article published on January 2010

Reducing the influence of geometry-induced gradient deformation in liquid chromatographic retention modelling

scientific article published on 13 November 2020

Self-Assembly of Cyclodextrins and Their Complexes in Aqueous Solutions.

scientific article published on 12 March 2016

Sensitivity enhancement in capillary electrophoresis-mass spectrometry of anionic metabolites using a triethylamine-containing background electrolyte and sheath liquid

scientific article published on 17 October 2011

The impact of guest compounds on cyclodextrin aggregation behavior: A series of structurally related parabens.

scientific article published on 10 July 2017

The trehalose 6-phosphate/SnRK1 signaling pathway primes growth recovery following relief of sink limitation

scientific article published on 4 June 2013

Thickness and morphology of polyelectrolyte coatings on silica surfaces before and after protein exposure studied by atomic force microscopy

scientific article published on 17 April 2013

Use of large-volume sample stacking in on-line solid-phase extraction-capillary electrophoresis for improved sensitivity

scientific article

Varespladib Inhibits the Phospholipase A2 and Coagulopathic Activities of Venom Components from Hemotoxic Snakes

scientific article published on 17 June 2020

Wheat grain development is characterized by remarkable trehalose 6-phosphate accumulation pregrain filling: tissue distribution and relationship to SNF1-related protein kinase1 activity.

scientific article published on 14 March 2011

Paulina is supported by:

About Paulina

Help