List of works - Makoto Kuro-o

A potential link between phosphate and aging--lessons from Klotho-deficient mice

scientific article

Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy ⬇️

scientific article published on September 2, 2010

Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction

scientific article

Association between circulating fibroblast growth factor 21 and mortality in end-stage renal disease

scientific article

BetaKlotho is required for metabolic activity of fibroblast growth factor 21

scientific article

Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease

scientific article

FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis

scientific article

FGF23 induces left ventricular hypertrophy

scientific article

Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism

scientific article

Improved protein arrays for quantitative systems analysis of the dynamics of signaling pathway interactions ⬇️

scientific article published on September 15, 2011

Interleukin-36α as a potential biomarker for renal tubular damage induced by dietary phosphate load

scientific article published on 19 March 2020

Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells

scientific article

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

scientific article

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice ⬇️

scientific article published on January 5, 2011

Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways

scientific article published on 9 October 2015

Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress

scientific article published on 30 October 2015

Klotho and aging

scientific article

Klotho and kidney disease ⬇️

scientific article published on November 1, 2010

Klotho and phosphate are modulators of pathologic uremic cardiac remodeling

scientific article

Klotho and the Aging Process ⬇️

scientific article published on June 1, 2011

Klotho deficiency causes vascular calcification in chronic kidney disease

scientific article

Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective ⬇️

scientific article published on September 22, 2010

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

scientific article

Life extension factor klotho enhances cognition

scientific article

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice

scientific article

Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System.

scientific article published on 21 May 2018

Molecular Regulation of Phosphate Metabolism by Fibroblast Growth Factor-23–Klotho System ⬇️

scientific article published on March 1, 2011

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

scientific article

Phosphate and Klotho

scientific article published on 23 February 2011

Pin1 null mice exhibit low bone mass and attenuation of BMP signaling

scientific article

Protective Roles of DMP1 in High Phosphate Homeostasis ⬇️

scientific article published on August 3, 2012

Regulation of fibroblast growth factor-23 signaling by klotho

scientific journal article

Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho

scientific article

Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

scientific article

Role of Klotho in aging, phosphate metabolism, and CKD.

scientific article

Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells

scientific article

Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate

scientific article published on 4 December 2014

Suppression of aging in mice by the hormone Klotho

scientific article

Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging

scientific article published on 30 November 2006

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging ⬇️

scientific article published on September 1, 2010

The FGF23 and Klotho system beyond mineral metabolism.

scientific article published on 12 November 2016

The Klotho gene family and the endocrine fibroblast growth factors

scientific article

The Urinary Phosphate to Serum Fibroblast Growth Factor 23 Ratio, Deemed the Nephron Index, Is a Useful Clinical Index for Early Stage Chronic Kidney Disease in Patients with Type 2 Diabetes: An Observational Pilot Study

scientific article published on 02 September 2018

The anti-aging protein Klotho affects early postnatal myogenesis by downregulating Jmjd3 and the canonical Wnt pathway

scientific article published on 01 March 2022

The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody

scientific article

The effect of lanthanum carbonate on calciprotein particles in hemodialysis patients

scientific article published on 26 December 2019

The parathyroid is a target organ for FGF23 in rats

scientific journal article

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

scientific article

Ultra‐short echo time (UTE) MR imaging of the lung: Comparison between normal and emphysematous lungs in mutant mice ⬇️

scientific article published on August 1, 2010

Urinary phosphate-containing nanoparticle contributes to inflammation and kidney injury in a salt-sensitive hypertension rat model

scientific article published on 15 October 2020

α-Klotho protects against oxidative damage in pulmonary epithelia

scientific article

αKlotho and vascular calcification: an evolving paradigm

scientific article

List of works by Makoto Kuro-o

A potential link between phosphate and aging--lessons from Klotho-deficient mice

Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy ⬇️

Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction

Association between circulating fibroblast growth factor 21 and mortality in end-stage renal disease

BetaKlotho is required for metabolic activity of fibroblast growth factor 21

Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease

FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis

FGF23 induces left ventricular hypertrophy

Fibroblast growth factor 23 and Klotho: physiology and pathophysiology of an endocrine network of mineral metabolism

Improved protein arrays for quantitative systems analysis of the dynamics of signaling pathway interactions ⬇️

Interleukin-36α as a potential biomarker for renal tubular damage induced by dietary phosphate load

Involvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice ⬇️

Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways

Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress

Klotho and aging

Klotho and kidney disease ⬇️

Klotho and phosphate are modulators of pathologic uremic cardiac remodeling

Klotho and the Aging Process ⬇️

Klotho deficiency causes vascular calcification in chronic kidney disease

Klotho deficiency is an early biomarker of renal ischemia–reperfusion injury and its replacement is protective ⬇️

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule

Life extension factor klotho enhances cognition

Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice

Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System.

Molecular Regulation of Phosphate Metabolism by Fibroblast Growth Factor-23–Klotho System ⬇️

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

Phosphate and Klotho

Pin1 null mice exhibit low bone mass and attenuation of BMP signaling

Protective Roles of DMP1 in High Phosphate Homeostasis ⬇️

Regulation of fibroblast growth factor-23 signaling by klotho

Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho

Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

Role of Klotho in aging, phosphate metabolism, and CKD.

Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells

Soluble Klotho Protects against Uremic Cardiomyopathy Independently of Fibroblast Growth Factor 23 and Phosphate

Suppression of aging in mice by the hormone Klotho

Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging ⬇️

The FGF23 and Klotho system beyond mineral metabolism.

The Klotho gene family and the endocrine fibroblast growth factors

The Urinary Phosphate to Serum Fibroblast Growth Factor 23 Ratio, Deemed the Nephron Index, Is a Useful Clinical Index for Early Stage Chronic Kidney Disease in Patients with Type 2 Diabetes: An Observational Pilot Study

The anti-aging protein Klotho affects early postnatal myogenesis by downregulating Jmjd3 and the canonical Wnt pathway

The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody

The effect of lanthanum carbonate on calciprotein particles in hemodialysis patients

The parathyroid is a target organ for FGF23 in rats

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

Ultra‐short echo time (UTE) MR imaging of the lung: Comparison between normal and emphysematous lungs in mutant mice ⬇️

Urinary phosphate-containing nanoparticle contributes to inflammation and kidney injury in a salt-sensitive hypertension rat model

α-Klotho protects against oxidative damage in pulmonary epithelia

αKlotho and vascular calcification: an evolving paradigm