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List of works by Alan S Verkman

3-(2-Benzyloxyphenyl)isoxazoles and isoxazolines: synthesis and evaluation as CFTR activators

scientific article published in August 2003

4,8-Dimethylcoumarin Inhibitors of Intestinal Anion Exchanger slc26a3 (Downregulated in Adenoma) for Anti-Absorptive Therapy of Constipation

scientific article published on 03 September 2019

A simple method to generate human airway epithelial organoids with externally orientated apical membranes

scientific article published in 2022

Aggregation state determines the localization and function of M1- and M23-aquaporin-4 in astrocytes

scientific article

Alpha-aminoazaheterocyclic-methylglyoxal adducts do not inhibit cystic fibrosis transmembrane conductance regulator chloride channel activity.

scientific article published on 13 February 2008

Altered channel gating mechanism for CFTR inhibition by a high-affinity thiazolidinone blocker

scientific article published on January 2004

Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia

scientific article

Antidiarrheal efficacy and cellular mechanisms of a Thai herbal remedy

scientific article (publication date: February 2014)

Aquaporin water channels in the nervous system.

scientific article published on 13 March 2013

Aquaporin-1 Expression in Herniated Human Lumbar Intervertebral Discs

scientific article

Aquaporin-3 mediates hydrogen peroxide-dependent responses to environmental stress in colonic epithelia

scientific article published on 03 January 2017

Aquaporin-4 and brain edema.

scientific article published on 9 March 2007

Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica.

scientific article

Aquaporins: important but elusive drug targets.

scientific article

Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain

scientific article published in September 2003

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity

scientific article published on 16 July 2019

CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds

scientific article published on 21 March 2003

CFTR chloride channel drug discovery--inhibitors as antidiarrheals and activators for therapy of cystic fibrosis

scientific article published on January 2006

CFTR inhibitors

scientific article

Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake

scientific article published on 27 August 2012

Chloride channels as drug targets

scientific article

Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G.

scientific article published on 20 October 2016

Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells

scientific article published on 2 September 2005

Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product

scientific article

Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging

scientific article

Discovery of glycine hydrazide pore-occluding CFTR inhibitors: mechanism, structure-activity analysis, and in vivo efficacy

scientific article

Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule

2005 scientific article

Drug discovery and epithelial physiology

scientific article published in September 2004

Evidence for direct CFTR inhibition by CFTR(inh)-172 based on Arg347 mutagenesis.

scientific article

Experimental animal models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders: progress and shortcomings

scientific article published on 21 October 2019

Experimental mouse model of optic neuritis with inflammatory demyelination produced by passive transfer of neuromyelitis optica-immunoglobulin G.

scientific article published on 27 January 2014

Function-Oriented Synthesis of a Didesmethyl Triazacryptand Analogue for Fluorescent Potassium Ion Sensing

scientific article published on March 2011

High-affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening

scientific article published on 2 August 2002

Hollow Micropillar Array Method for High-Capacity Drug Screening on Filter-Grown Epithelial Cells

scientific article published on 30 May 2018

Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry.

scientific article

Improved long-term outcome after transient cerebral ischemia in aquaporin-4 knockout mice

scientific article

Knock-out models reveal new aquaporin functions

scientific article published on January 2009

Lectin conjugates as potent, nonabsorbable CFTR inhibitors for reducing intestinal fluid secretion in cholera.

scientific article published on 7 February 2007

Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G.

scientific article published on 17 February 2017

Mechanism-based corrector combination restores ΔF508-CFTR folding and function

scientific article published on 12 May 2013

Mechanisms of Autoantibody-Induced Pathology.

scientific article

Microfluidics platform for measurement of volume changes in immobilized intestinal enteroids

scientific article published on March 2014

Mildly Reduced Brain Swelling and Improved Neurological Outcome in Aquaporin-4 Knockout Mice following Controlled Cortical Impact Brain Injury.

scientific article

Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG.

scientific article published on 19 March 2015

Nanomolar CFTR inhibition by pore-occluding divalent polyethylene glycol-malonic acid hydrazides

scientific article published in July 2008

Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases

scientific article

Phenylglycine and sulfonamide correctors of defective delta F508 and G551D cystic fibrosis transmembrane conductance regulator chloride-channel gating

scientific article

Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation

scientific article

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia

scientific article

Reduced PDZ interactions of rescued ΔF508CFTR increases its cell surface mobility.

scientific article

Salt-sparing diuretic action of a water-soluble urea analog inhibitor of urea transporters UT-A and UT-B in rats

scientific article published on 20 May 2015

Secretory diarrhoea: mechanisms and emerging therapies

scientific article published on 30 June 2015

Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening.

scientific article

Small-molecule inhibitors of urea transporters

scientific article

Solute and macromolecule diffusion in cellular aqueous compartments

scientific article

Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

scientific article published on July 2014

Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism.

scientific article

Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections

scientific article

Synthesis and evaluation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.

scientific article published on 22 January 2016

TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia

scientific article

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

scientific article

Tolerance checkpoint bypass permits emergence of pathogenic T cells to neuromyelitis optica autoantigen aquaporin-4.

scientific article published on 08 December 2016

Transient hyperckemia in the setting of neuromyelitis optica (NMO).

scientific article

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies

scientific article (publication date: September 2014)

Unimpaired osmotic water permeability and fluid secretion in bile duct epithelia of AQP1 null mice

scientific journal article

Urea transporter proteins as targets for small-molecule diuretics

scientific article published on 9 December 2014

ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter

scientific article published on 13 March 2018

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